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| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (305 aa) |
| | CA_C0018 | Putative NADPH-quinone reductase, YabF family. (200 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (360 aa) |
| | psdD | Phosphatidylserine decarboxilase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (294 aa) |
| | serA-2 | D-3 phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa) |
| | hemA | Glutamil-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (396 aa) |
| | hemW | Precorrin-2 dehydrogenase. (215 aa) |
| | hemC | Hydroxymrthylbilane syntase (porphobilinogen deaminase); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (291 aa) |
| | hemD | Uroporphyrinogen III syntase. (490 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase. (422 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. (320 aa) |
| | cysD | Sulfate adenylate transferase, CysD subfamily. (266 aa) |
| | cysN | GTPase, sulfate adenylate transferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (522 aa) |
| | pheA | Prephenate dehydrotase (pheA). (275 aa) |
| | ldh1 | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (313 aa) |
| | leuA-2 | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (558 aa) |
| | CA_C0278 | Aspartate kinase; Belongs to the aspartokinase family. (437 aa) |
| | CA_C0291 | FUSION: methionine sintase I (cobalamin dependent) and 5,10 methylenetetrahydrofolate reductase. (596 aa) |
| | argF/I | Ornithine carbomoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (333 aa) |
| | CA_C0353 | 2,3-cyclic-nucleotide 2'phosphodiesterase (duplication). (1193 aa) |
| | patA | PLP-dependent aminotransferase (gene patA). (386 aa) |
| | CA_C0390 | Cystathionine gamma-synthase. (384 aa) |
| | CA_C0391 | Cystathionine beta-lyase. (377 aa) |
| | CA_C0418 | Predicted phosphatase, HAD family. (216 aa) |
| | CA_C0424 | Fructokinase; Belongs to the carbohydrate kinase PfkB family. (316 aa) |
| | sacA | Sucrase-6-phosphate hydrolase (gene sacA); Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. (490 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (155 aa) |
| | fabV | Protein of short-chain alcohol dehydrogenase family; Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of the carbon-carbon double bond of crotonyl-CoA to yield butyryl-CoA. (398 aa) |
| | pfk | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | pykA | Pyruvate kinase (pykA). (473 aa) |
| | asd-2 | Aspartate semialdehyde dehydrogenase (gene asd); Belongs to the aspartate-semialdehyde dehydrogenase family. (359 aa) |
| | metH | Cobalamine-dependent methionine synthase I (methyltransferase and cobalamine-binding domain); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1212 aa) |
| | ribD | Riboflavin biosynthesis protein RIBD (pirimidine deaminase and pirimidine reductase); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (383 aa) |
| | ribB | Riboflavin synthase alpha chain. (213 aa) |
| | ribA | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (401 aa) |
| | ribH | Riboflavin synthase beta-chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (155 aa) |
| | lisA | Diaminopimelate decarboxilase, lisA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (431 aa) |
| | CA_C0673 | L-serine dehydratase, beta chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (227 aa) |
| | CA_C0674 | L-serine dehydratase, alpha chain; Belongs to the iron-sulfur dependent L-serine dehydratase family. (290 aa) |
| | pssA | Phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (179 aa) |
| | cysE | Serine acetyltransferase. (186 aa) |
| | CA_C0688 | 1-acyl-sn-glycerol-3-phosphate acyltransferase. (239 aa) |
| | CA_C0697 | Galactose mutarotase related enzyme. (340 aa) |
| | gapC | Glyceraldehyde 3-phosphate dehydrogenase, gene gapC; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG; Belongs to the glyceraldehyde-3-phosphate de [...] (334 aa) |
| | pgk | 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (397 aa) |
| | tpi | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa) |
| | pgm | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase gene; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (431 aa) |
| | CA_C0726 | Ribose 5-phosphate isomerase RpiB. (156 aa) |
| | CA_C0764 | NADPH-dependent glutamate synthase beta chain. (411 aa) |
| | CA_C0797 | Phosphoenolpyruvate synthase. (839 aa) |
| | CA_C0798 | Phosphatidylserine synthase. (205 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (291 aa) |
