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ML0919 ML0919 pks13 pks13 fadD22 fadD22 ML0135 ML0135 mas mas metZ metZ ilvX ilvX alr alr fadD9 fadD9 gabT gabT ML0596 ML0596 ML0842 ML0842 pdc pdc menD menD ML2353 ML2353 ML2354 ML2354 ML2355 ML2355 ML2356 ML2356 ML2357 ML2357 metB metB hemL hemL ML2502 ML2502 dxs dxs odhA odhA lysA lysA thrC thrC ilvA ilvA bioA bioA bioF bioF pks3 pks3 hisC hisC metH metH argD argD ML1488 ML1488 ilvB ilvB ML1708 ML1708 ML1794 ML1794 mutB mutB mutA mutA glyA glyA ilvG ilvG serC serC
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proteins of unknown 3D structure
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ML0919Possible DNA-binding protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. (260 aa)
pks13Similar to many polyketide synthases from M. tuberculosis e.g. ppsA, M. tuberculosis phenolpthiocerol synthesis polyketide synthase, SW:PPSA_MYCTU (Q10977) (1876 aa); Fasta score E(): 0, 36.1% identity in 1277 aa overlap. Similar to many others e.g. Streptomyces noursei nysI, nystatin biosynthesis polyketide synthase, TR:AAF71766 (EMBL:AF263912) (9477 aa); Fasta score E(): 0, 33.4% identity in 1215 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entr [...] (1784 aa)
fadD22Putative acyl-CoA synthetase; Similar to M. tuberculosis Rv2948c, acyl-CoA synthase, TR:P96283 (EMBL:AL123456) (705 aa); Fasta score E(): 0, 75.9% identity in 705 aa overlap. Similar to many acyl-CoA synthases e.g. Rhodopseudomonas palustris, badA, benzoate-coenzyme A ligase, TR:Q59760 (EMBL:L42322) (521 aa); Fasta score E(): 0, 31.4% identity in 494 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML1051, ML1994, ML2257 and ML2546. (707 aa)
ML0135Similar to many polyketide synthases from M. tuberculosis e.g. N-terminus is similar to Rv2947c, pks15, probable polyketide synthase, TR:P96284 (EMBL:Z83858) (496 aa); Fasta score E(): 0, 90.5% identity in 485 aa overlap and the remainder is similar to Rv2946c, pks1, probable polyketide synthase, TR:P96285 (EMBL:Z83858) (1616 aa); Fasta score E(): 0, 82.5% identity in 1620 aa overlap. Similar to many others e.g. Streptomyces noursei NysC, nystatin biosynthesis polyketide synthase, TR:AAF71776 (EMBL:AF263912) (11096 aa); Fasta score E(): 0, 50.2% identity in 2161 aa overlap. Contains Pf [...] (2103 aa)
masPutative mycocerosic synthase; Similar to many polyketide synthases from M. tuberculosis e.g. Rv2940c, mas, mycocerosic acid synthase, TR:P96291 (EMBL:AL123456) (2111 aa); Fasta score E(): 0, 88.0% identity in 2119 aa overlap. Similar to Mycobacterium bovis mas, mycocerosic acid synthase, SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 85.1% identity in 2122 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transf [...] (2116 aa)
metZPutative o-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (406 aa)
ilvXSimilar to M. tuberculosis ilvX, putative acetohydroxyacid synthase I large subunit, TR:O53554 (EMBL:AL123456) (515 aa); Fasta score E(): 0, 82.9% identity in 515 aa overlap. Similar to Escherichia coli ilvI, acetolactate synthase isozyme III large subunit, SW:ILVI_ECOLI (P00893) (574 aa); Fasta score E(): 1.8e-07, 23.7% identity in 540 aa overlap. Also similar to Pseudomonas putida mdlC, benzoylformate decarboxylase, SW:MDLC_PSEPU (P20906) (528 aa); Fasta score E(): 6.6e-13, 29.3% identity in 529 aa overlap. Previously sequenced as TR:Q49865 (EMBL:U00020) (515 aa); Fasta score E(): 0, [...] (515 aa)
alrPutative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (388 aa)
fadD9Putative acyl-CoA synthetase; Similar to M. tuberculosis fadD9, Rv2590, putative acyl-CoA synthetase, TR:Q5063 (EMBL:Al123456) (1168 aa); Fasta score E(): 0, 68.0% identity in 1178 aa overlap1. Similar to acyl-CoA ligases and to domains of polyketide/peptide synthetases e.g. Mycobacterium smegmatis mps, peptide synthetase, TR:Q9RLP6 (EMBL:AJ238027) (5990 aa); Fasta score E(): 0, 37.2% identity in 1168 aa overlap. C-terminal half is similar to eukaryotic aminoadipate-semialdehyde dehydrogenase e.g. Saccharomyces cerevisiae lys2, aminoadipate-semialdehyde dehydrogenase large subunit, SW: [...] (1188 aa)
