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ask ask leuD leuD leuC leuC leuB leuB serA serA ilvC ilvC ilvN ilvN ilvB ilvB ML1706 ML1706 ML1727 ML1727 ML1794 ML1794 glyA glyA ilvG ilvG serC serC asd asd ilvD ilvD ML2472 ML2472 proC proC cysM2 cysM2 metB metB leuA leuA gltB gltB gltD gltD pheA pheA serS serS panD panD metZ metZ ilvX ilvX alr alr carA carA carB carB folD folD metA metA cysE cysE cysK cysK ilvE ilvE asnB asnB trpD trpD glnA glnA metE metE dapF dapF ML1058 ML1058 dapE dapE lysA lysA hom hom thrC thrC thrB thrB ilvA ilvA hisA hisA trpE trpE trpC trpC trpB trpB trpA trpA metH metH argC argC argJ argJ argB argB argD argD argF argF argR argR argG argG argH argH proA proA proB proB ML1478 ML1478 dapA dapA folA folA glnA2 glnA2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
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gene neighborhood
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Your Input:
askAspartokinase; Similar to Mycobacterium tuberculosis aspartokinase ask or rv3709c or mtv025.057C SW:AK_MYCTU (P97048; O69676; P97181) (421 aa) fasta scores: E(): 0, 92.6% id in 421 aa, and to Mycobacterium smegmatis aspartokinase asK SW:AK_MYCSM (P41403) (421 aa) fasta scores: E(): 0, 85.3% id in 421 aa. Contains Pfam match to entry PF00696 aakinase, Amino acid kinase family. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains PS00324 Aspartokinase signature. (421 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (485 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity); Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (336 aa)
serAD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
ilvNHighly similar to many acetolactate synthases, small subunit, (EC 4.1.3.18) involved in valine and isoleucine biosynthesis, including: Mycobacterium avium SW:ILVH_MYCAV (Q59499) (167 aa); Fasta score E(): 0, 78.9% identity in 166 aa overlap and Mycobacterium tuberculosis RV3002C SW:ILVH_MYCTU (O53249) (168 aa); Fasta score E(): 0, 83.5% identity in 164 aa overlap. Contains Pfam match to entry PF01842 ACT, ACT domain. (169 aa)
ilvBHighly similar to many acetolactate synthases, large subunit, (EC 4.1.3.18) involved in valine and isoleucine biosynthesis, including: Mycobacterium avium SW:ILVB_MYCAV (Q59498) (621 aa); Fasta score E(): 0, 82.7% identity in 624 aa overlap and Mycobacterium tuberculosis RV3003C SW:ILVB_MYCTU (O53250) (618 aa); Fasta score E(): 0, 87.1% identity in 627 aa overlap. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00187 Thiamine pyrophosphate enzymes signature. (625 aa)
ML1706Conserved hypothetical protein; Highly similar to proteins of undefined function from Streptomyces coelicolor TR:Q9Z586 (EMBL:AL035569) (331 aa); Fasta score E(): 0, 38.6% identity in 337 aa overlap and Mycobacterium tuberculosis RV3015C TR:O53262 (EMBL:AL021287) (337 aa); Fasta score E(): 0, 78.3% identity in 337 aa overlap. (337 aa)
ML1727Similar in the C-terminus to many phosphoserine phosphatases (EC 3.1.3.3) including: Escherichia coli SW:SERB_ECOLI (P06862) (322 aa); Fasta score E(): 1.7e-29, 38.5% identity in 309 aa overlap and Mycobacterium tuberculosis RV3042C TR:O53289 (EMBL:AL021287) (409 aa); Fasta score E(): 0, 86.3% identity in 408 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. (411 aa)
ML1794Aminotransferase; Similar to M. tuberculosis predicted aminotransferase Rv2294 SW:YM94_MYCTU (Q50672) (407 aa); Fasta score E(): 0, 76.5% identity in 404 aa overlap, and to many others e.g. Escherichia coli MalY protein SW:MALY_ECOLI (P23256) (390 aa); Fasta score E(): 5.8e-27, 31.2% identity in 385 aa overlap; Similar to and ML2502; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily. (402 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
