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CA_C1048 CA_C1048 CA_C1054 CA_C1054 CA_C1063 CA_C1063 CA_C1064 CA_C1064 CA_C1067 CA_C1067 CA_C1094 CA_C1094 CA_C1192 CA_C1192 CA_C1197 CA_C1197 CA_C1218 CA_C1218 radc radc rpl21 rpl21 rpl27 rpl27 ispE ispE rpmE rpmE CA_C2876 CA_C2876 hpf hpf CA_C2843 CA_C2843 CA_C2801 CA_C2801 cysD-2 cysD-2 CA_C2775 CA_C2775 CA_C2767 CA_C2767 CA_C2762 CA_C2762 deaD deaD CA_C2738 CA_C2738 sbcD sbcD eutC eutC bcd bcd etfA-2 etfA-2 hbd hbd CA_C2707 CA_C2707 guaB guaB recQ recQ CA_C2684 CA_C2684 CA_C2682 CA_C2682 glnA glnA CA_C2623 CA_C2623 CA_C2585 CA_C2585 CA_C2576 CA_C2576 CA_C2553 CA_C2553 etfA etfA CA_C2540 CA_C2540 CA_C2526 CA_C2526 CA_C2514 CA_C2514 CA_C2481 CA_C2481 CA_C2476 CA_C2476 CA_C2468 CA_C2468 CA_C2453 CA_C2453 CA_C2412 CA_C2412 CA_C2402 CA_C2402 argC argC argB argB CA_C2371 CA_C2371 rpmL rpmL rplT rplT CA_C2336 CA_C2336 CA_C2334 CA_C2334 CA_C2310 CA_C2310 rpmH rpmH spoOJ-2 spoOJ-2 spoOJ spoOJ CA_C3728 CA_C3728 rpsF rpsF rpsR rpsR dnaC dnaC CA_C3642 CA_C3642 CA_C3636 CA_C3636 oppD oppD CA_C3624 CA_C3624 CA_C3588 CA_C3588 CA_C3587 CA_C3587 fabF fabF topB-2 topB-2 CA_C3538 CA_C3538 CA_C3514 CA_C3514 CA_C3508 CA_C3508 CA_C3503 CA_C3503 CA_C3498 CA_C3498 CA_C3459 CA_C3459 CA_C3454 CA_C3454 CA_C3441 CA_C3441 glvC glvC CA_C3412 CA_C3412 CA_C3396 CA_C3396 CA_C3376 CA_C3376 CA_C3355 CA_C3355 CA_C3314 CA_C3314 CA_C3303 CA_C3303 CA_C3290 CA_C3290 CA_C3289 CA_C3289 CA_C3288 CA_C3288 ada ada CA_C3256 CA_C3256 hbs hbs CA_C3206 CA_C3206 fhs fhs CA_C3199 CA_C3199 mcsB mcsB CA_C3183 CA_C3183 CA_C3182 CA_C3182 leuA leuA CA_C3166 CA_C3166 mrnC mrnC rpmG rpmG rplK rplK rplA rplA rplJ rplJ rplL rplL rpsL rpsL rpsG rpsG rpsJ rpsJ rplC rplC rplD rplD rplW rplW rplB rplB rpsS rpsS rplV rplV rpsC rpsC rplP rplP rpmC rpmC rpsQ rpsQ rplN rplN rplX rplX rplE rplE rpsN rpsN rpsH rpsH rplF rplF rplR rplR rpsE rpsE rpmD rpmD rplO rplO adk adk CA_C3110 CA_C3110 rpmJ rpmJ rpsM rpsM rpsK rpsK rpsD-3 rpsD-3 rplQ rplQ truA truA rplM rplM rpsI rpsI CA_C3083 CA_C3083 CA_C3027 CA_C3027 CA_C3013 CA_C3013 cshA cshA CA_C3006 CA_C3006 add add CA_C3002 CA_C3002 CA_C2996 CA_C2996 dtd dtd CA_C2992 CA_C2992 rnmV rnmV nifS-2 nifS-2 topB topB CA_C2938 CA_C2938 CA_C2935 CA_C2935 nifS nifS spsE spsE CA_C2166 CA_C2166 CA_C2137 CA_C2137 ychF ychF CA_C2116 CA_C2116 CA_C2080 CA_C2080 recN recN CA_C2055 CA_C2055 mmgB mmgB pksF pksF rpsA rpsA CA_C1934 CA_C1934 dnaL dnaL CA_C1897 CA_C1897 CA_C1858 CA_C1858 CA_C1809 CA_C1809 rpsO rpsO RibC RibC CA_C1804 CA_C1804 CA_C1801 CA_C1801 rpsB rpsB topA topA RbgA RbgA nadD-2 nadD-2 rplS rplS rpsP rpsP smc smc rpmF rpmF askA askA rpmB rpmB rpiA-2 rpiA-2 CA_C1697 CA_C1697 CA_C1680 CA_C1680 CA_C1676 CA_C1676 gltA gltA CA_C1672 CA_C1672 CA_C1671 CA_C1671 CA_C1661 CA_C1661 CA_C1654 CA_C1654 CA_C1633 CA_C1633 CA_C1632 CA_C1632 CA_C1631 CA_C1631 gyrB-2 gyrB-2 CA_C1625 CA_C1625 CA_C1621 CA_C1621 rpsD-2 rpsD-2 rnz rnz CA_C1559 CA_C1559 trxA trxA CA_C1537 CA_C1537 CA_C1517 CA_C1517 CA_C1492 CA_C1492 CA_C1489 CA_C1489 rpsD rpsD CA_C1436 CA_C1436 CA_C1407 CA_C1407 purD purD purF purF CA_C1353 CA_C1353 araD araD CA_C1330 CA_C1330 recO recO dnaG dnaG dgkA/pgpB dgkA/pgpB ybeY ybeY rpsU rpsU rpsT rpsT CA_C1269 CA_C1269 CA_C1265 CA_C1265 nadD nadD recF recF gyrB gyrB CA_C0014 CA_C0014 CA_C0026 CA_C0026 CA_C0033 CA_C0033 CA_C0045 CA_C0045 CA_C0087 CA_C0087 hemA hemA CA_C0102 CA_C0102 tadA tadA CA_C0126 CA_C0126 recR recR CA_C0145 CA_C0145 CA_C0148 CA_C0148 appD appD appF appF CA_C0184 CA_C0184 bioB bioB pheA pheA CA_C0221 CA_C0221 CA_C0225 CA_C0225 nifH nifH nifV nifV nifV-2 nifV-2 leuA-2 leuA-2 cobB-2 cobB-2 CA_C0295 CA_C0295 CA_C0318 CA_C0318 CA_C0326 CA_C0326 CA_C0327 CA_C0327 CA_C0339 CA_C0339 CA_C0364 CA_C0364 CA_C0372 CA_C0372 CA_C0376 