STRINGSTRING
serB serB ilvH ilvH ilvC ilvC GDI0211 GDI0211 GDI0420 GDI0420 nifV nifV argE argE mtnB mtnB mtnD mtnD mtnC mtnC GDI0637 GDI0637 dadB dadB cysB cysB argJ argJ proC proC proA proA GDI0940 GDI0940 GDI1033 GDI1033 trpA trpA trpB trpB dapB dapB folD folD trpF trpF GDI1373 GDI1373 asd asd argF argF argD argD GDI1468 GDI1468 GDI1480 GDI1480 GDI1502 GDI1502 tyrA tyrA carA carA argG argG serA serA pheA pheA dapA dapA lysC lysC trpD trpD trpC trpC GDI1991 GDI1991 GDI2052 GDI2052 deoD deoD thrC thrC gltB gltB gltD gltD dapE dapE dapD dapD argB argB serS serS mtnA mtnA GDI2257 GDI2257 argC argC dapF dapF leuA leuA cysE cysE dadB-2 dadB-2 ilvE-2 ilvE-2 metE metE metF metF cysE-2 cysE-2 putA putA GDI2703 GDI2703 argH argH lysA lysA glyA glyA carB carB leuB leuB leuD leuD leuC leuC thrB thrB mtnK mtnK proB proB metX metX sir2 sir2 metH metH ilvD ilvD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
serBPhosphoserine phosphatase. (298 aa)
ilvHPutative acetolactate synthase isozyme III small subunit. (171 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
GDI0211Putative D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
GDI0420Putative tartrate dehydrogenase/decarboxylase. (358 aa)
nifVHomocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (379 aa)
argEPutative acetylornithine deacetylase. (405 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (225 aa)
mtnD1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (179 aa)
mtnCEnolase-phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (237 aa)
GDI0637Putative prephenate dehydrogenase. (257 aa)
dadBPutative alanine racemase, catabolic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (387 aa)
cysBCysteine synthase. (345 aa)
argJArginine biosynthesis bifunctional protein argJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (410 aa)
proCPutative pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (357 aa)
GDI0940Hypothetical protein. (53 aa)
GDI1033Homoserine dehydrogenase. (451 aa)
trpAPutative Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa)
trpBPutative Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa)
dapBPutative Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (256 aa)
folDPutative FolD bifunctional protein [Includes: Methylenetetrahydrofolat dehydrogenase (EC 1.5.1.5); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa)
trpFPutative N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (224 aa)
GDI1373Conserved protein. (350 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa)
argFPutative Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (331 aa)
argDAcetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa)
GDI1468Putative asparagine synthetase protein. (513 aa)
GDI1480Cysteine synthase. (328 aa)
GDI1502Putative pyridine nucleotide-disulphide oxidoreductase. (440 aa)
tyrAPutative prephenate dehydrogenase. (302 aa)
carAPutative carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (467 aa)
argGArgininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (421 aa)
pheAPutative P-protein [Includes: Chorismate mutase (EC 5.4.99.5) (CM); Prephenat dehydratase (EC 4.2.1.51) (PDT). (287 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa)
lysCAspartokinase protein; Belongs to the aspartokinase family. (441 aa)
trpDPutative anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (376 aa)
trpCPutative indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (283 aa)
GDI1991Isocitrate dehydrogenase. (342 aa)
GDI2052Putative Usg-like protein. (86 aa)
deoD5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (292 aa)
thrCThreonine synthase. (465 aa)
gltBPutative glutamate synthase [NADPH] large chain precursor. (1516 aa)
gltDGlutamate synthase [NADPH] small chain. (522 aa)
dapEPutative succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (385 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferas; Belongs to the transferase hexapeptide repeat family. (300 aa)
argBPutative acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (322 aa)
serSSeryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (424 aa)
mtnATranslation initiation factor; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (365 aa)
GDI2257Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (393 aa)
argCPutative N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (328 aa)
dapFPutative diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa)
cysEPutative serine acetyltransferase. (283 aa)
dadB-2Putative alanine racemase, catabolic; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (383 aa)
ilvE-2Branched-chain-amino-acid aminotransferase. (364 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferas; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (785 aa)
metF5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (250 aa)
cysE-2Putative serine acetyltransferase. (291 aa)
putAPutative bifunctional protein putA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1190 aa)
GDI2703Putative peptidase. (423 aa)
argHPutative argininosuccinate lyase 1. (476 aa)
lysAPutative diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (491 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (440 aa)
carBPutative carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1084 aa)
leuBPutative 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (207 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (483 aa)
thrBPutative homoserine kinase; Belongs to the pseudomonas-type ThrB family. (321 aa)
mtnKPutative kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (437 aa)
proBPutative glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (382 aa)
metXPutative homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (412 aa)
sir2Putative sulfite reductase. (564 aa)
metHPutative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1168 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (624 aa)
Your Current Organism:
Gluconacetobacter diazotrophicus
NCBI taxonomy Id: 272568
Other names: G. diazotrophicus PA1 5, Gluconacetobacter diazotrophicus ATCC 49037, Gluconacetobacter diazotrophicus BR 11281, Gluconacetobacter diazotrophicus CCUG 37298, Gluconacetobacter diazotrophicus CIP 103539, Gluconacetobacter diazotrophicus DSM 5601, Gluconacetobacter diazotrophicus LMG 7603, Gluconacetobacter diazotrophicus NCCB 89154, Gluconacetobacter diazotrophicus PA1 5, Gluconacetobacter diazotrophicus str. PA1 5, Gluconacetobacter diazotrophicus strain PA1 5
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.