STRINGSTRING
lpg0055 lpg0055 lpg0057 lpg0057 proQm proQm sdhB sdhB lpg0167 lpg0167 oxyR oxyR lpg0215 lpg0215 yacG yacG lpg0223 lpg0223 np20 np20 lpg0274 lpg0274 lpg0280 lpg0280 efp efp tuf2 tuf2 nusG nusG rplA rplA fusA fusA tufB tufB lpg0370 lpg0370 cspD cspD lpg0433 lpg0433 lpg0476 lpg0476 lpg0477 lpg0477 argR argR fis fis lpg0562 lpg0562 lpg0600 lpg0600 lpg0715 lpg0715 nrdR nrdR nusB nusB csrA-2 csrA-2 birA birA rsbV rsbV fleQ fleQ prfC prfC lpg0907 lpg0907 mraZ mraZ mfd mfd csrA-2-2 csrA-2-2 lvrA lvrA lpg1060 lpg1060 lpg1068 lpg1068 lpg1078 lpg1078 lpg1090 lpg1090 kaiC2 kaiC2 lpg1135 lpg1135 lpg1136 lpg1136 lpg1150 lpg1150 pilR pilR lpg1192 lpg1192 lpg1205 lpg1205 lpg1206 lpg1206 lpg1208 lpg1208 lpg1212 lpg1212 umuD umuD lvrC lvrC lvrA-2 lvrA-2 prpA prpA lpg1261 lpg1261 lpg1269 lpg1269 rpoS rpoS lpg1286 lpg1286 lpg1292 lpg1292 lpg1332 lpg1332 fis-2 fis-2 rsfS rsfS cpxR cpxR lpg1448 lpg1448 lpg1486 lpg1486 lpg1525 lpg1525 rpoE rpoE lpg1593 lpg1593 lpg1611 lpg1611 lpg1612 lpg1612 lpg1620 lpg1620 putA putA lpg1698 lpg1698 lpg1704 lpg1704 tsf tsf fis-3 fis-3 fleR fleR infA infA prfB prfB fliA fliA lpg1796 lpg1796 oxyR-2 oxyR-2 lepA lepA lpg1889 lpg1889 lpg1891 lpg1891 lpg1946 lpg1946 lpg1967 lpg1967 oruR oruR lpg2086 lpg2086 csrA csrA lvrA-3 lvrA-3 lpg2096 lpg2096 recG-2 recG-2 lpg2121 lpg2121 lpg2125 lpg2125 lpg2138 lpg2138 lpg2140 lpg2140 lpg2163 lpg2163 lpg2167 lpg2167 lpg2288 lpg2288 rne rne hepA hepA prfA prfA dksA dksA rpoD rpoD lpg2367 lpg2367 lpg2368 lpg2368 lpg2376 lpg2376 lpg2377 lpg2377 lpg2383 lpg2383 lpg2402 lpg2402 lpg2434 lpg2434 lpg2457 lpg2457 lpg2458 lpg2458 lpg2517 lpg2517 lpg2524 lpg2524 lpg2534 lpg2534 lpg2549 lpg2549 lpg2557 lpg2557 recG-3 recG-3 lpg2560 lpg2560 lpg2562 lpg2562 lpg2563 lpg2563 lpg2564 lpg2564 lpg2593 lpg2593 greA greA gacA gacA rpoH rpoH ihfA ihfA infC infC hfq hfq legN legN lpg2723 lpg2723 lpg2760 lpg2760 pnp pnp infB infB nusA nusA lpg2825 lpg2825 lpg2850 lpg2850 rppH rppH hipB hipB lpg2998 lpg2998
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpg0055Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (302 aa)
lpg0057Putative regulator, MerR family transcription regulators. (134 aa)
proQmActivator of ProP osmoprotectant transporter; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. (230 aa)
sdhBSdhB. (1875 aa)
lpg0167Peptide chain release factor. (136 aa)
oxyRTranscriptional regulator, LysR; Belongs to the LysR transcriptional regulatory family. (286 aa)
lpg0215Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (294 aa)
yacGHypothetical protein; Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C- terminal domain of GyrB, which probably disrupts DNA binding by the gyrase. (70 aa)
lpg0223Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (283 aa)
np20Transcriptional regulator np20, Fur family; Belongs to the Fur family. (177 aa)
lpg0274Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (287 aa)
lpg0280Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (293 aa)
efpTranslation elongation factor P (EF-P); Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation; Belongs to the elongation factor P family. (205 aa)
tuf2Elongation factor Tu (EF-Tu); This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (396 aa)
nusGTranscription antitermination protein NusG; Participates in transcription elongation, termination and antitermination. (184 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (231 aa)
fusATranslation elongation factor G (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G [...] (694 aa)
tufBTranslation elongation factor Tu (EF-Tu). (396 aa)
lpg0370Oligoketide cyclase/lipid transporter protein. (144 aa)
cspDCold shock protein CspD. (77 aa)
lpg0433Hypothetical protein. (126 aa)
lpg0476Sigma-54 modulation protein. (99 aa)
lpg0477RNA polymerase signma-54 factor RpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (464 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (104 aa)
fisDNA binding protein Fis; Belongs to the transcriptional regulatory Fis family. (93 aa)
lpg0562Hypothetical protein. (132 aa)
lpg0600Rrf2 family protein. (153 aa)
lpg0715Two component response regulator. (223 aa)
