STRINGSTRING
mmaA4 mmaA4 umaA2 umaA2 ML0321 ML0321 ML0311 ML0311 pssA pssA glmU glmU fadD26 fadD26 ML2357 ML2357 ML2356 ML2356 ML2355 ML2355 ML2354 ML2354 ML2353 ML2353 ML2334 ML2334 ML2277 ML2277 desA1 desA1 pgsA2 pgsA2 desA2 desA2 cmaA2 cmaA2 ML1942 ML1942 lytB2 lytB2 ML0396 ML0396 ML0452 ML0452 ML0453 ML0453 pgsA pgsA bccA bccA lipA lipA ML2463 ML2463 ML2566 ML2566 fadD32 fadD32 pks13 pks13 ML0127 ML0127 fadD29 fadD29 ML0135 ML0135 fadD28 fadD28 mas mas ML0242 ML0242 ML0243 ML0243 ML0322 ML0322 ML2620 ML2620 ML2692 ML2692 mmaA1 mmaA1 inhA inhA gpdA gpdA kasB kasB kasA kasA acpM acpM ML1589 ML1589 ML1583 ML1583 gcpE gcpE ML1417 ML1417 plsB plsB ML1244 ML1244 ML1234 ML1234 papA3 papA3 pks3 pks3 acpS acpS fas fas dxs dxs suhB suhB ML0979 ML0979
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proteins of unknown 3D structure
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mmaA4Similar to M. tuberculosis methyl mycolic acid synthase 4 Rv0642C TR:P72028 (EMBL:U66108) (301 aa); Fasta score E(): 0, 87.5% identity in 296 aa overlap, and to many others e.g. M. tuberculosis cyclopropane-fatty-acyl-phospholipid synthase 1 SW:CFA1_MYCTU (Q11195) (287 aa); Fasta score E(): 0, 57.0% identity in 286 aa overlap; Similar to ML2459, ML2426 and ML2334. (298 aa)
umaA2Mycolic acid synthase; Highly similar to many mycobacterial mycolic acid synthases including: Mycobacterium tuberculosis cyclopropane-fatty-acyl-phospholipid synthase 1 Rv3392c SW:CFA1_MYCTU (Q11195) fasta scores: E(): 0, 69.0% id in 287 aa and to Mycobacterium bovis methyl mycolic acid synthase 3 mma3 TR:P94924 (EMBL:U77466) fasta scores: E(): 0, 61.1% id in 293 aa; Similar to ML1900 and ML1903. (295 aa)
ML0321Putative 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (241 aa)
ML0311Conserved hypothetical protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (243 aa)
pssASimilar to M. tuberculosis pssA, Rv0436c, CDP-diacylglycerol-serine o-phosphatidyltransferase, SW:PSS_MYCTU (P96282) (286 aa); Fasta score E(): 0, 77.9% identity in 285 aa overlap. Similar to many e.g. Helicobacter pylori pssA, CDP-diacylglycerol-serine o-phosphatidyltransferase, SW:PSS_HELPY (Q48269) (237 aa); Fasta score E(): 2.3e-14, 34.6% identity in 234 aa overlap. Previously sequenced as TR:Q9ZBM2 (EMBL:AL035159) (300 aa); Fasta score E(): 0, 100.0% identity in 300 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00 [...] (300 aa)
glmUPutative UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (492 aa)
fadD26Probable acyl-CoA synthase; Similar to Mycobacterium tuberculosis acyl-CoA synthase Rv1185c TR:O50441 (EMBL:AL010186) (578 aa) fasta scores: E(): 0, 56.9% id in 580 aa, and to Myxococcus xanthus saframycin synthetase B TR:Q50857 (EMBL:U24657) (1770 aa) fasta scores: E(): 0, 36.5% id in 578 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML0132, ML1234, ML0138 and ML0100. (583 aa)
ML2357Polyketide synthase; Highly similar to many Prokaryotic and Eukaryotic polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthase rv2931 SW:PPSA_MYCTU (Q10977) (1876 aa) fasta scores: E(): 0, 76.1% id in 1888 aa and to Penicillium patulum 6-methylsalicylic acid synthase SW:MSAS_PENPA (P22367) (1774 aa) fasta scores: E(): 0, 33.8% id in 1823 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantethe [...] (1871 aa)
