STRINGSTRING
sdhB sdhB sdhC sdhC glpD glpD bccA bccA ML0730 ML0730 accD5 accD5 birA birA rmlA2 rmlA2 ML0764 ML0764 rnpA rnpA dnaB dnaB ML2654 ML2654 pntB pntB ML2627 ML2627 ML2622 ML2622 ML2621 ML2621 ML2604 ML2604 yrbE1B yrbE1B yrbE1A yrbE1A ML2566 ML2566 ML2507 ML2507 ML2491 ML2491 ML2476 ML2476 ML2452 ML2452 gpm gpm ML2425 ML2425 lpd lpd ML2357 ML2357 ML2356 ML2356 ML2355 ML2355 ML2354 ML2354 ML2353 ML2353 ML2341 ML2341 dnaZX dnaZX ML2307 ML2307 ML2306 ML2306 ML2305 ML2305 ML2302 ML2302 ML2283 ML2283 cpsY cpsY ML2177 ML2177 fadB fadB ML2156 ML2156 ML2135 ML2135 fprB fprB ilvG ilvG secA2 secA2 gcvH gcvH gcvB gcvB guaB1 guaB1 rpoA rpoA fum fum xseB xseB xseA xseA ML1927 ML1927 ML1910 ML1910 ML1909 ML1909 ML1908 ML1908 rplA rplA ML1892 ML1892 rpoB rpoB rpoC rpoC rpsG rpsG rplC rplC rplB rplB rpsC rpsC rpsQ rpsQ rplN rplN rplE rplE rpsE rpsE rpmD rpmD rplO rplO secY secY trxB trxB inhA inhA uspE uspE uspA uspA ML1763 ML1763 nrdE nrdE nrdF nrdF ML1726 ML1726 ML1708 ML1708 gatA gatA pfkA pfkA gatB gatB ilvB ilvB ilvN ilvN leuC leuC leuD leuD ML1683 ML1683 ML1681 ML1681 gpdA gpdA recG recG ML1657 ML1657 fabD fabD aceE aceE ffh ffh rnhB rnhB ML1602 ML1602 rpsB rpsB ML1596 ML1596 ML1583 ML1583 ML1548 ML1548 ML1547 ML1547 ML1536 ML1536 ML1525 ML1525 ML1512 ML1512 ML1498 ML1498 ML1492 ML1492 fdxA fdxA clpP clpP clpP2 clpP2 clpX clpX ML1468 ML1468 rpmA rpmA ML1448 ML1448 ML1427 ML1427 ML1426 ML1426 ML1425 ML1425 ML1424 ML1424 ML1420 ML1420 argH argH argR argR pheT pheT uvrA uvrA ML1390 ML1390 uvrB uvrB rpsA rpsA ML1362 ML1362 ML1346 ML1346 ML1332 ML1332 ML1331 ML1331 ML1330 ML1330 ML1329 ML1329 ML1328 ML1328 prcA prcA prcB prcB ML1321 ML1321 ML1320 ML1320 ML1316 ML1316 ML1313 ML1313 ML1312 ML1312 metH metH ML1306 ML1306 ML1300 ML1300 trpE trpE ML1254 ML1254 papA3 papA3 pks3 pks3 dnaE dnaE fas fas rphA rphA atpC atpC atpD atpD atpG atpG atpA atpA atpH atpH atpF atpF atpE atpE atpB atpB ML1119 ML1119 odhA odhA ML1093 ML1093 ML1089 ML1089 ML1088 ML1088 ML1087 ML1087 ML1086 ML1086 ML1079 ML1079 sigE sigE glgC glgC ML1037 ML1037 ML1009 ML1009 lexA lexA ML0897 ML0897 ML0890 ML0890 ML0861 ML0861 ML0848 ML0848 ML0834 ML0834 dnaG dnaG dgt dgt ML0825 ML0825 furB furB secA secA ML0778 ML0778 dnaN dnaN gyrA gyrA pabA pabA gltD gltD menG menG pks13 pks13 accD4 accD4 ML0112 ML0112 ML0115 ML0115 ML0116 ML0116 ML0135 ML0135 mas mas uvrD uvrD sucC sucC sucD sucD rpmF rpmF ML0180 ML0180 ML0187 ML0187 ML0192 ML0192 topA topA ML0202 ML0202 folK folK pabB pabB prsA prsA mfd mfd eno eno thiG thiG ML0298 ML0298 ML0336 ML0336 ilvX ilvX rpsI rpsI ML0378 ML0378 guaB2 guaB2 guaB3 guaB3 ML0393 ML0393 ML0450 ML0450 ML0474 ML0474 ruvC ruvC ruvA ruvA ruvB ruvB nusB nusB pyrB pyrB carA carA ML0542 ML0542 dfp dfp priA priA ribH ribH uvrC uvrC ML0563 ML0563 ML0593 ML0593 ML0597 ML0597 ML0603 ML0603 rpsT rpsT uvrD2 uvrD2 fprA fprA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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sdhBSimilar to M. tuberculosis sdhB, Rv3319, succinate dehydrogenase subunit B, TR:O53371 (EMBL:AL123456) (263 aa); Fasta score E(): 0, 89.8% identity in 264 aa overlap. Similar to many e.g. Escherichia coli sdhB, succinate dehydrogenase iron-sulfur protein, SW:DHSB_ECOLI (P07014) (238 aa); Fasta score E(): 0, 42.9% identity in 240 aa overlap. Previously sequenced as TR:Q49916 (EMBL:U00022) (264 aa); Fasta score E(): 0, 100.0% identity in 264 aa overlap. Contains Pfam match to entry PF00111 fer2, 2Fe-2S iron-sulfur cluster binding domains. Contains PS00198 4Fe-4S ferredoxins, iron-sulfur b [...] (264 aa)
sdhCSimilar to M. tuberculosis sdhC, Rv3316, putative membrane anchor of succinate dehydrogenase, TR:O53368 (EMBL:AL123456) (112 aa); Fasta score E(): 0, 88.4% identity in 112 aa overlap. Similar to many e.g. Escherichia coli sdhC, succinate dehydrogenase cytochrome B-556, SW:DHSC_ECOLI (P10446) (129 aa); Fasta score E(): 0.074, 24.3% identity in 136 aa overlap. Previously sequenced as TR:Q49919 (EMBL:U00022) (244 aa); Fasta score E(): 0, 100.0% identity in 153 aa overlap. Contains Pfam match to entry PF01127 Sdh_cyt, Succinate dehydrogenase cytochrome b subunit. (153 aa)
glpDSimilar to M. tuberculosis glpD2, Rv3302c, glycerol-3-phosphate dehydrogenase, TR:O07168 (EMBL:AL123456) (585 aa); Fasta score E(): 0, 90.8% identity in 584 aa overlap. Similar to many e.g. Escherichia coli, glpD, glycerol-3-phosphate dehydrogenase, SW:GLPD_ECOLI (P13035) (501 aa); Fasta score E(): 0, 35.2% identity in 492 aa overlap. Also similar to Brucella abortus eriB, erythritol phosphate dehydrogenase, TR:Q9ZB31 (EMBL:U57100) (502 aa); Fasta score E(): 0, 35.4% identity in 483 aa overlap. Previously sequenced as SW:GLPD_MYCLE (P53435) (585 aa); Fasta score E(): 0, 99.8% identity [...] (585 aa)
bccAAcetyl/propionyl CoA carboxylase [alpha] subunit; This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase. (598 aa)
ML0730ML0730 protein; Similar to Mycobacterium tuberculosis hypothetical 19.0 kda protein RV3281 OR MTCY71.21 TR:P96886 (EMBL:Z92771) fasta scores: E(): 2.4e-22, 69.0% id in 87 aa. Previously sequenced as TR:Q49671 (EMBL:U00012). Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. (84 aa)
accD5Acetyl/propionyl CoA carboxylase [beta] subunit; Similar to Mycobacterium tuberculosis pccb PCCB OR RV3280 OR MTCY71.20 TR:P96885 (EMBL:Z92771) fasta scores: E(): 0, 88.7% id in 549 aa, and to Saccharopolyspora erythraea propionyl-CoA carboxylase beta chain PCCB SW:PCCB_SACER (P53003) fasta scores: E(): 0, 69.1% id in 530 aa. Previously sequenced as SW:PCCB_MYCLE (P53002). Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain; Similar to ML0102 and ML1657. (549 aa)
birABiotin apo-protein ligase; Similar to Mycobacterium tuberculosis birA OR RV3279C OR MTCY71.19C TR:P96884 (EMBL:Z92771) fasta scores: E(): 0, 71.2% id in 271 aa, and to Escherichia coli birA bifunctional protein [includes: biotin operon repressor; biotin--[acetyl-coa-carboxylase] synthetase birA OR bioR OR dhbB SW:BIRA_ECOLI (P06709) fasta scores: E(): 2e-10, 31.3% id in 256 aa. Lacks the N-terminal helix-turn-helix domain, so may not act as a repressor. Contains Pfam match to entry PF01317 BPL, Biotin protein ligase. (274 aa)
rmlA2Putative sugar-phosphate nucleotidyl transferase; Similar to Mycobacterium tuberculosis hypothetical protein RV3264C OR MTCY71.04C TR:P96869 (EMBL:Z92771) fasta scores: E(): 0, 86.9% id in 359 aa. Similar to Saccharomyces cerevisiae mpg1, mannose-1-phosphate guanyltransferase SW:MPG1_YEAST (P41940) blastp score: 141.5 bits, 29% identity in 349 aa. Contains Pfam match to entry PF00483 NTP_transferase, Nucleotidyl transferase. Contains 3 Pfam matches to entry PF00132 hexapep, Bacterial transferase hexapeptide (four repeats); ML2503. (358 aa)
ML0764Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 35.3 kDa protein RV3256C OR MTV015.01C-MTCY20B11.31C TR:O05899 (EMBL:Z95121) fasta scores: E(): 0, 75.3% id in 365 aa. (365 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (120 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. (604 aa)
ML2654Conserved hypotehical protein; Similar to many proteins of undefined function e.g. Streptomyces coelicolor hypothetical 18.3 kda protein TR:Q9RJE5 (EMBL:AL133171) fasta scores: E(): 0, 60.1% in 163 aa. Contains Pfam match to entry PF01143 UPF0025, Uncharacterized protein family UPF0025. (165 aa)
pntBPyridine transhydrogenase subunit [beta]; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (472 aa)
ML2627Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 35.8 kda protein RV0216 OR MTCY08D5.11 TR:P96398 (EMBL:Z92669) fasta scores: E(): 0, 74.0% id in 338 aa. (339 aa)
ML2622Conserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (230 aa)
ML2621Hypothetical protein; Some similarity in regions to Mycobacterium tuberculosis hypothetical protein RV0207C TR:P96389 (EMBL:Z92669) fasta scores: E(): 0, 60.8% id in 199 aa, and to Schizosaccharomyces pombe hypothetical protein TR:O74960 (EMBL:AL023705) fasta scores: E(): 1, 22.2% id in 248 aa. (195 aa)
ML2604Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 26.8 kda protein RV0184 TR:O07428 (EMBL:Z97050) fasta scores: E(): 0, 81.9% id in 249 aa. (249 aa)