nrdRATP cone and Zn ribbon domains protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (155 aa)
nusBTranscription termination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (123 aa)
csrA-2Global regulator (carbon storage regulator); A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (82 aa)
birABiotin operon repressor and biotin [acetyl CoA carboxylase] synthetase BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. (331 aa)
rsbVHypothetical protein. (93 aa)
fleQTranscriptional regulator FleQ. (471 aa)
prfCPeptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (526 aa)
lpg0907Negative regulator of flagellin synthesis. (106 aa)
mraZMraZ protein; Belongs to the MraZ family. (167 aa)
mfdTranscription repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1153 aa)
csrA-2-2Carbon storage regulator. (66 aa)
lvrALvrA. (303 aa)
lpg1060Cold shock domain family protein. (87 aa)
lpg1068Hypothetical protein. (67 aa)
lpg1078Hypothetical protein. (123 aa)
lpg1090Hypothetical protein. (173 aa)
kaiC2DNA integration/recombination/inversion protein. (558 aa)
lpg1135Bacterial regulatory proteins, TetR family. (203 aa)
lpg1136Hypothetical protein. (300 aa)
lpg1150Transcription regulator protein. (359 aa)
pilRTwo component response regulator PilR. (442 aa)
lpg1192ThiJ/PfpI family. (251 aa)
lpg1205Cold shock domain family protein CspA. (79 aa)
lpg1206Sigma 54 modulation protein YhbH. (190 aa)
lpg1208Transcriptional regulator MarR family. (139 aa)
lpg1212IAA acetyltransferase/MarR transcriptional regulatory protein; Conserved gene, may be fused protein. (323 aa)
umuDSOS response transcriptional regulator; Belongs to the peptidase S24 family. (168 aa)
lvrCLvrC; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (67 aa)
lvrA-2LvrA. (288 aa)
prpAPhage repressor. (246 aa)
lpg1261Hypothetical protein. (129 aa)
lpg1269Hypothetical protein. (678 aa)
rpoSStationary phase specific sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (359 aa)
lpg1286YebC. (247 aa)
lpg1292DNA-binding response regulator. (225 aa)
lpg1332Hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. (241 aa)
fis-2Hypothetical protein; Transcription factors / DNA binding proteins, Replication and Repair; Belongs to the transcriptional regulatory Fis family. (98 aa)
rsfSHypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (112 aa)
cpxRTranscriptional regulatory protein CpxR. (226 aa)
lpg1448Transcription regulator protein, response regulator containing CheY-like receiver domain and HTH DNA-binding domain. (261 aa)
lpg1486AsnC family transcription regulator protein. (173 aa)
lpg1525CAAX amino terminal protease family protein. (412 aa)
rpoERNA polymerase sigma E factor RpoE; Belongs to the sigma-70 factor family. ECF subfamily. (187 aa)
lpg1593Carbon storage regulator CsrA. (65 aa)
lpg1611Transcriptional regulator, MerR family, mercury resistance. (315 aa)
lpg1612Transcriptional regulator SkgA, mercury resistance. (250 aa)
lpg1620Hypothetical protein; Transcription factors / DNA binding proteins. (146 aa)
putAProline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase = bifunctional PutA protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1054 aa)
lpg1698ProQ-like, activator of ProP osmoprotectant transporter; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family. (123 aa)
lpg1704SOS (error prone) mutagenesis protein UmuD (RumA); Belongs to the peptidase S24 family. (184 aa)
tsfTranslation elongation factor Ts (EF-Ts); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (299 aa)
fis-3Fis transcriptional activator; Belongs to the transcriptional regulatory Fis family. (95 aa)
fleRSigma 54-dependent response regulator. (453 aa)
infATranslation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (73 aa)
prfBPeptide chain release factor 2 (RF-2); Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (335 aa)
fliAFlagellar biosynthesis sigma factor FliA; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes; Belongs to the sigma-70 factor family. FliA subfamily. (262 aa)
lpg1796Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (335 aa)
