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leuA leuA ML2158 ML2158 hemZ hemZ ML0190 ML0190 ML0129 ML0129 ML2276 ML2276 bioB bioB argC argC argB argB xclC xclC folC folC ML1644 ML1644 ML1689 ML1689 ML1708 ML1708 eftA eftA mutB mutB ML2401 ML2401 mutA mutA fadE25 fadE25 fadE24 fadE24 ML0587 ML0587 ML0314 ML0314 folK folK
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (607 aa)
ML2158Hypothetical protein; No database matches. (130 aa)
hemZFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (336 aa)
ML0190Conserved hypothetical protein; Unknown but orthologue of equivalent to new M. tuberculosis CDS, Rv1000. Very similar to conserved hypothetical proteins in various bacteria e.g. Streptomyces coelicolor, Xylella fastidiosa. FASTA scores: gp|AL357613|AL357613_12 Streptomyces coelicolor cosmid (210 aa) E(): 2.4e-44; 55.122% identity in 205 aa overlap; AE003963|AE003963_5 Xylella fastidiosa, E(): 9.7e-14; 3 9.894% identity in 188 aa overlap. Weak similarity to proteins involved in DNA repair. (205 aa)
ML0129Conserved hypothetical protein; Involved in the reduction of the double bond between C-4 and C-5 during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis. (418 aa)
ML2276Putative FAD-linked oxidoreductase; Similar to Mycobacterium tuberculosis hypothetical protein Rv0561c or MTCY25D10.40C TR:O06427 (EMBL:Z95558) (408 aa) fasta scores: E(): 0, 84.5% id in 406 aa. Shows weak similarity to many oxidoreductases e.g. Escherichia coli FixC protein fixC SW:FIXC_ECOLI (P31575; P75626) (428 aa) fasta scores: E(): 1.7e-05, 25.4% id in 417 aa. Contains Pfam match to entry PF01494 FAD_binding_3, FAD binding domain. (408 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (345 aa)
argCN-acetyl-[gamma]-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa)
xclCacyl-CoA synthase; Identical to the previously sequenced Mycobacterium leprae XclC TR:Q50017 (EMBL:U15181) (476 aa); Fasta score E(): 0, 99.8% identity in 476 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis acyl-CoA synthase Rv1193 fadD36 TR:O05295 (EMBL:Z93777) (473 aa); Fasta score E(): 0, 81.3% identity in 476 aa overlap and Escherichia coli long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) SW:LCFA_ECOLI (P29212) (561 aa); Fasta score E(): 1.3e-28, 31.7% identity in 378 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme [...] (476 aa)
folCHighly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2. (485 aa)
ML1644Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2235 SW:YM35_MYCTU (Q10517) (271 aa); Fasta score E(): 0, 74.2% identity in 271 aa overlap. Contains a possible N-terminal signal sequence and another possible membrane spanning hydrophobic domain. (270 aa)
ML1689Possible hydrolase; Similar in parts to several putative 2-hydroxyhepta-2,4-diene-1,7-dioate isomerases including: Methanobacterium thermoautotrophicum TR:O27551 (EMBL:AE000911) (260 aa); Fasta score E(): 0, 51.9% identity in 216 aa overlap and Mycobacterium tuberculosis RV2993C TR:O53242 (EMBL:AL021287) (239 aa); Fasta score E(): 0, 85.9% identity in 241 aa overlap. Contains Pfam match to entry PF01557 FAA_hydrolase, Fumarylacetoacetate (FAA) hydrolase family. (242 aa)
ML1708Highly similar to many aminotransferases resembling NifS, a protein of unknown function located within many nitrogen fixation gene clusters e.g. Azotobacter vinelandii SW:NIFS_AZOVI (P05341) (402 aa); Fasta score E(): 0, 39.1% identity in 394 aa overlap. Also highly similar to Mycobacterium tuberculosis NifS-like protein RV3025C TR:O53272 (EMBL:AL021287) (393 aa); Fasta score E(): 0, 84.9% identity in 391 aa overlap. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V; Similar to ML0596. (410 aa)
eftAElectron transfer flavoprotein [alpha] subunit; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). (318 aa)
mutBmethylmalonyl-CoA mutase, [alpha] subunit; Similar to M. tuberculosis mutB SW:MUTB_MYCTU (P71774) (750 aa); Fasta score E(): 0, 88.9% identity in 748 aa overlap, and many other methylmalonyl-CoA mutase alpha-subunit e.g. Streptomyces cinnamonensis SW:MUTB_STRCM (Q05065) (733 aa); Fasta score E(): 0, 74.7% identity in 726 aa overlap. Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. Contains PS00544 Methylmalonyl-CoA mutase signature; Similar to and ML1800. (758 aa)
