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| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (161 aa) |
| | dacA | Conserved hypothetical protein, CHP00159 family; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (279 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (142 aa) |
| | hpdB | Putative 4-hydroxyphenylacetate decarboxylase,catalytic subunit HpdB; Decarboxylates phenylacetates with a hydroxyl group in the p- position. Active toward 4-hydroxyphenylacetate, 3,4- dihydroxyphenylacetate and p-hydroxymandelate, forming 4-methylphenol, 4-methylcatechol and p-hydroxybenzylalcohol respectively (By similarity); Belongs to the glycyl radical enzyme (GRE) family. HPAD subfamily. (902 aa) |
| | hpdC | Putative 4-hydroxyphenylacetate decarboxylase,regulatory subunit HpdC; Decarboxylates phenylacetates with a hydroxyl group in the p- position. Active toward 4-hydroxyphenylacetate, 3,4- dihydroxyphenylacetate and p-hydroxymandelate, forming 4-methylphenol, 4-methylcatechol and p-hydroxybenzylalcohol respectively (By similarity). (85 aa) |
| | splB | Spore photoproduct (thymine dimer) lyase,radical S-adenosylmethionine superfamily; Experimentally verified as part of mature spore proteome PMID:19542279. (340 aa) |
| | hadI | Activator of 2-hydroxyisocaproyl-CoA dehydratase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (266 aa) |
| | hadB | Subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase B; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (408 aa) |
| | hadC | Subunit of oxygen-sensitive 2-hydroxyisocaproyl-CoA dehydratase C; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (375 aa) |
| | fba | Fructose-1,6-bisphosphate aldolase; Experimentally verified as part of mature spore proteome PMID:19542279. (308 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (201 aa) |
| | CD630_06790 | Fragment of conserved hypothetical protein (C-terminal region). (335 aa) |
| | CAJ67513.1 | Snoal-like polyketide cyclase. (475 aa) |
| | plfB | Formate acetyltransferase (Pyruvate formate-lyase); Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (743 aa) |
| | CAJ67623.2 | Conserved hypothetical protein. (225 aa) |
| | acnB | Aconitate hydratase (Citrate hydro-lyase). (641 aa) |
| | nnrD | Putative carbohydrate kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of [...] (526 aa) |
| | speH | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (137 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | CAJ67843.1 | Putative nucleotide/oligonucleotide binding protein; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (157 aa) |
| | fumA | Fumarate hydratase class I, subunit A. (279 aa) |
| | fumB | Fumarate hydratase class I, subunit B. (182 aa) |
| | pflD | Formate acetyltransferase (Pyruvate formate-lyase). (790 aa) |
| | gloA | Lactoylglutathione lyase. (123 aa) |
| | mgsA | Methylglyoxal synthase (MGS); Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate. (137 aa) |
| | mltG | Putative aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. Belongs to the transglycosylase MltG family. (359 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa) |
| | pabA | Para-aminobenzoate/anthranilate synthase glutamine amidotransferase component II [Includes: Para-aminobenzoate synthase glutamine amidotransferase component II; Anthranilate synthase component II]. (194 aa) |
| | pabC | Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase) (ADC lyase) (ADCL). (247 aa) |
| | folB | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (121 aa) |
| | folK | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridinepyrophosphokinase. (168 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase. (261 aa) |
| | CAJ68350.1 | Conserved hypothetical protein. (198 aa) |
| | deoC | Deoxyribose-phosphate aldolase (Phosphodeoxyriboaldolase) (Deoxyriboaldolase) (DERA); Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (219 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (192 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | ribBA | Riboflavin biosynthesis protein ribBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (397 aa) |
| | thiC | Thiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (433 aa) |
| | moaA | Molybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (319 aa) |
| | moaC | Molybdenum cofactor biosynthesis protein MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family. (156 aa) |
