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rpoB rpoB gyrB gyrB cwp11 cwp11 slpA slpA vanS vanS vanR vanR recA recA int1 int1 cwp25 cwp25 tcdC tcdC tcdE tcdE tcdB tcdB tcdR tcdR tndX tndX tetM tetM blaR blaR xis xis int int fliC fliC fliD fliD groL groL rpoA rpoA adk adk rpoC rpoC gyrA gyrA secA2 secA2 cwp84 cwp84 cwp66 cwp66 cme cme tpi tpi cwp2 cwp2 uppP2 uppP2 glyA1 glyA1 agrB agrB agrD agrD glyA glyA cdtR cdtR fbpA fbpA CAJ69406.1 CAJ69406.1 dxr dxr ermB ermB terD1 terD1 terD terD sodA sodA vanTG vanTG vanY vanY
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1238 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (633 aa)
cwp11Cell wall binding protein cwp11; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (533 aa)
slpAPrecursor of the S-layer proteins; Experimentally verified as part of mature spore proteome PMID:19542279. (719 aa)
vanSTwo-component sensor histidine kinase. (380 aa)
vanRTwo-component response regulator. (233 aa)
recAProtein RecA (Recombinase A); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (348 aa)
int1Fragment of two-component sensor histidine kinase (N-terminal region); Conjugative transposon 4. Carry lantibiotic resistance genes. Most of its conjugative functions are shared with Tn1549-like conjugative transposons (C. difficile ConTn2 and ConTn5). It also share regulatory functions (Orf7, 8 and 9) with Tn916-like conjugative transposons (C. difficile ConTn1, 3(Tn5397), 6 and 7; Belongs to the 'phage' integrase family. (397 aa)
cwp25Putative cell wall-binding protein cwp25. (313 aa)
tcdCNegative regulator of toxin gene expression. (232 aa)
tcdEHolin-like pore-forming protein. (166 aa)
tcdBToxin B. (2366 aa)
tcdRAlternative RNA polymerase sigma factors. (184 aa)
tndXRecombinase site-specific resolvase family Tn5397, CTn3-Orf3. (533 aa)
tetMTetracycline resistance protein Tn5397. (639 aa)
blaRBeta-lactamase-inducing penicillin-binding protein. (599 aa)
xisExcisionase Tn916-like, CTn1-Orf2. (67 aa)
intIntegrase Tn916-like, CTn1-Orf1; Belongs to the 'phage' integrase family. (396 aa)
fliCFlagellin C; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (290 aa)
fliDFlagellar hook-associated protein 2 FliD (or HAP2); Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (507 aa)
groL60 kDa chaperonin (Protein Cpn60) (GroEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (542 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (315 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1161 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (808 aa)
secA2Protein translocase subunit secA 2; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (781 aa)
cwp84Cell surface protein cwp84. (803 aa)
cwp66Cell surface protein cwp66. (610 aa)
cmeMultidrug resistance protein Cme; Transporter,Major Facilitator Superfamily (MFS). (416 aa)
tpiTriosephosphate isomerase (TIM) (Triose-phosphate isomerase); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (247 aa)
cwp2Cell wall binding protein cwp2; Experimentally verified as part of mature spore proteome PMID:19542279. (623 aa)
uppP2Undecaprenyl-diphosphatase 2; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (284 aa)
glyA1Serine hydroxymethyltransferase (Serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
agrBAccessory gene regulator. (192 aa)
agrDAutoinducer prepeptide. (48 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa)
cdtRClostridium difficile binary toxin regulatory gene, LytTR family. (248 aa)
fbpAFibronectin-binding protein A. (591 aa)
CAJ69406.1Integrase; Belongs to the 'phage' integrase family. (372 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (384 aa)
ermBRibosomal RNA adenine N-6-methyltransferase (erythromycin resistance protein); Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (245 aa)
terD1Tellurium resistance protein terD1. (192 aa)
terDTellurium resistance protein terD. (192 aa)
sodASpore coat protein-superoxide dismutase (Mn); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (234 aa)
vanTGAlanine racemase 1; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (712 aa)
vanYD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein). (268 aa)
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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