yrbE1BConserved membrane protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0168 TR:O07413 (EMBL:Z97050) fasta scores: E(): 0, 85.1% id in 289 aa. Orthologue of M. tuberculosis YrbE1B (Rv0168). Contains possible membrane spanning hydrophobic domains. (289 aa)
yrbE1AConserved membrane protein; Highly similar to several Mycobacterium tuberculosis hypothetical proteins found within the four Mce loci, associated with virulence, e.g. RV0167 TR:O07412 (EMBL:Z97050) fasta scores: E(): 0, 88.5% id in 262 aa. Orthologue of M. tuberculosis YrbE1A (Rv0167). Contains possible membrane spanning hydrophobic domains. (267 aa)
ML2566Similar to Mycobacterium tuberculosis hypothetical protein RV0241C TR:O53664 (EMBL:AL021929) fasta scores: E(): 0, 81.8% id in 280 aa, and to Streptomyces coelicolor putative dehydratase TR:CAB77291 (EMBL:AL160312) fasta scores: E(): 2.1e-27, 39.5% id in 271 aa. Contains Pfam match to entry PF01575 MaoC_dehydratas, MaoC like domain. Contains PS00211 ABC transporters family signature. (300 aa)
ML2507Probable deoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (190 aa)
ML2491Hypothetical protein; Similar to the C-terminus of Mycobacterium tuberculosis hypothetical protein RV1754C TR:O06790 (EMBL:Z95890) (563 aa) fasta scores: E(): 0, 71.1% id in 336 aa, and to Mycobacterium smegmatis hypothetical 35.9 kda protein in asd 3'region SW:YASD_MYCSM (P41402) fasta scores: E(): 0.0048, 25.0% id in 348 aa. (333 aa)
ML2476Similar in parts to several proteins of undefined function e.g. Streptomyces coelicolor hypothetical protein TR:Q9X8J2 (EMBL:AL049841) fasta scores: E(): 5.6e-10, 53.1% id in 64 aa. (55 aa)
ML2452Hypothetical protein; Weakly similar in parts to Mycobacterium tuberculosis hypothetical protein Rv0477 SW:Y477_MYCTU (Q11144) fasta scores: E(): 1.8e-23, 57.3% id in 110 aa; To M.tuberculosis Rv0477. (123 aa)
gpmPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (247 aa)
ML2425Similar to Mycobacterium tuberculosis hypothetical protein Rv0504c SW:Y504_MYCTU (Q11168) (166 aa) fasta scores: E(): 0, 83.1% id in 166 aa; Similar to ML1908 and ML1910; Belongs to the UPF0336 family. (166 aa)
lpdDihydrolipoamide dehydrogenase; Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes. Catalyzes the reoxidation of dihydrolipoyl groups which are covalently attached to the lipoate acyltransferase components (E2) of the complexes (By similarity); Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (467 aa)
ML2357Polyketide synthase; Highly similar to many Prokaryotic and Eukaryotic polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthase rv2931 SW:PPSA_MYCTU (Q10977) (1876 aa) fasta scores: E(): 0, 76.1% id in 1888 aa and to Penicillium patulum 6-methylsalicylic acid synthase SW:MSAS_PENPA (P22367) (1774 aa) fasta scores: E(): 0, 33.8% id in 1823 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantethe [...] (1871 aa)
ML2356Similar to many polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthesis polyketide synthase Rv2932 SW:PPSB_MYCTU (Q10978; O53234) (1538 aa) fasta scores: E(): 0, 76.3% id in 1561 aa and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 42.2% id in 879 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Be [...] (1540 aa)
ML2355Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...] (2201 aa)
ML2354Similar to many polyketide synthases e.g.Mycobacterium tuberculosis Rv2934 TR:P96203 (EMBL:Z83857) (1827 aa) fasta scores: E(): 0, 80.3% id in 1836 aa, and to Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 32.7% id in 2136 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00017 ATP/G [...] (1822 aa)
ML2353Similar to many polyketide synthases e.g. Mycobacterium tuberculosis Rv2935 TR:P96204 (EMBL:Z83857) (1488 aa) fasta scores: E(): 0, 82.0% id in 1493 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Beta-ketoacyl synthases active site; Similar to ML2355, ML0139, ML0135, ML2354, ML2356, ML2357, ML1229 and ML0101. (1489 aa)
ML2341Possible regulatory protein; The N-terminus of the predicted product of this CDS is similar to many adenylate cyclases e.g. Stigmatella aurantiaca adenylate cyclase 2 CyaB SW:CYAB_STIAU (P40138; O54080) (352 aa) fasta scores: E(): 3.8e-07, 35.9% id in 192 aa. The C-terminus is similar to many proteins of undefined function and to several proposed regulatory proteins e.g. Streptomyces coelicolor putative regulatory protein TR:Q9Z573 (EMBL:AL035569) (194 aa); BlastP Expect 6.1. Contains Pfam match to entry PF00211 guanylate_cyc, Adenylate and Guanylate cyclase catalytic domain. Contains [...] (732 aa)
dnaZXDNA polymerase III, subunit [gamma/tau]; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (611 aa)
ML2307Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (81 aa)
ML2306Probable anion transporter protein; Similar to Mycobacterium tuberculosis putative anion transporting ATPase Rv3680 TR:O69648 (EMBL:AL022121) (386 aa) fasta scores: E(): 0, 88.1% id in 370 aa, and to Streptomyces coelicolor putative ion-transporting ATPase TR:Q9XA35 (EMBL:AL079353) (481 aa) fasta scores: E(): 0, 48.6% id in 432 aa. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (381 aa)
ML2305Probable anion transporter protein; Similar to Mycobacterium tuberculosis putative ATPase Rv3679 SW:Y0H9_MYCTU (O69647) (340 aa) fasta scores: E(): 0, 84.2% id in 341 aa, and to Streptomyces coelicolor putative ion-transporting ATPase TR:Q9XA36 (EMBL:AL079353) (325 aa) fasta scores: E(): 0, 52.4% id in 330 aa. (341 aa)
ML2302Similar to Mycobacterium tuberculosis putative transcriptional regulator Rv3676 or MTV025.024 TR:O69644 (EMBL:AL022121) (224 aa) fasta scores: E(): 0, 96.0% id in 224 aa. Similar to many e.g. Haemophilus influenzae catabolite gene activator crp or cap or HI0957 SW:CRP_HAEIN (P29281) (224 aa) fasta scores: E(): 2.4e-14, 32.6% id in 187 aa. Contains a probable helix-turn-helix motif at aa 175-196 (Score 1990, SD +5.96) Contains Pfam match to entry PF00325 crp, Bacterial regulatory proteins, crp family. Contains Pfam match to entry PF00027 cNMP_binding, Cyclic nucleotide-binding domain. (224 aa)
ML2283Hypothetical protein; Unknown function. (104 aa)
cpsYProbable UDP-glucose-4-epimerase; Similar to Mycobacterium tuberculosis hypothetical 60.3 kda protein RV0806C TR:O06628 (EMBL:Z95618) fasta scores: E(): 0, 82.3% id in 530 aa, and to Neisseria meningitidis capsule gene complex upd-glucose-4-epimerase TR:Q51151 (EMBL:L09188) fasta scores: E(): 9.2e-26, 30.0% id in 317 aa. (542 aa)
ML2177Similar to Mus musculus uridine phosphorylase SW:UDP_MOUSE () fasta scores: E(): 1.9e-21, 34.0% in 268 aa, and to Homo sapiens uridine phosphorylase SW:UDP_HUMAN () fasta scores: E(): 2.2e-19, 32.4% in 275 aa. Contains PS01232 Purine and other phosphorylases family 1 signature. (317 aa)
fadBPutative fatty oxidation complex alpha subunit; Similar to Mycobacterium tuberculosis hypothetical 76.1 kda protein TR:O53872 (EMBL:AL022004) fasta scores: E(): 0, 88.6% in 719 aa, and to Escherichia coli fatty oxidation complex alpha subunit SW:FADB_ECOLI (P21177) fasta scores: E(): 0, 33.0% in 684 aa. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family; Similar to ML1724, ML2402, ML2401, ML1241 and ML2118. (714 aa)
ML2156Possible DNA-binding protein; Similar to Mycobacterium tuberculosis hypothetical 79.7 kda protein TR:O53874 (EMBL:AL022004) fasta scores: E(): 0, 77.6% in 753 aa, and to Streptomyces coelicolor hypothetical 90.4 kda protein TR:CAB93395 (EMBL:AL357524) fasta scores: E(): 3.9e-27, 34.6% in 856 aa. Contains a probable helix-turn-helix motif at aa 277-298 (Score 1075, SD +2.85). (753 aa)
ML2135Possible transmembrane protein; Similar to Mycobacterium tuberculosis hypothetical 39.8 kda protein rv0885 SW:Y885_MYCTU (Q10546) fasta scores: E(): 0, 83.9% in 341 aa, and to Streptomyces coelicolor putative membrane protein TR:Q9XAE8 (EMBL:AL079356) fasta scores: E(): 1.5e-13, 27.1% in 255 aa. Contains possible membrane spanning hydrophobic domains. (341 aa)
fprBFerredoxin, ferredoxin-NADP reductase; Similar to Mycobacterium tuberculosis probable ferredoxin/ferredoxin--NADP reductase SW:FPRB_MYCTU (Q10547) fasta scores: E(): 0, 76.6% in 560 aa, and to Homo sapiens NADPH:adrenodoxin oxidoreductase precursor SW:ADRO_HUMAN (P22570; Q13716) fasta scores: E(): 2.9e-30, 37.4% in 484 aa. Contains 2 Pfam matches to entry PF00037 fer4, 4Fe-4S binding domain. Contains PS00198 4Fe-4S ferredoxins. (555 aa)
