Your Input: | |
| | acoC | Acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase). (348 aa) |
| | acoL | Acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase). (576 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (237 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (161 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (216 aa) |
| | aspC | Aspartate aminotransferase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (394 aa) |
| | VorC1 | Putative 4Fe-4S ferredoxin, iron-sulfur binding domain protein, delta subunit; Experimentally verified as part of mature spore proteome PMID:19542279. (71 aa) |
| | VorB1 | Putative ferredoxin/flavodoxin oxidoreductase,alpha subunit. (359 aa) |
| | VorA1 | Putative ferredoxin/flavodoxin oxidoreductase,beta subunit. (250 aa) |
| | VorA'1 | Putative ferredoxin/flavodoxin oxidoreductase,gamma subunit; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (185 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (397 aa) |
| | CAJ67010.1 | Putative ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (308 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (158 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (232 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (455 aa) |
| | purG | Phosphoribosylformylglycinamidine cyclo-ligase; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (358 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa) |
| | purH | Bifunctional purine biosynthesis protein purH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase; IMP cyclohydrolase]. (510 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (416 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase. (1268 aa) |
| | CAJ67062.1 | Flagella glycosylation phosphoserine phosphatase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (200 aa) |
| | argE | Acetylornithine deacetylase ArgE; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (420 aa) |
| | adhE | Aldehyde-alcohol dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (880 aa) |
| | asnB | Asparagine synthetase [glutamine-hydrolyzing]. (527 aa) |
| | fba | Fructose-1,6-bisphosphate aldolase; Experimentally verified as part of mature spore proteome PMID:19542279. (308 aa) |
| | orr | Ornithine racemase. (354 aa) |
| | CAJ67296.1 | Oligo-1,6-glucosidase (Sucrase-isomaltase). (554 aa) |
| | PurC1 | Putative phosphoribosylaminoimidazole-succinocarboxamide synthetase; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (226 aa) |
| | ArcB | Putative ornithine cyclodeaminase. (329 aa) |
| | LpdA | Bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase, dihydrolipoyl dehydrogenase subunit. (461 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (125 aa) |
| | hisK | Histidinol-phosphatase (HolPase); Belongs to the PHP hydrolase family. HisK subfamily. (259 aa) |
| | CAJ67631.1 | Putative pyruvate carboxyltransferase. (298 aa) |
| | FloX | Putative flavodoxin/nitric oxide synthase; Experimentally verified as part of mature spore proteome PMID:19542279. (162 aa) |
| | acnB | Aconitate hydratase (Citrate hydro-lyase). (641 aa) |
| | icd | Isocitrate dehydrogenase NAD-dependent; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (331 aa) |
| | PurH | 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. (391 aa) |
| | glgC | Glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (386 aa) |
| | glgD | Glycogen biosynthesis protein; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. (376 aa) |
| | glgA | Glycogen synthase (Starch [bacterial glycogen] synthase); Synthesizes alpha-1,4-glucan chains using ADP-glucose. (480 aa) |
| | glgP | Glycogen phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (813 aa) |
| | AmyB | Putative alpha-amylase; Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (621 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (580 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (163 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (356 aa) |
| | serA | Putative D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (313 aa) |
| | fumA | Fumarate hydratase class I, subunit A. (279 aa) |
| | fumB | Fumarate hydratase class I, subunit B. (182 aa) |
| | bcd2 | Butyryl-CoA dehydrogenase; Function experimentally characterised PMID:23772070. Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (378 aa) |
