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htpG htpG fes fes entF entF fepB fepB entC entC yliJ yliJ dacC dacC osmB osmB narL narL rcsA rcsA yojN yojN rcsB rcsB rcsC rcsC ackA ackA aroC aroC clpB clpB rpoS rpoS nlpD nlpD barA barA crp crp ompR ompR hslU hslU ytfK ytfK hslV hslV dnaK dnaK leuO leuO ftsA ftsA ftsZ ftsZ rcsF rcsF rnhA rnhA ykgK ykgK yagZ yagZ phoB phoB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
htpGHeat shock protein 90; Molecular chaperone. Has ATPase activity. (624 aa)
fesEnterochelin esterase. (382 aa)
entFATP-dependent serine activating enzyme; May be part of enterobactin synthase as component F. (1300 aa)
fepBFerric enterobactin (enterochelin) binding protein; periplasmic component. (319 aa)
entCIsochorismate synthase. (391 aa)
yliJPutative glutathione S-transferase. (208 aa)
dacCD-alanyl-D-alanine carboxypeptidase; penicillin-binding protein 6; Belongs to the peptidase S11 family. (400 aa)
osmBLipoprotein, osmotically inducible. (46 aa)
narLPleiotrophic regulation of anaerobic respiration; Response regulator for nar, frd, dms and tor genes. (216 aa)
rcsAPositive regulator for ctr capsule biosynthesis, positive transcription factor; Component of the Rcs signaling system, which controls transcription of numerous genes. Binds to DNA to regulate expression of genes. (207 aa)
yojNPutative 2-component sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB. (885 aa)
rcsBPositive response regulator for colanic capsule biosynthesis, (sensor, RcsC); Component of the Rcs signaling system, which controls transcription of numerous genes. RcsB is the response regulator that binds to regulatory DNA regions. (216 aa)
rcsCHybrid sensory histidine kinase in two-component regulatory system with RcsB; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB. (946 aa)
ackAAcetate/propionate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (361 aa)
clpBATP-dependent protease, Hsp 100; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (857 aa)
rpoSRNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (330 aa)
nlpDLipoprotein. (378 aa)
barAHybrid sensory histidine kinase in two-component regulatory system with UvrY. (916 aa)
crpCyclic AMP receptor protein. (210 aa)
ompROsmolarity response regulator. (239 aa)
hslUATP-dependent protease ATP-binding subunit; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (444 aa)
ytfKHypothetical protein. (68 aa)
hslVATP-dependent protease peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (176 aa)
dnaKMolecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (638 aa)
leuOLeucine transcriptional activator; Belongs to the LysR transcriptional regulatory family. (294 aa)
ftsACell division protein; Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring. Belongs to the FtsA/MreB family. (420 aa)
ftsZCell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa)
rcsFRegulator in colanic acid synthesis; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (135 aa)
rnhARibonuclease H; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (155 aa)
ykgKPutative regulator; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP plays a dual role in early-stage biofilm development and host cell recognition. Positively regulates the expression of the ecp operon (By similarity); Belongs to the EcpR/MatA family. (180 aa)
yagZHypothetical protein; Part of the ecpRABCDE operon, which encodes the E.coli common pilus (ECP). ECP plays a dual role in early-stage biofilm development and host cell recognition. Major subunit of the fimbria (By similarity); Belongs to the EcpA/MatB fimbrillin family. (195 aa)
phoBPositive response regulator for pho regulon, sensor is PhoR (or CreC). (229 aa)
Your Current Organism:
Klebsiella pneumoniae MGH78578
NCBI taxonomy Id: 272620
Other names: K. pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae MCG 78578, Klebsiella pneumoniae str. MCG 78578, Klebsiella pneumoniae subsp. pneumoniae ATCC 700721, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae subsp. pneumoniae str. MGH 78578, Klebsiella pneumoniae subsp. pneumoniae strain MGH 78578
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