ilvGAcetolactate synthase II; Similar to Mycobacterium tuberculosis probable acetolactate synthase SW:ILVG_MYCTU (Q50613) fasta scores: E(): 0, 86.1% in 548 aa, and to Bacillus subtilis acetolactate synthase large subunit SW:ILVB_BACSU (P37251; P94564) fasta scores: E(): 1.2e-32, 28.5% in 543 aa. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00187 Thiamine pyrophosphate enzymes signature; Similar to ML1696, ML2167 and ML0354. (548 aa)
secA2SecA, preprotein translocase subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (778 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (132 aa)
gcvBGlycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (952 aa)
guaB1Inosine-5'-monophosphate dehydrogenase; Previously sequenced as TR:O32912 (EMBL:AL008609) fasta scores: E(): 0, 100.0% in 478 aa. Similar to Mycobacterium tuberculosis inosine-5'-monophosphate dehydrogenase rv1843c SW:YI43_MYCTU (Q50591) fasta scores: E(): 0, 86.4% in 478 aa, and to Bacillus subtilis inosine-5'-monophosphate dehydrogenase SW:IMDH_BACSU (P21879) fasta scores: E(): 0, 37.7% in 472 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C terminus. Contains Pfam match to entry PF01574 IM [...] (478 aa)
rpoA[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (347 aa)
fumFumarase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (474 aa)
xseBExonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (87 aa)
xseAExonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (428 aa)
ML1927Similar to M. tuberculosis hypothetical protein Rv0430 TR:P96276 (EMBL:Z84724) (102 aa); Fasta score E(): 0, 93.1% identity in 102 aa overlap, and to Streptomyces coelicolor hypothetical protein SCD95A.20 TR:CAB93047 (EMBL:AL357432) (84 aa); Fasta score E(): 4.1e-11, 52.8% identity in 72 aa overlap. (102 aa)
ML1910Similar to Mycobacterium tuberculosis hypothetical proteins e.g. Rv0635 or MTCY20H10.16 TR:P96926 (EMBL:Z92772) (158 aa) fasta scores: E(): 0, 84.9% id in 159 aa. Also similar to Streptomyces coelicolor hypothetical protein SCD82.07 TR:CAB77410 (EMBL:AL160431) (150 aa) fasta scores: E(): 1.9e-11, 30.4% id in 148 aa; Belongs to the UPF0336 family. (159 aa)
ML1909Similar to M. tuberculosis hypothetical protein Rv0636 TR:P96927 (EMBL:Z92772) (142 aa); Fasta score E(): 0, 93.0% identity in 142 aa overlap. Contains Pfam match to entry PF01575 MaoC_dehydratas, MaoC like domain; Similar to and ML2566. (142 aa)
ML1908Similar to M. tuberculosis hypothetical protein Rv0637 TR:P96928 (EMBL:Z92772) (166 aa); Fasta score E(): 0, 88.6% identity in 166 aa overlap, and to others e.g. Streptomyces coelicolor SCD82.07 TR:CAB77410 (EMBL:AL160431) (150 aa); Fasta score E(): 4.7e-11, 29.3% identity in 150 aa overlap; Similar to ML1910 and ML2425; Belongs to the UPF0336 family. (166 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (235 aa)
ML1892ABC transporter ATP-binding protein; Not known, could be involved in the transport of ribonucleotides. (338 aa)
rpoB[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1178 aa)
rpoC[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1316 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (218 aa)
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (280 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (281 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (127 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (113 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (187 aa)
rpsE30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (217 aa)
rpmDSimilar to M. tuberculosis 50S ribosomal protein L30 Rv0722 SW:RL30_MYCTU (Z84395) (65 aa); Fasta score E(): 1.1e-21, 89.2% identity in 65 aa overlap. Contains Pfam match to entry PF00327 Ribosomal_L30, Ribosomal protein L30p/L7e. (71 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa)
secYSecY subunit of preprotein translocase; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (438 aa)
trxBThioredoxin; Similar to M. tuberculosis thioredoxin trxB Rv1471 TR:O53162 (EMBL:AL021184) (123 aa); Fasta score E(): 2.4e-25, 65.4% identity in 107 aa overlap, and M. tuberculosis thioredoxin trxA Rv1470 TR:O53161 (EMBL:AL021184) (124 aa); Fasta score E(): 1.6e-17, 47.0% identity in 117 aa overlap. Also similar to Escherichia coli thioredoxin 2 SW:THI2_ECOLI (P33636) (139 aa); Fasta score E(): 1.7e-07, 37.1% identity in 89 aa overlap. Contains Pfam match to entry PF00085 thiored, Thioredoxin; Similar to and ML2703. (130 aa)
inhAenoyl-[ACP] reductase; Similar to M. tuberculosis inhA Rv1484 SW:INHA_MYCTU (P46533) (269 aa); Fasta score E(): 0, 90.3% identity in 269 aa overlap, and to many others e.g. Escherichia coli enoyl-[acyl-carrier-protein] reductase [NADH] SW:FABI_ECOLI (P29132) (261 aa); Fasta score E(): 1.2e-17, 33.2% identity in 268 aa overlap; Similar to and ML1807. (269 aa)
uspESugar transport integral membrane protein; Similar to M. tuberculosis Rv2317 TR:P71895 (EMBL:Z79702) (274 aa); Fasta score E(): 0, 85.0% identity in 274 aa overlap probable sugar transport protein uspE, and to many others e.g. Thermomonospora fusca cellobiose transport permease bglB TR:AAF37729 (EMBL:AF086819) (305 aa); Fasta score E(): 1.9e-24, 30.2% identity in 275 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component; Similar to ML1425 and ML1088. (274 aa)
uspASugar transport integral membrane protein; Similar to M. tuberculosis Rv2316 TR:P71896 (EMBL:Z79702) (290 aa); Fasta score E(): 0, 82.4% identity in 289 aa overlap probable sugar transport protein uspA, and to many others e.g. Thermococcus litoralis maltore transporter malF TR:O51924 (EMBL:AF012836) (300 aa); Fasta score E(): 4.7e-28, 33.6% identity in 283 aa overlap. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component; Similar to ML1426, ML1087, ML1425 and ML1088. (328 aa)
ML1763Hypothetical protein; Unknown function. (71 aa)
nrdERibonucleoside diphosphate reductase [alpha] chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). (693 aa)
nrdFRibonucleotide reductase small subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). (325 aa)
ML1726Highly similar to many putative ABC transport, ATP-binding proteins including:Streptomyces coelicolor TR:CAB76322 (EMBL:AL158060) (279 aa); Fasta score E(): 0, 44.4% identity in 277 aa overlap and Mycobacterium tuberculosis RV3041C TR:O53288 (EMBL:AL021287) (287 aa); Fasta score E(): 0, 83.4% identity in 289 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (305 aa)
ML1708Highly similar to many aminotransferases resembling NifS, a protein of unknown function located within many nitrogen fixation gene clusters e.g. Azotobacter vinelandii SW:NIFS_AZOVI (P05341) (402 aa); Fasta score E(): 0, 39.1% identity in 394 aa overlap. Also highly similar to Mycobacterium tuberculosis NifS-like protein RV3025C TR:O53272 (EMBL:AL021287) (393 aa); Fasta score E(): 0, 84.9% identity in 391 aa overlap. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V; Similar to ML0596. (410 aa)
gatAglutamyl-tRNA(Gln) amidotransferase, subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln) (By similarity). (497 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (343 aa)
gatBglutamyl-tRNA(Gln) amidotransferase, subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity); Belongs to the GatB/GatE family. GatB subfamily. (509 aa)
ilvBHighly similar to many acetolactate synthases, large subunit, (EC 4.1.3.18) involved in valine and isoleucine biosynthesis, including: Mycobacterium avium SW:ILVB_MYCAV (Q59498) (621 aa); Fasta score E(): 0, 82.7% identity in 624 aa overlap and Mycobacterium tuberculosis RV3003C SW:ILVB_MYCTU (O53250) (618 aa); Fasta score E(): 0, 87.1% identity in 627 aa overlap. Contains Pfam match to entry PF00205 TPP_enzymes, Thiamine pyrophosphate enzymes. Contains PS00187 Thiamine pyrophosphate enzymes signature. (625 aa)
