STRINGSTRING
lpg2153 lpg2153 lpg2154 lpg2154 sidJ sidJ lpg2156 lpg2156 sdeA sdeA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpg2153Sid related protein-like; SdeC, SdeB, AliA, SdeA, SdeD-like. (1533 aa)
lpg2154Sid related protein-like; SdeC, SdeB, AliA, SdeA, SdeD-like. (301 aa)
sidJHypothetical protein; Glutamylase that mediates the covalent attachment of glutamate moieties to SdeA on one of the catalytic residues that is required for its mono-ADP-ribosyltransferase activity. In turn, inhibits SdeA ubiquitinating activity. Glutamylates also related SdeB, SdeC and SidE. Glutamylase activity only occurs in the host since it requires host calmodulin. May also reverse the SdeA-mediated substrate ubiquitination by cleaving the phosphodiester bond that links phosphoribosylated ubiquitin to protein substrates via its deubiquitinase activity. (873 aa)
lpg2156Sid related protein-like; SdeC, SdeB, SdeA, SidE, AliA-like. (1926 aa)
sdeASid related protein-like; Secreted effector that interferes with the host cell ubiquitin pathway and is required for intracellular bacterial replication. Catalyzes the ubiquitination of several mammalian Rab proteins (Rab33b, Rab1, Rab6a and Rab30) during L.pneumophila infection, without engaging the standard cellular enzyme cascade (E1 and E2). Transfers an ADP-ribose moiety from NAD to the 'Arg-42' residue of ubiquitin in a reaction that releases nicotinamide. The modified ubiquitin is subsequently transferred to serine residues of the substrate protein via a phosphoribose linker tha [...] (1506 aa)
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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