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echA1 echA1 fadE23 fadE23 fadE24 fadE24 fadE25 fadE25 ML0845 ML0845 ML1241 ML1241 eftA eftA eftB eftB echA6 echA6 ML2158 ML2158 fadB fadB ML2401 ML2401 ML2402 ML2402 fadB2 fadB2 fadE5 fadE5 fadA2 fadA2 fabG4 fabG4 ML2566 ML2566
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
echA1Similar to M. tuberculosis Rv3774, putative enoyl-CoA hydratase, TR:P75019 (EMBL:AL123456) (274 aa); Fasta score E(): 0, 88.3% identity in 274 aa overlap. Similar to many e.g. Rattus norvegicus ech1, delta3,5-delta2,4-dienoyl-coa isomerase precursor, SW:ECH1_RAT (Q62651) (327 aa); Fasta score E(): 3.5e-31, 38.8% identity in 276 aa overlap and bacterial putative enoyl-CoA hydratases. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family; Similar to ML1241, ML1724, ML2118 and ML2402. (278 aa)
fadE23Putative acyl-CoA dehydrogenase; Similar to M. tuberculosis fadE23, Rv3140, acyl-CoA dehydrogenase, TR:P95186 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 89.5% identity in 401 aa overlap. Similar to many e.g. Homo sapiens acadS, acyl-coa dehydrogenase, short-chain specific precursor, SW:ACDS_HUMAN (P16219) (412 aa); Fasta score E(): 4.1e-31, 31.8% identity in 393 aa overlap. Previously sequenced as TR:O32891 (EMBL:Z98271) (400 aa); Fasta score E(): 0, 100.0% identity in 400 aa overlap. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase; Similar to ML0737. (400 aa)
fadE24Putative acyl-CoA dehydrogenase; Similar to M. tuberculosis fadE24, Rv3139, acyl-CoA dehydrogenase, TR:P95187 (EMBL:AL123456) (468 aa); Fasta score E(): 0, 83.6% identity in 464 aa overlap. Similar to many e.g. Streptomyces lividans fadE, fatty acid acyl-CoA dehydrogenase, TR:Q9RIQ5 (EMBL:AJ250495) (385 aa); Fasta score E(): 5.1e-27, 28.5% identity in 376 aa overlap. Previously sequenced as TR:O32890 (EMBL:Z98271) (465 aa); Fasta score E(): 0, 100.0% identity in 465 aa overlap. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehyd [...] (465 aa)
fadE25Putative acyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis RV3274C OR MTCY71.14C, putative acyl-CoA dehydrogenase, TR:P96879 (EMBL:Z92771) fasta scores: E(): 0, 92.0% id in 389 aa, and to Streptomyces lividans fatty acid acyl-CoA dehydrogenase fadE TR:Q9RIQ5 (EMBL:AJ250495) fasta scores: E(): 0, 67.6% id in 383 aa. Previously sequenced as SW:ACD_MYCLE (P46703). Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehydrogenases signature 2. Contains PS00072 Acyl-CoA dehydrogenases signature 1; Similar to ML0660, ML0661 and show [...] (389 aa)
ML0845Hypothetical protein; Unknown function. Similar to part of some acyl-CoA oxidases e.g. Arabidopsis thaliana acyl-CoA oxidase cx2 TR:O65201 (EMBL:AF057043) (692 aa) fasta scores: E(): 1.5e-06, 35.2% id in 125 aa. Previously sequenced as TR:O32973 (EMBL:Z98741) (193 aa) fasta scores: E(): 0, 99.5% id in 193 aa. (193 aa)
ML1241Possible enoyl-CoA hydratase/isomerase; Could possibly oxidize fatty acids using specific components. (294 aa)
eftAElectron transfer flavoprotein [alpha] subunit; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). (318 aa)
eftBElectron transfer flavoprotein [beta] subunit; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). (266 aa)
echA6enoyl-CoA hydratase/isomerase superfamily member; Could possibly oxidize fatty acids using specific components. (247 aa)
ML2158Hypothetical protein; No database matches. (130 aa)
fadBPutative fatty oxidation complex alpha subunit; Similar to Mycobacterium tuberculosis hypothetical 76.1 kda protein TR:O53872 (EMBL:AL022004) fasta scores: E(): 0, 88.6% in 719 aa, and to Escherichia coli fatty oxidation complex alpha subunit SW:FADB_ECOLI (P21177) fasta scores: E(): 0, 33.0% in 684 aa. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family; Similar to ML1724, ML2402, ML2401, ML1241 and ML2118. (714 aa)
ML2401Similar to several putative Prokaryotic and Eukaryotic enoyl-CoA hydratases including: Mycobacterium tuberculosis Rv1071c TR:O53419 (EMBL:AL021897) (345 aa) fasta scores: E(): 0, 77.7% id in 345 aa and Arabidopsis thaliana putative 3-hydroxyisobutyryl-coenzyme A hydrolase TR:O49330 (EMBL:AC002340) (410 aa) fasta scores: E(): 0, 35.1% id in 345 aa. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. (345 aa)
ML2402Putative enoyl-CoA hydratase/isomerase; Could possibly oxidize fatty acids using specific components. (257 aa)
fadB23-hydroxyacyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis putative 3-hydroxyacyl-CoA dehydrogenase Rv0468 TR:O53753 (EMBL:AL021933) fasta scores: E(): 0, 89.5% id in 287 aa, and to Clostridium acetobutylicum 3-hydroxybutyryl-CoA dehydrogenase SW:HBD_CLOAB (P52041) fasta scores: E(): 0, 43.3% id in 282 aa. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. (287 aa)
fadE5acyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis putative acyl-CoA dehydrogenase RV0244C TR:O53666 (EMBL:AL021929) fasta scores: E(): 0, 89.4% id in 611 aa. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. (611 aa)
fadA2acetyl-CoA C-acetyltransferase; Similar to many Prokaryotic and Eukaryotic thiolases including: Escherichia coli probable 3-ketoacyl-coa thiolase YFCY SW:YFCY_ECOLI (P76503) fasta scores: E(): 0, 36.9% id in 434 aa and to Rattus norvegicus trifunctonal enzyme beta subunit, mitochondrial precursor SW:ECHB_RAT (Q60587) fasta scores: E(): 0, 37.2% id in 462 aa. Contains Pfam match to entry PF00108 thiolase, Thiolase. Contains PS00099 Thiolases active site; Belongs to the thiolase-like superfamily. Thiolase family. (457 aa)
fabG4Possible oxidoreductase; The C-terminal portion of the predicted product of this CDS is highly similar to many 3-oxoacyl-[acyl-carrier protein] reductases e.g. Vibrio harveyi FabG SW:FABG_VIBHA (P55336) fasta scores: E(): 4.5e-27, 41.1% id in 241 aa. The N-terminus does not appear to be related to anything currently in the database except for the highly similar Mycobacterium tuberculosis putative 3-oxoacyl-[acyl-carrier protein] reductase RV0242C TR:O53665 (EMBL:AL021929) fasta scores: E(): 0, 84.8% id in 454 aa. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogen [...] (454 aa)
ML2566Similar to Mycobacterium tuberculosis hypothetical protein RV0241C TR:O53664 (EMBL:AL021929) fasta scores: E(): 0, 81.8% id in 280 aa, and to Streptomyces coelicolor putative dehydratase TR:CAB77291 (EMBL:AL160312) fasta scores: E(): 2.1e-27, 39.5% id in 271 aa. Contains Pfam match to entry PF01575 MaoC_dehydratas, MaoC like domain. Contains PS00211 ABC transporters family signature. (300 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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