ilvNHighly similar to many acetolactate synthases, small subunit, (EC 4.1.3.18) involved in valine and isoleucine biosynthesis, including: Mycobacterium avium SW:ILVH_MYCAV (Q59499) (167 aa); Fasta score E(): 0, 78.9% identity in 166 aa overlap and Mycobacterium tuberculosis RV3002C SW:ILVH_MYCTU (O53249) (168 aa); Fasta score E(): 0, 83.5% identity in 164 aa overlap. Contains Pfam match to entry PF01842 ACT, ACT domain. (169 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (485 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (198 aa)
ML1683Probable histone-like protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (200 aa)
ML1681Possible polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP); Belongs to the polyphosphate kinase 1 (PPK1) family. (739 aa)
gpdAHighly similar to many glycerol-3-phosphate dehydrogenases (EC 1.1.1.8) including: Escherichia coli SW:GPDA_ECOLI (P37606) (339 aa); Fasta score E(): 0, 39.9% identity in 341 aa overlap and Mycobacterium tuberculosis RV2982C TR:P95113 (EMBL:Z83018) (334 aa); Fasta score E(): 0, 77.9% identity in 349 aa overlap. Contains Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (351 aa)
recGATP-dependent DNA helicase; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA) (By similarity); Belongs to the helicase family. RecG subfamily. (743 aa)
ML1657Acetyl/propionyl CoA carboxylase [beta] subunit; Highly similar to many propionyl-CoA carboxylases involved in fatty acid catabolism including: Rhodococcus erythropolis SW:PCCB_RHOER (Q06101) (476 aa); Fasta score E(): 0, 70.9% identity in 477 aa overlap and Mycobacterium tuberculosis RV2247 SW:PCCB_MYCTU (Q10506) (473 aa); Fasta score E(): 0, 92.8% identity in 473 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML0731. (473 aa)
fabDMalonyl CoA-[ACP] transacylase; Similar to many malonyl CoA-acyl carrier protein transacylases (EC 2.3.1.39) involved in fatty acid biosynthesis, including: Salmonella typhimurium SW:FABD_SALTY (O85140) (308 aa); Fasta score E(): 1.6e-19, 32.7% identity in 303 aa overlap and Mycobacterium tuberculosis SW:FABD_MYCTU (Q10501) (302 aa); Fasta score E(): 0, 82.2% identity in 304 aa overlap. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. (304 aa)
aceEPyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (936 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (521 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (240 aa)
ML1602Hypothetical protein; Function unknown. (106 aa)
rpsBHighly similar to many 30s ribosomal proteins (S2) including: Bacillus subtilis SW:RS2_BACSU (P21464) (245 aa); Fasta score E(): 0, 57.6% identity in 250 aa overlap and Mycobacterium tuberculosis RV2890C SW:RS2_MYCTU (Q10796) (287 aa); Fasta score E(): 0, 91.5% identity in 270 aa overlap. Contains Pfam match to entry PF00318 Ribosomal_S2, Ribosomal protein S2. Contains PS00962 Ribosomal protein S2 signature 1; Belongs to the universal ribosomal protein uS2 family. (277 aa)
ML1596Possible amidase; Highly similar to several proposed amidases including: Pseudomonas putida SW:AMID_PSEPU (O69768) (466 aa); Fasta score E(): 2.9e-19, 29.0% identity in 469 aa overlap and Mycobacterium tuberculosis Rv2888c SW:AMI3_MYCTU (Q10811) (473 aa); Fasta score E(): 0, 76.7% identity in 468 aa overlap. Contains Pfam match to entry PF01425 Amidase, Amidase. Contains PS00571 Amidases signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (468 aa)
ML1583Possible 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (406 aa)
ML1548Conserved hypothetical protein; Highly similar to several proteins of unknown function including: Streptomyces coelicolor TR:O88028 (EMBL:AL031107) (295 aa); Fasta score E(): 0, 54.4% identity in 285 aa overlap and Mycobacterium tuberculosis TR:O33337 (EMBL:AL00896) (324 aa); Fasta score E(): 0, 87.4% identity in 318 aa overlap. (321 aa)
ML1547Conserved hypothetical protein; Similar to a number of proteins essential for the production of iron chelators e.g. Escherichia coli enterobactin synthetase component D SW:ENTD_ECOLI (P19925) (209 aa); Fasta score E(): 0.002, 29.4% identity in 177 aa overlap. Also similar to Streptomyces sp. L-proline 3-hydroxylase TR:O24813 (EMBL:AB007189) (208 aa); Fasta score E(): 0, 50.7% identity in 209 aa overlap and a hypothetical protein from Mycobacterium tuberculosis RV2794C TR:O33336 (EMBL:AL008967) (227 aa); Fasta score E(): 0, 79.7% identity in 227 aa overlap; Belongs to the P-Pant transfe [...] (227 aa)
ML1536Conserved hypothetical protein; Highly similar to several Mycobacterium tuberculosis proteins of undefined function e.g. SW:YH98_MYCTU (O53947) (610 aa); Fasta score E(): 0, 89.7% identity in 609 aa overlap. The C-terminus of this protein is also similar to several including: Bacillus subtilis stage V sporulation protein K SW:SP5K_BACSU (P27643) (322 aa); Fasta score E(): 2.2e-20, 34.5% identity in 310 aa overlap. Contains PS00017 ATP/GTP-binding site motif A (P-loop). (610 aa)
ML1525Similar to hypothetical proteins from Streptomyces coelicolor TR:Q9RD46 (EMBL:AL133424) (151 aa); Fasta score E(): 1.3e-28, 56.1% identity in 148 aa overlap and Mycobacterium tuberculosis RV2771C TR:O33313 (EMBL:AL008967) (150 aa); Fasta score E(): 2.2e-26, 52.7% identity in 148 aa overlap. (151 aa)
ML1512Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (558 aa)
ML1498Possible GTP-binding, protein elongation factor; Highly similar to several GTP-binding proteins including: Escherichia coli SW:TYPA_ECOLI (P32132) (591 aa); Fasta score E(): 0, 46.1% identity in 610 aa overlap which belongs to the GTP-binding elongation factor family and Mycobacterium tuberculosis hypothetical protein RV1165 TR:O06563 (EMBL:Z95584) (628 aa); Fasta score E(): 0, 85.2% identity in 628 aa overlap. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family. Contains PS00301 GTP-binding elongation factors signature. Contains PS00017 ATP/GTP-binding site moti [...] (628 aa)
ML1492Conserved hypothetical protein; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine; In the C-terminal section; belongs to the radical SAM superfamily. CofH family. (863 aa)
fdxAFerredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (108 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (224 aa)
clpP2ATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (214 aa)
clpXATP-dependent Clp protease ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa)
ML1468Possible ribonuclease; Highly similar in parts to many ribonucleases e.g. Escherichia coli ribonuclease E (EC 3.1.4.-) SW:RNE_ECOLI (P21513) (1061 aa); Fasta score E(): 1.6e-22, 36.4% identity in 429 aa overlap and Mycobacterium tuberculosis RV2444C TR:P71905 (EMBL:Z81451) (953 aa); Fasta score E(): 0, 74.2% identity in 966 aa overlap. Contains Pfam match to entry PF00575 S1, S1 RNA binding domain. (924 aa)
rpmAHighly similar to many 50s ribosomal proteins (L27) including: Escherichia coli SW:RL27_ECOLI (P02427) (84 aa); Fasta score E(): 5.8e-16, 63.9% identity in 83 aa overlap and Mycobacterium tuberculosis RV2441C SW:RL27_MYCTU (Z8145) (86 aa); Fasta score E(): 3.3e-28, 93.8% identity in 81 aa overlap. Contains Pfam match to entry PF01016 Ribosomal_L27, Ribosomal L27 protein. Contains PS00831 Ribosomal protein L27 signature; Belongs to the bacterial ribosomal protein bL27 family. (88 aa)
ML1448Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature. (184 aa)
ML1427Possible ABC-transport lipoprotein; Similar to several putative ABC_transport proteins e.g. Mycobacterium tuberculosis lipoprotein component of sugar transport system RV2041C TR:O53485 (EMBL:AL021899) (439 aa); Fasta score E(): 0, 77.4% identity in 446 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein lipid attachment site. Contains Pfam match to entry PF01547 SBP_bacterial_1, Bacterial extracellular solute-binding protein. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (445 aa)
ML1426Probable ABC-transport protein, inner membrane component; Highly similar to many putative ABC_transport proteins e.g. Mycobacterium tuberculosis sugar transport protein RV2040C TR:O53484 (EMBL:AL021899) (300 aa); Fasta score E(): 0, 81.6% identity in 293 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign.; Similar to ML1768. (319 aa)
ML1425Probable ABC-transport protein, inner membrane component; Highly similar to many putative ABC_transport proteins e.g. Mycobacterium tuberculosis sugar transport protein RV2039C TR:O53483 (EMBL:AL021899) (280 aa); Fasta score E(): 0, 79.2% identity in 283 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00528 BPD_transp, Binding-protein-dependent transport systems inner membrane component. Contains PS00402 Binding-protein-dependent transport systems inner membrane comp sign.; Similar to ML1769. (283 aa)