| | thlA1 | Acetoacetyl-CoA thiolase 1; Function experimentally characterised PMID:23772070. Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | acpP | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (75 aa) |
| | CAJ67913.1 | Putative histidinol phosphatase/hydrolase, PHP family; Belongs to the PHP hydrolase family. HisK subfamily. (264 aa) |
| | hom1 | Homoserine dehydrogenase. (401 aa) |
| | CAJ68026.1 | Putative FAD-linked oxidase. (463 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (340 aa) |
| | fabD | Malonyl CoA-acyl carrier protein transacylase (MCT). (316 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier protein] reductase (3-ketoacyl-acyl carrier protein reductase); Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa) |
| | acpP1 | Acyl carrier protein (ACP); Carrier of the growing fatty acid chain in fatty acid biosynthesis. (74 aa) |
| | fbp | Fructose-1,6-bisphosphatase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651. (661 aa) |
| | ispA | Geranyltranstransferase; Belongs to the FPP/GGPP synthase family. (295 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (621 aa) |
| | pupG | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (270 aa) |
| | CAJ68119.1 | Putative FMN-dependent dehydrogenase. (338 aa) |
| | ribC | Riboflavin biosynthesis protein; Belongs to the ribF family. (309 aa) |
| | dapG | Aspartokinase 1 (Aspartokinase I) (1spartate kinase I); Belongs to the aspartokinase family. (407 aa) |
| | purB | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa) |
| | aspB | Aspartate aminotransferase (AspAT) (Transaminase A); Experimentally verified as part of mature spore proteome PMID:19542279. (398 aa) |
| | aroF | Phospho-2-dehydro-3-deoxyheptonate aldolase. (261 aa) |
| | wrbA | Putative flavodoxin protein. (191 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | panC | Pantothenate synthetase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (282 aa) |
| | panB | Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (275 aa) |
| | aspB1 | Putative glutamate synthase. (464 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit. (314 aa) |
| | hisG | ATP phosphoribosyltransferase (ATP-PRTase) (ATP-PRT); Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (208 aa) |
| | hisC | Histidinol-phosphate aminotransferase (Imidazole acetol-phosphate transaminase); Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (349 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (192 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (240 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (252 aa) |
| | hisI | Histidine biosynthesis bifunctional protein HisIE [Includes: Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphatase]; In the N-terminal section; belongs to the PRA-CH family. (222 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (329 aa) |
| | ilvB | Acetolactate synthase large subunit. (564 aa) |
| | pgm | Alpha-phosphoglucomutase. (565 aa) |
| | hom2 | Homoserine dehydrogenase. (405 aa) |
| | cysK | O-acetyl-serine thiol-lyase A (O-acetyl-sulfhydrylase)(OAS-TL); Experimentally verified as part of mature spore proteome PMID:19542279. (302 aa) |
| | cysE | Serine acetyltransferase (SAT); Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. (196 aa) |
| | asnB1 | Asparagine synthetase. (624 aa) |
| | gcvTPA | Bi-functional glycine dehydrogenase/aminomethyl transferase protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. N-terminal subunit subfamily. (824 aa) |
| | gcvPB | Glycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (485 aa) |
| | ppnP | Uncharacterised protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (105 aa) |
| | cysM | O-acetylserine (thiol)-lyase (O-acetylserine sulfhydrylase) (OAS-TL). (320 aa) |
| | CAJ68546.1 | Putative flavodoxin. (159 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (153 aa) |
| | ribBA | Riboflavin biosynthesis protein ribBA [Includes: 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (397 aa) |
| | ribE | Riboflavin synthase alpha subunit. (221 aa) |
| | ribD | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (370 aa) |
| | PlsC1 | Putative acyltransferase. (254 aa) |
| | hemE | Uroporphyrinogen decarboxylase (URO-D); Belongs to the uroporphyrinogen decarboxylase family. (340 aa) |
