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| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa) |
| | ML1454 | Conserved hypothetical protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (214 aa) |
| | ML1417 | Similar to several CDP-diacylglycerol pyrophosphatases (EC 3.6.1.26) involved in phospholipid biosynthesis, including: Salmonella typhimurium SW:CDH_SALTY (P26219) (251 aa); Fasta score E(): 1.6e-25, 39.1% identity in 220 aa overlap and Mycobacterium tuberculosis RV2289 SW:CDH_MYCTU (Q50676) (260 aa); Fasta score E(): 0, 66.4% identity in 256 aa overlap. (268 aa) |
| | ML1399 | Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV1647 TR:P94982 (EMBL:Z85982) (316 aa); Fasta score E(): 0, 74.0% identity in 312 aa overlap. (324 aa) |
| | ML1383 | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; In the C-terminal section; belongs to the UPF0157 (GrpB) family. (410 aa) |
| | cmk | Cytidylate kinase; Highly similar to several cytidylate kinases (EC 2.7.4.14) including: Bacillus subtilis SW:KCY_BACSU (P38493) (224 aa); Fasta score E(): 1.9e-28, 42.7% identity in 218 aa overlap and Mycobacterium tuberculosis RV1712TR:O33211 (EMBL:Z98268) (230 aa); Fasta score E(): 0, 74.8% identity in 222 aa overlap. Contains Pfam match to entry PF02224 Cytidylate_kin, Cytidylate kinase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (223 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (590 aa) |
| | ML1361 | Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv1697 TR:O33198 (EMBL:Z98268) (393 aa); Fasta score E(): 0, 90.6% identity in 393 aa overlap. Contains possible membrane spanning hydrophobic domain. (393 aa) |
| | ML1359 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (311 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (357 aa) |
| | plsB | Highly similar to many acyltransferases including: Escherichia coli glycerol-3-phosphate acyltransferase (EC 2.3.1.15) SW:PLSB_ECOLI (P00482) (806 aa); Fasta score E(): 1.5e-27, 24.4% identity in 693 aa overlap and Mycobacterium tuberculosis putative acyltransferase PlsB2 (RV2482C) SW:PLS2_MYCTU (O53207) (789 aa); Fasta score E(): 0, 80.7% identity in 783 aa overlap. Contains Pfam match to entry PF01553 Acyltransferase, Acyltransferase; Belongs to the GPAT/DAPAT family. (775 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphatase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (286 aa) |
| | nadB | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (527 aa) |
| | nadA | Quinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (352 aa) |
| | atpC | ATP synthase [epsilon] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (121 aa) |
| | atpD | ATP synthase [beta] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (485 aa) |
| | atpG | ATP synthase [gamma] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (298 aa) |
| | atpA | ATP synthase [alpha] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (558 aa) |
| | atpH | Bi-domained ATP synthase B, [Delta] chain protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). (446 aa) |
| | atpF | Probable ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (170 aa) |
| | atpE | Probable ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa) |
| | atpB | Probable ATP synthase A chain protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (251 aa) |
| | dxs | 1-deoxy-D-xylulose 5-phosphate synthase (DXP synthase); Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (643 aa) |
| | dut | Probable deoxyuridine triphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (154 aa) |
| | suhB | Putative inositol monophosphatase; Identical to the previously sequenced Mycobacterium leprae extragenic suppressor protein SuhB homologue SW:SUHB_MYCLE (P46813) (291 aa); Fasta score E(): 0, 99.7% identity in 291 aa overlap. Also highly similar to many other members of the inositol monophosphatase family including: Mycobacterium tuberculosis, Rv2701c or ShuB, SW:SUHB_MYCTU (O07203) (290 aa); Fasta score E(): 0, 77.6% identity in 294 aa overlap and Escherichia coli ShuB, SW:SUHB_ECOLI (P22783) (267 aa); Fasta score E(): 1.6e-18, 34.7% identity in 239 aa overlap, shown to suppress the e [...] (291 aa) |