ilvGAcetolactate synthase II; Similar to Mycobacterium tuberculosis probable acetolactate synthase SW:ILVG_MYCTU (Q50613) fasta scores: E(): 0, 86.1% in 548 aa, and to Bacillus subtilis acetolactate synthase large subunit SW:ILVB_BACSU (P37251; P94564) fasta scores: E(): 1.2e-32, 28.5% in 543 aa. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00187 Thiamine pyrophosphate enzymes signature; Similar to ML1696, ML2167 and ML0354. (548 aa)
serCPutative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (376 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (351 aa)
ilvDDihydroxy-acid dehydratase; Similar to many Prokaryotic and Eukaryotic dihydroxy-acid dehydratases involved in valine and isoleucine biosynthesis e.g. Mycobacterium tuberculosis RV0189C SW:ILVD_MYCTU (O07433) fasta scores: E(): 0, 90.0% id in 560 aa, Saccharomyces cerevisiae dihydroxy-acid dehydratase, mitochondrial precursor ILV3 OR YJR016C OR J1450 SW:ILV3_YEAST (P39522) fasta scores: E(): 0, 48.5% id in 555 aa. Contains Pfam match to entry PF00920 ILVD_EDD, Dehydratase family. Contains PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. (564 aa)
ML2472Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. (327 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (294 aa)
cysM2Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839. (464 aa)
metBCystathionine [gamma]-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). (388 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (607 aa)
gltBSimilar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. (1527 aa)
gltDSimilar to M. tuberculosis Rv3858c, gltD, putative NADH-dependent glutamate synthase small subunit, TR:P96219 (EMBL:Al123456) (488 aa); Fasta score E(): 0, 87.7% identity in 488 aa overlap and to many other putative glutamate synthase small subunits e.g. Escherichia coli gltD, glutamate synthase [NADPH] small chain, SW:GLTD_ECOLI (P09832) (471 aa); Fasta score E(): 0, 37.8% identity in 474 aa overlap. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. (488 aa)
pheAPutative prephenate dehydratase; Similar to M. tuberculosis Rv3838c, pheA, prephenate dehydratase, TR:P96240 (EMBL:AL123456) (321 aa); Fasta score E(): 0, 83.9% identity in 311 aa overlap. Similar to Amycolatopsis methanolica pheA, prephenate dehydratase, SW:PHEA_AMYME (Q44104) (304 aa); Fasta score E(): 0, 44.4% identity in 315 aa overlap. Contains Pfam match to entry PF01842 ACT, ACT domain. Contains Pfam match to entry PF00800 PDT, Prephenate dehydratase. Contains PS00858 Prephenate dehydratase signature 2. (322 aa)
serSPutative seryl-tRNA synthase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (417 aa)
panDPutative aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (142 aa)
metZPutative o-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (406 aa)
ilvXSimilar to M. tuberculosis ilvX, putative acetohydroxyacid synthase I large subunit, TR:O53554 (EMBL:AL123456) (515 aa); Fasta score E(): 0, 82.9% identity in 515 aa overlap. Similar to Escherichia coli ilvI, acetolactate synthase isozyme III large subunit, SW:ILVI_ECOLI (P00893) (574 aa); Fasta score E(): 1.8e-07, 23.7% identity in 540 aa overlap. Also similar to Pseudomonas putida mdlC, benzoylformate decarboxylase, SW:MDLC_PSEPU (P20906) (528 aa); Fasta score E(): 6.6e-13, 29.3% identity in 529 aa overlap. Previously sequenced as TR:Q49865 (EMBL:U00020) (515 aa); Fasta score E(): 0, [...] (515 aa)
alrPutative alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (388 aa)
carASimilar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] (375 aa)
carBSimilar to M. tuberculosis carB, Rv1384, carbamoyl-phosphate synthase subunit. Similar to many e.g. Escherichia coli carB, carbamoyl-phosphate synthase subunit, SW:CARB_ECOLI (P00968) (1072 aa); Fasta score E(): 0, 51.4% identity in 1116 aa overlap. Contains 2 Pfam matches to entry PF00289 CPSase_L_chain, Carbamoyl-phosphate synthase (CPSase). Contains 2 x PS00867 Carbamoyl-phosphate synthase subdomain signature 2. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00866 Carbamoyl-phosphate synthase subdomain signature 1. (1129 aa)
