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rpoC rpoC nusA nusA ML1448 ML1448 rho rho sigE sigE rpoT rpoT ML1014 ML1014 ML0542 ML0542 nusB nusB rpoA rpoA nusG nusG rpoB rpoB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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Your Input:
rpoC[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1316 aa)
nusAProbable transcription termination/antitermination factor; Participates in both transcription termination and antitermination. (347 aa)
ML1448Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature. (184 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (610 aa)
sigEECF subfamily sigma subunit; Highly similar to many proposed ECF-family RNA-polymerase sigma factors including: Mycobacterium tuberculosis SigE TR:O06289 (EMBL:U87242) (257 aa); Fasta score E(): 0, 82.1% identity in 252 aa overlap, Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa); Fasta score E(): 0, 80.6% identity in 247 aa overlap and Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa); Fasta score E(): 2.9e-16, 35.7% identity in 171 aa overlap. Contains a probable helix-turn-helix motif at aa 213-234 (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 Sigma70_ECF, Sig [...] (263 aa)
rpoTRNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (574 aa)
ML1014RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (319 aa)
ML0542Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (110 aa)
nusBPutative transcription termination protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (190 aa)
rpoA[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (347 aa)
nusGTranscription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (228 aa)
rpoB[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1178 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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