| | ubiA | 4-hydroxybenzoate octaprenyltranferase related protein. (297 aa) |
| | CA_C0801 | Phosphoenolpyruvate synthase. (856 aa) |
| | CA_C0819 | Phosphoribosylpyrophosphate synthetase; Belongs to the ribose-phosphate pyrophosphokinase family. (371 aa) |
| | CA_C0827 | Fructose-bisphosphate aldolase. (287 aa) |
| | CA_C0857 | Glucan phosphorylase. (540 aa) |
| | xpt | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (189 aa) |
| | CA_C0892 | DAHP synthase related protein. (337 aa) |
| | CA_C0893 | Prephenate dehydrogenase. (286 aa) |
| | aroB | 3-dehydroquinate synthetase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (356 aa) |
| | aroA | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (356 aa) |
| | aro | Fusion: chorismate mutase and shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (367 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (165 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (144 aa) |
| | metB | Cystathionine gamma-synthase. (381 aa) |
| | CA_C0931 | Cysteine synthase. (303 aa) |
| | hisZ | Histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity). (407 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity); Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (215 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (197 aa) |
| | hisH | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (203 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase. (239 aa) |
| | hisF | Imidazoleglycerol-phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (253 aa) |
| | hisI_1 | Phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (115 aa) |
| | his_2 | Phosphoribosyl-ATP pyrophosphohydrolase. (110 aa) |
| | tkt | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (662 aa) |
| | CA_C0965 | 1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (241 aa) |
| | CA_C0970 | Isopropylmalate synthase. (448 aa) |
| | citB | Aconitase A. (642 aa) |
| | citC | Isocitrate dehydrogenase. (334 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (400 aa) |
| | argH | Argininosuccinate lyase. (437 aa) |
| | gltX | Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (485 aa) |
| | CA_C0998 | Homoserine dehydrogenase. (429 aa) |
| | thrC | Threonine synthase. (496 aa) |
| | CA_C1001 | Aspartate aminotransferase. (395 aa) |
| | CA_C1019 | Phospholipase C related protein. (245 aa) |
| | pykA-2 | Pyruvate kinase; Belongs to the pyruvate kinase family. (472 aa) |
| | CA_C1054 | Arginase; Belongs to the arginase family. (299 aa) |
| | CA_C1075 | Beta-glucosidase family protein. (665 aa) |
| | glpX | GlpX-like protein (Fructose-1,6-bisphosphatase related protein). (324 aa) |
| | pheB | Chorismate mutase PheB of B.subtilis ortholog; Belongs to the UPF0735 family. (155 aa) |
| | thrB | Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (296 aa) |
| | dgkA/pgpB | Ciacylglycerol kinase/phosphatase B domain fusion protein. (232 aa) |
| | glpA | Glycerol-3-phosphate dehydrogenase, GLPA. (475 aa) |
| | tal | Transaldolase, TAL; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa) |
| | CA_C1348 | Transketolase, TKT; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (663 aa) |
| | galM | Aldose-1-epimerase; Converts alpha-aldose to the beta-anomer. (345 aa) |
| | purE | Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (159 aa) |
| | purC | Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (235 aa) |
| | purF | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (475 aa) |
| | purM | Phosphoribosylaminoimidazol (AIR) synthetase. (332 aa) |
| | PurN | Folate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (204 aa) |
| | purH | AICAR transformylase/IMP cyclohydrolase. (499 aa) |
| | purD | Phosphoribosylamine-glycine ligase. (416 aa) |
| | rpiA | Ribose 5-phosphate isomerase. (227 aa) |
| | CA_C1432 | Undecaprenyl pyrophosphate synthase related enzyme. (213 aa) |
| | ilvE | Branched-chain-amino-acid transaminase (ilvE). (341 aa) |
| | CA_C1523 | Fructokinase. (288 aa) |
| | fbp | Fructose-1,6-bisphosphatase (YYDE B.subtils ortholog). (665 aa) |
| | purQ/purL | Phosphoribosylformylglycinamidine (FGAM) synthase; Bifunctional enzyme; synthetase domain/glutamine amidotransferase domain. (1255 aa) |
| | glgP | Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (812 aa) |
| | gltA | Large subunit of NADH-dependent glutamate synthase. (1507 aa) |
| | gltB | Small subunit of NADPH-dependent glutamate synthase. (479 aa) |
| | gpsA | Glycerol 3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa) |
| | ansA | L-asparaginase. (331 aa) |
