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carB2 carB2 pyrF pyrF purA purA etfB1 etfB1 etfA1 etfA1 PurC1 PurC1 tcdB tcdB tcdA tcdA PurH PurH etfB3 etfB3 etfA3 etfA3 purB purB thiE thiE aroF1 aroF1 nadC nadC nadA nadA atpE atpE carB1 carB1 pyrB pyrB pyrD pyrD purC purC purF purF purG purG purH purH purD purD purL purL fliM fliM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
carB2Carbamoyl-phosphate synthase large chain 2; Belongs to the CarB family. (1068 aa)
pyrFOrotidine 5'-phosphate decarboxylase (OMP decarboxylase) (OMPDCase) (OMPdecase); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (238 aa)
purAAdenylosuccinate synthetase (IMP--aspartate ligase) (AdSS) (AMPSase); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
etfB1Beta-subunit of electron transfer flavoprotein; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (261 aa)
etfA1Alpha-subunit of electron transfer flavoprotein; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (345 aa)
PurC1Putative phosphoribosylaminoimidazole-succinocarboxamide synthetase; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (226 aa)
tcdBToxin B. (2366 aa)
tcdAExperimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (2710 aa)
PurH5-aminoimidazole-4-carboxamide ribonucleotide transformylase. (391 aa)
etfB3Electron transfer flavoproteins subunit beta; Function experimentally characterised PMID:23772070. Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (260 aa)
etfA3Electron transfer flavoprotein subunit alpha; Function experimentally characterised PMID:23772070. Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant .Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (336 aa)
purBAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (210 aa)
aroF13-deoxy-D-arabino-heptulosonate 7-phosphate synthase. (337 aa)
nadCNicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (270 aa)
nadAQuinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa)
atpEV-type ATP synthase subunit E (V-type ATPase subunit E); Produces ATP from ADP in the presence of a proton gradient across the membrane. (187 aa)
carB1Carbamoyl-phosphate synthase large chain 1; Belongs to the CarB family. (1068 aa)
pyrBAspartate carbamoyltransferase (Aspartate transcarbamylase) (ATCase); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (306 aa)
pyrDDihydroorotate dehydrogenase catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. (300 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (232 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (455 aa)
purGPhosphoribosylformylglycinamidine cyclo-ligase; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (358 aa)
purHBifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase]. (510 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (416 aa)
purLPhosphoribosylformylglycinamidine synthase. (1268 aa)
fliMFlagellar motor switch protein FliM. (293 aa)
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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