STRINGSTRING
cspC cspC gyrB gyrB gyrA gyrA rpoB rpoB bclA1 bclA1 xis xis tcdR tcdR tcdB tcdB tcdE tcdE tcdC tcdC cdd2 cdd2 cspA cspA xis1 xis1 sigK sigK cotB cotB pdcA pdcA CAJ68736.2 CAJ68736.2 ermB ermB SinR SinR cspBA cspBA cdtR cdtR treR treR alr2 alr2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cspCSubtilisin-like serine germination related protease; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (557 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (633 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (808 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1238 aa)
bclA1Putative exosporium glycoprotein; Experimentally verified as part of mature spore proteome PMID:19542279. (693 aa)
xisExcisionase Tn916-like, CTn1-Orf2. (67 aa)
tcdRAlternative RNA polymerase sigma factors. (184 aa)
tcdBToxin B. (2366 aa)
tcdEHolin-like pore-forming protein. (166 aa)
tcdCNegative regulator of toxin gene expression. (232 aa)
cdd2ABC-type transport system,lantibiotic/multidrug-family permease. (245 aa)
cspACold shock protein. (66 aa)
xis1Excisionase Tn1549-like, CTn4-Orf33. (67 aa)
sigKSigma K; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (219 aa)
cotBSpore coat protein; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (304 aa)
pdcADiguanylate kinase signaling protein; PMID:22522894. (697 aa)
CAJ68736.2Putative DNA/RNA helicase Tn1549-like,CTn5-Orf21. (2993 aa)
ermBRibosomal RNA adenine N-6-methyltransferase (erythromycin resistance protein); Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (245 aa)
SinRTranscriptional regulator, HTH-type; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (112 aa)
cspBASubtilisin-like serine germination related protease; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (1132 aa)
cdtRClostridium difficile binary toxin regulatory gene, LytTR family. (248 aa)
treRTranscriptional regulator, GntR family. (240 aa)
alr2Alanine racemase 2; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (385 aa)
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.