6 items (Mycobacterium leprae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ML0320	Similar to M. tuberculosis Rv3583c, putative transcription factor, TR:O53568 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 97.5% identity in 162 aa overlap. Shows weak similarity to Myxococcus xanthus carD, transcription factor, TR:Q50887 (EMBL:Z56280) (316 aa); Fasta score E(): 9.1e-13, 31.2% identity in 154 aa overlap and to many hypothetical transcription factors. (165 aa)
	ML0542	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (110 aa)
	ML1014	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (319 aa)
	ML1439	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family. (111 aa)
	rpoB	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1178 aa)
	rpoA	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (347 aa)

Your Current Organism:

Mycobacterium leprae

NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ML0320	ML0542	gene:17574139	gene:17574363	Similar to M. tuberculosis Rv3583c, putative transcription factor, TR:O53568 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 97.5% identity in 162 aa overlap. Shows weak similarity to Myxococcus xanthus carD, transcription factor, TR:Q50887 (EMBL:Z56280) (316 aa); Fasta score E(): 9.1e-13, 31.2% identity in 154 aa overlap and to many hypothetical transcription factors.	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	0.999
ML0320	ML1014	gene:17574139	gene:17574840	Similar to M. tuberculosis Rv3583c, putative transcription factor, TR:O53568 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 97.5% identity in 162 aa overlap. Shows weak similarity to Myxococcus xanthus carD, transcription factor, TR:Q50887 (EMBL:Z56280) (316 aa); Fasta score E(): 9.1e-13, 31.2% identity in 154 aa overlap and to many hypothetical transcription factors.	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.999
ML0320	ML1439	gene:17574139	gene:17575277	Similar to M. tuberculosis Rv3583c, putative transcription factor, TR:O53568 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 97.5% identity in 162 aa overlap. Shows weak similarity to Myxococcus xanthus carD, transcription factor, TR:Q50887 (EMBL:Z56280) (316 aa); Fasta score E(): 9.1e-13, 31.2% identity in 154 aa overlap and to many hypothetical transcription factors.	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.	0.999
ML0320	rpoA	gene:17574139	gene:17575809	Similar to M. tuberculosis Rv3583c, putative transcription factor, TR:O53568 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 97.5% identity in 162 aa overlap. Shows weak similarity to Myxococcus xanthus carD, transcription factor, TR:Q50887 (EMBL:Z56280) (316 aa); Fasta score E(): 9.1e-13, 31.2% identity in 154 aa overlap and to many hypothetical transcription factors.	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML0320	rpoB	gene:17574139	gene:17575739	Similar to M. tuberculosis Rv3583c, putative transcription factor, TR:O53568 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 97.5% identity in 162 aa overlap. Shows weak similarity to Myxococcus xanthus carD, transcription factor, TR:Q50887 (EMBL:Z56280) (316 aa); Fasta score E(): 9.1e-13, 31.2% identity in 154 aa overlap and to many hypothetical transcription factors.	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML0542	ML0320	gene:17574363	gene:17574139	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	Similar to M. tuberculosis Rv3583c, putative transcription factor, TR:O53568 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 97.5% identity in 162 aa overlap. Shows weak similarity to Myxococcus xanthus carD, transcription factor, TR:Q50887 (EMBL:Z56280) (316 aa); Fasta score E(): 9.1e-13, 31.2% identity in 154 aa overlap and to many hypothetical transcription factors.	0.999
ML0542	ML1014	gene:17574363	gene:17574840	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.999
ML0542	ML1439	gene:17574363	gene:17575277	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.	0.999
ML0542	rpoA	gene:17574363	gene:17575809	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML0542	rpoB	gene:17574363	gene:17575739	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML1014	ML0320	gene:17574840	gene:17574139	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Similar to M. tuberculosis Rv3583c, putative transcription factor, TR:O53568 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 97.5% identity in 162 aa overlap. Shows weak similarity to Myxococcus xanthus carD, transcription factor, TR:Q50887 (EMBL:Z56280) (316 aa); Fasta score E(): 9.1e-13, 31.2% identity in 154 aa overlap and to many hypothetical transcription factors.	0.999
ML1014	ML0542	gene:17574840	gene:17574363	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	0.999
ML1014	ML1439	gene:17574840	gene:17575277	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.	0.999
ML1014	rpoA	gene:17574840	gene:17575809	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML1014	rpoB	gene:17574840	gene:17575739	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML1439	ML0320	gene:17575277	gene:17574139	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.	Similar to M. tuberculosis Rv3583c, putative transcription factor, TR:O53568 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 97.5% identity in 162 aa overlap. Shows weak similarity to Myxococcus xanthus carD, transcription factor, TR:Q50887 (EMBL:Z56280) (316 aa); Fasta score E(): 9.1e-13, 31.2% identity in 154 aa overlap and to many hypothetical transcription factors.	0.999
ML1439	ML0542	gene:17575277	gene:17574363	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	0.999
ML1439	ML1014	gene:17575277	gene:17574840	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.999
ML1439	rpoA	gene:17575277	gene:17575809	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML1439	rpoB	gene:17575277	gene:17575739	Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999