STRINGSTRING
hom hom ML0108 ML0108 ML0118 ML0118 ML0129 ML0129 ML0135 ML0135 mas mas sucD sucD rmlB2 rmlB2 ML0229 ML0229 ML0315 ML0315 ML0396 ML0396 ML0429 ML0429 fadD9 fadD9 aroE aroE gap gap folD folD rmlD rmlD sahH sahH ML0860 ML0860 ephD ephD mdh mdh ML1094 ML1094 fas fas pks3 pks3 ML1249 ML1249 argC argC ald ald ML1583 ML1583 gpdA gpdA serA serA ilvC ilvC adhA adhA ML1740 ML1740 adhE2 adhE2 inhA inhA fabG1 fabG1 ML1942 ML1942 rmlB rmlB nrp nrp ML2053 ML2053 ML2059 ML2059 gnd gnd fadB fadB asd asd ML2354 ML2354 ML2355 ML2355 ML2356 ML2356 ML2357 ML2357 hemA hemA ML2428 ML2428 proC proC fadB2 fadB2 ML2472 ML2472 fabG4 fabG4 pntAA pntAA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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gene neighborhood
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homHomoserine dehydrogenase; Identical to the previously sequenced Mycobacterium leprae homoserine dehydrogenase (EC 1.1.1.3) SW:DHOM_MYCLE (P46806) (441 aa); Fasta score E(): 0, 99.8% identity in 441 aa overlap. Also highly similar to orthologues from Mycobacterium tuberculosis SW:DHOM_MYCTU (Q10601) (441 aa); Fasta score E(): 0, 89.5% identity in 438 aa overlap and Corynebacterium glutamicum SW:DHOM_CORGL (P08499) (445 aa); Fasta score E(): 0, 60.3% identity in 431 aa overlap. Contains Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase. Contains Pfam match to entry PF01 [...] (441 aa)
ML0108Similar To M. tuberculosis Rv3791, putative oxidoreductase, SW:Y1J1_MYCTU (P72057) (254 aa); Fasta score E(): 0, 89.0% identity in 254 aa overlap and to other putative oxidoreductases from the same organism. Shows weaker similarity to Alcaligenes eutrophus phbB, acetoacetyl-CoA reductase, SW:PHBB_ALCEU (P14697) (246 aa); Fasta score E(): 3e-09, 28.3% identity in 191 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature; Shows weak similarity to ML0429 and to the C-terminal half of ML2565. (254 aa)
ML0118Similar to M. tuberculosis Rv3777, putative oxidireductase, TR:P72043. Similar to many oxidoreductases from both bacteria and higher organisms e.g. Mus musculus cryZ, quinone oxidoreductase, SW:QOR_MOUSE (P47199) (331 aa); Fasta score E(): 5.5e-21, 31.0% identity in 306 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases; Similar to domains of polyketide synthases ML0135, ML0139, ML1229 and ML2355. (336 aa)
ML0129Conserved hypothetical protein; Involved in the reduction of the double bond between C-4 and C-5 during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis. (418 aa)
ML0135Similar to many polyketide synthases from M. tuberculosis e.g. N-terminus is similar to Rv2947c, pks15, probable polyketide synthase, TR:P96284 (EMBL:Z83858) (496 aa); Fasta score E(): 0, 90.5% identity in 485 aa overlap and the remainder is similar to Rv2946c, pks1, probable polyketide synthase, TR:P96285 (EMBL:Z83858) (1616 aa); Fasta score E(): 0, 82.5% identity in 1620 aa overlap. Similar to many others e.g. Streptomyces noursei NysC, nystatin biosynthesis polyketide synthase, TR:AAF71776 (EMBL:AF263912) (11096 aa); Fasta score E(): 0, 50.2% identity in 2161 aa overlap. Contains Pf [...] (2103 aa)
masPutative mycocerosic synthase; Similar to many polyketide synthases from M. tuberculosis e.g. Rv2940c, mas, mycocerosic acid synthase, TR:P96291 (EMBL:AL123456) (2111 aa); Fasta score E(): 0, 88.0% identity in 2119 aa overlap. Similar to Mycobacterium bovis mas, mycocerosic acid synthase, SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 85.1% identity in 2122 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transf [...] (2116 aa)
