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sdaB sdaB cdtR cdtR cwp84 cwp84 cwp66 cwp66 tcdE tcdE tcdB tcdB fliC fliC fliD fliD gyrA gyrA tcdR tcdR tcdC tcdC spo0A spo0A codY codY ermB ermB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
sdaBL-serine dehydratase; Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the iron-sulfur dependent L-serine dehydratase family. (397 aa)
cdtRClostridium difficile binary toxin regulatory gene, LytTR family. (248 aa)
cwp84Cell surface protein cwp84. (803 aa)
cwp66Cell surface protein cwp66. (610 aa)
tcdEHolin-like pore-forming protein. (166 aa)
tcdBToxin B. (2366 aa)
fliCFlagellin C; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (290 aa)
fliDFlagellar hook-associated protein 2 FliD (or HAP2); Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (507 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (808 aa)
tcdRAlternative RNA polymerase sigma factors. (184 aa)
tcdCNegative regulator of toxin gene expression. (232 aa)
spo0AStage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. (274 aa)
codYTranscriptional regulator, GTP-sensing pleiotropic repressor codY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (261 aa)
ermBRibosomal RNA adenine N-6-methyltransferase (erythromycin resistance protein); Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (245 aa)
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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