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| | hscA | Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. (616 aa) |
| | hda | DNA replication initiation factor; Mediates the interaction of DNA replication initiator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinitiation, a process called regulatory inhibition of DnaA or RIDA (By similarity); Belongs to the DnaA family. HdA subfamily. (225 aa) |
| | cutF | Copper homeostasis protein. (239 aa) |
| | xdhC | Putative xanthine dehydrogenase, Fe-S subunit; Belongs to the UPF0386 family. (85 aa) |
| | KPN_00275 | Fimbrial subunit. (172 aa) |
| | clpX | ATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa) |
| | htpG | Heat shock protein 90; Molecular chaperone. Has ATPase activity. (624 aa) |
| | KPN_00491 | Putative fimbrial-like protein. (179 aa) |
| | ureE | Urease accessory protein ureE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family. (158 aa) |
| | yqiC | Hypothetical protein. (90 aa) |
| | ygfE | Hypothetical protein; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (109 aa) |
| | fimF | Fimbrial morphology. (176 aa) |
| | fimI | Fimbrial protein. (175 aa) |
| | fimA-2 | Major type 1 subunit fimbrin (pilin). (182 aa) |
| | KPN_03276 | Putative fimbrial-like protein. (331 aa) |
| | pduU | Propanediol utilization: polyhedral bodies. (116 aa) |
| | pduK | Propanediol utilization: polyhedral bodies. (148 aa) |
| | pduJ | Propanediol utilization: polyhedral bodies. (91 aa) |
| | pduA | Propanediol utilization: polyhedral bodies. (94 aa) |
| | ftsB | Cell divison protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. (105 aa) |
| | stpA | DNA-bending protein with chaperone activity; Belongs to the histone-like protein H-NS family. (130 aa) |
| | fim-4 | Putative fimbrial-like protein. (193 aa) |
| | fimA | Major type 1 subunit fimbrin (pilin). (173 aa) |
| | KPN_02978 | L-fuculose phosphate aldolase. (242 aa) |
| | grpE | Hsp 24 nucleotide exchange factor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several roun [...] (196 aa) |
| | yfiO | Putative lipoprotein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa) |
| | hscB | Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (171 aa) |
| | yfgL | Putative dehydrogenase; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (392 aa) |
| | nlpB | Lipoprotein-34; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (344 aa) |
| | ypfE | Putative carboxysome structural protein, ethanol utilization. (111 aa) |
| | KPN_04886 | Putative prophage protein. (160 aa) |
| | dnaT | Primosomal protein I; This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'. (179 aa) |
| | yjgD | Hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. (140 aa) |
| | ulaA | Ascorbate-specific PTS system enzyme IIC. (466 aa) |
| | KPN_00494 | Putative fimbrial biogenesis outer membrane usher protein. (315 aa) |
| | groEL-2 | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (548 aa) |
| | cbpA | Putative chaperone DnaJ; DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM. (305 aa) |
| | groEL | Chaperonin GroEL. (318 aa) |
| | zraP | Zn-binding periplasmic protein; Binds zinc. Could be an important component of the zinc- balancing mechanism; Belongs to the ZraP family. (145 aa) |
| | secB | Export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (155 aa) |
| | yiiU | Hypothetical protein; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. (81 aa) |
| | uhpB | Sensor histidine protein kinase phosphorylates UhpA. (500 aa) |
| | ibpB | Heat shock protein; Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent. (142 aa) |
| | ibpA | Heat shock protein; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent. (152 aa) |
| | phoU | Negative regulator for pho regulon and putative enzyme in phosphate metabolism; Part of the phosphate (Pho) regulon, which plays a key role in phosphate homeostasis. PhoU is essential for the repression of the Pho regulon at high phosphate conditions. (241 aa) |
| | cpxP | Periplasmic repressor of cpx regulon by interaction with CpxA. (167 aa) |
| | menG | Ribonuclease activity regulator protein RraA; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome. (161 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (334 aa) |
| | yigP | Hypothetical protein. (201 aa) |
| | rsd | Regulator of sigma D; Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase. (165 aa) |
| | KPN_00522 | Hypothetical protein. (41 aa) |
| | KPN_00569 | Putative amidohydrolase. (422 aa) |
| | rnk | Nucleoside diphosphate kinase regulator; May act as an anti-Gre factor; Belongs to the Rnk family. (140 aa) |
| | cchA | Detox protein. (96 aa) |
| | tolB | Translocation protein TolB precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane. (418 aa) |
| | mntR | Conserved protein, Winged helix domain. (145 aa) |