| | gapB | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH); Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: up-regulated in Spo0A mutant PMID:24568651; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (338 aa) |
| | argG | Argininosuccinate synthase (Citrulline--aspartate ligase); Belongs to the argininosuccinate synthase family. Type 1 subfamily. (399 aa) |
| | scrB | Sucrose-6-phosphate hydrolase (Sucrase) (Invertase); Enables the bacterium to metabolize sucrose as a sole carbon source; Belongs to the glycosyl hydrolase 32 family. (493 aa) |
| | scrK | Fructokinase. (323 aa) |
| | CAJ68678.1 | Pyridoxal-dependent decarboxylase, group IV decarboxylase family. (403 aa) |
| | CAJ68684.1 | Putative phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. (213 aa) |
| | PlsC2 | Putative acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (198 aa) |
| | ispH | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (279 aa) |
| | metA | Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (296 aa) |
| | aroF1 | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. (337 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (354 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (437 aa) |
| | aroC | Chorismate synthase (5-enolpyruvylshikimate-3-phosphate phospholyase); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (359 aa) |
| | pheA | Bifunctional P-protein, chorismate mutase/prephenate dehydratase. (398 aa) |
| | aroE1 | Shikimate dehydrogenase 1; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (269 aa) |
| | aroK | Shikimate kinase (SK); Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (177 aa) |
| | tyrC | Prephenate dehydrogenase. (279 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (314 aa) |
| | accD | Acetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (284 aa) |
| | accC | Acetyl-CoA carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (453 aa) |
| | accB | Acetyl-CoA carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (150 aa) |
| | miaA | Transfer RNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (311 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (551 aa) |
| | argF | Ornithine carbamoyltransferase (OTCase); Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (340 aa) |
| | argM | Succinylornithine transaminase (ACOAT); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (286 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ [Includes: Glutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (405 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (430 aa) |
| | lysC | Aspartokinase; Belongs to the aspartokinase family. (397 aa) |
| | DagK | Putative lipid kinase. (299 aa) |
| | thrC | Threonine synthase. (493 aa) |
| | thrB | Homoserine kinase (HSK) (HK); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (297 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (351 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (384 aa) |
| | cdsA | Phosphatidate cytidylyltransferase CdsA; Belongs to the CDS family. (259 aa) |
| | uppS | Undecaprenyl pyrophosphate synthetase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (244 aa) |
| | ldh | L-lactate dehydrogenase (L-LDH); Catalyzes the conversion of lactate to pyruvate. (322 aa) |
| | CAJ69074.1 | Cyclomaltodextrinase (maltogenic alpha-amylase) (cyclomaltodextrin dextrin-hydrolase (decyclizing)); Belongs to the glycosyl hydrolase 13 family. (627 aa) |
| | CAJ69075.1 | Putative phosphoesterase; Belongs to the PHP hydrolase family. HisK subfamily. (273 aa) |
| | VorA'2 | Putative ferredoxin/flavodoxin oxidoreductase,gamma subunit. (179 aa) |
| | VorA2 | Putative ferredoxin/flavodoxin oxidoreductase,beta subunit. (246 aa) |
| | VorB2 | Putative ferredoxin/flavodoxin oxidoreductase,alpha subunit. (349 aa) |
| | VorC2 | Putative 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein. (78 aa) |
| | hisC-2 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (367 aa) |
| | aldH | Aldehyde dehydrogenase (aldehyde:NAD+ oxidoreductase); Belongs to the aldehyde dehydrogenase family. (454 aa) |
| | aroD | Dehydroquinate dehydratase (3-dehydroquinate dehydratase) (Dehydroquinase) (DHQase); Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. The reaction involves the formation of an imine intermediate between the keto group of 3-dehydroquinate and the epsylon-amino group of Lys-170 at the active site. (255 aa) |
