STRINGSTRING
sigH sigH CAJ66979.1 CAJ66979.1 CAJ67408.1 CAJ67408.1 CAJ67442.1 CAJ67442.1 CAJ67443.1 CAJ67443.1 CAJ67488.1 CAJ67488.1 cdu2 cdu2 cdu1 cdu1 tcdR tcdR tcdB tcdB tcdE tcdE CCA62809.1 CCA62809.1 tcdA tcdA tcdC tcdC CAJ67610.1 CAJ67610.1 ccpA ccpA rgbR rgbR codY codY CD630_14380 CD630_14380 CAJ68304.1 CAJ68304.1 CAJ68305.1 CAJ68305.1 CD630_17430 CD630_17430 CAJ68611.1 CAJ68611.1 CAJ68612.1 CAJ68612.1 SinR SinR CAJ69100.1 CAJ69100.1 CAJ69101.1 CAJ69101.1 CAJ69491.1 CAJ69491.1 CAJ69492.1 CAJ69492.1 cdtR cdtR agrB agrB CAJ69726.1 CAJ69726.1 CAJ69727.1 CAJ69727.1 rgaR rgaR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sigHRNA polymerase factor sigma-70. (220 aa)
CAJ66979.1Two-component response regulator. (237 aa)
CAJ67408.1Two-component sensor histidine kinase. (446 aa)
CAJ67442.1Two-component sensor histidine kinase. (445 aa)
CAJ67443.1Two-component response regulator. (236 aa)
CAJ67488.1Chloride ion channel protein. (406 aa)
cdu2Na(+)/H(+) antiporter. (397 aa)
cdu1Transcriptional regulator, beta-lactams repressor. (126 aa)
tcdRAlternative RNA polymerase sigma factors. (184 aa)
tcdBToxin B. (2366 aa)
tcdEHolin-like pore-forming protein. (166 aa)
CCA62809.1Conserved hypothetical protein. (43 aa)
tcdAExperimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (2710 aa)
tcdCNegative regulator of toxin gene expression. (232 aa)
CAJ67610.1Transcriptional regulator, LacI family. (338 aa)
ccpATranscriptional regulator, LacI family; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651 .Experimentally verified as part of mature spore proteome PMID:19542279. (338 aa)
rgbRTwo-component response regulator VirR-like. (237 aa)
codYTranscriptional regulator, GTP-sensing pleiotropic repressor codY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (261 aa)
CD630_14380Fragment of transcriptional regulator,sigma-54-dependent. (452 aa)
CAJ68304.1Putative transporter, LrgA family. (123 aa)
CAJ68305.1Putative transporter, LrgB family. (229 aa)
CD630_17430Two-component response regulator; Fragment of selenoprotein B,glycine/betaine/sarcosine/D-proline reductase family (sarcosine reductase). (235 aa)
CAJ68611.1Two-component sensor histidine kinase. (452 aa)
CAJ68612.1Conserved hypothetical protein. (144 aa)
SinRTranscriptional regulator, HTH-type; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (112 aa)
CAJ69100.1Transcriptional regulator, HTH-type; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (105 aa)
CAJ69101.1Uncharacterised protein; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. (225 aa)
CAJ69491.1Two-component response regulator. (256 aa)
CAJ69492.1Two-component sensor histidine kinase. (400 aa)
cdtRClostridium difficile binary toxin regulatory gene, LytTR family. (248 aa)
agrBAccessory gene regulator. (192 aa)
CAJ69726.1Two-component response regulator. (232 aa)
CAJ69727.1Two-component sensor histidine kinase. (501 aa)
rgaRTwo-component response regulator VirR-like. (236 aa)
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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