STRINGSTRING
pks3 pks3 ML0135 ML0135 ML0118 ML0118 ML2355 ML2355 ML2053 ML2053 adhE2 adhE2 adhA adhA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
pks3Mycocerosic acid synthase (polyketide synthase); Identical to many polyketide synthases involved in the biosynthesis of mycocerosyl lipids e.g. Mycobacterium tuberculosis probable mycocerosic acid synthase Rv2940c TR:P96291 (EMBL:Z83858) (2111 aa); Fasta score E(): 0, 60.8% identity in 2127 aa overlap and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 58.8% identity in 2127 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase [...] (2118 aa)
ML0135Similar to many polyketide synthases from M. tuberculosis e.g. N-terminus is similar to Rv2947c, pks15, probable polyketide synthase, TR:P96284 (EMBL:Z83858) (496 aa); Fasta score E(): 0, 90.5% identity in 485 aa overlap and the remainder is similar to Rv2946c, pks1, probable polyketide synthase, TR:P96285 (EMBL:Z83858) (1616 aa); Fasta score E(): 0, 82.5% identity in 1620 aa overlap. Similar to many others e.g. Streptomyces noursei NysC, nystatin biosynthesis polyketide synthase, TR:AAF71776 (EMBL:AF263912) (11096 aa); Fasta score E(): 0, 50.2% identity in 2161 aa overlap. Contains Pf [...] (2103 aa)
ML0118Similar to M. tuberculosis Rv3777, putative oxidireductase, TR:P72043. Similar to many oxidoreductases from both bacteria and higher organisms e.g. Mus musculus cryZ, quinone oxidoreductase, SW:QOR_MOUSE (P47199) (331 aa); Fasta score E(): 5.5e-21, 31.0% identity in 306 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases; Similar to domains of polyketide synthases ML0135, ML0139, ML1229 and ML2355. (336 aa)
ML2355Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...] (2201 aa)
ML2053Putative alcohol dehydrogenase; Similar to Mycobacterium tuberculosis adhA or Rv1862 or MTCY359.11 TR:P95153 (EMBL:Z83859) (346 aa) fasta scores: E(): 0, 84.5% id in 336 aa. Similar to Rhizobium meliloti alcohol dehydrogenase adhA SW:ADHA_RHIME (O31186) (340 aa) fasta scores: E(): 6.3e-26, 33.1% id in 344 aa and many putative alcohol dehydrogenases. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00059 Zinc-containing alcohol dehydrogenases signature; Similar to ML1730, ML1784 and ML2025. (335 aa)
adhE2Putative alcohol dehydrogenase (Zn dependent); Similar to M. tuberculosis adhE2 Rv2259 TR:O53533 (EMBL:AL021925) (361 aa); Fasta score E(): 0, 88.9% identity in 361 aa overlap, and to other alcohol dehydrogenases e.g. Amycolatopsis methanolica NAD/mycothiol-dependent formaldehyde dehydrogenase SW:FADH_AMYME (P80094) (360 aa); Fasta score E(): 0, 80.4% identity in 358 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00190 Cytochrome c family heme-binding site signature. Contains PS00059 Zinc-containing alcohol dehydrogenases signature; S [...] (361 aa)
adhAAlcohol dehydrogenase; Highly similar to many Prokaryotic and Eukaryotic dehydrogenases including: Mycobacterium tuberculosis RV3045 SW:ADH_MYCTU (P31975) (346 aa); Fasta score E(): 0, 85.8% identity in 346 aa overlap and Arabidopsis thaliana SW:CAD1_ARATH (P42734) (360 aa); Fasta score E(): 0, 48.8% identity in 344 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00059 Zinc-containing alcohol dehydrogenases signature; Similar to ML2053. (362 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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