CA_C0376 kdgK kdgK CA_C0412 CA_C0412 CA_C0416 CA_C0416 CA_C0423 CA_C0423 CA_C0424 CA_C0424 CA_C0482 CA_C0482 CA_C0532 CA_C0532 CA_C0556 CA_C0556 CA_C0570 CA_C0570 pdxS pdxS CA_C0606 CA_C0606 lisA lisA CA_C0650 CA_C0650 CA_C0672 CA_C0672 CA_C0683 CA_C0683 CA_C0684 CA_C0684 ntH ntH CA_C0731 CA_C0731 CA_C0754 CA_C0754 CA_C0784 CA_C0784 CA_C0786 CA_C0786 CA_C0787 CA_C0787 CA_C0796 CA_C0796 CA_C0841 CA_C0841 CA_C0907 CA_C0907 CA_C0908 CA_C0908 CA_C0921 CA_C0921 CA_C0925 CA_C0925 CA_C0926 CA_C0926 CA_C0954 CA_C0954 CA_C0962 CA_C0962 CA_C0970 CA_C0970 CA_C1014 CA_C1014
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CA_C1048Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily. (168 aa)
CA_C1054Arginase; Belongs to the arginase family. (299 aa)
CA_C1063TPR-repeat-containing protein. (359 aa)
CA_C1064TPR-repeat-containing protein. (254 aa)
CA_C1067TPR-repeat containing protein. (256 aa)
CA_C1094Cation efflux system protein; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (292 aa)
CA_C1192Phage replicative DNA helicase, YorI B.subtilis homolog. (489 aa)
CA_C1197Phage toprim domain containing protein, YorJ B.subtilis homolog. (348 aa)
CA_C1218Phage related protein, YorS B.subtilis homolog; Dephosphorylates nucleoside monophosphates such as the 5' and 2'(3')-phosphates of deoxyribonucleotides in vitro. Belongs to the 5'(3')-deoxyribonucleotidase family. (180 aa)
radcRadC protein ortholog; Belongs to the UPF0758 family. (229 aa)
rpl21Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
rpl27Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (100 aa)
ispEIsopentenyl monophosphate kinase, IPK; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (280 aa)
rpmE50S ribosomal protein L31; Binds the 23S rRNA. (70 aa)
CA_C2876Deoxycytidylate deaminase. (162 aa)
hpfRibosome-associated protein Y (PSrp-1); Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (174 aa)
CA_C2843Protein containing aminopeptidase domain (iap family). (449 aa)
CA_C2801TPR-repeat-containing protein, secreted. (273 aa)
cysD-2O-acetylhomoserine sulfhydrylase. (427 aa)
CA_C2775Phosphohydrolase from calcineurin family. (287 aa)
CA_C2767Uncharacterized conserved protein. (133 aa)
CA_C2762Polyferredoxin. (385 aa)
deaDATP dependent RNA helicase DeaD, superfamily II; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. (481 aa)
CA_C2738Uncharacterized conserved protein. (218 aa)
sbcDDNA repair exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (408 aa)
eutCEthanolamine ammonia lyase small subunit; Belongs to the EutC family. (242 aa)
bcdButyryl-CoA dehydrogenase; Belongs to the acyl-CoA dehydrogenase family. (379 aa)
etfA-2Electron transfer flavoprotein alpha-subunit; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). (336 aa)
hbdBeta-hydroxybutyryl-CoA dehydrogenase, NAD-dependent; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (282 aa)
CA_C27078-oxoguanine-DNA-glycosylase. (292 aa)
guaBIMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa)
recQRecQ protein, superfamily II DNA helicase. (714 aa)
CA_C2684Sugar kinase, ribokinase family. (329 aa)
CA_C2682Hypothetical protein. (69 aa)
glnAGlutamine synthetase type III. (696 aa)
CA_C2623Possible sensorory transduction protein, containing AAA ATPase domain, TPR repeats domain, GGDEF domain and GAF domain. (1787 aa)
CA_C25856-pyruvoyl-tetrahydropterin synthase related domain; conserved membrane protein. (153 aa)
CA_C25766-pyruvoyl-tetrahydropterin synthase related protein. (159 aa)
CA_C2553Uncharacterized mebrane protein, YOAS B.subtilis ortholog. (158 aa)
etfAElectron-transferring flavoprotein large subunit. (393 aa)
CA_C2540Co/Zn/Cd efflux system component. (303 aa)
CA_C25266-pyruvoyl-tetrahydropterin synthase related protein. (118 aa)