| | clpS | ATP-dependent Clp protease adaptor protein ClpS; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family. (105 aa) |
| | KPN_00965 | Putative peptidase. (412 aa) |
| | ycbW | Hypothetical protein; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. (180 aa) |
| | pqiB | Paraquat-inducible protein B. (545 aa) |
| | ymbA | Hypothetical protein. (187 aa) |
| | dinI | DNA damage-inducible protein I, inhibits UmuD processing. (83 aa) |
| | spy | Periplasmic protein; Related to spheroblast formation. (161 aa) |
| | pspA | Phage shock protein, inner membrane protein. (227 aa) |
| | KPN_01330 | Hypothetical protein. (403 aa) |
| | KPN_01344 | Hypothetical protein. (351 aa) |
| | KPN_01457 | Putative aldolase class II. (245 aa) |
| | paaG | enoyl-CoA hydratase. (262 aa) |
| | ydgA | Hypothetical protein. (525 aa) |
| | KPN_01556 | Hypothetical protein. (407 aa) |
| | KPN_01596 | Heat shock protein; Belongs to the small heat shock protein (HSP20) family. (157 aa) |
| | KPN_01673 | Putative fimbrial-like protein. (187 aa) |
| | KPN_01761 | Putative peptidase. (419 aa) |
| | KPN_01773 | Putative aspartate-semialdehyde dehydrogenase; Belongs to the aspartate-semialdehyde dehydrogenase family. (372 aa) |
| | narW | Cryptic nitrate reductase 2 delta subunit. (231 aa) |
| | mhpC | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase; Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6- oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid. (288 aa) |
| | hns | DNA-binding protein HLP-II (HU, BH2, HD, NS); pleiotropic regulator; Belongs to the histone-like protein H-NS family. (135 aa) |
| | narJ | Nitrate reductase 1, delta subunit, assembly function. (236 aa) |
| | narX | Nitrate/nitrate sensor, histidine protein kinase; Acts on NarL regulator. (592 aa) |
| | ychN | Putative phosphatase. (117 aa) |
| | KPN_02253 | Hypothetical protein. (88 aa) |
| | KPN_02263 | Hypothetical protein. (451 aa) |
| | KPN_02268 | Hypothetical protein. (451 aa) |
| | KPN_02272 | Hypothetical protein. (460 aa) |
| | minC | Septum formation inhibitor; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (232 aa) |
| | minE | Cell division topological specificity factor MinE; Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell. (89 aa) |
| | yeaY | Putative outer membrane protein. (193 aa) |
| | KPN_02350 | Hypothetical protein. (877 aa) |
| | yebV | Hypothetical protein. (79 aa) |
| | yfbU | Hypothetical protein. (121 aa) |
| | yfbU-2 | Hypothetical protein. (39 aa) |
| | usg | Hypothetical protein; Belongs to the aspartate-semialdehyde dehydrogenase family. (337 aa) |
| | pdxB | Erythronate-4-phosphate dehydrogenase; Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate. (370 aa) |
| | hemF | Coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (299 aa) |
| | cchB | Detox protein. (95 aa) |
| | dnaJ | Chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] (377 aa) |
| | kefC | Glutathione-regulated potassium-efflux system protein; Pore-forming subunit of a potassium efflux system that confers protection against electrophiles. Catalyzes K(+)/H(+) antiport. (621 aa) |
| | surA | Peptidyl-prolyl cis-trans isomerase (PPIase); Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (428 aa) |
| | djlA | Dna-J like membrane chaperone protein; Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB/RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host. (275 aa) |
| | ftsQ | Cell division protein; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (276 aa) |
| | yacF | Hypothetical protein; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (247 aa) |
| | pulD | Pullulanase D protein. (657 aa) |
| | hlpA | Periplasmic molecular chaperone for outer membrane proteins; Belongs to the skp family. (148 aa) |
| | uspA-2 | Universal stress protein A; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (145 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (368 aa) |
| | greB | Transcription elongation factor GreB; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length. (157 aa) |
| | hslO | Hsp33-like chaperonin; Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. (294 aa) |
| | rpoA | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (329 aa) |
| | dnaK | Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (638 aa) |
| | mreC | Rod shape-determining protein; Involved in formation and maintenance of cell shape. (330 aa) |
| | greA | Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (158 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (447 aa) |
| | KPN_03534 | Periplasmic protein; Related to spheroblast formation. (136 aa) |
| | yqjB | Hypothetical protein; Modulates the activity of the EnvZ/OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR. (128 aa) |
| | hdeB-2 | Hypothetical protein; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins. Belongs to the HdeB family. (101 aa) |
