STRINGSTRING
murA murA DacF1 DacF1 CAJ67615.1 CAJ67615.1 CAJ68001.1 CAJ68001.1 CAJ68083.1 CAJ68083.1 dacF dacF uppP1 uppP1 ddl ddl vanY vanY uppS uppS dacF1 dacF1 VanY2 VanY2 murG murG murD murD mraY mraY murF murF spoVD spoVD murE murE uppS1 uppS1 uppP2 uppP2 murB murB murC murC VanY3 VanY3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (423 aa)
DacF1D-alanyl-D-alanine carboxypeptidase, S11 peptidase family; Belongs to the peptidase S11 family. (409 aa)
CAJ67615.1Putative penicillin-binding protein; Experimentally verified as part of mature spore proteome PMID:19542279. (897 aa)
CAJ68001.1Putative penicillin-binding protein with a N-terminal TonB-box; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (992 aa)
CAJ68083.1Putative peptidoglycan glycosyltransferase. (554 aa)
dacFD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein); Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the peptidase S11 family. (387 aa)
uppP1Undecaprenyl-diphosphatase 1; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (274 aa)
ddlD-alanine--D-alanine ligase (D-alanylalanine synthetase) (D-Ala-D-Ala ligase); Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (299 aa)
vanYD-alanyl-D-alanine carboxypeptidase (penicillin-binding protein). (268 aa)
uppSUndecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (244 aa)
dacF1D-alanyl-D-alanine carboxypeptidase (putative sporulation-specific penicillin-binding protein); Belongs to the peptidase S11 family. (429 aa)
VanY2Putative D-alanyl-D-alanine carboxypeptidase. (215 aa)
murGUndecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (409 aa)
murDUDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (451 aa)
mraYPhospho-N-acetylmuramoyl-pentapeptide- transferase (UDP-MurNAc-pentapeptide phosphotransferase); First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (322 aa)
murFUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (457 aa)
spoVDStage V sporulation protein D (Sporulation-specific penicillin-binding protein); Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. (659 aa)
murEUDP-N-acetylmuramyl-tripeptide synthetase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (484 aa)
uppS1Putative undecaprenyl pyrophosphate synthetase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. (214 aa)
uppP2Undecaprenyl-diphosphatase 2; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (284 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (304 aa)
murCUDP-N-acetylmuramate--L-alanine ligase (UDP-N-acetylmuramoyl-L-alanine synthetase); Cell wall formation; Belongs to the MurCDEF family. (450 aa)
VanY3D-alanyl-D-alanine carboxypeptidase, M15 family (DD-peptidase) (DD-carboxypeptidase). (238 aa)
Your Current Organism:
Clostridioides difficile
NCBI taxonomy Id: 272563
Other names: C. difficile 630, Clostridioides difficile 630, Clostridium difficile 630, Clostridium difficile 630 (epidemic type X), Clostridium difficile str. 630, Clostridium difficile strain 630, Peptoclostridium difficile 630
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