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fadD32 fadD32 pks13 pks13 accD4 accD4 fadD29 fadD29 ML0133 ML0133 fadD22 fadD22 ML0135 ML0135 fadD28 fadD28 mas mas ML0243 ML0243 ML0447 ML0447 fadD9 fadD9 xclC xclC ML1189 ML1189 fas fas pks3 pks3 papA3 papA3 mmpL10 mmpL10 ML1234 ML1234 fabD fabD kasA kasA kasB kasB inhA inhA fabG1 fabG1 ML2088 ML2088 ML2170 ML2170 ML2354 ML2354 ML2355 ML2355 ML2356 ML2356 ML2357 ML2357 fadD26 fadD26 ML2359 ML2359 fadD2 fadD2 ML2661 ML2661
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fadD32Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv3801c, fadD32, putative acyl-CoA synthase, TR:O53580 (EMBL:AL123456) (637 aa); Fasta score E(): 0, 93.2% identity in 632 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 36.8% identity in 581 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 36.4% identity in 605 aa overlap. Contains Pfam match to entry PF005 [...] (635 aa)
pks13Similar to many polyketide synthases from M. tuberculosis e.g. ppsA, M. tuberculosis phenolpthiocerol synthesis polyketide synthase, SW:PPSA_MYCTU (Q10977) (1876 aa); Fasta score E(): 0, 36.1% identity in 1277 aa overlap. Similar to many others e.g. Streptomyces noursei nysI, nystatin biosynthesis polyketide synthase, TR:AAF71766 (EMBL:AF263912) (9477 aa); Fasta score E(): 0, 33.4% identity in 1215 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entr [...] (1784 aa)
accD4Similar to many acyl-CoA carboxylase subunits e.g. M. tuberculosis pccB, acetyl/propionyl-CoA carboxylase [beta] subunit, TR:O53578 (EMBL:AL123456) (518 aa); Fasta score E(): 0, 91.2% identity in 512 aa overlap and Streptomyces coelicolor pccB, propionyl-CoA carboxylase complex B subunit, TR:Q9X4K7 (EMBL:AF113605) (530 aa); Fasta score E(): 0, 48.2% identity in 521 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain; Similar to ML0731 and ML1657. (517 aa)
fadD29Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2950c, fadD29, putative acyl-CoA synthase, TR:P95141 (EMBL:AL123456) (619 aa); Fasta score E(): 0, 80.2% identity in 620 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 58.5% identity in 585 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 36.2% identity in 589 aa overlap. Contains Pfam match to entry PF005 [...] (680 aa)
ML0133Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. (210 aa)
fadD22Putative acyl-CoA synthetase; Similar to M. tuberculosis Rv2948c, acyl-CoA synthase, TR:P96283 (EMBL:AL123456) (705 aa); Fasta score E(): 0, 75.9% identity in 705 aa overlap. Similar to many acyl-CoA synthases e.g. Rhodopseudomonas palustris, badA, benzoate-coenzyme A ligase, TR:Q59760 (EMBL:L42322) (521 aa); Fasta score E(): 0, 31.4% identity in 494 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML1051, ML1994, ML2257 and ML2546. (707 aa)
ML0135Similar to many polyketide synthases from M. tuberculosis e.g. N-terminus is similar to Rv2947c, pks15, probable polyketide synthase, TR:P96284 (EMBL:Z83858) (496 aa); Fasta score E(): 0, 90.5% identity in 485 aa overlap and the remainder is similar to Rv2946c, pks1, probable polyketide synthase, TR:P96285 (EMBL:Z83858) (1616 aa); Fasta score E(): 0, 82.5% identity in 1620 aa overlap. Similar to many others e.g. Streptomyces noursei NysC, nystatin biosynthesis polyketide synthase, TR:AAF71776 (EMBL:AF263912) (11096 aa); Fasta score E(): 0, 50.2% identity in 2161 aa overlap. Contains Pf [...] (2103 aa)
fadD28Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2941, fadD29, putative acyl-CoA synthase, TR:P96290 (EMBL:AL123456) (580 aa); Fasta score E(): 0, 81.9% identity in 580 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 81.4% identity in 580 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 35.8% identity in 590 aa overlap. Contains Pfam match to entry PF0050 [...] (579 aa)
masPutative mycocerosic synthase; Similar to many polyketide synthases from M. tuberculosis e.g. Rv2940c, mas, mycocerosic acid synthase, TR:P96291 (EMBL:AL123456) (2111 aa); Fasta score E(): 0, 88.0% identity in 2119 aa overlap. Similar to Mycobacterium bovis mas, mycocerosic acid synthase, SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 85.1% identity in 2122 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transf [...] (2116 aa)
