STRINGSTRING
rpoS rpoS stpA stpA clpB clpB yfgF yfgF rcsB rcsB sodB sodB sodC sodC gst gst katG katG lacZ lacZ dnaK dnaK htpG htpG ybbN ybbN ahpC ahpC dinI dinI yeaL yeaL katE katE pspA pspA pspB pspB fumB fumB pspC pspC priB priB soxR soxR soxS soxS yjcC yjcC trxA trxA oxyR oxyR sodA sodA ibpA ibpA ibpB ibpB rpsL rpsL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpoSRNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
stpADNA-bending protein with chaperone activity; Belongs to the histone-like protein H-NS family. (130 aa)
clpBATP-dependent protease, Hsp 100; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
yfgFPutative cytochrome C-type biogenesis protein. (742 aa)
rcsBPositive response regulator for colanic capsule biosynthesis, (sensor, RcsC); Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. (216 aa)
sodBSuperoxide dismutase, iron; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (193 aa)
sodCSuperoxide dismutase precursor (Cu-Zn); Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (173 aa)
gstGlutathionine S-transferase; Belongs to the GST superfamily. (201 aa)
katGPutative catalase (hydroperoxidase I); Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (725 aa)
lacZbeta-D-galactosidase; Belongs to the glycosyl hydrolase 2 family. (1035 aa)
dnaKMolecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (638 aa)
htpGHeat shock protein 90; Molecular chaperone. Has ATPase activity. (624 aa)
ybbNPutative thioredoxin protein. (284 aa)
ahpCAlkyl hydroperoxide reductase, C22 subunit, thioredoxin-like protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (187 aa)
dinIDNA damage-inducible protein I, inhibits UmuD processing. (83 aa)
yeaLHypothetical protein. (148 aa)
katECatalase; Serves to protect cells from the toxic effects of hydrogen peroxide. (752 aa)
pspAPhage shock protein, inner membrane protein. (227 aa)
pspBPhage shock protein B. (74 aa)
fumBFumarase B (fumarate hydratase class I), anaerobic isozyme; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (550 aa)
pspCPhage shock protein: activates phage shock-protein expression. (119 aa)
priBPrimosomal replication protein N. (55 aa)
soxRRedox-sensing activator of soxS. (143 aa)
soxSRegulation of superoxide response regulon. (109 aa)
yjcCHypothetical protein. (534 aa)
trxAThioredoxin; Belongs to the thioredoxin family. (109 aa)
oxyRActivator, hydrogen peroxide-inducible genes; Belongs to the LysR transcriptional regulatory family. (305 aa)
sodASuperoxide dismutase, manganese; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (210 aa)
ibpAHeat shock protein; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent. (152 aa)
ibpBHeat shock protein; Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent. (142 aa)
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (124 aa)
Your Current Organism:
Klebsiella pneumoniae MGH78578
NCBI taxonomy Id: 272620
Other names: K. pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae MCG 78578, Klebsiella pneumoniae str. MCG 78578, Klebsiella pneumoniae subsp. pneumoniae ATCC 700721, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae subsp. pneumoniae str. MGH 78578, Klebsiella pneumoniae subsp. pneumoniae strain MGH 78578
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