ML2356Similar to many polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthesis polyketide synthase Rv2932 SW:PPSB_MYCTU (Q10978; O53234) (1538 aa) fasta scores: E(): 0, 76.3% id in 1561 aa and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 42.2% id in 879 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Be [...] (1540 aa)
ML2355Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...] (2201 aa)
ML2354Similar to many polyketide synthases e.g.Mycobacterium tuberculosis Rv2934 TR:P96203 (EMBL:Z83857) (1827 aa) fasta scores: E(): 0, 80.3% id in 1836 aa, and to Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 32.7% id in 2136 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00017 ATP/G [...] (1822 aa)
ML2353Similar to many polyketide synthases e.g. Mycobacterium tuberculosis Rv2935 TR:P96204 (EMBL:Z83857) (1488 aa) fasta scores: E(): 0, 82.0% id in 1493 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site; Similar to ML2355, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101. (1489 aa)
ML2334Hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 46.9 kDa protein Rv3720 TR:O69687 (EMBL:AL022121) (420 aa) fasta scores: E(): 0, 86.4% id in 420 aa. The C-terminus is similar to several proteins involved in cyclopropane-fatty-acyl-phospholipid synthesis e.g. Escherichia coli SW:CFA_ECOLI (P30010) (381 aa) fasta scores: E(): 1.3e-27, 34.5% id in 278 aa. Contains PS00107 Protein kinases ATP-binding region signature. (420 aa)
ML2277Similar to Mycobacterium tuberculosis putative heptaprenyl diphosphate synthase Rv0562 or MTCY25D10.41 TR:O06428 (EMBL:Z95558) (335 aa) fasta scores: E(): 0, 76.4% id in 335 aa and to Mycobacterium tuberculosis isoprene biosynthesis transferase Rv0989c or MTCI237.03C TR:O05572 (EMBL:Z94752) (325 aa) fasta scores: E(): 0, 53.6% id in 323 aa. Similar to many polyprenyl synthase components e.g. Bacillus stearothermophilus heptaprenyl diphosphate synthase component ii hepT or heps-2 SW:HEP2_BACST (P55785) (320 aa) fasta scores: E(): 1.2e-31, 33.8% id in 320 aa. Contains Pfam match to entry [...] (330 aa)
desA1acyl-[ACP] desaturase; Similar to Mycobacterium tuberculosis protein desA1 TR:Q50824 (EMBL:U49839) fasta scores: E(): 0, 79.9% in 338 aa, and to Oryza sativa acyl-[acyl-carrier protein] desaturase precursor SW:STAD_ORYSA (Q40731) fasta scores: E(): 2e-19, 28.3% in 300 aa; Similar to and ML1952. (338 aa)
pgsA2CDP-diacylglycerol-glycerol-3-phosphate; Similar to Mycobacterium tuberculosis putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase SW:PGSA_MYCTU (Q50611) fasta scores: E(): 0, 76.6% in 205 aa, and to Escherichia coli CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase SW:PGSA_ECOLI (P06978) fasta scores: E(): 4.5e-11, 30.5% in 177 aa. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature; Similar to and ML0979; Belongs to the CDP-alcohol phosphati [...] (206 aa)
desA2Similar to M. tuberculosis acyl-[ACP] desaturase desA2 TR:O53442 (EMBL:AL021897) (275 aa); Fasta score E(): 0, 78.1% identity in 274 aa overlap, and to others e.g. Gossypium hirsutum (Upland cotton) acyl-[acyl-carrier protein] desaturase precursor SW:STAD_GOSHI (X95988) (397 aa); Fasta score E(): 5.6e-05, 23.9% identity in 293 aa overlap; Similar to and ML2185. (275 aa)
cmaA2Cyclopropane mycolic acid synthase; Catalyzes the formation of trans cyclopropanated ketomycolate or methoxymycolate through the conversion of a double bond to a cyclopropane ring at the proximal position of an oxygenated mycolic acid via the transfer of a methylene group from S-adenosyl-L- methionine. In the absence of MmaA2, CmaA2 has a non-specific cis- cyclopropanating activity and is able to catalyze the conversion of a double bond to a cis cyclopropane ring at the distal position of an alpha mycolic acid. Cyclopropanated mycolic acids are key factors participating in cell envelop [...] (308 aa)
