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| | GDI2999 | Putative succinylglutamate desuccinylase. (348 aa) |
| | serB | Phosphoserine phosphatase. (298 aa) |
| | ilvH | Putative acetolactate synthase isozyme III small subunit. (171 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | cobQ | Putative cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (492 aa) |
| | cobD | Putative threonine-phosphate decarboxylase. (338 aa) |
| | hisH | Putative imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (223 aa) |
| | GDI0211 | Putative D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa) |
| | GDI0420 | Putative tartrate dehydrogenase/decarboxylase. (358 aa) |
| | nifV | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (379 aa) |
| | agaE | Putative deaminase. (441 aa) |
| | argE | Putative acetylornithine deacetylase. (405 aa) |
| | GDI0508 | Putative L-lysine 2,3-aminomutase. (382 aa) |
| | GDI0527 | Aminotransferase. (390 aa) |
| | hutH | Putative histidine ammonia-lyase; Belongs to the PAL/histidase family. (515 aa) |
| | mtnB | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (225 aa) |
| | mtnD | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (179 aa) |
| | mtnC | Enolase-phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (237 aa) |
| | GDI0607 | Putative aspartate aminotransferase. (381 aa) |
| | GDI0614 | Putative cysteine desulfurase. (491 aa) |
| | GDI0637 | Putative prephenate dehydrogenase. (257 aa) |
| | dadA | Putative D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids. (418 aa) |
| | dadB | Putative alanine racemase, catabolic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (387 aa) |
| | cysB | Cysteine synthase. (345 aa) |
| | metB | Putative cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (416 aa) |
| | argJ | Arginine biosynthesis bifunctional protein argJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (410 aa) |
| | proC | Putative pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (357 aa) |
| | GDI0940 | Hypothetical protein. (53 aa) |
| | GDI1033 | Homoserine dehydrogenase. (451 aa) |
| | GDI1034 | Aminotransferase protein. (407 aa) |
| | trpA | Putative Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa) |
| | trpB | Putative Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa) |
| | dapB | Putative Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (256 aa) |
| | puuD | Putative Gamma-glutamyl-gamma-aminobutyrate hydrolase. (243 aa) |
| | folD | Putative FolD bifunctional protein [Includes: Methylenetetrahydrofolat dehydrogenase (EC 1.5.1.5); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa) |
| | GDI1306 | Conserved hypothetical protein. (247 aa) |
| | trpF | Putative N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (224 aa) |
| | GDI1373 | Conserved protein. (350 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa) |
| | argF | Putative Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (331 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa) |
| | GDI1468 | Putative asparagine synthetase protein. (513 aa) |
| | GDI1480 | Cysteine synthase. (328 aa) |
| | GDI1502 | Putative pyridine nucleotide-disulphide oxidoreductase. (440 aa) |
| | tyrA | Putative prephenate dehydrogenase. (302 aa) |
| | GDI1630 | Conserved hypothetical protein. (738 aa) |
| | glmS | 3.1.0; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (607 aa) |
| | thiO | Thiamine biosynthesis oxidoreductase thiO. (360 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (421 aa) |
| | pheA | Putative P-protein [Includes: Chorismate mutase (EC 5.4.99.5) (CM); Prephenat dehydratase (EC 4.2.1.51) (PDT). (287 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | lysC | Aspartokinase protein; Belongs to the aspartokinase family. (441 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa) |
| | trpD | Putative anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (376 aa) |
| | trpC | Putative indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (283 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (233 aa) |
| | sseA | 3-mercaptopyruvate sulfurtransferase. (306 aa) |
| | metC | Putative cystathionine beta-lyase. (416 aa) |
| | GDI1991 | Isocitrate dehydrogenase. (342 aa) |
| | GDI2052 | Putative Usg-like protein. (86 aa) |
| | deoD | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (292 aa) |
| | thrC | Threonine synthase. (465 aa) |
| | gltB | Putative glutamate synthase [NADPH] large chain precursor. (1516 aa) |
| | gltD | Glutamate synthase [NADPH] small chain. (522 aa) |
| | dapE | Putative succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (385 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferas; Belongs to the transferase hexapeptide repeat family. (300 aa) |
| | argB | Putative acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (322 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (424 aa) |
| | mtnA | Translation initiation factor; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (365 aa) |
| | GDI2257 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (393 aa) |
| | argC | Putative N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (328 aa) |
| | dapF | Putative diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa) |
| | gcvP | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (960 aa) |
| | gcvH | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (121 aa) |
| | gcvT | Glycine cleavage system aminomethyltransferase T. (409 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa) |
| | GDI2348 | Putative amidohydrolase. (488 aa) |
| | cysE | Putative serine acetyltransferase. (283 aa) |
| | dadB-2 | Putative alanine racemase, catabolic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (383 aa) |
| | dadA-2 | Putative D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids. (417 aa) |
| | ilvE-2 | Branched-chain-amino-acid aminotransferase. (364 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferas; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (785 aa) |
| | metF | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (250 aa) |
| | cysE-2 | Putative serine acetyltransferase. (291 aa) |
| | putA | Putative bifunctional protein putA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1190 aa) |
| | GDI2703 | Putative peptidase. (423 aa) |
| | ooxA | Putative opine oxidase subunit A. (464 aa) |
| | GDI2714 | Putative FAD dependent oxidoreductase. (384 aa) |
| | argH | Putative argininosuccinate lyase 1. (476 aa) |
| | lysA | Putative diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (491 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (440 aa) |
| | sufS | Putative cysteine desulfurase; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. (415 aa) |
| | leuB | Putative 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (207 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (483 aa) |
| | thrB | Putative homoserine kinase; Belongs to the pseudomonas-type ThrB family. (321 aa) |
| | mtnK | Putative kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (437 aa) |
| | GDI3125 | Putative aspartate aminotransferase. (414 aa) |
| | aatA | Aspartate aminotransferase. (400 aa) |
| | guaA | Gmp synthase [glutamine-hydrolyzing] (glutamin amidotransferase) (gmp synthetase); Catalyzes the synthesis of GMP from XMP. (562 aa) |
| | proB | Putative glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (382 aa) |
| | metX | Putative homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (412 aa) |
| | sir2 | Putative sulfite reductase. (564 aa) |
| | GDI3334 | Putative acetyl transferase protein. (196 aa) |
| | carA | Putative carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (467 aa) |
| | carB | Putative carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1084 aa) |
| | GDI3360 | Conserved hypothetical protein. (715 aa) |
| | metH | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1168 aa) |
| | purF | Aidophosphoribosyltransferase precursor; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (517 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (624 aa) |