| | ML0979 | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Identical to the previously sequenced Mycobacterium leprae TR:Q49839 (EMBL:U00019) (193 aa); Fasta score E(): 0, 100.0% identity in 193 aa overlap. Also highly similar to many phosphatidylglycerophosphate synthases including: Mycobacterium tuberculosis Rv2746c TR:O33288 (EMBL:AL008967) (209 aa); Fasta score E(): 0, 77.1% identity in 188 aa overlap and Bacillus subtilis SW:PGSA_BACSU (P46322) (193 aa); Fasta score E(): 5.6e-17, 35.8% identity in 193 aa overlap. Contains multiple possible membrane spanning hydrophobic do [...] (193 aa) |
| | ribF | Putative riboflavin kinase; Similar to Mycobacterium tuberculosis riboflavin kinase ribF or Rv2786c or MTV002.51C TR:O33328 (EMBL:AL008967) (331 aa) fasta scores: E(): 0, 87.5% id in 327 aa and to many others e.g. Corynebacterium ammoniagenes riboflavin biosynthesis protein RibF (includes riboflavin kinase) ribF SW:RIBF_CORAM (Q59263) (338 aa) fasta scores: E(): 0, 47.7% id in 321 aa. Previously sequenced as TR:O32968 (EMBL:Z98741). Contains Pfam match to entry PF01687 FAD_Synth, Riboflavin kinase / FAD synthetase. (331 aa) |
| | tmk | Putative thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (210 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase ATPase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (439 aa) |
| | add | Putative adenosine deaminase; Similar to M. tuberculosis add, Rv3313c, probable adenosine deaminase, TR:O53365 (EMBL:AL123456) (365 aa); Fasta score E(): 0, 88.2% identity in 356 aa overlap. Similar to many e.g. Escherichia coli add, adenosine deaminase, SW:ADD_ECOLI (P22333) (333 aa); Fasta score E(): 6.8e-19, 29.7% identity in 340 aa overlap. Previously sequenced as TR:Q49907 (EMBL:U00022) (332 aa); Fasta score E(): 0, 99.7% identity in 332 aa overlap. Contains Pfam match to entry PF00962 A_deaminase, Adenosine/AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. A [...] (362 aa) |
| | folD | Putative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa) |
| | dfp | Putative flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (419 aa) |
| | gmk | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (210 aa) |
| | pyrF | Similar to M. tuberculosis pyrF, Rv1385, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCTU (P77898) (274 aa); Fasta score E(): 0, 77.3% identity in 282 aa overlap. Similar to many e.g. Mycobacterium smegmatis pyrF, orotidine 5'-phosphate decarboxylase, SW:DCOP_MYCSM (O08323) (276 aa); Fasta score E(): 0, 72.5% identity in 280 aa overlap. Contains Pfam match to entry PF00215 OMPdecase, Orotidine 5'-phosphate decarboxylases. Contains PS00156 Orotidine 5'-phosphate decarboxylase active site; Belongs to the OMP decarboxylase family. Type 2 subfamily. (282 aa) |
| | carB | Similar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. (1129 aa) |
| | carA | Similar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] (375 aa) |
| | pyrC | Putative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (430 aa) |
| | pyrB | Similar to M. tuberculosis pyrB, Rv1380, aspartate carbamoyltransferase, SW:PYRB_MYCTU (P71808) (319 aa); Fasta score E(): 0, 89.9% identity in 318 aa overlap. Similar to many e.g. Pseudomonas putida, aspartate carbamoyltransferase, SW:PYRB_PSEPU (Q59711) (334 aa); Fasta score E(): 0, 47.3% identity in 317 aa overlap. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature; Shows weak similarity to ML1410; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCas [...] (321 aa) |
| | relA | Putative GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp (By similarity). (787 aa) |
| | ML0474 | Conserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (223 aa) |
| | pgsA | Similar to M. tuberculosis pgsA, Rv2612c, putative CDP-alcohol phosphatidyltransferases, TR:O06202 (EMBL:AL123456) (217 aa); Fasta score E(): 0, 79.3% identity in 213 aa overlap. Shows weak similarity to Escherichia coli pgsA, CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, SW:PGSA_ECOLI (P06978) (738 aa); BlastP Expect 8.6. Previously sequenced as TR:O07149 (EMBL:Z96801) (239 aa); Fasta score E(): 0, 100.0% identity in 239 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyl [...] (239 aa) |
| | ML0452 | Putative glycosyltransferase; Involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM). Catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1); Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. (374 aa) |