ML0243Similar to several putative acyl-CoA synthases from M.tuberculosis e.g. pks16, Rv1013, possible polyketide synthase, TR:O05598 (EMBL:AL123456) (544 aa); Fasta score E(): 0, 82.2% identity in 544 aa overlap. Similar to domains of polyketide synthases e.g. Bacillus subtilis mycA, mycosubtilin synthetase, TR:Q9R9J1 (EMBL:AF184956) (3971 aa); Fasta score E(): 0, 33.7% identity in 404 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature; Similar to ML0887, ML0100, ML0132, ML0138, ML1051, ML1234, ML1994, ML23 [...] (544 aa)
ML0447Hypothetical protein; Similar to region of cytochrome P450s e.g. Bacillus megaterium CYP102A1, cytochrome P450(BM-3), SW:CPXB_BACME (P14779) (1048 aa); Fasta score E(): 0.00033, 31.8% identity in 132 aa overlap. previously sequenced as TR:O07142 (EMBL:Z96801) (126 aa); Fasta score E(): 0, 99.2% identity in 126 aa overlap. (158 aa)
fadD9Putative acyl-CoA synthetase; Similar to M. tuberculosis fadD9, Rv2590, putative acyl-CoA synthetase, TR:Q5063 (EMBL:Al123456) (1168 aa); Fasta score E(): 0, 68.0% identity in 1178 aa overlap1. Similar to acyl-CoA ligases and to domains of polyketide/peptide synthetases e.g. Mycobacterium smegmatis mps, peptide synthetase, TR:Q9RLP6 (EMBL:AJ238027) (5990 aa); Fasta score E(): 0, 37.2% identity in 1168 aa overlap. C-terminal half is similar to eukaryotic aminoadipate-semialdehyde dehydrogenase e.g. Saccharomyces cerevisiae lys2, aminoadipate-semialdehyde dehydrogenase large subunit, SW: [...] (1188 aa)
xclCacyl-CoA synthase; Identical to the previously sequenced Mycobacterium leprae XclC TR:Q50017 (EMBL:U15181) (476 aa); Fasta score E(): 0, 99.8% identity in 476 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis acyl-CoA synthase Rv1193 fadD36 TR:O05295 (EMBL:Z93777) (473 aa); Fasta score E(): 0, 81.3% identity in 476 aa overlap and Escherichia coli long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) SW:LCFA_ECOLI (P29212) (561 aa); Fasta score E(): 1.3e-28, 31.7% identity in 378 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme [...] (476 aa)
ML1189Hypothetical protein; Unknown function, identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q9X7D8. (127 aa)
fasFatty acid synthase; Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa); Fasta score E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa); Fasta score E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa); Fasta score E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 [...] (3076 aa)
pks3Mycocerosic acid synthase (polyketide synthase); Identical to many polyketide synthases involved in the biosynthesis of mycocerosyl lipids e.g. Mycobacterium tuberculosis probable mycocerosic acid synthase Rv2940c TR:P96291 (EMBL:Z83858) (2111 aa); Fasta score E(): 0, 60.8% identity in 2127 aa overlap and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 58.8% identity in 2127 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase [...] (2118 aa)
papA3PKS-associated protein, unknown function; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49618 (EMBL:U00010) (471 aa); Fasta score E(): 0, 99.8% identity in 471 aa overlap. Also highly similar to Mycobacterium tuberculosis proteins encoded downstream of several polyketide synthases e.g. Rv1182 TR:O50438 (EMBL:AL010186) (472 aa); Fasta score E(): 0, 75.8% identity in 471 aa overlap. (471 aa)
mmpL10Previously sequenced Mycobacterium leprae membrane protein MMPL10 SW:MMLA_MYCLE (Q49619) (1008 aa); Fasta score E(): 0, 100.0% identity in 983 aa overlap. Also highly similar to many MMPL-family Mycobacterium tuberculosis proteins e.g. Rv1183 SW:MMLA_MYCTU (O50439) (1002 aa); Fasta score E(): 0, 70.4% identity in 978 aa overlap. Contains possible membrane spanning hydrophobic domains; Similar to ML2378 and ML0137. (983 aa)
ML1234Highly similar to acyl-CoA synthases from Mycobacterium tuberculosis Rv1185c TR:O50441 (EMBL:AL010186) (578 aa); Fasta score E(): 0, 72.4% identity in 579 aa overlap and Mycobacterium bovis TR:P71495 (EMBL:U7568) (582 aa); Fasta score E(): 0, 63.4% identity in 579 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML0100, ML0132, ML0138, ML0243 and ML2358; Belongs to the ATP-dependent AMP-binding enzyme family. (579 aa)
fabDMalonyl CoA-[ACP] transacylase; Similar to many malonyl CoA-acyl carrier protein transacylases (EC 2.3.1.39) involved in fatty acid biosynthesis, including: Salmonella typhimurium SW:FABD_SALTY (O85140) (308 aa); Fasta score E(): 1.6e-19, 32.7% identity in 303 aa overlap and Mycobacterium tuberculosis SW:FABD_MYCTU (Q10501) (302 aa); Fasta score E(): 0, 82.2% identity in 304 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. (304 aa)
