STRINGSTRING
lpg2975 lpg2975 legL1 legL1 lpg0944 lpg0944 lem3 lem3 legA8 legA8 lpg0693 lpg0693 lpg0439 lpg0439 legA11 legA11 legA7 legA7 sidE sidE lpg0195 lpg0195 lpg0130 lpg0130 lpg0090 lpg0090 lpg0081 lpg0081 legC5 legC5 lpg1368 lpg1368 lpg1154 lpg1154 lpg1148 lpg1148 legC3 legC3 lpg1851 lpg1851 legC2 legC2 lpg1959 lpg1959 lpg2147 lpg2147 lpg2148 lpg2148 lpg2153 lpg2153 sidJ sidJ sdeA sdeA legC7 legC7 legA14 legA14 lpg2461 lpg2461 drrA drrA sidD sidD lpg2504 lpg2504 lpg2510 lpg2510 lpg2519 lpg2519 lpg2523 lpg2523 lpg2806 lpg2806 lpg2828 lpg2828 sidH sidH legU2 legU2 lpg1489 lpg1489 legC8 legC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpg2975Hypothetical protein. (871 aa)
legL1Gala protein type 1, 3 or 4; Leucine-rich repeat-containing protein; conserved gene. (296 aa)
lpg0944Hypothetical protein. (391 aa)
lem3Hypothetical protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine hydrolase by mediating the hydrolysis of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C). Dephosphocholination of target proteins restores accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. (570 aa)
legA8Ankyrin repeat-containing protein; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as a phosphocholine transferase by mediating the addition of phosphocholine to Ser residues of host RAB1 (RAB1A, RAB1B or RAB1C) and RAB35, leading to displacement of GDP dissociation inhibitors (GDI). Phosphocholination of target proteins also impairs accessibility to GTPase effector LepB. Can act on both GDP-bound and GTP-bound Rab proteins. (949 aa)
lpg0693LigA, interaptin. (1426 aa)
lpg0439Hypothetical protein. (349 aa)
legA11Ankyrin repeat-containing protein. (269 aa)
legA7Ankyrin repeat-containing protein; 1700007B22 gene product; conserved gene. (514 aa)
sidESidE; Effector that interferes with the host cell ubiquitin pathway and is required for intracellular bacterial replication. Catalyzes the ubiquitination of several host Rab small GTPases associated with the endoplasmic reticulum during L.pneumophila infection, without engaging the standard cellular enzyme cascade (E1 and E2). Transfers an ADP-ribose moiety from NAD to the 'Arg-42' residue of ubiquitin in a reaction that releases nicotinamide. The modified ubiquitin is subsequently transferred to serine residues of the substrate protein via a phosphoribose linker that results in the re [...] (1514 aa)
lpg0195Hypothetical protein. (334 aa)
lpg0130Hypothetical protein. (822 aa)
lpg0090Hypothetical protein. (1324 aa)
lpg0081Hypothetical protein. (441 aa)
legC5Coiled-coil-containing protein; Conserved gene; similar to surface antigen of Plasmodium and Entamoeba. (865 aa)
lpg1368Hypothetical protein. (525 aa)
lpg1154Hypothetical protein. (360 aa)
lpg1148Hypothetical protein. (503 aa)
legC3Kinectin 1 (kinesin receptor); Coiled-coil-containing protein; conserved gene. (560 aa)
lpg1851Hypothetical protein. (220 aa)
legC2Microtubule binding protein, putative; Conserved gene; coiled-coil-containing protein. (405 aa)
lpg1959Hypothetical protein. (664 aa)
lpg2147Hypothetical protein. (482 aa)
lpg2148Hypothetical protein. (426 aa)
lpg2153Sid related protein-like; SdeC, SdeB, AliA, SdeA, SdeD-like. (1533 aa)
sidJHypothetical protein; Glutamylase that mediates the covalent attachment of glutamate moieties to SdeA on one of the catalytic residues that is required for its mono-ADP-ribosyltransferase activity. In turn, inhibits SdeA ubiquitinating activity. Glutamylates also related SdeB, SdeC and SidE. Glutamylase activity only occurs in the host since it requires host calmodulin. May also reverse the SdeA-mediated substrate ubiquitination by cleaving the phosphodiester bond that links phosphoribosylated ubiquitin to protein substrates via its deubiquitinase activity. (873 aa)
sdeASid related protein-like; Secreted effector that interferes with the host cell ubiquitin pathway and is required for intracellular bacterial replication. Catalyzes the ubiquitination of several mammalian Rab proteins (Rab33b, Rab1, Rab6a and Rab30) during L.pneumophila infection, without engaging the standard cellular enzyme cascade (E1 and E2). Transfers an ADP-ribose moiety from NAD to the 'Arg-42' residue of ubiquitin in a reaction that releases nicotinamide. The modified ubiquitin is subsequently transferred to serine residues of the substrate protein via a phosphoribose linker tha [...] (1506 aa)
legC7Conserved gene; coiled-coil-containing protein. (425 aa)
legA14Ankyrin repeat-containing protein. (921 aa)
lpg2461Hypothetical protein. (212 aa)
drrAHypothetical protein; Virulence effector that plays a key role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella- containing vacuole (LCVs). Acts as a GDP-GTP exchange factor (GEF) for the small GTPase Rab1 (RAB1A, RAB1B or RAB1C), thereby converting Rab1 to an active GTP-bound state, leading to the incorporation of Rab1 into LCVs. Also shows RabGDI displacement factor (GDF) activity; however, this probably represents a passive activity following the GEF activity. Also acts as an adenylyltr [...] (647 aa)
sidDSidD; Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as an adenosine monophosphate-protein hydrolase (de-AMPylase) by mediating the hydrolysis of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby releasing RAB1B from bacterial phagosomes and rendering RAB1B accessible for inactivation by LepB. De- AMPylation of RAB1B cannot take place when LidA is bound to RAB1B. (507 aa)
lpg2504Hypothetical protein. (942 aa)
lpg2510SdcA. (908 aa)
lpg2519Hypothetical protein. (186 aa)
lpg2523Hypothetical protein. (779 aa)
lpg2806Hypothetical protein. (460 aa)
lpg2828Hypothetical protein. (418 aa)
sidHSidH. (2225 aa)
legU2UBOX-containing protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Acts in conjunction with host E2 ubiquitin-conjugating enzymes UBE2D1 (UBCH5A) or UBE2D3 (UBCH5C), and mediates polyubiquitination of host kinase CLK1. (246 aa)
lpg1489Hypothetical protein. (343 aa)
legC8Coiled-coil containing protein. (636 aa)
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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