| | ML0450 | Putative pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (307 aa) |
| | ML0396 | Similar to M. tuberculosis Rv0046c, conserved hypothetical protein, TR:P71703 (EMBL:AL123456) (367 aa); Fasta score E(): 0, 91.8% identity in 366 aa overlap. Similar to other bacterial hypothetical proteins. C-terminal half show weak similarity to eukaryotic myo-inositol-1-phosphate synthases e.g. Candida albicans ino1, myo-inositol-1-phosphate synthase, SW:INO1_CANAL (P42800) (520 aa); Fasta score E(): 0.22, 24.4% identity in 242 aa overlap. Previously sequenced as TR:Q57240 (EMBL:U00015) (369 aa); Fasta score E(): 0, 100.0% identity in 369 aa overlap. Contains Pfam match to entry PF0 [...] (369 aa) |
| | guaA | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. (529 aa) |
| | guaB3 | Similar to M. tuberculosis guaB3, Rv3410c, putative inosine-5'-monophosphate dehydrogenase, SW:YY10_MYCTU (Q50716) (375 aa); Fasta score E(): 0, 90.5% identity in 368 aa overlap. This ORF is similar in part to ML0387 and ML2066, which more closely resemble the experimentally characterised IMP-DH's (e.g. from Escherichia coli). This shorter homologue is conserved in several bacterial genera. Previously sequenced as SW:YY10_MYCLE (U00015) (375 aa); Fasta score E(): 0, 100.0% identity in 370 aa overlap. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C term [...] (370 aa) |
| | guaB2 | Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (529 aa) |
| | ML0322 | Putative 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (158 aa) |
| | ML0321 | Putative 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (241 aa) |
| | ML0311 | Conserved hypothetical protein; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (243 aa) |
| | pssA | Similar to M. tuberculosis pssA, Rv0436c, CDP-diacylglycerol-serine o-phosphatidyltransferase, SW:PSS_MYCTU (P96282) (286 aa); Fasta score E(): 0, 77.9% identity in 285 aa overlap. Similar to many e.g. Helicobacter pylori pssA, CDP-diacylglycerol-serine o-phosphatidyltransferase, SW:PSS_HELPY (Q48269) (237 aa); Fasta score E(): 2.3e-14, 34.6% identity in 234 aa overlap. Previously sequenced as TR:Q9ZBM2 (EMBL:AL035159) (300 aa); Fasta score E(): 0, 100.0% identity in 300 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00 [...] (300 aa) |
| | thiE | Putative thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (235 aa) |
| | ML0299 | Putative oxidoreductase; Similar to M. tuberculosis Rv0415, conserved hypothetical protein, TR:P96261 (EMBL:AL123456) (340 aa); Fasta score E(): 0, 82.0% identity in 338 aa overlap. Shows weak similarity to Bacillus subtilis goxB, glycine oxidase, SW:GLOX_BACSU (O31616) (369 aa); Fasta score E(): 6.6e-10, 28.7% identity in 352 aa overlap. Previously sequenced as TR:Q9ZBL4 (EMBL:AL035159) (340 aa); Fasta score E(): 0, 100.0% identity in 340 aa overlap. Contains Pfam match to entry PF01266 DAO, D-amino acid oxidase; Shows weak similarity to ML2011. (340 aa) |
| | thiG | Putative thiamine biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (261 aa) |
| | thiD | Putative phosphomethylpyrimidine kinase; Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. (279 aa) |
| | thiC | Putative thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (547 aa) |
| | purA | Putative adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | glmU | Putative UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (492 aa) |
| | prsA | Putative ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (327 aa) |
| | ML0242 | Putative isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (311 aa) |
| | ML0232 | Conserved hypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. (274 aa) |
| | folE | Similar to M. tuberculosis folE, Rv3609c, GTP cyclohydrolase I, SW:GCH1_MYCTU (O06273) (202 aa); Fasta score E(): 0, 82.0% identity in 205 aa overlap. Similar to many e.g. Bacillus subtilis mtrA, GTP cyclohydrolase I, SW:GCH1_BACSU (P19465) (190 aa); Fasta score E(): 0, 59.5% identity in 190 aa overlap. Previously sequenced as SW:GCH1_MYCLE (O69531) (205 aa); Fasta score E(): 0, 100.0% identity in 205 aa overlap. Contains Pfam match to entry PF01227 GTP_cyclohydroI, GTP cyclohydrolase I. Contains PS00859 GTP cyclohydrolase I signature 1. Contains PS00860 GTP cyclohydrolase I signature 2. (205 aa) |
