STRINGSTRING
metZ metZ serS serS ML0596 ML0596 cysE cysE cysK cysK ML0842 ML0842 gcvT gcvT folA folA serA serA ML1727 ML1727 glyA glyA gcvB gcvB gcvH gcvH serC serC metB metB cysM2 cysM2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene co-occurrence
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Your Input:
metZPutative o-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (406 aa)
serSPutative seryl-tRNA synthase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (417 aa)
ML0596Putative aminotransferase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (418 aa)
cysESimilar to Mycobacterium tuberculosis putative serine acetyltransferase cysE or Rv2335 or MTCY98.0031C TR:P95231 (EMBL:Z83860) (229 aa) fasta scores: E(): 0, 76.4% id in 229 aa, and to Bacillus subtilis serine acetyltransferase cysE or cysA SW:CYSE_BACSU (Q06750) (217 aa) fasta scores: E(): 0, 47.1% id in 204 aa. Previously sequenced as TR:O32979 (EMBL:Z98741). Contains 4 Pfam matches to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats). Contains PS00101 Hexapeptide-repeat containing-transferases signature. (227 aa)
cysKPutative cysteine synthase; Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide. (310 aa)
ML0842Conserved hypothetical protein; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (411 aa)
gcvTPutative aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (367 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). (165 aa)
serAD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
ML1727Similar in the C-terminus to many phosphoserine phosphatases (EC 3.1.3.3) including: Escherichia coli SW:SERB_ECOLI (P06862) (322 aa); Fasta score E(): 1.7e-29, 38.5% identity in 309 aa overlap and Mycobacterium tuberculosis RV3042C TR:O53289 (EMBL:AL021287) (409 aa); Fasta score E(): 0, 86.3% identity in 408 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. (411 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
gcvBGlycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (952 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (132 aa)
serCPutative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (376 aa)
metBCystathionine [gamma]-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). (388 aa)
cysM2Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. (464 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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