| | CA_C1715 | PLP-dependent aminotransferase. (384 aa) |
| | CA_C1730 | Pentose-5-phosphate-3-epimerase, YLOR B.subtilis ortholog; Belongs to the ribulose-phosphate 3-epimerase family. (216 aa) |
| | plsX | Fatty acid/phospholipid biosynthesis enzyme; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (331 aa) |
| | acpA | Acyl carrier protein, ACP; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (77 aa) |
| | uppS | Undecaprenyl pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (257 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (385 aa) |
| | gcpE | GcpE protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (349 aa) |
| | RibC | Riboflavin kinase/FAD synthase; Belongs to the ribF family. (303 aa) |
| | dapG | Aspartokinase; Belongs to the aspartokinase family. (399 aa) |
| | aspB | Aspartate Aminotransferase. (398 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (476 aa) |
| | metB-2 | Homoserine trans-succinylase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (301 aa) |
| | miaA | TRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (309 aa) |
| | lytB/rpsA | Penicillin tolerance LytB domain/S1 ribosomal protein fusion; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. In the N-terminal section; belongs to the IspH family. (642 aa) |
| | deoD | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (271 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (619 aa) |
| | CA_C2080 | Predicted geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family. (289 aa) |
| | CA_C2226 | Enzyme of ILVE/PABC family (branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase). (280 aa) |
| | CA_C2229 | Pyruvate:ferredoxin oxidoreductase. (1171 aa) |
| | cysK | Cysteine synthase/cystathionine beta-synthase, CysK. (309 aa) |
| | glgC | ADP-glucose pyrophosphorylase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (380 aa) |
| | glgC-2 | ADP-glucose pyrophosphorylase. (372 aa) |
| | glgA | Glycogen synthase, glgA; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (477 aa) |
| | asnB | N-terminal domain of asparagine synthase. (397 aa) |
| | CA_C2249 | C-terminal domain of asparagine synthase. (246 aa) |
| | CA_C2250 | UDP-glucose pyrophosphorylase. (287 aa) |
| | glyA | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (411 aa) |
| | CA_C2315 | DTDP-4-dehydrorhamnose reductase, rfbD ortholog; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (280 aa) |
| | CA_C2325 | Possible cell wall hydrolase containing N-acetylglucosaminidase domain and ChW-repeats. (765 aa) |
| | CA_C2331 | DTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (185 aa) |
| | spsJ | DTDP-D-glucose 4,6-dehydratase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (351 aa) |
| | spsI | DTDP-glucose pyrophosphorylase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (288 aa) |
| | CA_C2335 | UTP-glucose-1-phosphate uridylyltransferase. (303 aa) |
| | CA_C2337 | Phosphomannomutase. (575 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (250 aa) |
| | argD | N-acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (387 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (345 aa) |
| | argJ | Ornithine acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (408 aa) |
| | CA_C2414 | Uncharacterized conserved protein, related to alpha-amylase/alpha-mannosidase; Belongs to the glycosyl hydrolase 57 family. (527 aa) |
| | CA_C2445 | AICAR transformylase domain of PurH-like protein. (391 aa) |
| | CA_C2458 | 2-oxoacid ferredoxin oxidoreductase, beta subunit. (284 aa) |
| | CA_C2459 | 2-oxoacid:ferredoxin oxidoreductase, alpha subunit. (558 aa) |
| | CA_C2496 | Predicted phosphatase of HAD hydrolase superfamily. (208 aa) |
| | CA_C2499 | Pyruvate ferredoxin oxidoreductase. (1173 aa) |
| | plsY | Uncharacterized conserved membrane protein, YgiH/UPF0078 family; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (198 aa) |
| | CA_C2542 | FAD/FMN-containing dehydrogenase. (467 aa) |
| | glcK | Transcriptional regulators of NagC/XylR family. (313 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (333 aa) |
| | fabG | Possible 3-ketoacyl-acyl carrier protein reductase. (248 aa) |
| | CA_C2679 | Pullulanase; Belongs to the glycosyl hydrolase 13 family. (720 aa) |
| | pgi | Glucose-6-phosphate isomerase. (450 aa) |
| | guaB | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (485 aa) |
| | bcd | Butyryl-CoA dehydrogenase; Belongs to the acyl-CoA dehydrogenase family. (379 aa) |
