STRINGSTRING
metB metB GDI1033 GDI1033 ilvE ilvE metK metK asd asd ahcY ahcY GDI1480 GDI1480 sdaA sdaA GDI1519 GDI1519 GDI1619 GDI1619 GDI1643 GDI1643 serA serA lysC lysC sseA sseA metC metC deoD deoD gshB gshB scpB scpB mtnA mtnA GDI2257 GDI2257 spe spe spe-2 spe-2 cysE cysE GDI2458 GDI2458 ilvE-2 ilvE-2 metE metE GDI2589 GDI2589 cysE-2 cysE-2 GDI2751 GDI2751 GDI2836 GDI2836 mtnK mtnK GDI3125 GDI3125 aatA aatA metX metX GDI3250 GDI3250 ksgA ksgA GDI3334 GDI3334 vapC-3 vapC-3 metH metH GDI3575 GDI3575 DdeI DdeI vapC vapC GDI0095 GDI0095 GDI0211 GDI0211 GDI0283 GDI0283 vapC-2 vapC-2 speE speE mtnB mtnB mtnD mtnD mtnC mtnC GDI0607 GDI0607 cysB cysB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
metBPutative cystathionine gamma-synthase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (416 aa)
GDI1033Homoserine dehydrogenase. (451 aa)
ilvEPutative branched-chain-amino-acid aminotransferase (ec 2.6.1.42 (transaminase b) (bcat). (267 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa)
ahcYAdenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (448 aa)
GDI1480Cysteine synthase. (328 aa)
sdaAPutative L-serine deaminase /L-threonine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (452 aa)
GDI1519Putative membrane protein. (326 aa)
GDI1619Conserved hypothetical protein. (246 aa)
GDI1643Conserved hypothetical protein. (428 aa)
serAD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (421 aa)
lysCAspartokinase protein; Belongs to the aspartokinase family. (441 aa)
sseA3-mercaptopyruvate sulfurtransferase. (306 aa)
metCPutative cystathionine beta-lyase. (416 aa)
deoD5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (292 aa)
gshBGlutathione synthetase; Belongs to the prokaryotic GSH synthase family. (334 aa)
scpBPutative segregation and condensation protein B; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (231 aa)
mtnATranslation initiation factor; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (365 aa)
GDI2257Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (393 aa)
speSpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family. (289 aa)
spe-2Putaive S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (153 aa)
cysEPutative serine acetyltransferase. (283 aa)
GDI2458Putative cystathionine-beta-synthase. (167 aa)
ilvE-2Branched-chain-amino-acid aminotransferase. (364 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferas; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (785 aa)
GDI2589Conserved hypothetical protein. (158 aa)
cysE-2Putative serine acetyltransferase. (291 aa)
GDI2751Hypothetical protein. (208 aa)
GDI2836Putative autoinducer synthesis protein. (209 aa)
mtnKPutative kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. (437 aa)
GDI3125Putative aspartate aminotransferase. (414 aa)
aatAAspartate aminotransferase. (400 aa)
metXPutative homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (412 aa)
GDI3250Glutamate-cysteine ligase precursor; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). Belongs to the glutamate--cysteine ligase type 2 family. EgtA subfamily. (470 aa)
ksgAPutative dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (275 aa)
GDI3334Putative acetyl transferase protein. (196 aa)
vapC-3Conserved hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (140 aa)
metHPutative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1168 aa)
GDI3575Conserved hypothetical protein. (354 aa)
DdeIPutative cytosine-specifi methyltransferase DdeI. (435 aa)
vapCConserved hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (136 aa)
GDI0095Conserved hypothetical protein. (94 aa)
GDI0211Putative D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa)
GDI0283Conserved protein. (174 aa)
vapC-2Conserved hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (131 aa)
speEPutative spermidine synthase. (259 aa)
mtnBMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. (225 aa)
mtnD1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. (179 aa)
mtnCEnolase-phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. (237 aa)
GDI0607Putative aspartate aminotransferase. (381 aa)
cysBCysteine synthase. (345 aa)
Your Current Organism:
Gluconacetobacter diazotrophicus
NCBI taxonomy Id: 272568
Other names: G. diazotrophicus PA1 5, Gluconacetobacter diazotrophicus ATCC 49037, Gluconacetobacter diazotrophicus BR 11281, Gluconacetobacter diazotrophicus CCUG 37298, Gluconacetobacter diazotrophicus CIP 103539, Gluconacetobacter diazotrophicus DSM 5601, Gluconacetobacter diazotrophicus LMG 7603, Gluconacetobacter diazotrophicus NCCB 89154, Gluconacetobacter diazotrophicus PA1 5, Gluconacetobacter diazotrophicus str. PA1 5, Gluconacetobacter diazotrophicus strain PA1 5
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