| | hemE | Uroporphyrinogen decarboxylase (URO-D); Belongs to the uroporphyrinogen decarboxylase family. (340 aa) |
| | YjiM | Putative 2-hydroxyacyl-CoA dehydratase. (383 aa) |
| | YjiL | Putative CoA enzyme activase. (251 aa) |
| | CAJ68678.1 | Pyridoxal-dependent decarboxylase, group IV decarboxylase family. (403 aa) |
| | aroF1 | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. (337 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (354 aa) |
| | aroC | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (359 aa) |
| | eutA | Ethanolamine reactivating factor for ammonia lyase eutBC. (477 aa) |
| | eutB | Ethanolamine ammonia lyase large subunit. (454 aa) |
| | eutC | Ethanolamine ammonia lyase small subunit; Belongs to the EutC family. (293 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (551 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa) |
| | dpaL | Diaminopropionate ammonia-lyase. (404 aa) |
| | Tal1 | Putative transaldolase C-like; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (224 aa) |
| | thrC | Threonine synthase. (493 aa) |
| | cynT | Carbonic anhydrase. (188 aa) |
| | aroD | Dehydroquinate dehydratase (3-dehydroquinate dehydratase) (Dehydroquinase) (DHQase); Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of Lys-170 at the active site. (255 aa) |
| | nanA | Acetylneuraminate lyase; Catalyzes the reversible aldol cleavage of N-acetylneuraminic acid (sialic acid; Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate. (293 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa) |
| | argH | Argininosuccinate lyase (Arginosuccinase) (ASAL). (438 aa) |
| | tdcB | Threonine dehydratase II; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (405 aa) |
| | coaBC | Coenzyme A biosynthesis bifunctional protein CoaBC; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa) |
| | ltaE | Low specificity L-threonine aldolase. (344 aa) |
| | CAJ69707.1 | Putative amino acid racemase. (370 aa) |
| | uxaA | Putative N-terminus region of carbohydrate hydrolase, SAF domain. (91 aa) |
| | uxaA-2 | D-galactate dehydratase/Altronate hydrolase. (387 aa) |
| | dapA1 | Dihydrodipicolinate synthase 1; Belongs to the DapA family. (297 aa) |
| | uxaA-3 | D-galactate dehydratase/Altronate hydrolase. (386 aa) |
| | SuyA | Putative N-terminus region of carbohydrate hydrolase, SAF domain. (101 aa) |
| | murQ | N-acetylmuramic acid 6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. (304 aa) |
| | GatY1 | Tagatose-bisphosphate aldolase. (289 aa) |
| | GatY2 | Putative fructose-1-6-bisphosphate aldolase. (292 aa) |
| | CAJ70035.1 | Putative ThiJ/pfpI family protein. (209 aa) |
| | CAJ70064.1 | Conserved hypothetical protein. (132 aa) |
| | eno | Enolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | dpaL1 | Diaminopropionate ammonia-lyase. (404 aa) |
| | sdaB | L-serine dehydratase; Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the iron-sulfur dependent L-serine dehydratase family. (397 aa) |
| | dapA2 | Dihydrodipicolinate synthase 2; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | dapA3 | Dihydrodipicolinate synthase 3; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | CAJ70130.1 | Conserved hypothetical protein, UPF0597 family; Belongs to the UPF0597 family. (427 aa) |
| | pflD-2 | Pyruvate formate-lyase. (789 aa) |
| | sirC | Precorrin-2 dehydrogenase. (192 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. (321 aa) |
| | cobA | Bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase. (499 aa) |
| | cbiK | Sirohydrochlorin cobaltochelatase. (492 aa) |
| | cbiB | Cobalamin biosynthesis protein CbiB, CobD/CbiB family; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (323 aa) |
| | KbaY | Putative ketose-bisphophate aldolase class II; putative tagatose-bisphosphate aldolase GatY. (283 aa) |
| | phnJ | Putative phosphonate metabolism protein. (289 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (238 aa) |
| | luxS | S-ribosylhomocysteine lyase (Autoinducer-2 production protein luxS) (AI-2 synthesis protein); Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (151 aa) |
| | CAJ70533.1 | Putative 4-hydroxy-2-oxoglutarate aldolase. (210 aa) |
| | dapA4 | Dihydrodipicolinate synthase 4 (DHDPS); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa) |
| | CAJ70549.1 | Conserved hypothetical protein. (246 aa) |
