12 items (Mycobacterium leprae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rpoC	[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1316 aa)
	nusA	Probable transcription termination/antitermination factor; Participates in both transcription termination and antitermination. (347 aa)
	ML1448	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature. (184 aa)
	rho	Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (610 aa)
	sigE	ECF subfamily sigma subunit; Highly similar to many proposed ECF-family RNA-polymerase sigma factors including: Mycobacterium tuberculosis SigE TR:O06289 (EMBL:U87242) (257 aa); Fasta score E(): 0, 82.1% identity in 252 aa overlap, Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa); Fasta score E(): 0, 80.6% identity in 247 aa overlap and Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa); Fasta score E(): 2.9e-16, 35.7% identity in 171 aa overlap. Contains a probable helix-turn-helix motif at aa 213-234 (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 Sigma70_ECF, Sig [...] (263 aa)
	rpoT	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (574 aa)
	ML1014	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (319 aa)
	ML0542	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (110 aa)
	nusB	Putative transcription termination protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (190 aa)
	rpoA	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (347 aa)
	nusG	Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination. (228 aa)
	rpoB	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1178 aa)

Your Current Organism:

Mycobacterium leprae

NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ML0542	ML1014	gene:17574363	gene:17574840	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.999
ML0542	ML1448	gene:17574363	gene:17575286	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature.	0.527
ML0542	nusA	gene:17574363	gene:17575399	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	Probable transcription termination/antitermination factor; Participates in both transcription termination and antitermination.	0.879
ML0542	nusB	gene:17574363	gene:17574344	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	Putative transcription termination protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.	0.734
ML0542	nusG	gene:17574363	gene:17575754	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination.	0.627
ML0542	rho	gene:17574363	gene:17574959	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.	0.671
ML0542	rpoA	gene:17574363	gene:17575809	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML0542	rpoB	gene:17574363	gene:17575739	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML0542	rpoC	gene:17574363	gene:17575738	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML0542	rpoT	gene:17574363	gene:17574848	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.999
ML0542	sigE	gene:17574363	gene:17574902	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	ECF subfamily sigma subunit; Highly similar to many proposed ECF-family RNA-polymerase sigma factors including: Mycobacterium tuberculosis SigE TR:O06289 (EMBL:U87242) (257 aa); Fasta score E(): 0, 82.1% identity in 252 aa overlap, Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa); Fasta score E(): 0, 80.6% identity in 247 aa overlap and Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa); Fasta score E(): 2.9e-16, 35.7% identity in 171 aa overlap. Contains a probable helix-turn-helix motif at aa 213-234 (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 Sigma70_ECF, Sig [...]	0.527
ML1014	ML0542	gene:17574840	gene:17574363	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	0.999
ML1014	ML1448	gene:17574840	gene:17575286	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature.	0.460
ML1014	nusA	gene:17574840	gene:17575399	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Probable transcription termination/antitermination factor; Participates in both transcription termination and antitermination.	0.615
ML1014	rpoA	gene:17574840	gene:17575809	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML1014	rpoB	gene:17574840	gene:17575739	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML1014	rpoC	gene:17574840	gene:17575738	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML1014	sigE	gene:17574840	gene:17574902	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	ECF subfamily sigma subunit; Highly similar to many proposed ECF-family RNA-polymerase sigma factors including: Mycobacterium tuberculosis SigE TR:O06289 (EMBL:U87242) (257 aa); Fasta score E(): 0, 82.1% identity in 252 aa overlap, Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa); Fasta score E(): 0, 80.6% identity in 247 aa overlap and Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa); Fasta score E(): 2.9e-16, 35.7% identity in 171 aa overlap. Contains a probable helix-turn-helix motif at aa 213-234 (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 Sigma70_ECF, Sig [...]	0.530
ML1448	ML0542	gene:17575286	gene:17574363	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature.	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	0.527
ML1448	ML1014	gene:17575286	gene:17574840	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature.	RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.460