ML1424Highly similar to several binding-protein-dependent transport proteins including: Escherichia coli SN-glycerol-3-phosphate transport ATP-binding protein SW:UGPC_ECOLI (P10907) (356 aa); Fasta score E(): 0, 47.9% identity in 363 aa overlap and Mycobacterium tuberculosis ABC-type sugar transport protein RV2038C TR:O53482 (EMBL:AL021899) (357 aa); Fasta score E(): 0, 79.7% identity in 355 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature; Similar to ML1089, [...] (356 aa)
ML1420Hypothetical protein; Unknown function. (117 aa)
argHArginosuccinate lyase; Highly similar to many argininosuccinate lyases (EC 4.3.2.1) involved in arginine biosynthesis, including: Escherichia coli SW:ARLY_ECOLI (P11447) (172 aa); BlastP Expect 9.3 and Mycobacterium tuberculosis SW:ARLY_MYCTU (P94994) (470 aa); Fasta score E(): 0, 88.1% identity in 470 aa overlap. Contains Pfam match to entry PF00206 lyase_1, Lyase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00163 Fumarate lyases signature. (470 aa)
argRArginine repressor; Regulates arginine biosynthesis genes. (167 aa)
pheTphenylalanyl-tRNA synthase [beta] subunit; Highly similar to many phenylalanyl-tRNA synthetase beta chains including: Escherichia coli SW:SYFB_ECOLI (P07395) (795 aa); Fasta score E(): 0, 31.0% identity in 851 aa overlap and Mycobacterium tuberculosis RV1649 SW:SYFB_MYCTU (P94985) (831 aa); Fasta score E(): 0, 79.6% identity in 834 aa overlap. (836 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (969 aa)
ML1390Conserved hypothetical protein; Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis RV1636 TR:O06153 (EMBL:Z95554) (146 aa); Fasta score E(): 0, 89.0% identity in 146 aa overlap and Neisseria meningitidis TR:AAF41856 (EMBL:AE002499) (154 aa); Fasta score E(): 1.7e-07, 32.4% identity in 148 aa overlap. Contains Pfam match to entry PF00582 Usp, Universal stress protein family. (147 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (698 aa)
rpsA30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity). (481 aa)
ML1362Possible conserved secreted protein; Pore-forming protein, which is involved in efflux of copper across the outer membrane. Essential for copper resistance and maintenance of a low intracellular copper concentration (By similarity); Belongs to the MctB (TC 1.B.50) family. (317 aa)
ML1346Similar to many Prokaryotic and Eukaryotic long-chain acyl-CoA synthetases including: Mus musculus SW:VLCS_MOUSE (O35488) (620 aa); Fasta score E(): 1.5e-20, 24.7% identity in 570 aa overlap and Chromatium vinosum poly-beta-hydroxybutyrate polymerase (EC 2.3.1.-) SW:PHBC_CHRVI (P45370) (355 aa); Fasta score E(): 4.7e-17, 28.2% identity in 348 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein RV1683 TR:O33185 (EMBL:Z98268) (999 aa); Fasta score E(): 0, 85.6% identity in 1002 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme [...] (1002 aa)
ML1332Membrane transport protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (286 aa)
ML1331Possible secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (95 aa)
ML1330Possible DNA-binding protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafC family. (324 aa)
ML1329Conserved hypothetical protein; Does not seem to be involved in pupylation or substrate degradation; Belongs to the PafB family. (331 aa)
ML1328Possible DNA-binding protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine. (452 aa)
prcAProteasome [alpha]-type subunit 1; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family. (265 aa)
prcBProteasome [beta]-type subunit 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family. (291 aa)
ML1321Conserved hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation. (63 aa)
ML1320Conserved hypothetical protein; Highly similar to many proteins of undefined function including: Rhodococcus sp. TR:Q53081 (EMBL:U26422) (499 aa); Fasta score E(): 0, 83.5% identity in 502 aa overlap and Mycobacterium tuberculosis RV2112C TR:O33247 (EMBL:Z97559) (554 aa); Fasta score E(): 0, 95.4% identity in 504 aa overlap. (514 aa)
ML1316Probable AAA-family ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. (609 aa)
ML1313Conserved hypothetical protein; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. (281 aa)
ML1312Conserved hypothetical protein; Highly similar to several proteins of unknown function e.g. Mycobacterium tuberculosis RV2119 TR:O33254 (EMBL:Z97559) (278 aa); Fasta score E(): 0, 79.9% identity in 278 aa overlap. (294 aa)
metH5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity). (1206 aa)
ML1306Conserved hypothetical protein; Similar to several proteins of unkown function including: Mycobacterium tuberculosis RV2125 TR:O33260 (EMBL:Z97559) (292 aa); Fasta score E(): 0, 85.0% identity in 274 aa overlap and Streptomyces coelicolor TR:Q9S2K6 (EMBL:AL109732) (312 aa); Fasta score E(): 1.6e-07, 23.4% identity in 278 aa overlap. (274 aa)
ML1300Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV2133C TR:O06242 (EMBL:Z95388) (262 aa); Fasta score E(): 0, 79.4% identity in 262 aa overlap. (262 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (529 aa)
ML1254Conserved hypothetical protein; Highly similar to several proteins of unknown function including: Mycobacterium tuberculosis RV2469C TR:O53196 (EMBL:AL021246) (222 aa); Fasta score E(): 0, 77.9% identity in 222 aa overlap and Streptomyces coelicolor TR:CAB71830 (EMBL:AL138662) (178 aa); Fasta score E(): 0, 52.8% identity in 161 aa overlap. Contains Pfam match to entry PF01844 HNH, HNH endonuclease. (215 aa)
papA3PKS-associated protein, unknown function; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49618 (EMBL:U00010) (471 aa); Fasta score E(): 0, 99.8% identity in 471 aa overlap. Also highly similar to Mycobacterium tuberculosis proteins encoded downstream of several polyketide synthases e.g. Rv1182 TR:O50438 (EMBL:AL010186) (472 aa); Fasta score E(): 0, 75.8% identity in 471 aa overlap. (471 aa)
pks3Mycocerosic acid synthase (polyketide synthase); Identical to many polyketide synthases involved in the biosynthesis of mycocerosyl lipids e.g. Mycobacterium tuberculosis probable mycocerosic acid synthase Rv2940c TR:P96291 (EMBL:Z83858) (2111 aa); Fasta score E(): 0, 60.8% identity in 2127 aa overlap and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 58.8% identity in 2127 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase [...] (2118 aa)
dnaEDNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. (1177 aa)
fasFatty acid synthase; Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa); Fasta score E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa); Fasta score E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa); Fasta score E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 [...] (3076 aa)
rphARibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (259 aa)
atpCATP synthase [epsilon] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. (121 aa)
atpDATP synthase [beta] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (485 aa)
atpGATP synthase [gamma] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (298 aa)
atpAATP synthase [alpha] chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (558 aa)
atpHBi-domained ATP synthase B, [Delta] chain protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). (446 aa)
atpFProbable ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (170 aa)
atpEProbable ATP synthase C chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (81 aa)
atpBProbable ATP synthase A chain protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (251 aa)
ML1119Hypothetical protein; Highly similar, in parts,to Mycobacterium tuberculosis hypothetical protein Rv1277 TR:Q50699 (EMBL:Z77137) (417 aa); Fasta score E(): 0, 82.0% identity in 383 aa overlap. (383 aa)