ML1942Similar to M. tuberculosis cholesterol dehydrogenase Rv1106c TR:O53454 (EMBL:AL021897) (370 aa); Fasta score E(): 0, 75.5% identity in 375 aa overlap, and to Nocardia sp NAD(P)-dependent cholesterol dehydrogenase TR:Q03704 (EMBL:D90244) (364 aa); Fasta score E(): 0, 71.0% identity in 366 aa overlap. Contains Pfam match to entry PF01073 3Beta_HSD, 3-beta hydroxysteroid dehydrogenase/isomerase family; Similar to ML0204 and ML1964. (376 aa)
lytB2LytB homolog; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (335 aa)
ML0396Similar to M. tuberculosis Rv0046c, conserved hypothetical protein, TR:P71703 (EMBL:AL123456) (367 aa); Fasta score E(): 0, 91.8% identity in 366 aa overlap. Similar to other bacterial hypothetical proteins. C-terminal half show weak similarity to eukaryotic myo-inositol-1-phosphate synthases e.g. Candida albicans ino1, myo-inositol-1-phosphate synthase, SW:INO1_CANAL (P42800) (520 aa); Fasta score E(): 0.22, 24.4% identity in 242 aa overlap. Previously sequenced as TR:Q57240 (EMBL:U00015) (369 aa); Fasta score E(): 0, 100.0% identity in 369 aa overlap. Contains Pfam match to entry PF0 [...] (369 aa)
ML0452Putative glycosyltransferase; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (374 aa)
ML0453Similar to M. tuberculosis Rv2611c, conserved hypothetical protein, TR:O06203 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 71.5% identity in 312 aa overlap. Shows weak similarity to putative acyltransferases e.g. Campylobacter jejuni lipid A biosynthesis acyltransferase, TR:AAF31766 (EMBL:AF130984) (295 aa); Fasta score E(): 0.00017, 20.0% identity in 180 aa overlap. previously sequenced as TR:O07148 (EMBL:Z96801) (320 aa); Fasta score E(): 0, 99.7% identity in 320 aa overlap. (320 aa)
pgsASimilar to M. tuberculosis pgsA, Rv2612c, putative CDP-alcohol phosphatidyltransferases, TR:O06202 (EMBL:AL123456) (217 aa); Fasta score E(): 0, 79.3% identity in 213 aa overlap. Shows weak similarity to Escherichia coli pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, SW:PGSA_ECOLI (P06978) (738 aa); BlastP Expect 8.6. Previously sequenced as TR:O07149 (EMBL:Z96801) (239 aa); Fasta score E(): 0, 100.0% identity in 239 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyl [...] (239 aa)
bccAAcetyl/propionyl CoA carboxylase [alpha] subunit; This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. (598 aa)
lipAPutative lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (314 aa)
ML2463Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 30.2 kda protein Rv0466 TR:O53751 (EMBL:AL021933) fasta scores: E(): 0, 87.1% id in 264 aa. (264 aa)
ML2566Similar to Mycobacterium tuberculosis hypothetical protein RV0241C TR:O53664 (EMBL:AL021929) fasta scores: E(): 0, 81.8% id in 280 aa, and to Streptomyces coelicolor putative dehydratase TR:CAB77291 (EMBL:AL160312) fasta scores: E(): 2.1e-27, 39.5% id in 271 aa. Contains Pfam match to entry PF01575 MaoC_dehydratas, MaoC like domain. Contains PS00211 ABC transporters family signature. (300 aa)
fadD32Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv3801c, fadD32, putative acyl-CoA synthase, TR:O53580 (EMBL:AL123456) (637 aa); Fasta score E(): 0, 93.2% identity in 632 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 36.8% identity in 581 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 36.4% identity in 605 aa overlap. Contains Pfam match to entry PF005 [...] (635 aa)
