STRINGSTRING
phoQ phoQ galE galE rbsA-2 rbsA-2 recR recR clpX clpX sbcC sbcC rnhA rnhA dgt dgt dnaK dnaK yhcQ yhcQ dam dam atpG atpG rbsA rbsA rbsC rbsC sodA sodA rbsA-3 rbsA-3 groES groES tolC tolC sugE sugE emrB emrB clpB clpB cysK cysK wza wza wzb wzb wzc wzc yeeZ yeeZ zwf zwf oppD oppD marR marR phoP phoP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
phoQSensor protein PhoQ. (488 aa)
galEUDP-galactose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (338 aa)
rbsA-2Putative ABC transporter; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (494 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)
clpXATP-dependent protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (424 aa)
sbcCATP-dependent dsDNA exonuclease; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SMC family. SbcC subfamily. (1045 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (155 aa)
dgtDeoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs; Belongs to the dGTPase family. Type 1 subfamily. (504 aa)
dnaKMolecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (638 aa)
yhcQPutative membrane located multidrug resistance protein; Forms an efflux pump with AaeB; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (296 aa)
damDNA adenine methylase. (275 aa)
atpGATP synthase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (287 aa)
rbsAATP-binding component of D-ribose high-affinity transport system; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (501 aa)
rbsCRibose high-affinity ABC transporter permease component; Belongs to the binding-protein-dependent transport system permease family. (321 aa)
sodASuperoxide dismutase, manganese; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (210 aa)
rbsA-3Putative ABC transporter; Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system. Belongs to the ABC transporter superfamily. Ribose importer (TC 3.A.1.2.1) family. (506 aa)
groESCo-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (97 aa)
tolCOuter membrane channel precursor protein. (492 aa)
sugEQuarternary ammonium compound transport protein (SMR family). (105 aa)
emrBMultidrug resistance; probably membrane translocase; Belongs to the major facilitator superfamily. (512 aa)
clpBATP-dependent protease, Hsp 100; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
cysKCysteine synthase A, O-acetylserine sulfhydrolase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. (323 aa)
wzaCPS export - outer membrane protein. (377 aa)
wzbProtein tyrosine phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (147 aa)
wzcTyrosine autokinase. (720 aa)
yeeZPutative enzyme. (274 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (491 aa)
oppDOligopeptide transporter ATP-binding component; Belongs to the ABC transporter superfamily. (337 aa)
marRMultiple antibiotic resistance protein; repressor of mar operon. (144 aa)
phoPResponse regulator in two-component regulatory system with PhoQ, regulates gene expression at low. (223 aa)
Your Current Organism:
Klebsiella pneumoniae MGH78578
NCBI taxonomy Id: 272620
Other names: K. pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae MCG 78578, Klebsiella pneumoniae str. MCG 78578, Klebsiella pneumoniae subsp. pneumoniae ATCC 700721, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae subsp. pneumoniae str. MGH 78578, Klebsiella pneumoniae subsp. pneumoniae strain MGH 78578
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.