STRINGSTRING
KPN_02059 KPN_02059 KPN_01951 KPN_01951 cysB cysB KPN_01018 KPN_01018 ompA ompA ompX ompX kdpD kdpD kdpE kdpE fepA fepA betB betB htpG htpG hupB hupB clpX clpX clpP clpP gabT gabT panD panD gcd gcd speE speE nhaA nhaA pitA pitA ompR ompR groES groES lexA lexA ubiC ubiC hupA hupA atpI atpI treF treF dnaK dnaK dnaJ dnaJ speB speB otsB otsB otsA otsA sdaA sdaA narL narL cls cls
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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KPN_02059Acetolactate decarboxylase; Belongs to the alpha-acetolactate decarboxylase family. (225 aa)
KPN_01951Glucose dehydrogenase. (807 aa)
cysBTranscriptional regulator for cysteine regulon; Belongs to the LysR transcriptional regulatory family. (324 aa)
KPN_01018Aldehyde dehydrogenase; Prefers NADP over NAD; Belongs to the aldehyde dehydrogenase family. (496 aa)
ompAOuter membrane protein 3a (II*;G;d); Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (356 aa)
ompXOuter membrane protein X. (170 aa)
kdpDSensor for high-affinity potassium transport system. (895 aa)
kdpERegulator of kdp operon (transcriptional effector). (225 aa)
fepAOuter membrane porin, receptor for ferric enterobactin and colicins B and D. (742 aa)
betBNAD+-dependent betaine aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid. (487 aa)
htpGHeat shock protein 90; Molecular chaperone. Has ATPase activity. (624 aa)
hupBDNA-binding protein HU-beta, NS1 (HU-1); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
clpXATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (194 aa)
gabT4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (427 aa)
panDAspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (126 aa)
gcdGlucose dehydrogenase. (784 aa)
speESpermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. (286 aa)
nhaANa+/H antiporter, pH dependent; Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons; Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family. (395 aa)
pitALow-affinity phosphate transport. (498 aa)
ompROsmolarity response regulator. (239 aa)
groESCo-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (97 aa)
lexALexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single- stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa)
ubiCChorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway. (165 aa)
hupADNA-binding protein HU-alpha (HU-2); Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa)
atpIATP synthase subunit I. (126 aa)
treFCytoplasmic trehalase; Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity. (550 aa)
dnaKMolecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (638 aa)
dnaJChaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] (377 aa)
speBAgmatinase; Catalyzes the formation of putrescine from agmatine. Belongs to the arginase family. Agmatinase subfamily. (306 aa)
otsBTrehalose-6-phosphate phophatase, biosynthetic; Removes the phosphate from trehalose 6-phosphate to produce free trehalose. (262 aa)
otsATrehalose-6-phosphate synthase; Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-alpha-D- glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose- 6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor; Belongs to the glycosyltransferase 20 family. (474 aa)
sdaAL-serine deaminase; Belongs to the iron-sulfur dependent L-serine dehydratase family. (432 aa)
narLPleiotrophic regulation of anaerobic respiration; Response regulator for nar, frd, dms and tor genes. (216 aa)
clsCardiolipin synthetase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (486 aa)
Your Current Organism:
Klebsiella pneumoniae MGH78578
NCBI taxonomy Id: 272620
Other names: K. pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae MCG 78578, Klebsiella pneumoniae str. MCG 78578, Klebsiella pneumoniae subsp. pneumoniae ATCC 700721, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae subsp. pneumoniae str. MGH 78578, Klebsiella pneumoniae subsp. pneumoniae strain MGH 78578
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