STRINGSTRING
nadK nadK GDI0257 GDI0257 dhaK dhaK dhaL dhaL glpK glpK GDI0293 GDI0293 iolC iolC GDI0481 GDI0481 ribF ribF pckA pckA glxK glxK GDI0674 GDI0674 GDI0702 GDI0702 ispE ispE GDI0732 GDI0732 thiED thiED cobP cobP prs prs gmk gmk hldE hldE GDI1165 GDI1165 ptsI ptsI GDI1190 GDI1190 GDI1194 GDI1194 GDI1236 GDI1236 chvG chvG pykA pykA podA podA GDI1319 GDI1319 GDI1389 GDI1389 GDI1455 GDI1455 GDI1487 GDI1487 GDI1490 GDI1490 GDI1511 GDI1511 ackA ackA cheA cheA GDI1745 GDI1745 glpK-2 glpK-2 thiL thiL glk glk tmk tmk GDI1803 GDI1803 lysC lysC ppk ppk ndk ndk argB argB pyrH pyrH folK folK dgoK dgoK aroKB aroKB ntrY ntrY ntrB ntrB anmK anmK coaA coaA pgk pgk araB araB xylB xylB rbsK rbsK GDI2930 GDI2930 coaE coaE nnrD nnrD GDI3079 GDI3079 thrB thrB GDI3115 GDI3115 mtnK mtnK rbsK-2 rbsK-2 proB proB cysC cysC lpxK lpxK GDI3286 GDI3286 GDI3287 GDI3287 cheA-2 cheA-2 adk adk GDI3419 GDI3419 cmk cmk GDI3725 GDI3725 2_085 2_085 phoR phoR
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
nadKPutative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (267 aa)
GDI0257Putative sensor histidine kinase. (396 aa)
dhaKPutative PTS-dependent dihydroxyacetone kinase. (333 aa)
dhaLPutative PTS-dependent dihydroxyacetone kinase. (201 aa)
glpKPutative glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (499 aa)
GDI0293Putative shikimate kinase. (182 aa)
iolCPutative myo-inositol catabolism, sugar kinase protein. (642 aa)
GDI0481Putative type II secretion pathway kinase GspE. (567 aa)
ribFPutative riboflavin biosynthesis protein; Belongs to the ribF family. (315 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (539 aa)
glxKGlycerate kinase; Belongs to the glycerate kinase type-1 family. (379 aa)
GDI0674Putative two-component sensor histidine kinase. (479 aa)
GDI0702Inosine-guanosine kinase. (338 aa)
ispEPutative 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (305 aa)
GDI0732Putative two component sensor histidine kinase. (464 aa)
thiEDPutative bifunctional thiED protein. (269 aa)
cobPPutative bifunctional adenosylcobalamin biosynthesis protein cobP; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (200 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (230 aa)
hldED-beta-D-heptose 1-phosphate adenylyltransferase; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (484 aa)
GDI1165Putative diacylglycerol kinase family protein. (291 aa)
ptsIPutative phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (618 aa)
GDI1190Putative HPr kinase. (161 aa)
GDI1194Putative two-component system sensor protein. (368 aa)
GDI1236Putative histidine kinase. (369 aa)
chvGPutative histidine kinase sensory protein. (592 aa)
pykAPyruvate kinase; Belongs to the pyruvate kinase family. (479 aa)
podAPyruvate, phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (896 aa)
GDI1319Conserved hypothetical protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (282 aa)
GDI1389Putative histidine kinase. (463 aa)
GDI1455Putative two-component sensor histidine kinase. (515 aa)
GDI1487Putative carbohydrate kinase. (473 aa)
GDI1490Putative carbohydrate kinase protein. (424 aa)
GDI1511Putative sensor histidine kinase. (461 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (346 aa)
cheAPutative chemotaxis protein cheA. (751 aa)
GDI1745Putative signal transduction histidine kinase. (603 aa)
glpK-2Putative glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (499 aa)
thiLPutative thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (324 aa)
glkGlucokinase; Belongs to the bacterial glucokinase family. (322 aa)
tmkPutative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (215 aa)
GDI1803PrkA serine protein kinase. (648 aa)
lysCAspartokinase protein; Belongs to the aspartokinase family. (441 aa)
ppkPutative polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (764 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
argBPutative acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (322 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (246 aa)
folKPutative 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinas. (202 aa)
dgoKPutative 2-dehydro-3-deoxygalactonokinase. (316 aa)
aroKBPutative bifunctional protein: shikimate kinase and 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (591 aa)
ntrYPutatie histidine kinase, nitrogen regulation protein ntrY. (738 aa)
ntrBPutative histidine kinase, nitrogen regulation protein ntrB. (369 aa)
anmKConserved hypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (388 aa)
coaAPutative pantothenate kinase. (317 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (407 aa)
araBRibulokinase. (553 aa)
xylBPutative xylulose kinase. (492 aa)
rbsKPutative ribokinase. (292 aa)
GDI2930Putative diacylglycerol kinase (DAG) catalytic domain protein. (323 aa)
coaEPutative dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa)
nnrDPutative sugar kinase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both ep [...] (492 aa)
GDI3079Putative sensor signal transduction histidine kinase. (467 aa)
thrBPutative homoserine kinase; Belongs to the pseudomonas-type ThrB family. (321 aa)
GDI3115Shikimate kinase. (208 aa)
mtnKPutative kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (437 aa)
rbsK-2Ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (316 aa)
proBPutative glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (382 aa)
cysCPutative sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. (635 aa)
lpxKPutative tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (327 aa)
GDI3286Putative two-component sensor histidine kinase/response regulator hybrid protein. (621 aa)
GDI3287Putative histidine kinase. (636 aa)
cheA-2Putative chemotaxis protein cheA. (719 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (219 aa)
GDI3419Putative two-component sensor histidine kinase. (467 aa)
cmkCytidylate kinase. (219 aa)
GDI3725Two-component system, sensor histidine kinase. (421 aa)
2_085Unknown protein. (771 aa)
phoRPutative phosphate regulon, two-component sensor histidine kinase, phoR. (402 aa)
Your Current Organism:
Gluconacetobacter diazotrophicus
NCBI taxonomy Id: 272568
Other names: G. diazotrophicus PA1 5, Gluconacetobacter diazotrophicus ATCC 49037, Gluconacetobacter diazotrophicus BR 11281, Gluconacetobacter diazotrophicus CCUG 37298, Gluconacetobacter diazotrophicus CIP 103539, Gluconacetobacter diazotrophicus DSM 5601, Gluconacetobacter diazotrophicus LMG 7603, Gluconacetobacter diazotrophicus NCCB 89154, Gluconacetobacter diazotrophicus PA1 5, Gluconacetobacter diazotrophicus str. PA1 5, Gluconacetobacter diazotrophicus strain PA1 5
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