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| | lysC | Aspartokinase protein; Belongs to the aspartokinase family. (441 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (624 aa) |
| | GDI3717 | Conserved hypothetical protein. (124 aa) |
| | GDI3684 | Hypothetical protein. (158 aa) |
| | GDI3503 | Hypothetical protein. (148 aa) |
| | metH | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1168 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (449 aa) |
| | GDI3446 | Hypothetical protein. (52 aa) |
| | gpmI | 2,3-bisphosphoglycerate-independent phosphoglycerate mutas; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (516 aa) |
| | vapC-3 | Conserved hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (140 aa) |
| | GDI3341 | Putative threonine dehydratase catabolic. (398 aa) |
| | ksgA | Putative dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (275 aa) |
| | hisI | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (151 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (357 aa) |
| | metX | Putative homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (412 aa) |
| | proB | Putative glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (382 aa) |
| | aatA | Aspartate aminotransferase. (400 aa) |
| | GDI3125 | Putative aspartate aminotransferase. (414 aa) |
| | thrB | Putative homoserine kinase; Belongs to the pseudomonas-type ThrB family. (321 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (483 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (207 aa) |
| | leuB | Putative 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (440 aa) |
| | GDI3011 | Putative transketolase. (250 aa) |
| | GDI3010 | Putative transketolase. (320 aa) |
| | GDI2991 | Transposase. (347 aa) |
| | GDI2989 | Transposase IS116/IS110/IS902 family protein. (347 aa) |
| | lysA | Putative diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (491 aa) |
| | argH | Putative argininosuccinate lyase 1. (476 aa) |
| | aroE | Putative shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (292 aa) |
| | GDI2835 | Putative major facilitator superfamily (MFS) transporter. (405 aa) |
| | GDI2751 | Hypothetical protein. (208 aa) |
| | dapA-3 | Putative dihydrodipicolinate synthase; Belongs to the DapA family. (315 aa) |
| | GDI2703 | Putative peptidase. (423 aa) |
| | cysE-2 | Putative serine acetyltransferase. (291 aa) |
| | GDI2600 | Putative sugar fermentation stimulation protein B. (103 aa) |
| | metE | 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferas; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (785 aa) |
| | GDI2566 | Putative major facilitator superfamily (MFS) transporter. (436 aa) |
| | ilvE-2 | Branched-chain-amino-acid aminotransferase. (364 aa) |
| | GDI2458 | Putative cystathionine-beta-synthase. (167 aa) |
| | ltaE | Putative low specificity L-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa) |
| | GDI2382 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (245 aa) |
| | cysE | Putative serine acetyltransferase. (283 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (524 aa) |
| | dapF | Putative diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (407 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (340 aa) |
| | cbbT | Putative transketolase; Belongs to the transketolase family. (705 aa) |
| | argC | Putative N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (328 aa) |
| | GDI2257 | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (393 aa) |
| | hisZ | Putative histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (393 aa) |
| | aroG | 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase (DAHP synthetase, phenylalanine repressible). (470 aa) |
| | aroKB | Putative bifunctional protein: shikimate kinase and 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (591 aa) |
| | argB | Putative acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (322 aa) |
| | dapD | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferas; Belongs to the transferase hexapeptide repeat family. (300 aa) |
| | dapE | Putative succinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (385 aa) |
| | gltD | Glutamate synthase [NADPH] small chain. (522 aa) |
| | gltB | Putative glutamate synthase [NADPH] large chain precursor. (1516 aa) |
| | thrC | Threonine synthase. (465 aa) |
| | GDI1991 | Isocitrate dehydrogenase. (342 aa) |
| | metC | Putative cystathionine beta-lyase. (416 aa) |
| | trpC | Putative indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (283 aa) |
| | trpD | Putative anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (376 aa) |
| | trpG | Putative mnthranilate synthase component 2. (198 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (522 aa) |
| | tpiA | Putative triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (247 aa) |
| | eno | Enolase protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (297 aa) |
| | pheA | Putative P-protein [Includes: Chorismate mutase (EC 5.4.99.5) (CM); Prephenat dehydratase (EC 4.2.1.51) (PDT). (287 aa) |