| | rpe | Putative ribulose-phosphate 3-epimerase. (221 aa) |
| | rpiB1 | Ribose-5-phosphate isomerase B1 (Phosphoriboisomerase B). (148 aa) |
| | tkt | Transketolase, C-terminal section; Experimentally verified as part of mature spore proteome PMID:19542279. (306 aa) |
| | tkt1 | Transketolase, N-terminal section; Experimentally verified as part of mature spore proteome PMID:19542279. (270 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (216 aa) |
| | xpt | Xanthine phosphoribosyltransferase (XPRTase); Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa) |
| | guaB | Inositol-5'-monophosphate dehydrogenase (IMP dehydrogenase) (IMPDH) (IMPD); Experimentally verified as part of mature spore proteome PMID:19542279. (499 aa) |
| | cat1 | Succinyl-CoA:coenzyme A transferase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (514 aa) |
| | CAJ69267.1 | Putative pyridoxal phosphate-dependent transferase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. (419 aa) |
| | CAJ69272.1 | Alpha-hydroxy acid dehydrogenase,FMN-dependent. (340 aa) |
| | ppdK | Pyruvate phosphate dikinase (ATP:pyruvate,phosphate phosphotransferase); Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the PEP-utilizing enzyme family. (875 aa) |
| | CAJ69309.1 | Putative pyridoxal phosphate-dependent transferase. (402 aa) |
| | VorA'3 | Putative flavodoxin/ferredoxin oxidoreductase gamma subunit. (179 aa) |
| | VorA3 | Putative flavodoxin/ferredoxin oxidoreductase beta subunit. (239 aa) |
| | VorB3 | Putative flavodoxin/ferredoxin oxidoreductase alpha subunit. (358 aa) |
| | VorC3 | Putative 4Fe-4S ferredoxin, iron-sulfur binding domain protein, delta subunit. (65 aa) |
| | DgkA | Putative diacylglycerol kinase; Experimentally verified as part of mature spore proteome PMID:19542279. (239 aa) |
| | GlcK | Putative glucokinase, ROK family. (311 aa) |
| | PatB1 | Putative aminotransferase. (392 aa) |
| | pmi | Mannose-6-phosphate isomerase (Phosphomannose isomerase) (PMI) (Phosphohexomutase). (314 aa) |
| | argH | Argininosuccinate lyase (Arginosuccinase) (ASAL). (438 aa) |
| | tdcB | Threonine dehydratase II; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant. Experimentally verified through Mass Spectrometry as part of Spo0A regulated proteome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (405 aa) |
| | ansB | L-asparaginase. (331 aa) |
| | glgB | 1,4-alpha-glucan branching enzyme. (667 aa) |
| | CAJ69424.1 | Putative membrane-associated 5'-nucleotidase/phosphoesterase; Belongs to the 5'-nucleotidase family. (613 aa) |
| | CAJ69462.1 | Putative hydrolase, HAD superfamily, subfamily IA. (209 aa) |
| | rpe1 | Ribulose-phosphate 3-epimerase (Pentose-5-phosphate 3-epimerase) (PPE) (R5P3E); Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the ribulose-phosphate 3-epimerase family. (223 aa) |
| | fabG-2 | 3-oxoacyl-[acyl-carrier-protein] reductase (3-ketoacyl-acyl carrier protein reductase). (245 aa) |
| | dapF | Diaminopimelate epimerase (DAP epimerase); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (276 aa) |
| | ltaE | Low specificity L-threonine aldolase. (344 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase (NAD(P)+) (NAD(P)H-dependent glycerol-3-phosphate dehydrogenase); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (343 aa) |
| | plsY | Putative membrane protein, UPF0078 family; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (204 aa) |
| | thlA2 | Acetoacetyl-CoA thiolase 2; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa) |
| | pfo | Pyruvate-ferredoxin oxidoreductase; Experimentally verified as part of mature spore proteome PMID:19542279. (1179 aa) |
| | hpt | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (175 aa) |
| | asnA | Aspartate--ammonia ligase (Asparagine synthetase A). (333 aa) |
| | PatB2 | Putative pyridoxal phosphate-dependent transferase. (396 aa) |
| | aroE2 | Shikimate dehydrogenase 2; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (287 aa) |
| | gtaB | UTP--glucose-1-phosphate uridylyltransferase. (291 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (414 aa) |
| | CAJ69620.1 | Putative pyridoxal phosphate-dependent transferase. (388 aa) |
| | uppS1 | Putative undecaprenyl pyrophosphate synthetase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. (214 aa) |
| | manC | Putative mannose-1-phosphate guanylyltransferase. (357 aa) |
