STRINGSTRING
mutS2 mutS2 clpC clpC recD2 recD2 fliI fliI htpG htpG CAJ67135.1 CAJ67135.1 CAJ67144.1 CAJ67144.1 pcrA pcrA CAJ67283.1 CAJ67283.1 CAJ67284.1 CAJ67284.1 CAJ67423.1 CAJ67423.1 CAJ67457.1 CAJ67457.1 ftsH ftsH CAJ67583.1 CAJ67583.1 oppF oppF CAJ67878.1 CAJ67878.1 CAJ67879.1 CAJ67879.1 addB addB addA addA minD minD smc smc CAJ68132.2 CAJ68132.2 CAJ68188.1 CAJ68188.1 kdpB kdpB CAJ68502.1 CAJ68502.1 CAJ68524.1 CAJ68524.1 Mrp Mrp EcsC EcsC CAJ68694.1 CAJ68694.1 ftsH1 ftsH1 CAJ68740.1 CAJ68740.1 mutL mutL CD630_20080 CD630_20080 clpB clpB CAJ68961.1 CAJ68961.1 CAJ68979.2 CAJ68979.2 CAJ69000.1 CAJ69000.1 CAJ69030.1 CAJ69030.1 CAJ69135.1 CAJ69135.1 CAJ69389.1 CAJ69389.1 recG recG spoIVA spoIVA ychF ychF ruvB ruvB ruvA ruvA CAJ69721.1 CAJ69721.1 CAJ69932.1 CAJ69932.1 CAJ70092.1 CAJ70092.1 CAJ70114.1 CAJ70114.1 prdD prdD lon lon clpX clpX mgtA mgtA mgtA1 mgtA1 uvrA uvrA uvrB uvrB ftsH2 ftsH2 dnaC dnaC soj soj
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mutS2DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (792 aa)
clpCClass III stress response-related ATPase, AAA+ superfamily; Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the ClpA/ClpB family. (815 aa)
recD2Putative DNA helicase, RecD/TraA type; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (739 aa)
fliIATP synthase subunit beta FliI; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (439 aa)
htpGHeat shock protein 90 (Heat shock protein HtpG)(High temperature protein G); Experimentally verified as part of mature spore proteome PMID:19542279. (645 aa)
CAJ67135.1Putative K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporting P-type ATPase. (795 aa)
CAJ67144.1Putative ATPase. (301 aa)
pcrADNA helicase, UvrD/REP type. (754 aa)
CAJ67283.1Putative helicase, UvrD family. (704 aa)
CAJ67284.1ABC-type transport system, ATP-binding protein. (747 aa)
CAJ67423.1Putative ATPase, P-type, heavy metal translocating. (699 aa)
CAJ67457.1Putative replicative helicase DnaB-like. (433 aa)
ftsHPutative ATP-dependent peptidase, M41 family; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (467 aa)
CAJ67583.1Putative DNA helicase, UvrD/REP type. (688 aa)
oppFFragment of transcriptional regulator,sigma-54-dependent. (209 aa)
CAJ67878.1Conserved hypothetical protein. (637 aa)
CAJ67879.1Putative helicase, superfamily 1, UvrD-family. (739 aa)
addBATP-dependent nuclease subunit B (ATP-dependent helicase addB), Superfamily 1 UvrD-family; The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation; this subunit has 5' -> 3' nuclease activity. (1155 aa)
addAATP-dependent nuclease subunit A (ATP-dependent helicase addA); The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities; Belongs to the helicase family. AddA subfamily. (1275 aa)
minDSeptum site-determining protein MinD (Cell division inhibitor MinD). (265 aa)
smcStructural maintenance chromosome protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1184 aa)
CAJ68132.2Putative replication-associated recombination protein a rara. (421 aa)
CAJ68188.1Putative DNA helicase, UvrD/REP type. (593 aa)
kdpBPotassium-transporting ATPase B chain; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (685 aa)
CAJ68502.1Putative calcium-transporting ATPase. (919 aa)
CAJ68524.1Cation-transporting ATPase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (785 aa)
MrpPutative ATP-binding protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (270 aa)
EcsCConserved hypothetical protein. (246 aa)
CAJ68694.1P-type calcium transport ATPase. (885 aa)
ftsH1Cell division protease FtsH1; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (605 aa)
CAJ68740.1Putative conjugative transposon protein tn1549-like, CTn5-Orf25. (355 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (655 aa)
CD630_20080Fragment of conserved hypothetical protein (N-terminal region). (298 aa)
clpBChaperone protein; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (864 aa)
CAJ68961.1Conserved hypothetical protein. (363 aa)
CAJ68979.2Putative restriction enzyme. (644 aa)
CAJ69000.1Putative copper-transporting P-type ATPase. (833 aa)
CAJ69030.1DNA mismatch repair protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity. Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (636 aa)
CAJ69135.1Putative ATPase; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (273 aa)
CAJ69389.1Putative cation-transporting P-type ATPase. (879 aa)
recGATP-dependent DNA helicase RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (686 aa)
spoIVAStage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat and is required for proper coat localization to the forespore. (491 aa)
ychFPutative GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (365 aa)
ruvBHolliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (339 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (200 aa)
CAJ69721.1Putative calcium-transporting ATPase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. (924 aa)
CAJ69932.1Putative ATPase. (376 aa)
CAJ70092.1Putative UvrABC system protein A 2 (UvrA protein 2) (Excinuclease ABC subunit A 2). (806 aa)
CAJ70114.1ABC-type transport system, ATP-binding protein. (746 aa)
prdDProline reductase PrdD. (252 aa)
lonATP-dependent protease La, S16 peptidase family; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (787 aa)
clpXATP-dependent Clp protease ATP-binding subunit clpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (416 aa)
mgtAMagnesium-transporting ATPase, P-type 1; Tn916-like, CTn7-Orf7. (921 aa)
mgtA1Magnesium-transporting ATPase, P-type 1; Tn916-like, CTn7-Orf12. (887 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (941 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (656 aa)
ftsH2Cell division protease FtsH2; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (664 aa)
dnaCReplicative DNA helicase, dnaC; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (442 aa)
sojTranscriptional regulator, sporulation initiation inhibitor, chromosome partitioning protein. (257 aa)
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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