gabTSimilar to M. tuberculosis gabT, Rv2589, 4-aminobutyrate aminotransferase, SW:GABT_MYCTU (Q50632) (449 aa); Fasta score E(): 0, 83.7% identity in 449 aa overlap. Similar to many e.g. Escherichia coli gabT, 4-aminobutyrate aminotransferase, SW:GABT_ECOLI (P22256) (426 aa); Fasta score E(): 0, 43.1% identity in 422 aa overlap. Previously sequenced as SW:GABT_MYCLE (P40829) (446 aa); Fasta score E(): 0, 99.8% identity in 446 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal- [...] (446 aa)
ML0596Putative aminotransferase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (418 aa)
ML0842Conserved hypothetical protein; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (411 aa)
pdcPyruvate (or indolepyruvate) decarboxylase; Decarboxylates branched-chain and aromatic alpha-keto acids to aldehydes. (569 aa)
menD2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). (556 aa)
ML2353Similar to many polyketide synthases e.g. Mycobacterium tuberculosis Rv2935 TR:P96204 (EMBL:Z83857) (1488 aa) fasta scores: E(): 0, 82.0% id in 1493 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site; Similar to ML2355, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101. (1489 aa)
ML2354Similar to many polyketide synthases e.g.Mycobacterium tuberculosis Rv2934 TR:P96203 (EMBL:Z83857) (1827 aa) fasta scores: E(): 0, 80.3% id in 1836 aa, and to Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 32.7% id in 2136 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00017 ATP/G [...] (1822 aa)
ML2355Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...] (2201 aa)
ML2356Similar to many polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthesis polyketide synthase Rv2932 SW:PPSB_MYCTU (Q10978; O53234) (1538 aa) fasta scores: E(): 0, 76.3% id in 1561 aa and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 42.2% id in 879 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Be [...] (1540 aa)
ML2357Polyketide synthase; Highly similar to many Prokaryotic and Eukaryotic polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthase rv2931 SW:PPSA_MYCTU (Q10977) (1876 aa) fasta scores: E(): 0, 76.1% id in 1888 aa and to Penicillium patulum 6-methylsalicylic acid synthase SW:MSAS_PENPA (P22367) (1774 aa) fasta scores: E(): 0, 33.8% id in 1823 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantethe [...] (1871 aa)
metBCystathionine [gamma]-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). (388 aa)
hemLSimilar to Mycobacterium tuberculosis glutamate-1-semialdehyde 2,1-aminomutase HemL Rv0524 SW:GSA_MYCTU (O06390) (462 aa) fasta scores: E(): 0, 82.4% id in 460 aa, and to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL SW:GSA_ECOLI (P23893; P78277) (426 aa) fasta scores: E(): 0, 53.0% id in 419 aa. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Similar to ML1409. (446 aa)
ML2502Similar to Mycobacterium tuberculosis probable aspartate aminotransferase RV0337C SW:AAT_MYCTU (O33267) fasta scores: E(): 0, 91.4% id in 429 aa and to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) fasta scores: E(): 0, 32.4% id in 389 aa. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. (437 aa)
dxs1-deoxy-D-xylulose 5-phosphate synthase (DXP synthase); Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (643 aa)
odhA2-oxoglutarate dehydrogenase, E1 and E2 components; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxo [...] (1260 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (472 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (360 aa)
ilvAThreonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). (427 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (436 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa)
pks3Mycocerosic acid synthase (polyketide synthase); Identical to many polyketide synthases involved in the biosynthesis of mycocerosyl lipids e.g. Mycobacterium tuberculosis probable mycocerosic acid synthase Rv2940c TR:P96291 (EMBL:Z83858) (2111 aa); Fasta score E(): 0, 60.8% identity in 2127 aa overlap and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 58.8% identity in 2127 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase [...] (2118 aa)