CA_C2514Beta galactosidase; Belongs to the glycosyl hydrolase 35 family. (982 aa)
CA_C2481Predicted kinase from adenilate kinase family, FLAR-like protein. (177 aa)
CA_C2476Uncharacterized protein, homolog of Spirochaeta aurantia (gi:152901). (114 aa)
CA_C2468Predicted acetyltransferase. (140 aa)
CA_C2453CBS domain containing protein. (243 aa)
CA_C2412Hypothetical protein. (320 aa)
CA_C2402TPR repeats containing protein. (119 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (345 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa)
CA_C2371S-adenosylmethionine-dependent methyltransferase. (252 aa)
rpmLRibosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (65 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa)
CA_C2336TPR repeats containing protein. (357 aa)
CA_C2334UDP-glucose 4-epimerase. (301 aa)
CA_C2310Methenyl tetrahydrofolate cyclohydrolase (serine cycle enzyme). (211 aa)
rpmHL34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
spoOJ-2Stage 0 sporulation J, ParB family of DNA-binding proteins; Belongs to the ParB family. (260 aa)
spoOJStage 0 sporulation J, ParB family of DNA-binding proteins; Belongs to the ParB family. (283 aa)
CA_C3728Hypothetical protein. (169 aa)
rpsFRibosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (95 aa)
rpsRRibosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (90 aa)
dnaCReplicative DNA helicase, DNAC; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (442 aa)
CA_C3642Oligopeptide ABC transporter, ATPase component; Belongs to the ABC transporter superfamily. (340 aa)
CA_C3636Oligopeptide ABC transporter, ATPase component; Belongs to the ABC transporter superfamily. (340 aa)
oppDOligopeptide ABC transporter, ATPase component; Belongs to the ABC transporter superfamily. (339 aa)
CA_C36246-pyruvoyl-tetrahydropterin synthase. (136 aa)
CA_C3588DNA replication protein DnaC. (329 aa)
CA_C3587DNA replication protein DnaD. (328 aa)
fabF3-oxoacyl-(acyl-carrier-protein) synthase I; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (411 aa)
topB-2Topoisomerase B. (709 aa)
CA_C3538Metallo-beta-lactamase superfamily hydrolase. (261 aa)
CA_C3514Reverse transcriptase/maturase family protein. (470 aa)
CA_C3508Predicted aminopeptidase. (392 aa)
CA_C3503Nucleoside-diphosphate-sugar epimerase. (342 aa)
CA_C3498Sugar kinase, ribokinase family. (295 aa)
CA_C3459Homolog of cell division GTPase FtsZ, diverged. (342 aa)
CA_C3454Predicted TIM-barrel enzyme, nifR3 family; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (311 aa)
CA_C3441DNA/RNA helicase, SNF2. (949 aa)
glvCPTS system, (possibly glucose-specific) IIBC component. (518 aa)
CA_C3412Predicted protein-S-isoprenylcysteine methyltransferase. (182 aa)
CA_C3396Nudix (MutT) family hydrolase, C4-type Zn-finger domain containing. (271 aa)
CA_C3376Possible pectin degradation protein (sugar phosphate isomerase family). (114 aa)
CA_C3355Polyketide synthase pksE (short-chain alcohol dehydrogenase,acyl-carrier-protein S-malonyltransferase,3-oxoacyl-(acyl-carrier-protein) synthase I domains). (1795 aa)
CA_C3314Nitroreductase family protein. (198 aa)
CA_C3303Superfamily II DNA/RNA helicases, SNF2 family. (1077 aa)
CA_C3290Iron-regulated ABC-type transporter membrane component (SufB). (366 aa)
CA_C3289Iron-regulated ABC-type transporter membrane component (SufB). (466 aa)
CA_C3288Iron-regulated ABC transporter ATPase subunit (SufC), VEG296 B.subtilis ortholog. (248 aa)
adaMethylated DNA-protein cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (155 aa)
CA_C3256Predicted acetyltransferase. (140 aa)
hbsDNA binding protein HU; Belongs to the bacterial histone-like protein family. (91 aa)
CA_C3206Ribosomal protein S1 domain family protein. (135 aa)