| | hpt | Putative hypoxanthine phosphoribosyltransferase; Similar to M. tuberculosis hpt, Rv3624c, probable hypoxanthine-guanine phosphoribosyltransferase, SW:HPRT_MYCTU (O06383) (216 aa); Fasta score E(): 0, 83.1% identity in 207 aa overlap. Similar to many e.g. Salmonella typhimurium hprt, hypoxanthine phosphoribosyltransferase, TR:O33799 (EMBL:AF008931) (178 aa); Fasta score E(): 9.6e-32, 50.9% identity in 169 aa overlap. Previously sequenced as TR:O69537 (EMBL:AL023093) (213 aa); Fasta score E(): 0, 99.5% identity in 213 aa overlap. Contains Pfam match to entry PF00156 Pribosyltran, Phospho [...] (213 aa) |
| | ML0201 | Putative membrane protein; Similar to M. tuberculosis Rv3645, probable transmembrane protein, TR:O06362 (EMBL:AL123456) (549 aa); Fasta score E(): 0, 85.3% identity in 530 aa overlap and to several other putative membrane proteins from M. tuberculosis. Shares regions of similarity with adenylate cyclases e.g. Anabaena sp. (strain PCC 7120) cyaA, adenylate cyclase, TR:P94180 (EMBL:D89622) (735 aa); Fasta score E(): 1.5e-16, 33.3% identity in 228 aa overlap. Previously sequenced as TR:O69547 (EMBL:AL023093) (530 aa); Fasta score E(): 0, 99.8% identity in 530 aa overlap. Contains hydropho [...] (530 aa) |
| | moeA | Putative molybdopterin biosynthesis protein; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (424 aa) |
| | purH | Similar to M. tuberculosis Rv0957, purH, putative phosphoribosylaminoimidazolecarboxamide formyltransferase. (527 aa) |
| | purN | Putative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (266 aa) |
| | gcpE | Conserved hypothetical protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (392 aa) |
| | ML1583 | Possible 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (406 aa) |
| | ML1589 | Possible phosphatidate cytidylyltransferase; The C-terminus of this protein is highly similar to many proteins involved with phospholipid biosynthesis e.g. Escherichia coli phosphatidate cytidylyltransferase (EC 2.7.7.41) SW:CDSA_ECOLI (P06466) (249 aa); Fasta score E(): 6.6e-15, 40.6% identity in 160 aa overlap and Mycobacterium tuberculosis Rv2881c SW:CDSA_MYCTU (Q10807) (306 aa); Fasta score E(): 0, 70.3% identity in 313 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF01148 Cytidylyltrans, Phosphatidate cytidylyltransferas [...] (312 aa) |
| | ML1591 | Possible uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (279 aa) |
| | coaD | Probable phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (157 aa) |
| | thiL | Probable thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (325 aa) |
| | gpdA | Highly similar to many glycerol-3-phosphate dehydrogenases (EC 1.1.1.8) including: Escherichia coli SW:GPDA_ECOLI (P37606) (339 aa); Fasta score E(): 0, 39.9% identity in 341 aa overlap and Mycobacterium tuberculosis RV2982C TR:P95113 (EMBL:Z83018) (334 aa); Fasta score E(): 0, 77.9% identity in 349 aa overlap. Contains Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (351 aa) |
| | nrdF | Ribonucleotide reductase small subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). (325 aa) |
| | adk | Probable adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (181 aa) |
| | lytB2 | LytB homolog; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (335 aa) |
| | coaA | Pantothenate kinase; Similar to M. tuberculosis pantothenate kinase coaA Rv1092c SW:COAA_MYCTU (O53440) (312 aa); Fasta score E(): 0, 93.6% identity in 312 aa overlap, and to many others e.g. Escherichia coli pantothenate kinase SW:COAA_ECOLI (P15044) (316 aa); Fasta score E(): 0, 53.1% identity in 311 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (312 aa) |
| | guaB1 | Inosine-5'-monophosphate dehydrogenase; Previously sequenced as TR:O32912 (EMBL:AL008609) fasta scores: E(): 0, 100.0% in 478 aa. Similar to Mycobacterium tuberculosis inosine-5'-monophosphate dehydrogenase rv1843c SW:YI43_MYCTU (Q50591) fasta scores: E(): 0, 86.4% in 478 aa, and to Bacillus subtilis inosine-5'-monophosphate dehydrogenase SW:IMDH_BACSU (P21879) fasta scores: E(): 0, 37.7% in 472 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. Contains Pfam match to entry PF01574 IM [...] (478 aa) |
