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accC accC GDI0423 GDI0423 thiE thiE mtnB mtnB mtnD mtnD mtnC mtnC thiC thiC cysB cysB thiED thiED GDI1033 GDI1033 accD accD metK metK folD folD accC-2 accC-2 GDI1373 GDI1373 asd asd GDI1480 GDI1480 ackA ackA pdhA pdhA thiL thiL thiS thiS thiG thiG thiE-2 thiE-2 dxs-2 dxs-2 bioA bioA bioF bioF bioD bioD phdA phdA pdhB-2 pdhB-2 lipA lipA ggt ggt GDI2006 GDI2006 deoD deoD gshB gshB pta pta accA accA GDI2186 GDI2186 mtnA mtnA ggt-2 ggt-2 cysE cysE klb klb acsA acsA GDI2504 GDI2504 GDI2561 GDI2561 metE metE metF metF cysE-2 cysE-2 kbl kbl bioB bioB mtnK mtnK metX metX cysD cysD cysC cysC sir2 sir2 GDI3250 GDI3250 ggt-3 ggt-3 metH metH GDI3750 GDI3750
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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accCPutative Biotin carboxylase (Acetyl-CoA carboxylase subunit A); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (452 aa)
GDI0423Putative aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (477 aa)
thiEPutative thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (212 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (225 aa)
mtnD1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (179 aa)
mtnCEnolase-phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (237 aa)
thiCThiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (626 aa)
cysBCysteine synthase. (345 aa)
thiEDPutative bifunctional thiED protein. (269 aa)
GDI1033Homoserine dehydrogenase. (451 aa)
accDAcetyl-coenzyme A carboxylase carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (309 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa)
folDPutative FolD bifunctional protein [Includes: Methylenetetrahydrofolat dehydrogenase (EC 1.5.1.5); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa)
accC-2Biotin carboxylase protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
GDI1373Conserved protein. (350 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa)
GDI1480Cysteine synthase. (328 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (346 aa)
pdhAPutative pyruvate dehydrogenase E1 component subunit alpha. (321 aa)
thiLPutative thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (324 aa)
thiSPutative thiamine biosynthesis protein ThiS. (65 aa)
thiGThiazole biosynthesis protein thiG; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (256 aa)
thiE-2Thiamine-phosphate pyrophosphorylase. (202 aa)
dxs-21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (667 aa)
bioAPutative adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (421 aa)
bioFPutative 8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (407 aa)
bioDPutative biotin synthesis protein; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (474 aa)
phdAPyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (363 aa)
pdhB-2Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (448 aa)
lipAPutative lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa)
ggtPutative gamma-glutamyltranspeptidase precursor. (520 aa)
GDI2006Omega-amino acid--pyruvate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (437 aa)
deoD5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (292 aa)
gshBGlutathione synthetase; Belongs to the prokaryotic GSH synthase family. (334 aa)
ptaPutative phosphate acetyltransferase. (329 aa)
accAAcetyl-coenzyme A carboxylase carboxyl transferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (318 aa)
GDI2186Thiaminase-2 protein. (234 aa)
mtnATranslation initiation factor; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (365 aa)
ggt-2Gamma-glutamyltranspeptidase precursor. (501 aa)
cysEPutative serine acetyltransferase. (283 aa)
klbPutative 2-amino-3-ketobutyrate coenzyme A ligase. (428 aa)
acsAPutative acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (645 aa)
GDI2504Putative 2-oxoglutarate dehydrogenase E1 component beta subunit. (311 aa)
GDI2561Putative GPI biosynthesis protein. (244 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferas; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (785 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (250 aa)
cysE-2Putative serine acetyltransferase. (291 aa)
kbl2-amino-3-ketobutyrate coenzyme A ligase. (400 aa)
bioBPutative biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (366 aa)
mtnKPutative kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (437 aa)
metXPutative homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (412 aa)
cysDPutative sulfate adenylyltransferase subunit 2. (264 aa)
cysCPutative sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. (635 aa)
sir2Putative sulfite reductase. (564 aa)
GDI3250Glutamate-cysteine ligase precursor; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (470 aa)
ggt-3Putaive gamma-glutamyltranspeptidase precursor. (594 aa)
metHPutative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1168 aa)
GDI3750Putative Propionate--CoA ligase. (586 aa)
Your Current Organism:
Gluconacetobacter diazotrophicus
NCBI taxonomy Id: 272568
Other names: G. diazotrophicus PA1 5, Gluconacetobacter diazotrophicus ATCC 49037, Gluconacetobacter diazotrophicus BR 11281, Gluconacetobacter diazotrophicus CCUG 37298, Gluconacetobacter diazotrophicus CIP 103539, Gluconacetobacter diazotrophicus DSM 5601, Gluconacetobacter diazotrophicus LMG 7603, Gluconacetobacter diazotrophicus NCCB 89154, Gluconacetobacter diazotrophicus PA1 5, Gluconacetobacter diazotrophicus str. PA1 5, Gluconacetobacter diazotrophicus strain PA1 5
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