fhsFormate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. (556 aa)
CA_C3199NifR3 family enzyme; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (321 aa)
mcsBArginine kinase related enzyme, YACI B.subtilis ortholog; Catalyzes the specific phosphorylation of arginine residues in proteins; Belongs to the ATP:guanido phosphotransferase family. (340 aa)
CA_C3183Oligopeptide ABC transporter, ATPase component; Belongs to the ABC transporter superfamily. (323 aa)
CA_C3182Oligopeptide ABC transporter, ATPase component; Belongs to the ABC transporter superfamily. (324 aa)
leuA2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (547 aa)
CA_C3166Predicted DNA-binding protein; Belongs to the UPF0251 family. (143 aa)
mrnCUncharacterized conserved protein, YACZ B.subtilis ortholog; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (141 aa)
rpmGL33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa)
rplKRibosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa)
rplARibosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa)
rplJRibosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (168 aa)
rplLRibosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (123 aa)
rpsLRibosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (125 aa)
rpsGRibosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rpsJRibosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
rplCRibosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (209 aa)
rplDRibosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (206 aa)
rplWRibosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (98 aa)
rplBRibosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa)
rpsSRibosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (93 aa)
rplVRibosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (111 aa)
rpsCRibosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (222 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (147 aa)
rpmCRibosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (67 aa)
rpsQRibosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (84 aa)
rplNRibosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rplXRibosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (106 aa)
rplERibosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa)
rpsNRibosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rpsHRibosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rplFRibosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (179 aa)
rplRRibosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (117 aa)
rpsERibosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (165 aa)
rpmDRibosomal protein L30. (57 aa)
rplORibosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
CA_C3110Ribosomal protein L14E (archaeal/eukaryotic type). (92 aa)
rpmJRibosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa)
rpsMRibosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (123 aa)
rpsKRibosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (131 aa)
rpsD-3Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (206 aa)
rplQRibosomal protein L17. (114 aa)
truAPseudouridylate synthase, TRUA; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (244 aa)
rplMRibosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (144 aa)
rpsIRibosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (130 aa)
CA_C3083Thioredoxin; Belongs to the thioredoxin family. (105 aa)
CA_C3027Predicted phosphohydrolase. (392 aa)
CA_C3013Hypothetical protein. (242 aa)
cshAATP-dependent RNA helicase (superfamily II), YDBR B.subtilis ortholog; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (528 aa)
CA_C3006Zn-dependent peptidase, insulinase family. (976 aa)
addAdenosine deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (334 aa)