| | pgmA | Alpha-phosphoglucomutase. (568 aa) |
| | PatA | Putative pyridoxal phosphate-dependent transferase. (399 aa) |
| | glyA1 | Serine hydroxymethyltransferase (Serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | adhE1 | Aldehyde-alcohol dehydrogenase; Experimentally verified as part of mature spore proteome PMID:19542279; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (867 aa) |
| | CAJ69864.1 | Putative thiolase; Belongs to the thiolase-like superfamily. Thiolase family. (378 aa) |
| | AdhB | Alcohol dehydrogenase. (381 aa) |
| | malY | Bifunctional protein: cystathionine beta-lyase / repressor. (394 aa) |
| | tagK | Tagatose-6-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (306 aa) |
| | garK | Glycerate kinase; Belongs to the glycerate kinase type-1 family. (384 aa) |
| | pfp | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (404 aa) |
| | TreP | Glycosyl hydrolase/phosphorylase. (796 aa) |
| | GatY2 | Putative fructose-1-6-bisphosphate aldolase. (292 aa) |
| | eno | Enolase (2-phosphoglycerate dehydratase) (2-phospho-D-glycerate hydro-lyase); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (430 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (510 aa) |
| | tpi | Triosephosphate isomerase (TIM) (Triose-phosphate isomerase); Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (247 aa) |
| | pgk | Phosphoglycerate kinase; Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the phosphoglycerate kinase family. (400 aa) |
| | gapA | Glyceraldehyde-3-phosphate dehydrogenase (GAPDH); Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | CAJ70119.1 | Putative peptidase, M20D family; Experimentally verified as part of mature spore proteome PMID:19542279. (372 aa) |
| | sdaB | L-serine dehydratase; Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the iron-sulfur dependent L-serine dehydratase family. (397 aa) |
| | dapA2 | Dihydrodipicolinate synthase 2; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (333 aa) |
| | dapA3 | Dihydrodipicolinate synthase 3; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa) |
| | dapB1 | Dihydrodipicolinate reductase 1 (DHPR 1); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (249 aa) |
| | dapB2 | Dihydrodipicolinate reductase 2 (DHPR 2); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (251 aa) |
| | hpt1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (179 aa) |
| | CAJ70169.1 | Putative membrane protein. (169 aa) |
| | proC1 | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | pgi | Glucose-6-phosphate isomerase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: down-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the GPI family. (449 aa) |
| | pyk | Pyruvate kinase (PK); Experimentally verified as part of mature spore proteome PMID:19542279; Belongs to the pyruvate kinase family. (586 aa) |
| | pfkA | 6-phosphofructokinase (Phosphofructokinase) (Phosphohexokinase); Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (319 aa) |
| | sirC | Precorrin-2 dehydrogenase. (192 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase); Belongs to the ALAD family. (321 aa) |
| | cobA | Bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase. (499 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (301 aa) |
| | PatB3 | Putative pyridoxal phosphate-dependent transferase (PLP-dependent transferase). (395 aa) |
| | tkt2 | Transketolase, pyridine binding subunit. (313 aa) |
| | tkt3 | Transketolase, thiamine diphosphate binding subunit. (275 aa) |
| | rpiB2 | Ribose-5-phosphate isomerase 2. (150 aa) |
| | gtaB1 | UTP--glucose-1-phosphate uridylyltransferase (general stress protein 33); Experimentally verified as part of mature spore proteome PMID:19542279. (321 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (316 aa) |
| | ispE | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (296 aa) |
| | MetH | Putative homocysteine S-methyltransferase. (793 aa) |
| | CAJ70512.1 | Putative phosphatase. (216 aa) |
| | dapA4 | Dihydrodipicolinate synthase 4 (DHDPS); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (301 aa) |
| | CAJ70573.1 | Putative aminotransferase; Experimentally verified through RNA-seq as part of Spo0A regulated transcriptome: up-regulated in Spo0A mutant PMID:24568651. Experimentally verified as part of mature spore proteome PMID:19542279. (398 aa) |