pks13Similar to many polyketide synthases from M. tuberculosis e.g. ppsA, M. tuberculosis phenolpthiocerol synthesis polyketide synthase, SW:PPSA_MYCTU (Q10977) (1876 aa); Fasta score E(): 0, 36.1% identity in 1277 aa overlap. Similar to many others e.g. Streptomyces noursei nysI, nystatin biosynthesis polyketide synthase, TR:AAF71766 (EMBL:AF263912) (9477 aa); Fasta score E(): 0, 33.4% identity in 1215 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entr [...] (1784 aa)
ML0127Hypothetical protein; Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p- hydroxybenzoic acid derivatives (p-HBAD). (229 aa)
fadD29Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2950c, fadD29, putative acyl-CoA synthase, TR:P95141 (EMBL:AL123456) (619 aa); Fasta score E(): 0, 80.2% identity in 620 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 58.5% identity in 585 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 36.2% identity in 589 aa overlap. Contains Pfam match to entry PF005 [...] (680 aa)
ML0135Similar to many polyketide synthases from M. tuberculosis e.g. N-terminus is similar to Rv2947c, pks15, probable polyketide synthase, TR:P96284 (EMBL:Z83858) (496 aa); Fasta score E(): 0, 90.5% identity in 485 aa overlap and the remainder is similar to Rv2946c, pks1, probable polyketide synthase, TR:P96285 (EMBL:Z83858) (1616 aa); Fasta score E(): 0, 82.5% identity in 1620 aa overlap. Similar to many others e.g. Streptomyces noursei NysC, nystatin biosynthesis polyketide synthase, TR:AAF71776 (EMBL:AF263912) (11096 aa); Fasta score E(): 0, 50.2% identity in 2161 aa overlap. Contains Pf [...] (2103 aa)
fadD28Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2941, fadD29, putative acyl-CoA synthase, TR:P96290 (EMBL:AL123456) (580 aa); Fasta score E(): 0, 81.9% identity in 580 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 81.4% identity in 580 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 35.8% identity in 590 aa overlap. Contains Pfam match to entry PF0050 [...] (579 aa)
masPutative mycocerosic synthase; Similar to many polyketide synthases from M. tuberculosis e.g. Rv2940c, mas, mycocerosic acid synthase, TR:P96291 (EMBL:AL123456) (2111 aa); Fasta score E(): 0, 88.0% identity in 2119 aa overlap. Similar to Mycobacterium bovis mas, mycocerosic acid synthase, SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 85.1% identity in 2122 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transf [...] (2116 aa)
ML0242Putative isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (311 aa)
ML0243Similar to several putative acyl-CoA synthases from M.tuberculosis e.g. pks16, Rv1013, possible polyketide synthase, TR:O05598 (EMBL:AL123456) (544 aa); Fasta score E(): 0, 82.2% identity in 544 aa overlap. Similar to domains of polyketide synthases e.g. Bacillus subtilis mycA, mycosubtilin synthetase, TR:Q9R9J1 (EMBL:AF184956) (3971 aa); Fasta score E(): 0, 33.7% identity in 404 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature; Similar to ML0887, ML0100, ML0132, ML0138, ML1051, ML1234, ML1994, ML23 [...] (544 aa)
ML0322Putative 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa)
ML2620Conserved integral membrane protein; Transports trehalose monomycolate (TMM) across the inner membrane; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily. (955 aa)