hisCHighly similar to many histidinol-phosphate aminotransferases (EC 2.6.1.9) involved in histidine biosynthesis e.g. Mycobacterium tuberculosis RV1600 TR:SW:HIS8_MYCTU (O06591) (380 aa); Fasta score E(): 0, 83.6% identity in 366 aa overlap and Mycobacterium smegmatis SW:HIS8_MYCSM (P28735) (219 aa); Fasta score E(): 0, 77.2% identity in 219 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II. (377 aa)
metH5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1206 aa)
argDHighly similar to many acetylornithine aminotransferases (EC 2.6.1.11) involved in arginine biosynthesis, including: Escherichia coli SW:ARGD_ECOLI (P18335) (405 aa); Fasta score E(): 0, 38.7% identity in 390 aa overlap and Mycobacterium tuberculosis RV1655 SW:ARGD_MYCTU (P94990) (400 aa); Fasta score E(): 0, 82.9% identity in 397 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. (404 aa)
ML1488Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. (367 aa)
ilvBHighly similar to many acetolactate synthases, large subunit, (EC 4.1.3.18) involved in valine and isoleucine biosynthesis, including: Mycobacterium avium SW:ILVB_MYCAV (Q59498) (621 aa); Fasta score E(): 0, 82.7% identity in 624 aa overlap and Mycobacterium tuberculosis RV3003C SW:ILVB_MYCTU (O53250) (618 aa); Fasta score E(): 0, 87.1% identity in 627 aa overlap. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00187 Thiamine pyrophosphate enzymes signature. (625 aa)
ML1708Highly similar to many aminotransferases resembling NifS, a protein of unknown function located within many nitrogen fixation gene clusters e.g. Azotobacter vinelandii SW:NIFS_AZOVI (P05341) (402 aa); Fasta score E(): 0, 39.1% identity in 394 aa overlap. Also highly similar to Mycobacterium tuberculosis NifS-like protein RV3025C TR:O53272 (EMBL:AL021287) (393 aa); Fasta score E(): 0, 84.9% identity in 391 aa overlap. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V; Similar to ML0596. (410 aa)
ML1794Aminotransferase; Similar to M. tuberculosis predicted aminotransferase Rv2294 SW:YM94_MYCTU (Q50672) (407 aa); Fasta score E(): 0, 76.5% identity in 404 aa overlap, and to many others e.g. Escherichia coli MalY protein SW:MALY_ECOLI (P23256) (390 aa); Fasta score E(): 5.8e-27, 31.2% identity in 385 aa overlap; Similar to and ML2502; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily. (402 aa)
mutBmethylmalonyl-CoA mutase, [alpha] subunit; Similar to M. tuberculosis mutB SW:MUTB_MYCTU (P71774) (750 aa); Fasta score E(): 0, 88.9% identity in 748 aa overlap, and many other methylmalonyl-CoA mutase alpha-subunit e.g. Streptomyces cinnamonensis SW:MUTB_STRCM (Q05065) (733 aa); Fasta score E(): 0, 74.7% identity in 726 aa overlap. Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. Contains PS00544 Methylmalonyl-CoA mutase signature; Similar to and ML1800. (758 aa)
mutAmethylmalonyl-CoA mutase, [beta] subunit; Similar to M. tuberculosis mutA SW:MUTA_MYCTU (P71773) (615 aa); Fasta score E(): 0, 75.3% identity in 636 aa overlap, and many other methylmalonyl-CoA mutase beta-subunit e.g. Streptomyces cinnamonensis SW:SW:MUTA_STRCM (Q05064) (616 aa); Fasta score E(): 0, 42.7% identity in 626 aa overlap. Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. Contains PS00544 Methylmalonyl-CoA mutase signature; Similar to and ML1799. (636 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
ilvGAcetolactate synthase II; Similar to Mycobacterium tuberculosis probable acetolactate synthase SW:ILVG_MYCTU (Q50613) fasta scores: E(): 0, 86.1% in 548 aa, and to Bacillus subtilis acetolactate synthase large subunit SW:ILVB_BACSU (P37251; P94564) fasta scores: E(): 1.2e-32, 28.5% in 543 aa. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00187 Thiamine pyrophosphate enzymes signature; Similar to ML1696, ML2167 and ML0354. (548 aa)
serCPutative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (376 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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