CA_C3002Uncharacterized consrved protein, YHJR B.subtilis family. (187 aa)
CA_C2996Superfamily II DNA/RNA helicase, SNF2 family. (1052 aa)
dtdUncharacterized protein YihZ family; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD [...] (149 aa)
CA_C2992Predicted short-chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (262 aa)
rnmVPrimase-like protein, containing TOPRIM domain, YABF B.subtilis ortholog; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (185 aa)
nifS-2Possible cysteine desulphurase from NifS family. (379 aa)
topBTopoisomerase B; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoi [...] (728 aa)
CA_C2938Hypothetical protein. (339 aa)
CA_C2935Predicted acetyltransferase. (156 aa)
nifSNifS family enzyme (cysteine desulfurase/cysteine sulfinate desulfinase). (376 aa)
spsESialic acid synthase. (350 aa)
CA_C2166Nucleoside-diphosphate-sugar epimerase. (332 aa)
CA_C2137Cation transport P-type ATPase. (845 aa)
ychFPredicted GTPase, YYAF B.subtilis ortholog; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (365 aa)
CA_C2116General stress protein, DnaK suppressor DskA, YTEA B.subtilis ortholog. (200 aa)
CA_C2080Predicted geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (289 aa)
recNDNA repair protein recN, ATPase; May be involved in recombinational repair of damaged DNA. (570 aa)
CA_C2055Predicted transcriptional regulator. (136 aa)
mmgB3-Hydroxyacyl-CoA dehydrogenase. (379 aa)
pksF3-oxoacyl-(acyl-carrier-protein) synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (406 aa)
rpsARibosomal protein S1. (276 aa)
CA_C1934Hypothetical protein. (279 aa)
dnaLDNA replication protein DnaC. (282 aa)
CA_C1897Phage-related, Zn finger domain containing protein. (103 aa)
CA_C1858MoxR-like ATPase. (377 aa)
CA_C1809Uncharacterized conserved protein, YLMC B.subtilis ortholog. (91 aa)
rpsORibosomal Protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (87 aa)
RibCRiboflavin kinase/FAD synthase; Belongs to the ribF family. (303 aa)
CA_C1804Exopolyphosphatase family protein. (321 aa)
CA_C1801Possibly nucleic acid binding protein similar to ribosomal protein HS6-type, YLXQ B.subtilis ortholog. (102 aa)
rpsBRibosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (233 aa)
topATopoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoi [...] (697 aa)
RbgAPredicted GTPase, YLQF B.subtilis ortholog; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (283 aa)
nadD-2Predicted nucleotidyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (201 aa)
rplSRibosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (114 aa)
rpsPRibosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (81 aa)
smcChromosome segregation SMC protein, ATPase; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1191 aa)
rpmFRibosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (60 aa)
askAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (401 aa)
rpmBRibosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (63 aa)
rpiA-2Primosomal protein N', superfamily II helicase; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (733 aa)
CA_C1697Uncharacterized conserved protein, YMXH B.subtilis homolog; Belongs to the YlmC/YmxH family. (87 aa)
CA_C1680Predicted endonuclease involved in recombination; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (135 aa)
CA_C1676Uncharacterized conserved protein. (170 aa)
gltALarge subunit of NADH-dependent glutamate synthase. (1507 aa)
CA_C1672Rad3-related DNA helicase. (791 aa)
CA_C1671Predicted ATPase related to the helicase subunit of the Holliday junction resolvase. (421 aa)
CA_C1661Predicted secreted nucleic acid binding protein. (113 aa)
CA_C1654Zn-dependent metalloprotease, insulinase family. (976 aa)
