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lpg2536 lpg2536 lpg0899 lpg0899 lpg1044 lpg1044 lpg1170 lpg1170 lpg1276 lpg1276 lpg0288 lpg0288 nadA nadA edd edd miaB miaB nth nth lpg2881 lpg2881 grlA grlA erpA erpA rlmD rlmD bioB bioB prpD prpD rlmN rlmN lpg1634 lpg1634 acnA acnA ydiC ydiC lpg1745 lpg1745 mrp mrp lpg1923 lpg1923 queE queE lpg2218 lpg2218 lpg2354 lpg2354 lpg2468 lpg2468 hydG-2 hydG-2 lpg2470 lpg2470 lpg2534 lpg2534 sdhB-2 sdhB-2 lpg0600 lpg0600 ycf24 ycf24 lpg0605 lpg0605 lpg0606 lpg0606 rimO rimO ttcA ttcA lipA lipA sda-2 sda-2 yrbA yrbA petA petA lpg2708 lpg2708 queH queH nuoI nuoI nuoG nuoG nuoF nuoF lpg2785 lpg2785 nuoB2 nuoB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpg2536Ferredoxin reductase. (318 aa)
lpg0899A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (355 aa)
lpg1044Oxidoreductase, FAD-binding. (657 aa)
lpg1170Pyruvate formate lyase-activating enzyme PflA. (364 aa)
lpg1276Electron transferring flavoprotein dehydrogenase; Accepts electrons from ETF and reduces ubiquinone. (543 aa)
lpg0288L-lysine 2,3-aminomutase, radical SAM domain protein. (326 aa)
nadAQuinolinate synthetase A (NadA); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (447 aa)
edd6-phosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (612 aa)
miaBtRNA thiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (447 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (211 aa)
lpg2881Iron-sulfur cluster binding protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily. (204 aa)
grlAGlutaredoxin-related protein; Belongs to the glutaredoxin family. Monothiol subfamily. (89 aa)
erpAHypothetical protein; Required for insertion of 4Fe-4S clusters for at least IspG. (130 aa)
rlmD23S rRNA (uracil-5-)methyltransferase RumA; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (444 aa)
bioBBiotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (315 aa)
prpD2-methylcitrate dehydratase PrpD. (490 aa)
rlmNRadical SAM enzyme, Cfr family; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (386 aa)
lpg1634Oxidase. (1000 aa)
acnAAconitate hydratase; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis- aconitate. The apo form of AcnA functions as a RNA-binding regulatory protein. Could catalyze the hydration of 2-methyl-cis- aconitate to yield (2R,3S)-2-methylisocitrate (By similarity). (891 aa)
ydiCHesB family protein; Belongs to the HesB/IscA family. (122 aa)
lpg1745NifU family iron binding protein, [Fe-S] cluster formation/repair protein IscU, HesB. (127 aa)
mrpATPase (Mrp); Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (357 aa)
lpg1923Ferredoxin II (4Fe-4S); Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (111 aa)
queERadical activating enzyme; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (217 aa)
lpg2218Choline monooxygenase. (363 aa)
lpg2354(oxygen-independent) coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (375 aa)
lpg2468Sulfhydrogenase delta subunit. (261 aa)
hydG-2Hydrogenase/sulfur reductase gamma subunit. (281 aa)
lpg2470Cytochrome c3 hydrogenase alpha (or beta) chain. (403 aa)
lpg2534Hypothetical protein; Transcription factors / DNA binding proteins. (143 aa)
sdhB-2Succinate dehydrogenase iron-sulfur protein subunit B. (240 aa)
lpg0600Rrf2 family protein. (153 aa)
ycf24ABC transporter, permease. (482 aa)
lpg0605Nitrogen fixation protein (Fe-S cluster formation) NifU. (149 aa)
lpg0606Metal-sulfur cluster biosynthetic enzyme. (123 aa)
rimOFe-S oxidoreductase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (435 aa)
ttcAHypothetical protein; Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system. (283 aa)
lipALipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (329 aa)
sda-2L-serine dehydratase (iron, sulfur-dependent); Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
yrbAHypothetical BolA like protein; Belongs to the BolA/IbaG family. (81 aa)
petAUbiquinol-cytochrome c reductase, iron-sulfur subunit; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (208 aa)
lpg2708Ferredoxin 2Fe-2S protein. (71 aa)
queHHypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (220 aa)
nuoINADH dehydrogenase I, I subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (166 aa)
nuoGNADH dehydrogenase I, G subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (783 aa)
nuoFNADH dehydrogenase I, F subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (428 aa)
lpg2785NADH dehydrogenase I, E subunit. (167 aa)
nuoB2NADH dehydrogenase I, B subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity). (158 aa)
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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