Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ML0175 | ML1681 | gene:17573990 | gene:17575524 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Possible polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.555 |
| ML0175 | ML2124 | gene:17573990 | gene:17575977 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | 0.555 |
| ML0175 | ML2440 | gene:17573990 | gene:17576303 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Probable two-component system sensor histidine kinase; Probably forms part of a two-component regulatory system SenX3/RegX3. Phosphorylates RegX3 (Probable). | 0.438 |
| ML0175 | mtrB | gene:17573990 | gene:17574598 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Putative two-component system sensor kinase; Member of the two-component regulatory system MtrA/MtrB. Seems to function as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals (By similarity). | 0.407 |
| ML0202 | ML0603 | gene:17574018 | gene:17574424 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.999 |
| ML0202 | dnaE | gene:17574018 | gene:17575038 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | DNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. | 0.998 |
| ML0202 | dnaG | gene:17574018 | gene:17574658 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.568 |
| ML0202 | dnaN | gene:17574018 | gene:17573811 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.999 |
| ML0202 | dnaZX | gene:17574018 | gene:17576196 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | DNA polymerase III, subunit [gamma/tau]; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.998 |
| ML0202 | polA | gene:17574018 | gene:17575220 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.960 |
| ML0202 | tmk | gene:17574018 | gene:17574596 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.694 |
| ML0232 | coaA | gene:17574049 | gene:17575806 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Pantothenate kinase; Similar to M. tuberculosis pantothenate kinase coaA Rv1092c SW:COAA_MYCTU (O53440) (312 aa); Fasta score E(): 0, 93.6% identity in 312 aa overlap, and to many others e.g. Escherichia coli pantothenate kinase SW:COAA_ECOLI (P15044) (316 aa); Fasta score E(): 0, 53.1% identity in 311 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). | 0.932 |
| ML0232 | coaD | gene:17574049 | gene:17575506 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Probable phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.941 |
| ML0232 | folK | gene:17574049 | gene:17574043 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Similar to M. tuberculosis folK, Rv3607c, probable 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase, SW:HPPK_MYCTU (O06276) (188 aa); Fasta score E(): 0, 63.2% identity in 190 aa overlap. Similar to others e.g. to the C-terminal half of Streptococcus pneumoniae sulD, bifunctional folate synthesis protein (includes: dihydroneopterin aldolase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase), SW:SULD_STRPN (P22291) (270 aa); Fasta score E(): 1.8e-07, 37.8% identity in 135 aa overlap. Previously sequenced as SW:HPPK_MYCLE (O69528) (191 aa); Fasta sc [...] | 0.535 |
| ML0232 | tmk | gene:17574049 | gene:17574596 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.481 |
| ML0242 | ML0321 | gene:17574059 | gene:17574140 | Putative isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Putative 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | 0.997 |
| ML0242 | ML1383 | gene:17574059 | gene:17575222 | Putative isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; In the C-terminal section; belongs to the UPF0157 (GrpB) family. | 0.419 |
| ML0321 | ML0242 | gene:17574140 | gene:17574059 | Putative 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). | Putative isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. | 0.997 |
| ML0542 | aroK | gene:17574363 | gene:17574338 | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | Putative shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.468 |
| ML0542 | gmk | gene:17574363 | gene:17574362 | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. | 0.990 |
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