| | serA | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (421 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa) |
| | GDI1832 | Putative chorismate mutase. (111 aa) |
| | GDI1637 | Putative tranposase protein. (299 aa) |
| | tyrA | Putative prephenate dehydrogenase. (302 aa) |
| | GDI1619 | Conserved hypothetical protein. (246 aa) |
| | GDI1558 | Putative transposase. (346 aa) |
| | GDI1545 | Transposase. (362 aa) |
| | GDI1519 | Putative membrane protein. (326 aa) |
| | sdaA | Putative L-serine deaminase /L-threonine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (452 aa) |
| | GDI1480 | Cysteine synthase. (328 aa) |
| | GDI1468 | Putative asparagine synthetase protein. (513 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (401 aa) |
| | argF | Putative Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (331 aa) |
| | GDI1450 | Putative acetyltransferase. (199 aa) |
| | hisG | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (235 aa) |
| | hisD | Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa) |
| | maf | Inhibitor of septum formation, Maf-like protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (212 aa) |
| | GDI1409 | Putative transposase. (314 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (342 aa) |
| | acnA | Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (897 aa) |
| | aroQ | Putative 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (206 aa) |
| | trpF | Putative N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (224 aa) |
| | GDI1304 | Putative threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (350 aa) |
| | pykA | Pyruvate kinase; Belongs to the pyruvate kinase family. (479 aa) |
| | pqqC | Putative Pyrroloquinoline-quinone synthase; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ. (249 aa) |
| | dapB | Putative Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (256 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (395 aa) |
| | trpB | Putative Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (411 aa) |
| | trpA | Putative Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (274 aa) |
| | Maf-like | Putative septum formation inhibitor protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (251 aa) |
| | ilvE | Putative branched-chain-amino-acid aminotransferase (ec 2.6.1.42 (transaminase b) (bcat). (267 aa) |
| | GDI1127 | Putative transposase (fragment). (379 aa) |
| | GDI1034 | Aminotransferase protein. (407 aa) |
| | GDI1033 | Homoserine dehydrogenase. (451 aa) |
| | GDI0940 | Hypothetical protein. (53 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (357 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa) |
| | proC | Putative pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa) |
| | icd | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa) |
| | rimJ | Putative ribosomal-protein-alanine acetyltransferase. (168 aa) |
| | argJ | Arginine biosynthesis bifunctional protein argJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (410 aa) |
| | cysB | Cysteine synthase. (345 aa) |
| | GDI0684 | Putative major facilitator superfamily (MFS) transporter. (419 aa) |
| | GDI0637 | Putative prephenate dehydrogenase. (257 aa) |
| | aroD | Putative 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (268 aa) |
| | GDI0607 | Putative aspartate aminotransferase. (381 aa) |
| | GDI0527 | Aminotransferase. (390 aa) |
| | glnA | Glutamine synthetase. (486 aa) |
| | fbaB | Fructose-bisphosphate aldolase class 1. (309 aa) |
| | argE | Putative acetylornithine deacetylase. (405 aa) |
| | nifV | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (379 aa) |
| | GDI0420 | Putative tartrate dehydrogenase/decarboxylase. (358 aa) |
| | GDI0402 | Putative transposase. (354 aa) |
| | vapC-2 | Conserved hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (131 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (234 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the GPI family. (955 aa) |
| | tktA | Putative outer membrane protein (pseudogene); Belongs to the transketolase family. (775 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa) |
| | GDI0241 | Putative transketolase. (688 aa) |
| | GDI0211 | Putative D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (319 aa) |
| | GDI0095 | Conserved hypothetical protein. (94 aa) |
| | hisB | Putative imidazoleglycerol-phosphate dehydratase. (198 aa) |
| | hisH | Putative imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (223 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase. (451 aa) |
| | hisF | Putative imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisE | Putative phosphoribosyl-ATP pyrophosphatase. (175 aa) |
| | vapC | Conserved hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (136 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | ilvH | Putative acetolactate synthase isozyme III small subunit. (171 aa) |
| | serB | Phosphoserine phosphatase. (298 aa) |
| | aroE-2 | Putative shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (285 aa) |