kasA3-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (416 aa)
kasB3-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (425 aa)
inhAenoyl-[ACP] reductase; Similar to M. tuberculosis inhA Rv1484 SW:INHA_MYCTU (P46533) (269 aa); Fasta score E(): 0, 90.3% identity in 269 aa overlap, and to many others e.g. Escherichia coli enoyl-[acyl-carrier-protein] reductase [NADH] SW:FABI_ECOLI (P29132) (261 aa); Fasta score E(): 1.2e-17, 33.2% identity in 268 aa overlap; Similar to and ML1807. (269 aa)
fabG13-oxoacyl-[ACP] reductase (aka MabA); Similar to M. tuberculosis fabG Rv1483 SW:FABG_MYCTU (Q48930) (247 aa); Fasta score E(): 0, 68.6% identity in 245 aa overlap, and to many others e.g. Escherichia coli fabG 3-oxoacyl-[acyl-carrier protein] reductase SW:FABG_ECOLI (P25716) (244 aa); Fasta score E(): 0, 47.3% identity in 241 aa overlap. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature; Simil [...] (253 aa)
ML2088Putative cytochrome p450; Similar to Streptomyces coelicolor putative cytochrome p-450 hydroxylase TR:Q9X8Q3 (EMBL:AL049754) fasta scores: E(): 0, 37.4% in 401 aa, and to Mycobacterium tuberculosis putative cytochrome p450 rv1880c SW:YI80_MYCTU (O08464) fasta scores: E(): 0, 38.0% in 416 aa, and to Bacillus subtilis biotin biosynthesis; cytochrome p450-like enzyme SW:BIOI_BACSU (P53554) fasta scores: E(): 0, 37.1% in 383 aa. Contains Pfam match to entry PF00067 p450, Cytochrome P450. (434 aa)
ML2170Hypothetical protein; No database matches. (74 aa)
ML2354Similar to many polyketide synthases e.g.Mycobacterium tuberculosis Rv2934 TR:P96203 (EMBL:Z83857) (1827 aa) fasta scores: E(): 0, 80.3% id in 1836 aa, and to Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 32.7% id in 2136 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00017 ATP/G [...] (1822 aa)
ML2355Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...] (2201 aa)
ML2356Similar to many polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthesis polyketide synthase Rv2932 SW:PPSB_MYCTU (Q10978; O53234) (1538 aa) fasta scores: E(): 0, 76.3% id in 1561 aa and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 42.2% id in 879 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Be [...] (1540 aa)
ML2357Polyketide synthase; Highly similar to many Prokaryotic and Eukaryotic polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthase rv2931 SW:PPSA_MYCTU (Q10977) (1876 aa) fasta scores: E(): 0, 76.1% id in 1888 aa and to Penicillium patulum 6-methylsalicylic acid synthase SW:MSAS_PENPA (P22367) (1774 aa) fasta scores: E(): 0, 33.8% id in 1823 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantethe [...] (1871 aa)
fadD26Probable acyl-CoA synthase; Similar to Mycobacterium tuberculosis acyl-CoA synthase Rv1185c TR:O50441 (EMBL:AL010186) (578 aa) fasta scores: E(): 0, 56.9% id in 580 aa, and to Myxococcus xanthus saframycin synthetase B TR:Q50857 (EMBL:U24657) (1770 aa) fasta scores: E(): 0, 36.5% id in 578 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML0132, ML1234, ML0138 and ML0100. (583 aa)
ML2359Thioesterase; Involved in the synthesis of both phthiocerol dimycocerosates (PDIMs) and phenolic glycolipids (PGLs), which are structurally related lipids non-covalently bound to the outer cell wall layer of M.tuberculosis and are important virulence factors. Belongs to the thioesterase family. (261 aa)
fadD2acyl-CoA synthase; Similar to Rhizobium trifolii malonyl CoA synthetase MATB TR:Q9ZIP5 (EMBL:AF117694) fasta scores: E(): 2.4e-31, 31.2% id in 507 aa and Mycobacterium tuberculosis hypothetical 59.9 kda protein RV0270 TR:P95227 (EMBL:Z86089) fasta scores: E(): 0, 82.3% id in 558 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (548 aa)
ML2661acyl-CoA synthase; Similar to many Prokaryotic and Eukaryotic acyl-CoA synthases including: Mycobacterium tuberculosis fadd7 protein TR:O07169 (EMBL:Z96071) fasta scores: E(): 0, 71.3% in 520 aa, and to Saccharomyces cerevisiae peroxisomal-coenzyme a synthetase SW:FAT2_YEAST (P38137) fasta scores: E(): 0, 35.6% in 526 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (548 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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