odhA2-oxoglutarate dehydrogenase, E1 and E2 components; Shows three enzymatic activities that share a first common step, the attack of thiamine-PP on 2-oxoglutarate (alpha-ketoglutarate, KG), leading to the formation of an enamine-thiamine-PP intermediate upon decarboxylation. Thus, displays KGD activity, catalyzing the decarboxylation from five-carbon 2-oxoglutarate to four-carbon succinate semialdehyde (SSA). Also catalyzes C-C bond formation between the activated aldehyde formed after decarboxylation of alpha- ketoglutarate and the carbonyl of glyoxylate (GLX), to yield 2-hydroxy- 3-oxo [...] (1260 aa)
ML1093Lipoprotein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49982 (EMBL:U15180) (227 aa); Fasta score E(): 0, 100.0% identity in 227 aa overlap. Also highly similar to Mycobacterium tuberculosis lipoprotein Rv1244, TR:O50459 (EMBL:AL021006) (286 aa); Fasta score E(): 0, 73.5% identity in 287 aa overlap and weakly similar to several others e.g. Streptomyces coelicolor TR:Q9X832 (EMBL:AL049727) (320 aa); Fasta score E(): 2.9, 26.1% identity in 299 aa overlap putative secreted substrate-binding protein. Contains a possible N-terminal signal sequence an [...] (285 aa)
ML1089Probable ABC-transport protein, ATP-binding component; Identical to the previously sequenced Mycobacterium leprae TR:Q49978 (EMBL:U15180) (392 aa); Fasta score E(): 0, 100.0% identity in 392 aa overlap. Also highly similar to many ABC-transport proteins including: Mycobacterium tuberculosis Rv1238 TR:O50454 (EMBL:AL021006) (393 aa); Fasta score E(): 0, 79.9% identity in 389 aa overlap and Agrobacterium radiobacter SW:LACK_AGRRD (Q01937) (363 aa); Fasta score E(): 0, 53.1% identity in 339 aa overlap lactose transport ATP-binding protein. Contains Pfam match to entry PF00005 ABC_tran, AB [...] (392 aa)
ML1088Probable ABC-transport protein, inner membrane component; Previously sequenced Mycobacterium leprae MalG TR:Q49977 (EMBL:U15180) (296 aa); Fasta score E(): 0, 100.0% identity in 287 aa overlap. Also highly similar to many putative membrane transport proteins including: Mycobacterium tuberculosis probable sugar transport protein Rv1237 TR:O50453 (EMBL:AL021006) (274 aa); Fasta score E(): 0, 89.4% identity in 274 aa overlap and Thermococcus litoralis inner membrane protein MalG TR:O51925 (EMBL:AF012836) (278 aa); Fasta score E(): 4.1e-31, 35.9% identity in 270 aa overlap. Contains multip [...] (287 aa)
ML1087Probable ABC-transport protein, inner membrane component; Previously sequenced Mycobacterium leprae MalF TR:Q49976 (EMBL:U15180) (310 aa); Fasta score E(): 0, 100.0% identity in 304 aa overlap. Also highly similar to many putative membrane transport proteins including: Mycobacterium tuberculosis probable sugar transport protein Rv1236 TR:O50452 (EMBL:AL021006) (307 aa); Fasta score E(): 0, 81.8% identity in 292 aa overlap and Thermococcus litoralis inner membrane protein MalF TR:O51924 (EMBL:AF012836) (300 aa); Fasta score E(): 0, 39.1% identity in 279 aa overlap. Contains multiple pos [...] (304 aa)
ML1086Probable solute-binding transport lipoprotein; Previously sequenced Mycobacterium leprae TR:Q49975 (EMBL:U15180) (469 aa); Fasta score E(): 0, 100.0% identity in 468 aa overlap. Also similar to many solute-binding transport proteins e.g. from Mycobacterium tuberculosis Rv1235 TR:O31095 (EMBL:AF028830) (468 aa); Fasta score E(): 0, 77.6% identity in 469 aa overlap and Escherichia coli SW:MALE_ECOLI (P02928) (396 aa); Fasta score E(): 0.00081, 23.4% identity in 295 aa overlap. Contains a possible N-terminal signal sequence and an appropriately positioned Prokaryotic membrane lipoprotein [...] (468 aa)
ML1079Possible secreted protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (120 aa)
sigEECF subfamily sigma subunit; Highly similar to many proposed ECF-family RNA-polymerase sigma factors including: Mycobacterium tuberculosis SigE TR:O06289 (EMBL:U87242) (257 aa); Fasta score E(): 0, 82.1% identity in 252 aa overlap, Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa); Fasta score E(): 0, 80.6% identity in 247 aa overlap and Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa); Fasta score E(): 2.9e-16, 35.7% identity in 171 aa overlap. Contains a probable helix-turn-helix motif at aa 213-234 (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 Sigma70_ECF, Sig [...] (263 aa)
glgCProbable glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block, required in the biosynthesis of maltose-1-phosphate (M1P) and in the elongation reactions to produce linear alpha-1,4-glucans. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (404 aa)
ML1037Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49999 (EMBL:U15181) (184 aa); Fasta score E(): 0, 99.5% identity in 184 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2683 TR:O07185 (EMBL:Z96072) (165 aa); Fasta score E(): 0, 73.8% identity in 164 aa overlap. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. (184 aa)
ML1009Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49847 (EMBL:U00019) (326 aa); Fasta score E(): 0, 100.0% identity in 326 aa overlap. Also highly similar to a number of other proteins of unknown function e.g. Mycobacterium tuberculosis Rv2714 TR:O07213 (EMBL:Z96072) (324 aa); Fasta score E(): 0, 89.7% identity in 320 aa overlap. (326 aa)
lexALexA, SOS repressor protein; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (235 aa)
ML0897Serine-threonine protein kinase; Identical to the previously sequenced Mycobacterium leprae putative serine/threonine protein kinase TR:O69568 (EMBL:AL022602) (400 aa); Fasta score E(): 0, 99.8% identity in 400 aa overlap(EMBL:AL022602). Also highly similar to many other putative serine/threonine protein kinases e.g. from Mycobacterium tuberculosis: TR:O53510 (EMBL:AL021957) (399 aa); Fasta score E(): 0, 75.3% identity in 400 aa overlap(EMBL:AL021957) and SW:PKNB_MYCTU (SW:P71584) (626 aa); Fasta score E(): 2e-31, 39.5% identity in 311 aa overlap(SW:P71584). Contains Pfam match to entr [...] (400 aa)
ML0890Possible membrane transport ATPase; Previously sequenced Mycobacterium leprae hypothetical protein TR:O69574 (EMBL:AL022602) (415 aa); Fasta score E(): 0, 99.8% identity in 415 aa overlap(EMBL:AL022602). Also highly similar, in parts, to Mycobacterium tuberculosis hypothetical protein TR:O53518 (EMBL:AL021957) (379 aa); Fasta score E(): 0, 79.4% identity in 378 aa overlap(EMBL:AL021957) and weakly similar to many anion-transporting ATPases e.g. SW:ARA2_ECOLI (SW:P52145) (583 aa); Fasta score E(): 5.2e-07, 29.6% identity in 314 aa overlap(SW:P52145). Contains PS00017 ATP/GTP-binding sit [...] (415 aa)
ML0861Putative dihydrolipoamide acyltransferase; Similar to Mycobacterium tuberculosis dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex sucB or Rv2215 or MTCY190.26 SW:ODO2_MYCTU (Q10381) (553 aa) fasta scores: E(): 0, 81.8% id in 555 aa. Similar to Streptomyces seoulensis dihydrolipoamide acetyltransferase pdhB TR:Q9Z6I4 (EMBL:AF047034) (612 aa) fasta scores: E(): 0, 51.6% id in 614 aa and to many succinyltransferases e.g. Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex sucB SW:ODO2_ECOLI (P07016) [...] (530 aa)
ML0848ABC transporter; Similar to Mycobacterium tuberculosis hypothetical ABC transporter ATP-binding protein Rv2326c or MTCY3G12.08 SW:YN26_MYCTU (P71886) (697 aa) fasta scores: E(): 0, 76.9% id in 697 aa. Shares similar domains with many ABC-type transporters e.g. Streptomyces roseofulvus ATPase component of putative ABC transporter frnD TR:O68910 (EMBL:AF058302) (524 aa) fasta scores: E(): 8.4e-14, 31.5% id in 495 aa and Synechococcus sp. nitrate transport ATP-binding protein NrtD nrtD SW:NRTD_SYNP7 (P38046) (274 aa) fasta scores: E(): 1.6e-12, 34.8% id in 198 aa. Previously sequenced as [...] (724 aa)
ML0834Similar to Mycobacterium tuberculosis hypothetical protein Rv2342 or MTCY98.11 TR:P95238 (EMBL:Z83860) (85 aa) fasta scores: E(): 3e-21, 76.9% id in 78 aa and shows weak similarity to Streptomyces coelicolor putative secreted protein SCC24.32 TR:CAB86126 (EMBL:AL163003) (108 aa) fasta scores: E(): 0.035, 30.5% id in 95 aa. (100 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (642 aa)
dgtSimilar to Mycobacterium tuberculosis deoxyguanosinetriphosphate triphosphohydrolase dgt or Rv2344c or MTCY98.13c SW:DGTP_MYCTU (P95240) (431 aa) fasta scores: E(): 0, 83.8% id in 421 aa and to many hypothetical deoxyguanosine hydrolases. Contains Pfam match to entry PF01966 HD, HD domain; Belongs to the dGTPase family. Type 2 subfamily. (429 aa)