folDPutative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
metAPutative homoserine o-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (382 aa)
cysESimilar to Mycobacterium tuberculosis putative serine acetyltransferase cysE or Rv2335 or MTCY98.0031C TR:P95231 (EMBL:Z83860) (229 aa) fasta scores: E(): 0, 76.4% id in 229 aa, and to Bacillus subtilis serine acetyltransferase cysE or cysA SW:CYSE_BACSU (Q06750) (217 aa) fasta scores: E(): 0, 47.1% id in 204 aa. Previously sequenced as TR:O32979 (EMBL:Z98741). Contains 4 Pfam matches to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats). Contains PS00101 Hexapeptide-repeat containing-transferases signature. (227 aa)
cysKPutative cysteine synthase; Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide. (310 aa)
ilvEPutative branched-chain-amino-acid transaminase; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (368 aa)
asnBSimilar to Mycobacterium tuberculosis putative asparagine synthetase [glutamine-hydrolyzing] Rv2201 or mtcy190.12 SW:ASNH_MYCTU (Q10374) (652 aa) fasta scores: E(): 0, 83.3% id in 659 aa and to Bacillus subtilis asparagine synthetase [glutamine-hydrolyzing] 1 asnB or asn SW:ASNB_BACSU (P54420; O34902) (632 aa) fasta scores: E(): 0, 49.0% id in 614 aa. Contains Pfam match to entry PF00310 GATase_2, Glutamine amidotransferases class-II. Contains Pfam match to entry PF00733 Asn_synthase, Asparagine synthase. (677 aa)
trpDPutative anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (366 aa)
glnAHighly similar to many glutamine synthetases (EC 6.3.1.2) including examples from: Mycobacterium tuberculosis SW:GLN1_MYCTU (Q10377) (478 aa); Fasta score E(): 0, 91.8% identity in 478 aa overlap and Salmonella typhimurium SW:GLNA_SALTY (P06201) (468 aa); Fasta score E(): 0, 51.5% identity in 474 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase. Contains PS00182 Glutamine synthetase class-I adenylation site. Contains PS00180 Glutamine synthetase signature 1. Contains PS00181 Glutamine synthetase putative ATP-binding region signature; Similar to ML1631. (478 aa)
metE5-methyltetrahydropteroyltriglutamate- homocysteinmethyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation.; Belongs to the vitamin-B12 independent methionine synthase family. (760 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (296 aa)
ML1058Possible tranferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (317 aa)
dapESuccinyl-diaminopimelate desuccinylase; Identical to the previously sequenced Mycobacterium leprae TR:Q49949 (EMBL:U15180) (400 aa); Fasta score E(): 0, 100.0% identity in 354 aa overlap. Also highly similar to succinyl-diaminopimelate desuccinylases from Mycobacterium tuberculosis Rv1202 TR:O05303 (EMBL:Z93777) (354 aa); Fasta score E(): 0, 86.7% identity in 354 aa overlap and Corynebacterium glutamicum SW:DAPE_CORG (Q59284) (369 aa); Fasta score E(): 0, 56.3% identity in 359 aa overlapL. Contains Pfam match to entry PF01546 Peptidase_M20, Peptidase family M20/M25/M40. Contains PS0075 [...] (354 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (472 aa)
homHomoserine dehydrogenase; Identical to the previously sequenced Mycobacterium leprae homoserine dehydrogenase (EC 1.1.1.3) SW:DHOM_MYCLE (P46806) (441 aa); Fasta score E(): 0, 99.8% identity in 441 aa overlap. Also highly similar to orthologues from Mycobacterium tuberculosis SW:DHOM_MYCTU (Q10601) (441 aa); Fasta score E(): 0, 89.5% identity in 438 aa overlap and Corynebacterium glutamicum SW:DHOM_CORGL (P08499) (445 aa); Fasta score E(): 0, 60.3% identity in 431 aa overlap. Contains Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase. Contains Pfam match to entry PF01 [...] (441 aa)
thrCThreonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (360 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (315 aa)
ilvAThreonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). (427 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (245 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (529 aa)
trpCHighly similar to many indole-3-glycerol phosphate synthases (EC 4.1.1.48) involved in tryptophan biosynthesis e.g. Mycobacterium tuberculosis Rv1611 SW:TRPC_MYCTU (O06129) (272 aa); Fasta score E(): 0, 90.8% identity in 272 aa overlap and Streptomyces coelicolor SW:TRC1_STRCO (O68814) (269 aa); Fasta score E(): 0, 64.1% identity in 262 aa overlap. Contains Pfam match to entry PF00218 IGPS, Indole-3-glycerol phosphate synthases. Contains PS00614 Indole-3-glycerol phosphate synthase signature. (272 aa)
trpBTryptophan synthase [beta] chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (417 aa)
trpATryptophan synthase [alpha] chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa)
metH5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1206 aa)
argCN-acetyl-[gamma]-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa)
argJGlutamate N-acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (407 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa)
argDHighly similar to many acetylornithine aminotransferases (EC 2.6.1.11) involved in arginine biosynthesis, including: Escherichia coli SW:ARGD_ECOLI (P18335) (405 aa); Fasta score E(): 0, 38.7% identity in 390 aa overlap and Mycobacterium tuberculosis RV1655 SW:ARGD_MYCTU (P94990) (400 aa); Fasta score E(): 0, 82.9% identity in 397 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. (404 aa)
argFOrnithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (320 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (167 aa)
argGArginosuccinate synthase; Highly similar to many argininosuccinate synthases (EC 6.3.4.5) involved in arginine biosynthesis, including: Streptomyces clavuligerus SW:ASSY_STRCL (P50986) (397 aa); Fasta score E(): 0, 67.0% identity in 397 aa overlap and Mycobacterium tuberculosis SW:ASSY_MYCTU (P94993) (398 aa); Fasta score E(): 0, 91.0% identity in 398 aa overlap. Contains Pfam match to entry PF00764 Arginosuc_synth, Arginosuccinate synthase. Contains PS00564 Argininosuccinate synthase signature 1. Contains PS00565 Argininosuccinate synthase signature 2. (399 aa)
argHArginosuccinate lyase; Highly similar to many argininosuccinate lyases (EC 4.3.2.1) involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa); BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa); Fasta score E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature. (470 aa)
proA[gamma]-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (409 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (367 aa)
ML1478Highly similar to many transferases e.g. Escherichia coli homocysteine S-methyltransferase (EC 2.1.1.10) involved in methionine biosynthesis SW:MMUM_ECOLI (Q47690) (310 aa); Fasta score E(): 0, 49.8% identity in 293 aa overlap and Mycobacterium tuberculosis putative transferase RV2458 TR:O53185. (293 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (300 aa)
folADihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). (165 aa)
glnA2Glutamine synthase class II; Highly similar to many glutamine synthetases (EC 6.3.1.2) including: Bacillus subtilis SW:GLNA_BACSU (P12425) (443 aa); Fasta score E(): 0, 45.4% identity in 445 aa overlap and Mycobacterium tuberculosis RV2222C SW:GLN2_MYCTU (Q10378) (446 aa); Fasta score E(): 0, 93.3% identity in 448 aa overlap. Contains Pfam match to entry PF00120 gln-synt, Glutamine synthetase; Similar to ML0925. (448 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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