STRINGSTRING
CAJ67024.1 CAJ67024.1 pcrA pcrA CAJ67283.1 CAJ67283.1 CAJ67284.1 CAJ67284.1 nfo nfo nth nth mutS2 mutS2 CAJ67583.1 CAJ67583.1 dinB dinB sbcD sbcD sbcC sbcC polA polA recA recA exoA exoA CAJ68296.1 CAJ68296.1 recQ recQ mutL mutL mutS mutS CAJ68961.1 CAJ68961.1 CAJ69030.1 CAJ69030.1 CAJ69064.1 CAJ69064.1 CAJ69289.1 CAJ69289.1 ung ung CAJ69835.2 CAJ69835.2 CAJ70059.1 CAJ70059.1 CAJ70092.1 CAJ70092.1 CAJ70114.1 CAJ70114.1 ligA ligA MitS MitS uvrC uvrC uvrA uvrA uvrB uvrB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CAJ67024.1Putative UvrABC system protein A 1 (UvrA protein 1) (Excinuclease ABC subunit A 1); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (1142 aa)
pcrADNA helicase, UvrD/REP type. (754 aa)
CAJ67283.1Putative helicase, UvrD family. (704 aa)
CAJ67284.1ABC-type transport system, ATP-binding protein. (747 aa)
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (278 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (201 aa)
mutS2DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (792 aa)
CAJ67583.1Putative DNA helicase, UvrD/REP type. (688 aa)
dinBDNA polymerase IV (Pol IV); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (365 aa)
sbcDNuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (403 aa)
sbcCNuclease SbcCD subunit C. (1175 aa)
polADNA polymerase I (POLI); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (882 aa)
recAProtein RecA (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (348 aa)
exoAExodeoxyribonuclease. (250 aa)
CAJ68296.1Putative helicase, DinG family. (1039 aa)
recQATP-dependent DNA helicase. (827 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (655 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (947 aa)
CAJ68961.1Conserved hypothetical protein. (363 aa)
CAJ69030.1DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (636 aa)
CAJ69064.1Putative DEAD-like helicase. (1062 aa)
CAJ69289.1DNA topoisomerase type IA. (742 aa)
ungUracil-DNA glycosylase (UDG); Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (224 aa)
CAJ69835.2Putative phage essential recombination function protein. (196 aa)
CAJ70059.1Conserved hypothetical protein. (163 aa)
CAJ70092.1Putative UvrABC system protein A 2 (UvrA protein 2) (Excinuclease ABC subunit A 2). (806 aa)
CAJ70114.1ABC-type transport system, ATP-binding protein. (746 aa)
ligADNA ligase (Polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (674 aa)
MitSPutative DNA mismatch repair ATPase MutS. (598 aa)
uvrCExcinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (605 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (941 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (656 aa)
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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