STRINGSTRING
murA murA tcdR tcdR gluD gluD slpA slpA cwp84 cwp84 codY codY ccpA ccpA tcdC tcdC tcdA tcdA tcdB tcdB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (423 aa)
tcdRAlternative RNA polymerase sigma factors. (184 aa)
gluDNAD-specific glutamate dehydrogenase; Previously characterized in Clostridium difficile as NAD-specific glutamate dehydrogenase GluD (SWALL:P27346).Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (421 aa)
slpAPrecursor of the S-layer proteins; Experimentally verified as part of mature spore proteome PMID:19542279. (719 aa)
cwp84Cell surface protein cwp84. (803 aa)
codYTranscriptional regulator, GTP-sensing pleiotropic repressor codY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (261 aa)
ccpATranscriptional regulator, LacI family; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651 .Experimentally verified as part of mature spore proteome PMID:19542279. (338 aa)
tcdCNegative regulator of toxin gene expression. (232 aa)
tcdAExperimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (2710 aa)
tcdBToxin B. (2366 aa)
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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