STRINGSTRING
glk glk KPN_02957 KPN_02957 KPN_02959 KPN_02959 srlD srlD hycD hycD hycB hycB gudD gudD eno eno gpmB gpmB deoC deoC KPN_04797 KPN_04797 KPN_04796 KPN_04796 KPN_04721 KPN_04721 iolE iolE araD araD araA araA araB araB aceE aceE aceF aceF pul-2 pul-2 KPN_00349 KPN_00349 KPN_00381 KPN_00381 KPN_00504 KPN_00504 KPN_00505 KPN_00505 KPN_00506 KPN_00506 KPN_00507 KPN_00507 KPN_00540 KPN_00540 iolG iolG KPN_04674 KPN_04674 KPN_04671 KPN_04671 treC treC sgaE sgaE sgaU sgaU sgaH sgaH yjfR yjfR pgi pgi gldA gldA pfkA pfkA rhaB rhaB rhaA rhaA rhaD rhaD KPN_04206 KPN_04206 KPN_04203 KPN_04203 KPN_04196 KPN_04196 KPN_04193 KPN_04193 rbsD rbsD dgoK dgoK dgoA dgoA dgoD dgoD KPN_04027 KPN_04027 glpK glpK tpiA tpiA yibO yibO malS malS KPN_03889 KPN_03889 bcsC bcsC treF treF glgX glgX rpe rpe slyX slyX KPN_00591 KPN_00591 ybdH ybdH gpmA gpmA galT galT KPN_01120 KPN_01120 gapA gapA KPN_01201 KPN_01201 ydjC ydjC kduD kduD lacZ lacZ uxaB uxaB KPN_01687 KPN_01687 KPN_01700 KPN_01700 deoC-2 deoC-2 fucO fucO fucI fucI fucK fucK KPN_03255 KPN_03255 kduD-2 kduD-2 tolB-2 tolB-2 fbaA fbaA pgk pgk KPN_03423 KPN_03423 dhaT dhaT dhaD dhaD dhaM dhaM yneB yneB ygjR ygjR uxaA uxaA garL garL garD garD gatY gatY gatZ gatZ KPN_01710 KPN_01710 KPN_01744 KPN_01744 KPN_01784 KPN_01784 KPN_01796 KPN_01796 KPN_01797 KPN_01797 KPN_01838 KPN_01838 pykF pykF treA treA edd edd pykA pykA KPN_02547 KPN_02547 fbaB fbaB glpA glpA glpB glpB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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glkGlucokinase; Belongs to the bacterial glucokinase family. (321 aa)
KPN_02957Putative hexulose 6 phosphate synthase. (211 aa)
KPN_02959Putative cytoplasmic protein. (280 aa)
srlDSorbitol-6-phosphate 2-dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (259 aa)
hycDHydrogenase 3, membrane subunit (part of FHL complex). (307 aa)
hycBHydrogenase-3, Fe-S subunit (part of FHL complex). (169 aa)
gudD(D)-glucarate dehydratase 1. (446 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa)
gpmBPhosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. GpmB subfamily. (215 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily. (259 aa)
KPN_04797Keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase. (199 aa)
KPN_047962-oxo-3-deoxygalactonate kinase. (290 aa)
KPN_04721Puative beta-1,4-xylosidase; XynB; Belongs to the glycosyl hydrolase 43 family. (559 aa)
iolEPutative sugar phosphate isomerases/epimerases; Catalyzes the dehydration of inosose (2-keto-myo-inositol, 2KMI or 2,4,6/3,5-pentahydroxycyclohexanone) to 3D-(3,5/4)- trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi-inositol). Belongs to the IolE/MocC family. (299 aa)
araDL-ribulose-5-phosphate 4-epimerase; Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5- phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction). (231 aa)
araAL-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (500 aa)
araBRibulokinase. (569 aa)
aceEPyruvate dehydrogenase (decarboxylase component); Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
aceFDihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (632 aa)
pul-2Pullulanase protein; Belongs to the glycosyl hydrolase 13 family. (1086 aa)
KPN_00349Putative fructose-1,6-bisphosphate aldolase type II. (286 aa)
KPN_00381Oxidoreductase, N-terminal; Oxidoreductase, C-terminal. (392 aa)
KPN_00504Hypothetical protein. (306 aa)
KPN_00505Putative oxidoreductase. (390 aa)
KPN_00506Putative oxidoreductase. (343 aa)
KPN_00507Putative oxidoreductase. (335 aa)
KPN_00540Putative NADH-dependent dehydrogenase. (393 aa)