ML2401Similar to several putative Prokaryotic and Eukaryotic enoyl-CoA hydratases including: Mycobacterium tuberculosis Rv1071c TR:O53419 (EMBL:AL021897) (345 aa) fasta scores: E(): 0, 77.7% id in 345 aa and Arabidopsis thaliana putative 3-hydroxyisobutyryl-coenzyme A hydrolase TR:O49330 (EMBL:AC002340) (410 aa) fasta scores: E(): 0, 35.1% id in 345 aa. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. (345 aa)
mutAmethylmalonyl-CoA mutase, [beta] subunit; Similar to M. tuberculosis mutA SW:MUTA_MYCTU (P71773) (615 aa); Fasta score E(): 0, 75.3% identity in 636 aa overlap, and many other methylmalonyl-CoA mutase beta-subunit e.g. Streptomyces cinnamonensis SW:SW:MUTA_STRCM (Q05064) (616 aa); Fasta score E(): 0, 42.7% identity in 626 aa overlap. Contains Pfam match to entry PF01642 MM_CoA_mutase, Methylmalonyl-CoA mutase. Contains PS00544 Methylmalonyl-CoA mutase signature; Similar to and ML1799. (636 aa)
fadE25Putative acyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis RV3274C OR MTCY71.14C, putative acyl-CoA dehydrogenase, TR:P96879 (EMBL:Z92771) fasta scores: E(): 0, 92.0% id in 389 aa, and to Streptomyces lividans fatty acid acyl-CoA dehydrogenase fadE TR:Q9RIQ5 (EMBL:AJ250495) fasta scores: E(): 0, 67.6% id in 383 aa. Previously sequenced as SW:ACD_MYCLE (P46703). Contains Pfam match to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehydrogenases signature 2. Contains PS00072 Acyl-CoA dehydrogenases signature 1; Similar to ML0660, ML0661 and show [...] (389 aa)
fadE24Putative acyl-CoA dehydrogenase; Similar to M. tuberculosis fadE24, Rv3139, acyl-CoA dehydrogenase, TR:P95187 (EMBL:AL123456) (468 aa); Fasta score E(): 0, 83.6% identity in 464 aa overlap. Similar to many e.g. Streptomyces lividans fadE, fatty acid acyl-CoA dehydrogenase, TR:Q9RIQ5 (EMBL:AJ250495) (385 aa); Fasta score E(): 5.1e-27, 28.5% identity in 376 aa overlap. Previously sequenced as TR:O32890 (EMBL:Z98271) (465 aa); Fasta score E(): 0, 100.0% identity in 465 aa overlap. Contains 2 Pfam matches to entry PF00441 Acyl-CoA_dh, Acyl-CoA dehydrogenase. Contains PS00073 Acyl-CoA dehyd [...] (465 aa)
ML0587Putative membrane protein; Similar to M. tuberculosis Rv1456c, putative membrane protein, TR:O53148 (EMBL:AL123456) (310 aa); Fasta score E(): 0, 83.3% identity in 300 aa overlap. Similar to bacterial hypothetical proteins e.g. Mycobacterium smegmatis fxtF, hypothetical protein, TR:O87318 (EMBL:AF027770) (236 aa); Fasta score E(): 0, 67.5% identity in 228 aa overlap. Previously sequenced as TR:O33142 (EMBL:Z99125) (311 aa); Fasta score E(): 0, 99.7% identity in 311 aa overlap. Contains hydrophobic, possible membrane-spanning regions. (311 aa)
ML0314Putative esterase; Similar to M. tuberculosis lipU, Rv1076, probable esterase, TR:O53424 (EMBL:AL123456) (297 aa); Fasta score E(): 0, 79.7% identity in 296 aa overlap. Also similar to other putative esterases from M. tuberculosis. Similar to esterases e.g. Streptomyces hygroscopicus bah, acetyl-hydrolase, SW:BAH_STRHY (Q01109) (299 aa); Fasta score E(): 6.6e-19, 36.2% identity in 246 aa overlap. Previuosly sequenced as TR:Q9ZBM4 (EMBL:AL035159) (335 aa); Fasta score E(): 0, 99.7% identity in 335 aa overlap. Contains PS01174 Lipolytic enzymes 'G-D-X-G' family, putative serine active site. (335 aa)
folKSimilar to M. tuberculosis folK, Rv3607c, probable 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase, SW:HPPK_MYCTU (O06276) (188 aa); Fasta score E(): 0, 63.2% identity in 190 aa overlap. Similar to others e.g. to the C-terminal half of Streptococcus pneumoniae sulD, bifunctional folate synthesis protein (includes: dihydroneopterin aldolase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase), SW:SULD_STRPN (P22291) (270 aa); Fasta score E(): 1.8e-07, 37.8% identity in 135 aa overlap. Previously sequenced as SW:HPPK_MYCLE (O69528) (191 aa); Fasta sc [...] (191 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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