17 items (Mycobacterium leprae) - STRING interaction network

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Your Input:
	ML0180	Similar to M.tuberculosis Rv0991c, hypothetical protein with Ser-rich C-terminus, TR:O05574 (EMBL:AL123456) (110 aa); Fasta score E(): 1.1e-23, 78.5% identity in 93 aa overlap. Similar to other bacterial Ser-rich hypothetical proteins e.g. Streptomyces coelicolor SCE22.04, hypothetical protein, TR:CAB90971 (EMBL:AL355832) (110 aa); Fasta score E(): 2.6e-15, 54.5% identity in 99 aa overlap. Previously sequenced as TR:Q9Z5G3 (EMBL:AL035500) (120 aa); Fasta score E(): 1.1e-32, 100.0% identity in 99 aa overlap. (99 aa)
	ML0542	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (110 aa)
	dgt	Similar to Mycobacterium tuberculosis deoxyguanosinetriphosphate triphosphohydrolase dgt or Rv2344c or MTCY98.13c SW:DGTP_MYCTU (P95240) (431 aa) fasta scores: E(): 0, 83.8% id in 421 aa and to many hypothetical deoxyguanosine hydrolases. Contains Pfam match to entry PF01966 HD, HD domain; Belongs to the dGTPase family. Type 2 subfamily. (429 aa)
	dnaG	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (642 aa)
	sigE	ECF subfamily sigma subunit; Highly similar to many proposed ECF-family RNA-polymerase sigma factors including: Mycobacterium tuberculosis SigE TR:O06289 (EMBL:U87242) (257 aa); Fasta score E(): 0, 82.1% identity in 252 aa overlap, Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa); Fasta score E(): 0, 80.6% identity in 247 aa overlap and Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa); Fasta score E(): 2.9e-16, 35.7% identity in 171 aa overlap. Contains a probable helix-turn-helix motif at aa 213-234 (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 Sigma70_ECF, Sig [...] (263 aa)
	dnaE	DNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. (1177 aa)
	ML1448	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature. (184 aa)
	rpmA	Highly similar to many 50s ribosomal proteins (L27) including: Escherichia coli SW:RL27_ECOLI (P02427) (84 aa); Fasta score E(): 5.8e-16, 63.9% identity in 83 aa overlap and Mycobacterium tuberculosis RV2441C SW:RL27_MYCTU (Z8145) (86 aa); Fasta score E(): 3.3e-28, 93.8% identity in 81 aa overlap. Contains Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein. Contains PS00831 Ribosomal protein L27 signature; Belongs to the bacterial ribosomal protein bL27 family. (88 aa)
	ML1512	Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (558 aa)
	rpoC	[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1316 aa)
	rpoB	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1178 aa)
	ML1927	Similar to M. tuberculosis hypothetical protein Rv0430 TR:P96276 (EMBL:Z84724) (102 aa); Fasta score E(): 0, 93.1% identity in 102 aa overlap, and to Streptomyces coelicolor hypothetical protein SCD95A.20 TR:CAB93047 (EMBL:AL357432) (84 aa); Fasta score E(): 4.1e-11, 52.8% identity in 72 aa overlap. (102 aa)
	rpoA	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (347 aa)
	ML2307	Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (81 aa)
	ML2452	Hypothetical protein; Weakly similar in parts to Mycobacterium tuberculosis hypothetical protein Rv0477 SW:Y477_MYCTU (Q11144) fasta scores: E(): 1.8e-23, 57.3% id in 110 aa; To M.tuberculosis Rv0477. (123 aa)
	ML2476	Similar in parts to several proteins of undefined function e.g. Streptomyces coelicolor hypothetical protein TR:Q9X8J2 (EMBL:AL049841) fasta scores: E(): 5.6e-10, 53.1% id in 64 aa. (55 aa)
	ML2621	Hypothetical protein; Some similarity in regions to Mycobacterium tuberculosis hypothetical protein RV0207C TR:P96389 (EMBL:Z92669) fasta scores: E(): 0, 60.8% id in 199 aa, and to Schizosaccharomyces pombe hypothetical protein TR:O74960 (EMBL:AL023705) fasta scores: E(): 1, 22.2% id in 248 aa. (195 aa)

Your Current Organism:

Mycobacterium leprae

NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ML0542	ML1448	gene:17574363	gene:17575286	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature.	0.527
ML0542	ML2307	gene:17574363	gene:17576167	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.	0.646
ML0542	rpmA	gene:17574363	gene:17575304	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	Highly similar to many 50s ribosomal proteins (L27) including: Escherichia coli SW:RL27_ECOLI (P02427) (84 aa); Fasta score E(): 5.8e-16, 63.9% identity in 83 aa overlap and Mycobacterium tuberculosis RV2441C SW:RL27_MYCTU (Z8145) (86 aa); Fasta score E(): 3.3e-28, 93.8% identity in 81 aa overlap. Contains Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein. Contains PS00831 Ribosomal protein L27 signature; Belongs to the bacterial ribosomal protein bL27 family.	0.709
ML0542	rpoA	gene:17574363	gene:17575809	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML0542	rpoB	gene:17574363	gene:17575739	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML0542	rpoC	gene:17574363	gene:17575738	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
ML0542	sigE	gene:17574363	gene:17574902	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	ECF subfamily sigma subunit; Highly similar to many proposed ECF-family RNA-polymerase sigma factors including: Mycobacterium tuberculosis SigE TR:O06289 (EMBL:U87242) (257 aa); Fasta score E(): 0, 82.1% identity in 252 aa overlap, Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa); Fasta score E(): 0, 80.6% identity in 247 aa overlap and Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa); Fasta score E(): 2.9e-16, 35.7% identity in 171 aa overlap. Contains a probable helix-turn-helix motif at aa 213-234 (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 Sigma70_ECF, Sig [...]	0.527
ML1448	ML0542	gene:17575286	gene:17574363	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature.	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	0.527
ML1448	rpoA	gene:17575286	gene:17575809	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature.	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.527
ML1448	rpoB	gene:17575286	gene:17575739	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature.	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.566
ML1448	rpoC	gene:17575286	gene:17575738	Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature.	[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.576
ML2307	ML0542	gene:17576167	gene:17574363	Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.	Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).	0.646
ML2307	rpoA	gene:17576167	gene:17575809	Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.527
ML2307	rpoB	gene:17576167	gene:17575739	Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.566
ML2307	rpoC	gene:17576167	gene:17575738	Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.	[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.576
dgt	dnaG	gene:17574656	gene:17574658	Similar to Mycobacterium tuberculosis deoxyguanosinetriphosphate triphosphohydrolase dgt or Rv2344c or MTCY98.13c SW:DGTP_MYCTU (P95240) (431 aa) fasta scores: E(): 0, 83.8% id in 421 aa and to many hypothetical deoxyguanosine hydrolases. Contains Pfam match to entry PF01966 HD, HD domain; Belongs to the dGTPase family. Type 2 subfamily.	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	0.858
dnaE	dnaG	gene:17575038	gene:17574658	DNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.	DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.	0.656
dnaE	rpoA	gene:17575038	gene:17575809	DNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.	[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.426
dnaE	rpoB	gene:17575038	gene:17575739	DNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.	[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.790
dnaE	rpoC	gene:17575038	gene:17575738	DNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily.	[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.565