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| | pyrB | Aspartate carbamoyltransferase (Aspartate transcarbamylase) (ATCase); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa) |
| | pyrK | Dihydroorotate dehydrogenase electron transfer subunit. (230 aa) |
| | pyrD | Dihydroorotate dehydrogenase catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (300 aa) |
| | pyrE | Orotate phosphoribosyltransferase (OPRT) (OPRTase); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (194 aa) |
| | guaA | Fragment of conserved hypothetical protein,DUF111 family; Catalyzes the synthesis of GMP from XMP. (511 aa) |
| | CAJ67020.1 | Putative membrane-associated nucleotidase; Belongs to the 5'-nucleotidase family. (463 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (232 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (455 aa) |
| | purG | Phosphoribosylformylglycinamidine cyclo-ligase; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (358 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa) |
| | purH | Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase]. (510 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (416 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase. (1268 aa) |
| | PurC1 | Putative phosphoribosylaminoimidazole-succinocarboxamide synthetase; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (226 aa) |
| | ThrS_udk | Putative uridine kinase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. (555 aa) |
| | CAJ67401.1 | Putative lipoprotein. (334 aa) |
| | CAJ67402.1 | Putative lipoprotein. (370 aa) |
| | fhs | Formate--tetrahydrofolate ligase (Formyltetrahydrofolate synthetase) (FHS) (FTHFS). (558 aa) |
| | fchA | Methenyltetrahydrofolate cyclohydrolase (5,10-methenyltetrahydrofolate 5-hydrolase). (210 aa) |
| | folD | Bifunctional protein folD [Includes: Methylenetetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651; Belongs to the methylenetetrahydrofolate reductase family. (293 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | PurH | 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. (391 aa) |
| | pupG | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (270 aa) |
| | pdp | Pyrimidine-nucleoside phosphorylase; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (446 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa) |
| | pyrC | Dihydroorotase (DHOase); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (421 aa) |
| | NfnA | Ferredoxin--NADP(+) reductase subunit alpha. (297 aa) |
| | aspB1 | Putative glutamate synthase. (464 aa) |
| | gcvTPA | Bi-functional glycine dehydrogenase/aminomethyl transferase protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. N-terminal subunit subfamily. (824 aa) |
| | gcvPB | Glycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (485 aa) |
| | ppnP | Uncharacterised protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (105 aa) |
| | guaD | Guanine deaminase (Guanase) (Guanine aminase) (Guanine aminohydrolase) (GAH). (423 aa) |
| | add | Adenosine deaminase (Adenosine aminohydrolase); Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (329 aa) |
| | ade | Adenine deaminase. (551 aa) |
| | pbuX | Putative xanthine permease. (452 aa) |
| | pyrD1 | Dihydroorotate dehydrogenase, catalytic subunit. (361 aa) |
| | CAJ68968.1 | D-hydantoinase (Dihydropyrimidinase). (456 aa) |
| | CAJ68975.1 | Putative xanthine/uracile permease. (453 aa) |
| | CAJ68976.2 | Putative xanthine/uracil permease. (449 aa) |
| | PbuG | Xanthine/uracil/thiamine/ascorbate permease family protein. (458 aa) |
| | xpt | Xanthine phosphoribosyltransferase (XPRTase); Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa) |
| | guaB | Inositol-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Experimentally verified as part of mature spore proteome PMID:19542279. (499 aa) |
| | cdd | Cytidine deaminase (Cytidine aminohydrolase) (CDA); This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (133 aa) |
| | CAJ69424.1 | Putative membrane-associated 5'-nucleotidase/phosphoesterase; Belongs to the 5'-nucleotidase family. (613 aa) |
| | uraA | ABC-type transport system, uracil-specific permease. (403 aa) |
| | pyrR | Bifunctional protein PyrR [Includes: Pyrimidine operon regulatory protein; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (177 aa) |
| | hpt | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (175 aa) |
| | AdeP | Putative permease. (447 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa) |
| | apt | Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (170 aa) |
| | glyA1 | Serine hydroxymethyltransferase (Serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | CAJ70075.1 | D-hydantoinase (Dihydropyrimidinase). (463 aa) |
| | pyrD2 | Dihydroorotate dehydrogenase, catalytic subunit. (369 aa) |
| | CAJ70077.1 | Putative purine permease. (450 aa) |
| | hpt1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa) |
| | upp | Uracil phosphoribosyltransferase (UMP pyrophosphorylase) (UPRTase); Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (209 aa) |
| | carB1 | Carbamoyl-phosphate synthase large chain 1; Belongs to the CarB family. (1068 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the CarA family. (349 aa) |
| | carB2 | Carbamoyl-phosphate synthase large chain 2; Belongs to the CarB family. (1068 aa) |
| | carA1 | Carbamoyl-phosphate synthase small chain; Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the CarA family. (347 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (238 aa) |
| | MetH | Putative homocysteine S-methyltransferase. (793 aa) |
| | purA | Adenylosuccinate synthetase (IMP--aspartate ligase) (AdSS) (AMPSase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