ML0825Similar to Mycobacterium tuberculosis putative transcriptional regulator Rv2358 or MTCY27.22c TR:O05840 (EMBL:Z95208) (135 aa) fasta scores: E(): 0, 72.9% id in 140 aa. Contains a probable helix-turn-helix motif at aa 77-98 (Score 1179, SD +3.20) Contains Pfam match to entry PF01022 HTH_5, Bacterial regulatory protein, arsR family. (140 aa)
furBPutative ferric uptake regulatory protein; Similar to Mycobacterium tuberculosis cosmid y27 fur or Rv2359 or MTCY27.21c TR:O05839 (EMBL:Z95208) (130 aa) fasta scores: E(): 0, 86.9% id in 130 aa, and to Escherichia coli ferric uptake regulation protein fur SW:FUR_ECOLI (P06975) (148 aa) fasta scores: E(): 2.1e-13, 37.2% id in 129 aa. Contains Pfam match to entry PF01475 FUR, Ferric uptake regulator family. (131 aa)
secAPutative preprotein translocase subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (940 aa)
ML0778Conserved hypothetical protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (229 aa)
dnaNPutative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] (399 aa)
gyrAPutative DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (1249 aa)
pabAEC_number=4.1.3.-; Similar to M. tuberculosis pabA, p-aminobenzoate synthase glutamine amidotransferase, TR:Q50183 (EMBL:Z70722) (232 aa); Fasta score E(): 0, 100.0% identity in 232 aa overlap (EMBL:AL123456) (232 aa); Fasta score E(): 0, 100.0% identity in 232 aa overlap and to Azospirillum brasilense trpG, anthranilate synthase component II, SW:TRPG_AZOBR (P26922) (196 aa); Fasta score E(): 0, 56.1% identity in 187 aa overlap. Previously sequenced as TR:Q50183. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferase [...] (232 aa)
gltDSimilar to M. tuberculosis Rv3858c, gltD, putative NADH-dependent glutamate synthase small subunit, TR:P96219 (EMBL:Al123456) (488 aa); Fasta score E(): 0, 87.7% identity in 488 aa overlap and to many other putative glutamate synthase small subunits e.g. Escherichia coli gltD, glutamate synthase [NADPH] small chain, SW:GLTD_ECOLI (P09832) (471 aa); Fasta score E(): 0, 37.8% identity in 474 aa overlap. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. (488 aa)
menGPutative S-adenosylmethionine:2-demethylmenaquinone methyltransferase; Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). (157 aa)
pks13Similar to many polyketide synthases from M. tuberculosis e.g. ppsA, M. tuberculosis phenolpthiocerol synthesis polyketide synthase, SW:PPSA_MYCTU (Q10977) (1876 aa); Fasta score E(): 0, 36.1% identity in 1277 aa overlap. Similar to many others e.g. Streptomyces noursei nysI, nystatin biosynthesis polyketide synthase, TR:AAF71766 (EMBL:AF263912) (9477 aa); Fasta score E(): 0, 33.4% identity in 1215 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entr [...] (1784 aa)
accD4Similar to many acyl-CoA carboxylase subunits e.g. M. tuberculosis pccB, acetyl/propionyl-CoA carboxylase [beta] subunit, TR:O53578 (EMBL:AL123456) (518 aa); Fasta score E(): 0, 91.2% identity in 512 aa overlap and Streptomyces coelicolor pccB, propionyl-CoA carboxylase complex B subunit, TR:Q9X4K7 (EMBL:AF113605) (530 aa); Fasta score E(): 0, 48.2% identity in 521 aa overlap. Contains Pfam match to entry PF01039 Carboxyl_trans, Carboxyl transferase domain; Similar to ML0731 and ML1657. (517 aa)
ML0112Putative ABC transporter component; Similar to M. tuberculosis Rv3783, integral membrane protein, TR:P72049 (EMBL:AL123456) (280 aa); Fasta score E(): 0, 84.3% identity in 280 aa overlap. Similar to Yersinia enterocolitica rfbD, O-antigen export system permease protein, SW:RFBD_YEREN (Z18920) (259 aa); Fasta score E(): 2.9e-32, 28.2% identity in 259 aa overlap and to other membrane proteins involved in lipopolysaccharide transport. Contains Pfam match to entry PF01061 ABC2_membrane, ABC-2 type transporter. (276 aa)
ML0115Conserved hypothetical protein; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Belongs to the Bpa family. (174 aa)
ML0116Putative membrane protein; Similar to M. tuberculosis Rv3779, unknown membrane protein, TR:P72045 (EMBL:AL123456) (666 aa); Fasta score E(): 0, 66.5% identity in 666 aa overlap. Contains hydrophobic, possible membrane-spanning regions. (654 aa)
ML0135Similar to many polyketide synthases from M. tuberculosis e.g. N-terminus is similar to Rv2947c, pks15, probable polyketide synthase, TR:P96284 (EMBL:Z83858) (496 aa); Fasta score E(): 0, 90.5% identity in 485 aa overlap and the remainder is similar to Rv2946c, pks1, probable polyketide synthase, TR:P96285 (EMBL:Z83858) (1616 aa); Fasta score E(): 0, 82.5% identity in 1620 aa overlap. Similar to many others e.g. Streptomyces noursei NysC, nystatin biosynthesis polyketide synthase, TR:AAF71776 (EMBL:AF263912) (11096 aa); Fasta score E(): 0, 50.2% identity in 2161 aa overlap. Contains Pf [...] (2103 aa)
masPutative mycocerosic synthase; Similar to many polyketide synthases from M. tuberculosis e.g. Rv2940c, mas, mycocerosic acid synthase, TR:P96291 (EMBL:AL123456) (2111 aa); Fasta score E(): 0, 88.0% identity in 2119 aa overlap. Similar to Mycobacterium bovis mas, mycocerosic acid synthase, SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 85.1% identity in 2122 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transf [...] (2116 aa)
uvrDPutative ATP-dependent DNA helicase; DNA-dependent ATPase, acting on dsDNA with a 3'-ssDNA tail, unwinding with 3'-to 5'-polarity. Also highly efficient on nicked DNA. Involved in the post-incision events of nucleotide excision repair (By similarity); Belongs to the helicase family. UvrD subfamily. (778 aa)
sucCsuccinyl-CoA synthase [beta] chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
sucDsuccinyl-CoA synthase [alpha] chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
rpmFHypothetical protein (pseudogene); Probable ribosomal protein L32, rpmF,similar to many e.g. tr|Q9RL50|Q9RL50 PROBABLE 50S RIBOSOMAL PROTEIN (56 aa) E(): 1.5e-09; 63.462% identity in 52 aa overlap; Belongs to the bacterial ribosomal protein bL32 family. (57 aa)
ML0180Similar to M.tuberculosis Rv0991c, hypothetical protein with Ser-rich C-terminus, TR:O05574 (EMBL:AL123456) (110 aa); Fasta score E(): 1.1e-23, 78.5% identity in 93 aa overlap. Similar to other bacterial Ser-rich hypothetical proteins e.g. Streptomyces coelicolor SCE22.04, hypothetical protein, TR:CAB90971 (EMBL:AL355832) (110 aa); Fasta score E(): 2.6e-15, 54.5% identity in 99 aa overlap. Previously sequenced as TR:Q9Z5G3 (EMBL:AL035500) (120 aa); Fasta score E(): 1.1e-32, 100.0% identity in 99 aa overlap. (99 aa)
ML0187Similar to M. tuberculosis Rv0998, hypothetical protein, TR:O05581 (EMBL:AL123456) (333 aa); Fasta score E(): 0, 69.7% identity in 330 aa overlap. Contains Pfam match to entry PF00027 cNMP_binding, Cyclic nucleotide-binding domain. Contains PS00889 Cyclic nucleotide-binding domain signature 2. (353 aa)
ML0192Putative membrane protein; Similar to M. tuberculosis Rv1002c, probable membrane protein, TR:O05586 (EMBL:AL123456) (503 aa); Fasta score E(): 0, 80.4% identity in 510 aa overlap. Also similar to Streptomyces coelicolor SCE87.05, putative integral membrane protein, TR:Q9RKD3 (EMBL:AL132674) (591 aa); Fasta score E(): 0, 36.7% identity in 531 aa overlap. Contains hydrophobic, possible membrane-spanning regions. (510 aa)
topAPutative DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] (947 aa)
ML0202Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. (405 aa)
folKSimilar to M. tuberculosis folK, Rv3607c, probable 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase, SW:HPPK_MYCTU (O06276) (188 aa); Fasta score E(): 0, 63.2% identity in 190 aa overlap. Similar to others e.g. to the C-terminal half of Streptococcus pneumoniae sulD, bifunctional folate synthesis protein (includes: dihydroneopterin aldolase and 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase), SW:SULD_STRPN (P22291) (270 aa); Fasta score E(): 1.8e-07, 37.8% identity in 135 aa overlap. Previously sequenced as SW:HPPK_MYCLE (O69528) (191 aa); Fasta sc [...] (191 aa)