oxyR-2Hydrogen peroxide-inducible genes activator OxyR; Belongs to the LysR transcriptional regulatory family. (296 aa)
lepAGTP binding elongation factor LepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (610 aa)
lpg1889Lipase. (321 aa)
lpg1891Hypothetical protein HI1736. (100 aa)
lpg1946Transcriptional regulator LuxR. (223 aa)
lpg1967Transcriptional regulator, TetR family. (188 aa)
oruRTranscriptional regulator OruR, AraC family. (337 aa)
lpg2086TraW. (202 aa)
csrACarbon storage regulator RsmA; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). (78 aa)
lvrA-3LvrA. (294 aa)
lpg2096Hypothetical prophage repressor CI-like. (234 aa)
recG-2ATP dependent DNA helicase-like. (66 aa)
lpg2121Cold shock DNA binding domain protein. (69 aa)
lpg2125Hypothetical protein; Transport and binding. (153 aa)
lpg2138Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (304 aa)
lpg2140Hypothetical transcriptional regulator, MarR family. (126 aa)
lpg2163(AraC family) transcriptional regulator. (281 aa)
lpg2167Transcription regulator protein, DeoR family. (234 aa)
lpg2288Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (306 aa)
rneRibonuclease E. (667 aa)
hepAATP-dependent RNA helicase; Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair; Belongs to the SNF2/RAD54 helicase family. RapA subfamily. (958 aa)
prfAPeptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (362 aa)
dksADnaK suppressor protein; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. (158 aa)
rpoDRNA polymerase sigma 70 factor (RpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (623 aa)
lpg2367Hypothetical protein. (91 aa)
lpg2368Hypothetical protein; Transcription factors / DNA binding proteins. (75 aa)
lpg2376Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (305 aa)
lpg2377Hypothetical protein; Transcription factors / DNA binding proteins. (75 aa)
lpg2383Transcriptional regulator, LysR family; Belongs to the LysR transcriptional regulatory family. (308 aa)
lpg2402Regulatory protein (LysR transcriptional regulator). (306 aa)
lpg2434Hypothetical protein. (164 aa)
lpg2457Two component response regulator. (136 aa)
lpg2458Sensory box histidine kinase. (426 aa)
lpg2517Transcriptional regulator, AsnC family. (157 aa)
lpg2524Transcriptional regulator, LuxR family. (287 aa)
lpg2534Hypothetical protein; Transcription factors / DNA binding proteins. (143 aa)
lpg2549Transcriptional regulator, AraC-family. (256 aa)
lpg2557Hypothetical; probable transcriptional regulator-like. (242 aa)
recG-3ATP-dependent DNA helicase. (485 aa)
lpg2560Hypothetical protein. (195 aa)
lpg2562Phage repressor. (225 aa)
lpg2563Prophage regulatory protein-like. (68 aa)
lpg2564LvrA. (132 aa)
lpg2593rRNA methyltransferase (SUN protein); Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (427 aa)
greATranscription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (160 aa)
gacAResponse regulator GacA. (225 aa)
rpoHRNA polymerase sigma-32 factor RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (292 aa)
ihfAIntegration host factor (IHF) alpha subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (99 aa)
infCTranslational initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (129 aa)
hfqHost factor-I protein for bacteriophage Q beta replication; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (85 aa)
legNcNMP binding domain-containing protein. (343 aa)
lpg2723Transcriptional regulator. (99 aa)
lpg2760DNA-binding response regulator. (242 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (729 aa)
infBInitiation factor IF2-beta (IF-2 gamma, IF-2 alpha); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (868 aa)
nusAN utilization substance protein A; Participates in both transcription termination and antitermination. (492 aa)
lpg2825Cold shock protein CspE. (68 aa)
lpg2850Cold shock transcriptional regulator CspA. (71 aa)
rppH(di)nucleoside polyphosphate hydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. (175 aa)
hipBIntegration host factor beta subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family. (103 aa)
lpg2998Sulfate transporter. (725 aa)
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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