| | pgsA2 | CDP-diacylglycerol-glycerol-3-phosphate; Similar to Mycobacterium tuberculosis putative CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyl-transferase SW:PGSA_MYCTU (Q50611) fasta scores: E(): 0, 76.6% in 205 aa, and to Escherichia coli CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase SW:PGSA_ECOLI (P06978) fasta scores: E(): 4.5e-11, 30.5% in 177 aa. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00379 CDP-alcohol phosphatidyltransferases signature; Similar to and ML0979; Belongs to the CDP-alcohol phosphati [...] (206 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (206 aa) |
| | purM | Similar to Mycobacterium tuberculosis 5'-phosphoribosyl-5-aminoimidazole synthetase RV0809 TR:O53823 (EMBL:AL022004) fasta scores: E(): 0, 87.1% id in 364 aa, and to Bacillus subtilis phosphoribosylformylglycinamidine cyclo-ligase PURM SW:PUR5_BACSU (P12043) fasta scores: E(): 0, 46.4% id in 334 aa. Contains Pfam match to entry PF00586 AIRS, AIR synthase related protein. (364 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (556 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] (754 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (224 aa) |
| | ML2219A | Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...] (79 aa) |
| | purC | Similar to Mycobacterium tuberculosis phosphoribosylaminoimidazole-succinocarboxamide synthase PURC OR RV0780 OR MTCY369.24 SW:PUR7_MYCTU (Q59566; P77904) fasta scores: E(): 0, 81.5% id in 297 aa, and to Haemophilus influenzae putative phosphoribosylaminoimidazole-succinocarboxamide synthase PURC OR HI1726 SW:PUR7_HAEIN (P43851) fasta scores: E(): 0, 46.0% id in 287 aa, and to Candida maltosa phosphoribosylamidoimidazole-succinocarboxamide synthase ADE1 SW:PUR7_CANMA (P27602) fasta scores: E(): 0, 45.1% id in 288 aa. Contains Pfam match to entry PF01259 SAICAR_synt, SAICAR synthetase. [...] (297 aa) |
| | purB | Adenylosuccinate lyase; Similar to Mycobacterium tuberculosis hypothetical 51.0 kda protein cy369.21b RV0777 OR MTCY369.21B TR:P71832 (EMBL:Z80226) fasta scores: E(): 0, 86.4% id in 472 aa, and to Saccharomyces cerevisiae adenylosuccinate lyase ADE13 OR YLR359W OR L8039.12 SW:PUR8_YEAST (Q05911) fasta scores: E(): 0, 34.5% id in 449 aa. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00163 Fumarate lyases signature. (472 aa) |
| | purD | Phosphoribosylamine-glycine ligase; Similar to Mycobacterium tuberculosis phosphoribosylamine--glycine ligase PurD OR RV0772 OR MTCY369.17 SW:PUR2_MYCTU (P71827) fasta scores: E(): 0, 81.8% id in 418 aa, and to Salmonella typhimurium phosphoribosylamine--glycine ligase PurD SW:PUR2_SALTY (P26977) fasta scores: E(): 0, 43.2% id in 426 aa. Contains Pfam match to entry PF01071 GARS, Phosphoribosylglycinamide synthetase (GARS). Contains PS00184 Phosphoribosylglycinamide synthetase signature. (422 aa) |
| | ML2341 | Possible regulatory protein; The N-terminus of the predicted product of this CDS is similar to many adenylate cyclases e.g. Stigmatella aurantiaca adenylate cyclase 2 CyaB SW:CYAB_STIAU (P40138; O54080) (352 aa) fasta scores: E(): 3.8e-07, 35.9% id in 192 aa. The C-terminus is similar to many proteins of undefined function and to several proposed regulatory proteins e.g. Streptomyces coelicolor putative regulatory protein TR:Q9Z573 (EMBL:AL035569) (194 aa); BlastP Expect 6.1. Contains Pfam match to entry PF00211 guanylate_cyc, Adenylate and Guanylate cyclase catalytic domain. Contains [...] (732 aa) |
| | ML2487 | Probable purine/pyrimidine phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (179 aa) |
| | ML2507 | Probable deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (190 aa) |
| | ML2692 | Similar to Mycobacterium tuberculosis hypothetical protein Rv0046c TR:P71703 (EMBL:Z80775) fasta scores: E(): 0, 91.8% in 366 aa, and to Streptomyces coelicolor hypothetical 39.2 kda protein TR:Q9X8T5 (EMBL:AL049826) fasta scores: E(): 0, 76.4% in 351 aa. The C-terminus is also weakly similar to several myo-inositol-1-phosphate synthases e.g. Candida albicans SW:INO1_CANAL (P42800) fasta scores: E(): 0.22, 24.4% in 242 aa. Contains Pfam match to entry PF01658 Inos-1-P_synth, Myo-inositol-1-phosphate synthase; Identical in sequence to ML0396. (369 aa) |
| | ML1514 | Putative mycobacteriophage protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (254 aa) |
| | ML1463 | Possible NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (680 aa) |