pabBEC_number=4.1.3.-; Similar to M. tuberculosis pabB, Rv1005c, putative para-aminobenzoate synthase component I, TR:O05591 (EMBL:Z94752) (458 aa); Fasta score E(): 0, 79.1% identity in 412 aa overlap. Similar to many e.g. Escherichia coli para-aminobenzoate synthase component I, SW:PABB_ECOLI (P05041) (453 aa); Fasta score E(): 5.5e-31, 35.2% identity in 378 aa overlap. When compared to the predicted M. tuberculosis translation, this CDS is missing the N-terminal 30 aa, thus it may be a pseudogene. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar t [...] (418 aa)
prsAPutative ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (327 aa)
mfdPutative transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1224 aa)
enoPutative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (447 aa)
thiGPutative thiamine biosynthesis protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (261 aa)
ML0298Similar to M. tuberculosis Rv0416, conserved hypothetical protein, TR:P96262 (EMBL:AL123456) (68 aa); Fasta score E(): 5.9e-17, 71.6% identity in 74 aa overlap. Similar to bacterial hypothetical protein e.g. Escherichia coli thiS, hypothetical protein, SW:THIS_ECOLI (O32583) (66 aa); Fasta score E(): 0.41, 32.0% identity in 50 aa overlap. Previously sequenced as TR:Q9ZBL3 (EMBL:AL035159) (74 aa); Fasta score E(): 1.2e-28, 100.0% identity in 74 aa overlap. (74 aa)
ML0336Similar to many putative ABC-tranporter ATP-binding proteins e.g. Chlamydia trachomatis troB, ABC transporter ATPase, TR:O87477 (EMBL:AF077010) (286 aa); Fasta score E(): 4.7e-16, 31.4% identity in 223 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00211 ABC transporters family signature. (275 aa)
ilvXSimilar to M. tuberculosis ilvX, putative acetohydroxyacid synthase I large subunit, TR:O53554 (EMBL:AL123456) (515 aa); Fasta score E(): 0, 82.9% identity in 515 aa overlap. Similar to Escherichia coli ilvI, acetolactate synthase isozyme III large subunit, SW:ILVI_ECOLI (P00893) (574 aa); Fasta score E(): 1.8e-07, 23.7% identity in 540 aa overlap. Also similar to Pseudomonas putida mdlC, benzoylformate decarboxylase, SW:MDLC_PSEPU (P20906) (528 aa); Fasta score E(): 6.6e-13, 29.3% identity in 529 aa overlap. Previously sequenced as TR:Q49865 (EMBL:U00020) (515 aa); Fasta score E(): 0, [...] (515 aa)
rpsISimilar to M. tuberculosis rpsI, 30S ribosomal protein S9, SW:RS9_MYCTU (O06259) (151 aa); Fasta score E(): 0, 83.2% identity in 155 aa overlap. Previously sequenced as SW:RS9_MYCLE (P40828) (153 aa); Fasta score E(): 0, 99.3% identity in 153 aa overlap. Contains Pfam match to entry PF00380 Ribosomal_S9, Ribosomal protein S9/S16. Contains PS00360 Ribosomal protein S9 signature; Belongs to the universal ribosomal protein uS9 family. (153 aa)
ML0378Similar to M. tuberculosis rimI, Rv3420c, putative ribosomal protein S18 acetyltransferase, TR:Q50708 (EMBL:Z77165) (158 aa); Fasta score E(): 0, 72.1% identity in 154 aa overlap in the C-terminus and to M. tuberculosis Rv3421c hypothetical protein, SW:YY21_MYCTU (Q50707) (211 aa); Fasta score E(): 0, 75.6% identity in 205 aa overlap in the N-terminus. Appears to be a fusion of two M. tuberculosis homologues. Similar to many hypothetical acetyltransferases. Previously sequenced as SW:YY21_MYCLE (Q49857) (359 aa); Fasta score E(): 0, 100.0% identity in 359 aa overlap. Contains Pfam matc [...] (359 aa)
guaB2Putative inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (529 aa)
guaB3Similar to M. tuberculosis guaB3, Rv3410c, putative inosine-5'-monophosphate dehydrogenase, SW:YY10_MYCTU (Q50716) (375 aa); Fasta score E(): 0, 90.5% identity in 368 aa overlap. This ORF is similar in part to ML0387 and ML2066, which more closely resemble the experimentally characterised IMP-DH's (e.g. from Escherichia coli). This shorter homologue is conserved in several bacterial genera. Previously sequenced as SW:YY10_MYCLE (U00015) (375 aa); Fasta score E(): 0, 100.0% identity in 370 aa overlap. Contains Pfam match to entry PF00478 IMPDH_C, IMP dehydrogenase / GMP reductase C term [...] (370 aa)
ML0393Putative hydrolase; Similar to M. tuberculosis Rv3400, hypothetical protein, SW:YY00_MYCTU (Q50725) (262 aa); Fasta score E(): 0, 74.4% identity in 262 aa overlap. Previously sequenced as SW:YY00_MYCLE (Q49741) (261 aa); Fasta score E(): 0, 100.0% identity in 261 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase. (261 aa)
ML0450Putative pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (307 aa)
ML0474Conserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (223 aa)
ruvCCrossover junction endodeoxyribonuclease; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity). (188 aa)
ruvAHolliday junction DNA helicase component; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (203 aa)
ruvBHolliday junction helicase component; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (349 aa)
nusBPutative transcription termination protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (190 aa)
pyrBSimilar to M. tuberculosis pyrB, Rv1380, aspartate carbamoyltransferase, SW:PYRB_MYCTU (P71808) (319 aa); Fasta score E(): 0, 89.9% identity in 318 aa overlap. Similar to many e.g. Pseudomonas putida, aspartate carbamoyltransferase, SW:PYRB_PSEPU (Q59711) (334 aa); Fasta score E(): 0, 47.3% identity in 317 aa overlap. Contains 2 Pfam matches to entry PF00185 OTCace, Aspartate/ornithine carbamoyltransferase. Contains PS00097 Aspartate and ornithine carbamoyltransferases signature; Shows weak similarity to ML1410; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCas [...] (321 aa)
carASimilar to M. tuberculosis carA, Rv1383, carbamoyl-phosphate synthase subunit, TR:P71811 (EMBL:AL123456) (376 aa); Fasta score E(): 0, 85.4% identity in 377 aa overlap. Similar to many e.g. Escherichia coli carA, carbamoyl-phosphate synthase subunit, SW:CARA_ECOLI (P00907) (382 aa); Fasta score E(): 0, 43.2% identity in 389 aa overlap. Contains Pfam match to entry PF00988 CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active si [...] (375 aa)
ML0542Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). (110 aa)
dfpPutative flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (419 aa)
priAPutative primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (651 aa)
ribH6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family. (160 aa)
uvrCPutative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (647 aa)
ML0563Conserved hypothetical protein; Displays ATPase and GTPase activities. (298 aa)
ML0593Similar to M. tuberculosis Rv1461, hypothetical protein, SW:YE61_MYCTU (O53152) (846 aa); Fasta score E(): 0, 54.3% identity in 920 aa overlap. N- and C-termini are similar to various bacterial hypothetical proteins e.g. Streptomyces coelicolor SCC22.07C, conserved hypothetical protein, TR:Q9XAD1 (EMBL:AL096839) (473 aa); Fasta score E(): 0, 45.5% identity in 853 aa overlap. Contains an intein from amino acids 202-587 inclusive. The intein is different to the one in the M. tuberculosis orthologue and at a different relative position. Previously sequenced as SW:YE61_MYCLE (Q49689) (869 [...] (869 aa)
ML0597Similar to M. tuberculosis Rv1465, conserved hypothetical protein, TR:O53156 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 79.4% identity in 165 aa overlap. Similar to many hypothetical proteins and shows very weak similarity to proteins from N-fixation loci e.g. Anabaena azollae nifU, nitrogen fixation protein, SW:NIFU_ANAAZ (Q43885) (300 aa); Fasta score E(): 1.9, 24.4% identity in 90 aa overlap. Previously sequenced as TR:Q49683 (EMBL:U00013) (165 aa); Fasta score E(): 0, 100.0% identity in 165 aa overlap. Contains Pfam match to entry PF01883 DUF59, Domain of unknown function. Conta [...] (165 aa)
ML0603Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. (371 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (86 aa)
uvrD2Putative ATP-dependent DNA helicase; DNA-dependent ATPase, stimulated equally by ss- and dsDNA. Has both ATPase and helicase activities (By similarity). (717 aa)
fprAPutative NADPH-ferredoxin reductase; May serve as electron transfer protein and supply electrons to P450 systems; Belongs to the ferredoxin--NADP reductase type 1 family. (456 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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