ML2692Similar to Mycobacterium tuberculosis hypothetical protein Rv0046c TR:P71703 (EMBL:Z80775) fasta scores: E(): 0, 91.8% in 366 aa, and to Streptomyces coelicolor hypothetical 39.2 kda protein TR:Q9X8T5 (EMBL:AL049826) fasta scores: E(): 0, 76.4% in 351 aa. The C-terminus is also weakly similar to several myo-inositol-1-phosphate synthases e.g. Candida albicans SW:INO1_CANAL (P42800) fasta scores: E(): 0.22, 24.4% in 242 aa. Contains Pfam match to entry PF01658 Inos-1-P_synth, Myo-inositol-1-phosphate synthase; Identical in sequence to ML0396. (369 aa)
mmaA1Similar to M. tuberculosis methyl mycolic acid synthase 1 Rv0645C TR:P94922 (EMBL:U77466) (286 aa); Fasta score E(): 0, 87.4% identity in 286 aa overlap, and to many others e.g. M. tuberculosis cyclopropane-fatty-acyl-phospholipid synthase 1 SW:CFA1_MYCTU (Q11195) (287 aa); Fasta score E(): 0, 54.9% identity in 284 aa overlap; Similar to ML2459, ML2426 and ML2334. (286 aa)
inhAenoyl-[ACP] reductase; Similar to M. tuberculosis inhA Rv1484 SW:INHA_MYCTU (P46533) (269 aa); Fasta score E(): 0, 90.3% identity in 269 aa overlap, and to many others e.g. Escherichia coli enoyl-[acyl-carrier-protein] reductase [NADH] SW:FABI_ECOLI (P29132) (261 aa); Fasta score E(): 1.2e-17, 33.2% identity in 268 aa overlap; Similar to and ML1807. (269 aa)
gpdAHighly similar to many glycerol-3-phosphate dehydrogenases (EC 1.1.1.8) including: Escherichia coli SW:GPDA_ECOLI (P37606) (339 aa); Fasta score E(): 0, 39.9% identity in 341 aa overlap and Mycobacterium tuberculosis RV2982C TR:P95113 (EMBL:Z83018) (334 aa); Fasta score E(): 0, 77.9% identity in 349 aa overlap. Contains Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (351 aa)
kasB3-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (425 aa)
kasA3-oxoacyl-[acyl-carrier-protein] synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (416 aa)
acpMAcyl carrier protein (meromycolate extension); Acyl carrier protein involved in meromycolate extension. (115 aa)
ML1589Possible phosphatidate cytidylyltransferase; The C-terminus of this protein is highly similar to many proteins involved with phospholipid biosynthesis e.g. Escherichia coli phosphatidate cytidylyltransferase (EC 2.7.7.41) SW:CDSA_ECOLI (P06466) (249 aa); Fasta score E(): 6.6e-15, 40.6% identity in 160 aa overlap and Mycobacterium tuberculosis Rv2881c SW:CDSA_MYCTU (Q10807) (306 aa); Fasta score E(): 0, 70.3% identity in 313 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01148 Cytidylyltrans, Phosphatidate cytidylyltransferas [...] (312 aa)
ML1583Possible 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (406 aa)
gcpEConserved hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (392 aa)
ML1417Similar to several CDP-diacylglycerol pyrophosphatases (EC 3.6.1.26) involved in phospholipid biosynthesis, including: Salmonella typhimurium SW:CDH_SALTY (P26219) (251 aa); Fasta score E(): 1.6e-25, 39.1% identity in 220 aa overlap and Mycobacterium tuberculosis RV2289 SW:CDH_MYCTU (Q50676) (260 aa); Fasta score E(): 0, 66.4% identity in 256 aa overlap. (268 aa)
plsBHighly similar to many acyltransferases including: Escherichia coli glycerol-3-phosphate acyltransferase (EC 2.3.1.15) SW:PLSB_ECOLI (P00482) (806 aa); Fasta score E(): 1.5e-27, 24.4% identity in 693 aa overlap and Mycobacterium tuberculosis putative acyltransferase PlsB2 (RV2482C) SW:PLS2_MYCTU (O53207) (789 aa); Fasta score E(): 0, 80.7% identity in 783 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase; Belongs to the GPAT/DAPAT family. (775 aa)