iolGPutative NADH-dependent dehydrogenase; Involved in the oxidation of myo-inositol (MI) to 2-keto-myo- inositol (2KMI or 2-inosose). (363 aa)
KPN_04674Putative acetolactate synthase large subunit; Belongs to the TPP enzyme family. (646 aa)
KPN_04671Hypothetical protein. (269 aa)
treCTrehalase 6-P hydrolase. (551 aa)
sgaEL-ribulose-5-phosphate 4-epimerase; Catalyzes the isomerization of L-ribulose 5-phosphate to D- xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization. (228 aa)
sgaUL-xylulose 5-phosphate 3-epimerase. (284 aa)
sgaH3-keto-L-gulonate 6-phosphate decarboxylase. (212 aa)
yjfRPutative enzyme with metallo-hydrolase domain. (354 aa)
pgiGlucose-6-phosphate isomerase; Belongs to the GPI family. (549 aa)
gldAGlycerol dehydrogenase. (367 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (320 aa)
rhaBRhamnulokinase; Involved in the catabolism of L-rhamnose (6-deoxy-L-mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1- hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate. Belongs to the rhamnulokinase family. (488 aa)
rhaAL-rhamnose isomerase. (419 aa)
rhaDRhamnulose-1-phosphate aldolase; Catalyzes the reversible cleavage of L-rhamnulose-1-phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde. Belongs to the aldolase class II family. RhaD subfamily. (276 aa)
KPN_04206Putative alcohol dehydrogenase. (379 aa)
KPN_04203Putative glycoprotein. (707 aa)
KPN_04196Putative Ketose-bisphosphate aldolase, class-II. (280 aa)
KPN_04193Putative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (326 aa)
rbsDD-ribose high-affinity transport system; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. (139 aa)
dgoK2-oxo-3-deoxygalactonate kinase. (292 aa)
dgoAPutative keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase. (205 aa)
dgoDPutative mandelate racemase/muconate lactonizing enzyme; Catalyzes the dehydration of D-galactonate to 2-keto-3-deoxy- D-galactonate. (382 aa)
KPN_04027Putative beta-lactamase-like protein. (259 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate. (503 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
yibOPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (507 aa)
malSPeriplasmic alpha-amylase precursor. (677 aa)
KPN_03889endo-1,4-D-glucanase; Belongs to the glycosyl hydrolase 8 (cellulase D) family. (333 aa)
bcsCendo-1,4-D-glucanase. (369 aa)
treFCytoplasmic trehalase; Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity. (550 aa)
glgXGlycogen debranching enzyme; Removes maltotriose and maltotetraose chains that are attached by 1,6-alpha-linkage to the limit dextrin main chain, generating a debranched limit dextrin. (658 aa)
rpeRibulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (225 aa)
slyXHypothetical protein; Belongs to the SlyX family. (72 aa)
KPN_00591Putative carbohydrate kinase; Belongs to the FGGY kinase family. (499 aa)
ybdHPutative alcohol dehydrogenase. (362 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (250 aa)
galTGalactose-1-phosphate uridylyltransferase. (348 aa)
KPN_01120Triosephosphate isomerase. (265 aa)
gapAGlyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
KPN_01201Putative chitinase II; Belongs to the glycosyl hydrolase 18 family. (417 aa)
ydjCHypothetical protein; Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, t [...] (252 aa)
kduDPutative 2-deoxy-D-gluconate 3-dehydrogenase. (253 aa)
lacZbeta-D-galactosidase; Belongs to the glycosyl hydrolase 2 family. (1035 aa)
uxaBTagaturonate reductase; Belongs to the mannitol dehydrogenase family. UxaB subfamily. (483 aa)
KPN_01687Putative dehydrogenase. (277 aa)