CA_C1633Protein from bacterioferritin family; Belongs to the Dps family. (236 aa)
CA_C1632Endonuclease IV. (272 aa)
CA_C1631Biotin synthase family enzyme. (350 aa)
gyrB-2DNA gyrase B subunit. (650 aa)
CA_C1625Phosphoserine phosphatase family protein. (219 aa)
CA_C1621Predicted Fe-S oxidoreductase. (308 aa)
rpsD-2Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (196 aa)
rnzMetal-dependent hydrolase of the beta-lactamase superfamily; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (313 aa)
CA_C1559Predicted transcriptional regulator. (118 aa)
trxAThioredoxin, trx; Belongs to the thioredoxin family. (105 aa)
CA_C1537Uncharacterized conserved protein. (260 aa)
CA_C1517Membrane associated sensory transduction histidine kinase. (349 aa)
CA_C1492Uncharacterized protein, YhhW/pirin family; Belongs to the pirin family. (337 aa)
CA_C1489Protein of phosphatidic acid phosphatase family, YNBD E.coli ortholog. (219 aa)
rpsDRibosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (192 aa)
CA_C1436Hypothetical protein. (2091 aa)
CA_C1407PTS system, beta-glucosides-specific IIABC component. (628 aa)
purDPhosphoribosylamine-glycine ligase. (416 aa)
purFGlutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (475 aa)
CA_C1353Phosphotransferase system IIC component, possibly N-acetylglucosamine-specific. (488 aa)
araDRibulose-5-phosphate 4-epimerase family protein. (233 aa)
CA_C1330Metal-dependent hydrolases of the beta-lactamase superfamily, possible sulfatase. (268 aa)
recOHypothetical protein; Involved in DNA repair and RecF pathway recombination. (218 aa)
dnaGDNA primase, DNAG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (596 aa)
dgkA/pgpBCiacylglycerol kinase/phosphatase B domain fusion protein. (232 aa)
ybeYUncharacterized conserved predicted metal-binding protein, YQFG ortholog; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (166 aa)
rpsURibosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (58 aa)
rpsTRibosomal protein S20; Binds directly to 16S ribosomal RNA. (88 aa)
CA_C1269Cation transport ATPase. (847 aa)
CA_C1265Translation initiation inhibitor, yabJ B.subtilis ortholog. (127 aa)
nadDPredicted nucleotidyltransferases of NarD/TagD family (N-term. domain), yqeJ ortholog; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (200 aa)
recFRecF, ABC family ATPase; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (363 aa)
gyrBDNA gyrase (topoisomerase II) B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-depen [...] (637 aa)
CA_C0014Aminotransferase. (356 aa)
CA_C0026Hypothetical protein. (204 aa)
CA_C0033ABC1 family protein kinase. (532 aa)
CA_C0045TPR-repeat-containing protein. (444 aa)
CA_C0087Predicted Co/Zn/Cd cation transporter; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (292 aa)
hemAGlutamil-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (396 aa)
CA_C0102O-acetylhomoserine sulfhydrylase. (409 aa)
tadACytosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (147 aa)
CA_C0126Uncharacterized conserved protein, YbaB family; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (112 aa)
recRRecombination protein (recR); May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa)
CA_C0145N-terminal Zn-ribbon domain and C-terminal MutT domain, YJAD ortholog. (174 aa)
CA_C0148Predicted enzyme with TIM-barrel fold. (228 aa)
appDOligopeptide transport ATP-binding protein; Belongs to the ABC transporter superfamily. (325 aa)
appFOligopeptide ABC transporter, ATP-binding protein; Belongs to the ABC transporter superfamily. (321 aa)
CA_C0184Predicted acetyltransferase. (320 aa)
bioBBiotine synthase (gene bioB); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (328 aa)
pheAPrephenate dehydrotase (pheA). (275 aa)
CA_C0221Aspartate aminotransferase. (377 aa)