ML1244Conserved membrane protein; Highly similar to a family of Mycobacterium tuberculosis proteins e.g. Rv2484c SW:YO84_MYCTU (O53209) (491 aa); Fasta score E(): 0, 75.2% identity in 483 aa overlap. Contains possible membrane spanning hydrophobic domains; Belongs to the long-chain O-acyltransferase family. (491 aa)
ML1234Highly similar to acyl-CoA synthases from Mycobacterium tuberculosis Rv1185c TR:O50441 (EMBL:AL010186) (578 aa); Fasta score E(): 0, 72.4% identity in 579 aa overlap and Mycobacterium bovis TR:P71495 (EMBL:U7568) (582 aa); Fasta score E(): 0, 63.4% identity in 579 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML0100, ML0132, ML0138, ML0243 and ML2358; Belongs to the ATP-dependent AMP-binding enzyme family. (579 aa)
papA3PKS-associated protein, unknown function; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49618 (EMBL:U00010) (471 aa); Fasta score E(): 0, 99.8% identity in 471 aa overlap. Also highly similar to Mycobacterium tuberculosis proteins encoded downstream of several polyketide synthases e.g. Rv1182 TR:O50438 (EMBL:AL010186) (472 aa); Fasta score E(): 0, 75.8% identity in 471 aa overlap. (471 aa)
pks3Mycocerosic acid synthase (polyketide synthase); Identical to many polyketide synthases involved in the biosynthesis of mycocerosyl lipids e.g. Mycobacterium tuberculosis probable mycocerosic acid synthase Rv2940c TR:P96291 (EMBL:Z83858) (2111 aa); Fasta score E(): 0, 60.8% identity in 2127 aa overlap and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 58.8% identity in 2127 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase [...] (2118 aa)
acpSHolo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (130 aa)
fasFatty acid synthase; Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa); Fasta score E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa); Fasta score E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa); Fasta score E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 [...] (3076 aa)
dxs1-deoxy-D-xylulose 5-phosphate synthase (DXP synthase); Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (643 aa)
suhBPutative inositol monophosphatase; Identical to the previously sequenced Mycobacterium leprae extragenic suppressor protein SuhB homologue SW:SUHB_MYCLE (P46813) (291 aa); Fasta score E(): 0, 99.7% identity in 291 aa overlap. Also highly similar to many other members of the inositol monophosphatase family including: Mycobacterium tuberculosis, Rv2701c or ShuB, SW:SUHB_MYCTU (O07203) (290 aa); Fasta score E(): 0, 77.6% identity in 294 aa overlap and Escherichia coli ShuB, SW:SUHB_ECOLI (P22783) (267 aa); Fasta score E(): 1.6e-18, 34.7% identity in 239 aa overlap, shown to suppress the e [...] (291 aa)
ML0979CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Identical to the previously sequenced Mycobacterium leprae TR:Q49839 (EMBL:U00019) (193 aa); Fasta score E(): 0, 100.0% identity in 193 aa overlap. Also highly similar to many phosphatidylglycerophosphate synthases including: Mycobacterium tuberculosis Rv2746c TR:O33288 (EMBL:AL008967) (209 aa); Fasta score E(): 0, 77.1% identity in 188 aa overlap and Bacillus subtilis SW:PGSA_BACSU (P46322) (193 aa); Fasta score E(): 5.6e-17, 35.8% identity in 193 aa overlap. Contains multiple possible membrane spanning hydrophobic do [...] (193 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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