KPN_01700Putative ribulose-phosphate 3-epimerase. (218 aa)
deoC-2Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (249 aa)
fucOL-1,2-propanediol oxidoreductase. (378 aa)
fucIL-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose. (591 aa)
fucKL-fuculokinase; Catalyzes the phosphorylation of L-fuculose. Belongs to the FGGY kinase family. (472 aa)
KPN_03255Hypothetical protein. (108 aa)
kduD-22-deoxy-D-gluconate 3-dehydrogenase. (253 aa)
tolB-2Translocation protein TolB precursor. (391 aa)
fbaAFructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (359 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (382 aa)
KPN_03423Putative glycoside hydrolase; Belongs to the glycosyl hydrolase 43 family. (507 aa)
dhaT1,3-propanediol oxidoreductase. (387 aa)
dhaDPutative glycerol dehydrogenase. (365 aa)
dhaMPutative PTS hybrid protein; Belongs to the PEP-utilizing enzyme family. (473 aa)
yneBHypothetical protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the transfer of an acetyl moiety from 3-hydroxy-5- phosphonooxypentane-2,4-dione to CoA to form glycerone phosphate and acetyl-CoA; Belongs to the DeoC/FbaB aldolase family. (295 aa)
ygjRPutative NAD(P)-binding dehydrogenase. (329 aa)
uxaAAltronate hydrolase. (495 aa)
garLalpha-dehydro-beta-deoxy-D-glucarate aldolase; Catalyzes the reversible retro-aldol cleavage of both 5-keto- 4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde; Belongs to the HpcH/HpaI aldolase family. KDGluc aldolase subfamily. (256 aa)
garD(D)-galactarate dehydrogenase; Catalyzes the dehydration of galactarate to form 5-dehydro-4- deoxy-D-glucarate. (523 aa)
gatYTagatose 1,6-diphosphate aldolase; Catalytic subunit of the tagatose-1,6-bisphosphate aldolase GatYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP). Requires GatZ subunit for full activity and stability. Is involved in the catabolism of galactitol. (284 aa)
gatZPutative tagatose 6-phosphate kinase 1; Component of the tagatose-1,6-bisphosphate aldolase GatYZ that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of GatY. When expressed alone, GatZ does not show any aldolase activity. Is involved in the catabolism of galactitol. (423 aa)
KPN_01710Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
KPN_01744D-allulose-6-phosphate 3-epimerase. (215 aa)
KPN_01784Phosphoglycerate mutase. (206 aa)
KPN_01796Putative epimerase/isomerase. (313 aa)
KPN_01797Hypothetical oxidoreductase. (390 aa)
KPN_01838Putative glycosidase. (541 aa)
pykFPyruvate kinase; Belongs to the pyruvate kinase family. (470 aa)
treATrehalase, periplasmic; Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system; Belongs to the glycosyl hydrolase 37 family. (581 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (599 aa)
pykAPyruvate kinase; Belongs to the pyruvate kinase family. (480 aa)
KPN_02547Ribulokinase. (535 aa)
fbaBFructose-bisphosphate aldolase. (350 aa)
glpASn-glycerol-3-phosphate dehydrogenase (anaerobic), large subunit; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (540 aa)
glpBAnaerobic glycerol-3-phosphate dehydrogenase subunit B; Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor. (419 aa)
Your Current Organism:
Klebsiella pneumoniae MGH78578
NCBI taxonomy Id: 272620
Other names: K. pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae MCG 78578, Klebsiella pneumoniae str. MCG 78578, Klebsiella pneumoniae subsp. pneumoniae ATCC 700721, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae subsp. pneumoniae str. MGH 78578, Klebsiella pneumoniae subsp. pneumoniae strain MGH 78578
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