CA_C0225Sensory transduction histidine kinase. (339 aa)
nifHNitrogenase iron protein (nitrogenase component II) gene nifH; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein. (272 aa)
nifVHomocitrate syntase, omega subunit nifV (nivO). (356 aa)
nifV-2Homocitrate synthase,alpha subunit nifV(nioA); Belongs to the alpha-IPM synthase/homocitrate synthase family. (265 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (558 aa)
cobB-2Transcriptional regulatory protein, Sir2 family; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (245 aa)
CA_C0295Metal-dependent amidohydrolases. (380 aa)
CA_C0318Membrane permease, predicted cation efflux pumps; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (392 aa)
CA_C0326ATPase related to the helicase subunit of Holliday junction resolvase. (443 aa)
CA_C0327Bacterioferritin comigratory protein (AHPC/TSA family). (151 aa)
CA_C0339ADP-ribosylglycohydrolase. (341 aa)
CA_C0364Metal-dependent hydrolases of the metallobeta-lactamase superfamily. (167 aa)
CA_C0372Sensory transduction histidine kinase (HisKA and HATPase damains). (334 aa)
CA_C0376N-dimethylarginine dimethylaminohydrolase (similar to ykgA B.subtilis). (293 aa)
kdgK2-keto-3-deoxygluconate kinase (gene kdgK). (315 aa)
CA_C0412TPR-repeat-containing protein. (378 aa)
CA_C0416TPR-repeat-containing protein. (376 aa)
CA_C0423Fusion: PTS system, beta-glucosides specific IIABC component. (627 aa)
CA_C0424Fructokinase; Belongs to the carbohydrate kinase PfkB family. (316 aa)
CA_C0482Zn-dependent hydrolases of the metallo-beta-lactamase superfamily. (211 aa)
CA_C0532PTS system, arbutin-like IIBC component. (531 aa)
CA_C0556Uncharacterised conserved protein. (252 aa)
CA_C0570PTS enzyme II, ABC component. (665 aa)
pdxSPredicted phosphate-utilizing enzyme involved in pyridoxine/purine/histidine biosynthesis; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (291 aa)
CA_C0606C-terminal region cation efflux system protein CZCD; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (403 aa)
lisADiaminopimelate decarboxilase, lisA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (431 aa)
CA_C0650Adenilate cyclase, class2 (thermophilic). (180 aa)
CA_C0672Fision threonyl-tRNA synthetase (N-terminal part) and uridine kinase. (553 aa)
CA_C0683Hypothetical protein. (129 aa)
CA_C0684CBS domains. (261 aa)
ntHPredicted endonuclease, gene nth; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa)
CA_C0731FUSION: Nucleoside-diphosphate-sugar epimerase and GAF domain. (725 aa)
CA_C0754Hypothetical protein. (449 aa)
CA_C0784ATP-dependent RNA helicase, superfamily II. (374 aa)
CA_C0786Uncharacterized conserved protein, repeats. (123 aa)
CA_C0787Uncharacterized conserved protein, repeats. (149 aa)
CA_C0796CDP-diglyceride synthetase. (195 aa)
CA_C0841Predicted transcriptional regulator. (179 aa)
CA_C0907Uncharacterized conserved protein YjbQ/UPF0047 family, ortholog yugU B.subtilis. (132 aa)
CA_C0908Dinucleotide-utilizing enzyme involved in molybdopterin and thiamine biosynthesis family 1. (251 aa)
CA_C0921Metal-dependent amidohydrolase. (382 aa)
CA_C0925TPR-repeat-containing protein. (346 aa)
CA_C0926TPR-repeat-containing protein. (119 aa)
CA_C0954Uncharacterized membrane protein. (328 aa)
CA_C0962UDP-N-acetylmuramyl tripeptide synthetase. (435 aa)
CA_C0970Isopropylmalate synthase. (448 aa)
CA_C1014IAA-like amino acid hydrolase. (396 aa)
Your Current Organism:
Clostridium acetobutylicum
NCBI taxonomy Id: 272562
Other names: C. acetobutylicum ATCC 824, Clostridium acetobutylicum ATCC 824, Clostridium acetobutylicum DSM 792, Clostridium acetobutylicum str. ATCC 824, Clostridium acetobutylicum strain ATCC 824
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