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lpg0385 | LemA protein. (193 aa) | ||||
legLC8 | Leucine-rich repeat- and coiled coil-containing protein; Conserved gene, like GALA proteins. (573 aa) | ||||
lpg2153 | Sid related protein-like; SdeC, SdeB, AliA, SdeA, SdeD-like. (1533 aa) | ||||
lpg2156 | Sid related protein-like; SdeC, SdeB, SdeA, SidE, AliA-like. (1926 aa) | ||||
sdeA | Sid related protein-like; Secreted effector that interferes with the host cell ubiquitin pathway and is required for intracellular bacterial replication. Catalyzes the ubiquitination of several mammalian Rab proteins (Rab33b, Rab1, Rab6a and Rab30) during L.pneumophila infection, without engaging the standard cellular enzyme cascade (E1 and E2). Transfers an ADP-ribose moiety from NAD to the 'Arg-42' residue of ubiquitin in a reaction that releases nicotinamide. The modified ubiquitin is subsequently transferred to serine residues of the substrate protein via a phosphoribose linker tha [...] (1506 aa) | ||||
legU2 | UBOX-containing protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Acts in conjunction with host E2 ubiquitin-conjugating enzymes UBE2D1 (UBCH5A) or UBE2D3 (UBCH5C), and mediates polyubiquitination of host kinase CLK1. (246 aa) |