STRINGSTRING
metZ metZ metA metA sahH sahH ML0901 ML0901 metE metE ilvA ilvA metH metH ML1478 ML1478 ML1727 ML1727 sdaA sdaA ML1794 ML1794 metB metB cysM2 cysM2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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metZPutative o-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (406 aa)
metAPutative homoserine o-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (382 aa)
sahHPutative S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (492 aa)
ML0901Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69565 (EMBL:AL022602) (304 aa); Fasta score E(): 0, 99.7% identity in 304 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53506 (EMBL:AL021957) (301 aa); Fasta score E(): 0, 80.9% identity in 299 aa overlap(EMBL:AL021957). (304 aa)
metE5-methyltetrahydropteroyltriglutamate- homocysteinmethyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation.; Belongs to the vitamin-B12 independent methionine synthase family. (760 aa)
ilvAThreonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). (427 aa)
metH5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1206 aa)
ML1478Highly similar to many transferases e.g. Escherichia coli homocysteine S-methyltransferase (EC 2.1.1.10) involved in methionine biosynthesis SW:MMUM_ECOLI (Q47690) (310 aa); Fasta score E(): 0, 49.8% identity in 293 aa overlap and Mycobacterium tuberculosis putative transferase RV2458 TR:O53185. (293 aa)
ML1727Similar in the C-terminus to many phosphoserine phosphatases (EC 3.1.3.3) including: Escherichia coli SW:SERB_ECOLI (P06862) (322 aa); Fasta score E(): 1.7e-29, 38.5% identity in 309 aa overlap and Mycobacterium tuberculosis RV3042C TR:O53289 (EMBL:AL021287) (409 aa); Fasta score E(): 0, 86.3% identity in 408 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. (411 aa)
sdaAHighly similar to many L-serine dehydratases (EC 4.2.1.13) including: Escherichia coli SW:TDCG_ECOLI (P42630) (454 aa); Fasta score E(): 0, 53.2% identity in 457 aa overlap and Mycobacterium tuberculosis RV0069 SW:SDHL_MYCTU (O53614) (461 aa); Fasta score E(): 0, 69.2% identity in 461 aa overlap; Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
ML1794Aminotransferase; Similar to M. tuberculosis predicted aminotransferase Rv2294 SW:YM94_MYCTU (Q50672) (407 aa); Fasta score E(): 0, 76.5% identity in 404 aa overlap, and to many others e.g. Escherichia coli MalY protein SW:MALY_ECOLI (P23256) (390 aa); Fasta score E(): 5.8e-27, 31.2% identity in 385 aa overlap; Similar to and ML2502; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily. (402 aa)
metBCystathionine [gamma]-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). (388 aa)
cysM2Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. (464 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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