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ML0596 ML0596 ML0842 ML0842 bioA bioA bioF bioF hisC hisC argD argD ML1488 ML1488 ML1708 ML1708 ML1794 ML1794 glyA glyA gcvB gcvB serC serC ML2336 ML2336 metB metB hemL hemL ML2502 ML2502 adi adi gabT gabT metZ metZ ML0117 ML0117
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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ML0596Putative aminotransferase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (418 aa)
ML0842Conserved hypothetical protein; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (411 aa)
bioAAdenosylmethionine-8-amino-7-oxononanoate aminotransferase; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. (436 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (385 aa)
hisCHighly similar to many histidinol-phosphate aminotransferases (EC 2.6.1.9) involved in histidine biosynthesis e.g. Mycobacterium tuberculosis RV1600 TR:SW:HIS8_MYCTU (O06591) (380 aa); Fasta score E(): 0, 83.6% identity in 366 aa overlap and Mycobacterium smegmatis SW:HIS8_MYCSM (P28735) (219 aa); Fasta score E(): 0, 77.2% identity in 219 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II. (377 aa)
argDHighly similar to many acetylornithine aminotransferases (EC 2.6.1.11) involved in arginine biosynthesis, including: Escherichia coli SW:ARGD_ECOLI (P18335) (405 aa); Fasta score E(): 0, 38.7% identity in 390 aa overlap and Mycobacterium tuberculosis RV1655 SW:ARGD_MYCTU (P94990) (400 aa); Fasta score E(): 0, 82.9% identity in 397 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site. (404 aa)
ML1488Possible aminotransferase; Weakly similar to several putative aminotransferases including: Neisseria meningitidis TR:AAF41303 (EMBL:AE002441) (395 aa); Fasta score E(): 5.1e-13, 29.8% identity in 373 aa overlap and Mycobacterium tuberculosis RV1178 TR:O50434 (EMBL:AL010186) (362 aa); Fasta score E(): 0, 83.4% identity in 361 aa overlap. Contains PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. (367 aa)
ML1708Highly similar to many aminotransferases resembling NifS, a protein of unknown function located within many nitrogen fixation gene clusters e.g. Azotobacter vinelandii SW:NIFS_AZOVI (P05341) (402 aa); Fasta score E(): 0, 39.1% identity in 394 aa overlap. Also highly similar to Mycobacterium tuberculosis NifS-like protein RV3025C TR:O53272 (EMBL:AL021287) (393 aa); Fasta score E(): 0, 84.9% identity in 391 aa overlap. Contains Pfam match to entry PF00266 aminotran_5, Aminotransferases class-V; Similar to ML0596. (410 aa)
ML1794Aminotransferase; Similar to M. tuberculosis predicted aminotransferase Rv2294 SW:YM94_MYCTU (Q50672) (407 aa); Fasta score E(): 0, 76.5% identity in 404 aa overlap, and to many others e.g. Escherichia coli MalY protein SW:MALY_ECOLI (P23256) (390 aa); Fasta score E(): 5.8e-27, 31.2% identity in 385 aa overlap; Similar to and ML2502; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily. (402 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (426 aa)
gcvBGlycine decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (952 aa)
serCPutative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (376 aa)
ML2336Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 44.4 kDa protein Rv3722c TR:O69689 (EMBL:AL022121) (408 aa) fasta scores: E(): 0, 87.6% id in 396 aa, and to Deinococcus radiodurans conserved hypothetical protein TR:Q9RU17 (EMBL:AE002001) (452 aa) fasta scores: E(): 0, 43.1% id in 450 aa. (463 aa)
metBCystathionine [gamma]-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). (388 aa)
hemLSimilar to Mycobacterium tuberculosis glutamate-1-semialdehyde 2,1-aminomutase HemL Rv0524 SW:GSA_MYCTU (O06390) (462 aa) fasta scores: E(): 0, 82.4% id in 460 aa, and to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL SW:GSA_ECOLI (P23893; P78277) (426 aa) fasta scores: E(): 0, 53.0% id in 419 aa. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal-phosphate attachment site; Similar to ML1409. (446 aa)
ML2502Similar to Mycobacterium tuberculosis probable aspartate aminotransferase RV0337C SW:AAT_MYCTU (O33267) fasta scores: E(): 0, 91.4% id in 429 aa and to Bacillus stearothermophilus aspartate aminotransferase AspC SW:AAT_BACST (Q59228) fasta scores: E(): 0, 32.4% id in 389 aa. Contains Pfam match to entry PF00155 aminotran_1, Aminotransferases class-I. (437 aa)
adiPutative amino acid decarboxylase; Similar to M. tuberculosis adi, Rv2531c, putative ornithine/arginine decarboxylase, TR:P95022 (EMBL:AL123456) (947 aa); Fasta score E(): 0, 86.4% identity in 951 aa overlap. Similar to decarboxylases of ornithine and lysine e.g. Escherichia coli speC, ornithine decarboxylase, constitutive, SW:DCOR_ECOLI (P21169) (731 aa); Fasta score E(): 3e-16, 26.8% identity in 650 aa overlap. Contains Pfam match to entry PF01276 OKR_DC_1, Orn/Lys/Arg decarboxylase. (950 aa)
gabTSimilar to M. tuberculosis gabT, Rv2589, 4-aminobutyrate aminotransferase, SW:GABT_MYCTU (Q50632) (449 aa); Fasta score E(): 0, 83.7% identity in 449 aa overlap. Similar to many e.g. Escherichia coli gabT, 4-aminobutyrate aminotransferase, SW:GABT_ECOLI (P22256) (426 aa); Fasta score E(): 0, 43.1% identity in 422 aa overlap. Previously sequenced as SW:GABT_MYCLE (P40829) (446 aa); Fasta score E(): 0, 99.8% identity in 446 aa overlap. Contains Pfam match to entry PF00202 aminotran_3, Aminotransferases class-III pyridoxal-phosphate. Contains PS00600 Aminotransferases class-III pyridoxal- [...] (446 aa)
metZPutative o-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (406 aa)
ML0117Similar to M. tuberculosis Rv3778c, conserved hypothetical protein, TR:P72044 (EMBL:AL123456) (398 aa); Fasta score E(): 0, 83.4% identity in 398 aa overlap. Also similar to many bacterial hypothetical proteins; Similar to ML0596 and to the C-terminal half of ML0842. (398 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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