| | hisK | Predicted PHP family hydrolase; Belongs to the PHP hydrolase family. HisK subfamily. (255 aa) |
| | gpmA | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (243 aa) |
| | CA_C2795 | MoaA/NirJ family Fe-S oxidoreductase. (335 aa) |
| | CA_C2796 | MoaA/NirJ family Fe-S oxidoreductase. (394 aa) |
| | CA_C2832 | PLP-dependent aminotransferase. (393 aa) |
| | CA_C2834 | Uncharacterized conserved protein, YHAD family; Belongs to the glycerate kinase type-1 family. (380 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (391 aa) |
| | thlA | Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | CA_C2880 | Ribose 5-phosphate isomerase, RpiB. (152 aa) |
| | CA_C2891 | Fusion of alpha-glucosidase (family 31 glycosyl hydrolase) and glycosidase (TreA/MalS family). (1157 aa) |
| | ispE | Isopentenyl monophosphate kinase, IPK; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (280 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (276 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa) |
| | panD | Aspartate 1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (127 aa) |
| | pmi | Mannose-6 phospate isomelase. (326 aa) |
| | CA_C2937 | Ketopantoate reductase PanE/ApbA; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (307 aa) |
| | CA_C2945 | Possible phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa) |
| | CA_C2968 | Mannose-1-phosphate guanylyltransferase. (356 aa) |
| | PatB | PLP-dependent aminotransferase. (384 aa) |
| | CA_C2981 | Mannose-1-phosphate guanyltransferase (pyrophosphorylase domain and phosphomannomutase domain). (815 aa) |
| | argJ2 | Ornithine acetyltransferase/N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (388 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (352 aa) |
| | CA_C3058 | Mannose-1-phosphate guanylyltransferase. (350 aa) |
| | CA_C3072 | Mannose-1-phosphate guanylyltransferase. (350 aa) |
| | CA_C3090 | Fumarate hydratase, subunit B (C-terminal domain of FumA E.coli) class I. (187 aa) |
| | CA_C3091 | Fumarate hydratase, subunit A (N-terminal domain of FumA E.coli) class I. (282 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa) |
| | trpF | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. (205 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (262 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (331 aa) |
| | pabA | Para-aminobenzoate synthase component II. (195 aa) |
| | parB | Para-aminobenzoate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high co [...] (475 aa) |
| | ilvB | Acetolactate synthase large subunit. (554 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (552 aa) |
| | leuB | Isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (357 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuC | 3-Isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (422 aa) |
| | leuA | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (547 aa) |
| | ilvN | Acetolactate synthase, small subunit. (165 aa) |
| | ispD | 4-diphosphocytidyl-2-methylerithritol synthase (Sugar Nucleotide Phosphorylase family); Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (229 aa) |
| | hprT | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | prs | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (319 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (270 aa) |
| | proB | ProB; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (267 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (418 aa) |
| | CA_C3313 | Acyl carrier protein, ACP. (75 aa) |
| | MmuM | Possible homocysteine S-methyltransferase. (314 aa) |
| | CA_C3375 | Alcohol dehydrogenase. (377 aa) |
| | CA_C3420 | Low specificity L-threonine aldolase. (344 aa) |
| | fabG-2 | 3-oxoacyl-acyl carrier protein reductase. (262 aa) |
| | ldh2 | Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (320 aa) |
| | accA | Acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (274 aa) |
| | accD | Acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (285 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa) |
| | accB | Biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (159 aa) |
| | fabG-3 | 3-ketoacyl-acyl carrier protein reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase. (308 aa) |
| | acp | Acyl Carrier Protein, ACP; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (76 aa) |
| | dapA-2 | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (286 aa) |
| | ilvD-2 | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. (572 aa) |
| | alsS | Acetolactate synthase; Belongs to the TPP enzyme family. (563 aa) |