sucDsuccinyl-CoA synthase [alpha] chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
rmlB2Putative sugar-nucleotide dehydratase; Similar to M. tuberculosis rmlB2, possible dTDP-Glucose 4,6-dehydratase, TR:O06373 (EMBL:AL123456) (314 aa); Fasta score E(): 0, 86.1% identity in 309 aa overlap. Similar to bacterial sugar-nucleotide dehydratases (many putative) e.g. Streptomyces venezuelae desIV, TDP-glucose-4,6-dehydratase, TR:Q9ZGH3 (EMBL:AF079762) (337 aa); Fasta score E(): 1.4e-24, 34.3% identity in 321 aa overlap. Previously sequenced as TR:O69544 (EMBL:AL023093) (319 aa); Fasta score E(): 0, 100.0% identity in 319 aa overlap. Contains Pfam match to entry PF01370 Epimerase, [...] (319 aa)
ML0229Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap. (309 aa)
ML0315Similar to M. tuberculosis Rv0068, putative oxidoreductase, TR:O53613 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 73.9% identity in 306 aa overlap and to other M. tuberculosis putative oxidoreductases (e.g. Rv0439c). Similar to many bacterial putative oxidoreductases e.g. Streptomyces coelicolor SC7A8.30C, putative oxidoreductase, TR:CAB69779 (EMBL:AL137187) (310 aa); Fasta score E(): 0, 47.9% identity in 311 aa overlap. Previously sequenced as TR:Q9ZBM5 (EMBL:AL035159) (304 aa); Fasta score E(): 0, 100.0% identity in 304 aa overlap. Contains Pfam match to entry PF00106 adh_short, sh [...] (304 aa)
ML0396Similar to M. tuberculosis Rv0046c, conserved hypothetical protein, TR:P71703 (EMBL:AL123456) (367 aa); Fasta score E(): 0, 91.8% identity in 366 aa overlap. Similar to other bacterial hypothetical proteins. C-terminal half show weak similarity to eukaryotic myo-inositol-1-phosphate synthases e.g. Candida albicans ino1, myo-inositol-1-phosphate synthase, SW:INO1_CANAL (P42800) (520 aa); Fasta score E(): 0.22, 24.4% identity in 242 aa overlap. Previously sequenced as TR:Q57240 (EMBL:U00015) (369 aa); Fasta score E(): 0, 100.0% identity in 369 aa overlap. Contains Pfam match to entry PF0 [...] (369 aa)
ML0429Similar to M. tuberculosis Rv2509, putative oxidoreductase, TR:O06172 (EMBL:AL123456) (268 aa); Fasta score E(): 0, 88.8% identity in 267 aa overlap. Similar to many putative dehydrogenases. Previously sequenced as TR:O07709 (EMBL:Z97179) (268 aa); Fasta score E(): 0, 100.0% identity in 268 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. (268 aa)
fadD9Putative acyl-CoA synthetase; Similar to M. tuberculosis fadD9, Rv2590, putative acyl-CoA synthetase, TR:Q5063 (EMBL:Al123456) (1168 aa); Fasta score E(): 0, 68.0% identity in 1178 aa overlap1. Similar to acyl-CoA ligases and to domains of polyketide/peptide synthetases e.g. Mycobacterium smegmatis mps, peptide synthetase, TR:Q9RLP6 (EMBL:AJ238027) (5990 aa); Fasta score E(): 0, 37.2% identity in 1168 aa overlap. C-terminal half is similar to eukaryotic aminoadipate-semialdehyde dehydrogenase e.g. Saccharomyces cerevisiae lys2, aminoadipate-semialdehyde dehydrogenase large subunit, SW: [...] (1188 aa)
aroESimilar to M. tuberculosis aroE, Rv2552c, shikimate 5-dehydrogenase, TR:P95001 (EMBL:AL123456) (269 aa); Fasta score E(): 0, 81.5% identity in 270 aa overlap. Similar to many e.g. Neisseria meningitidis aroE, shikimate dehydrogenase, TR:P95388 (EMBL:U82841) (269 aa); Fasta score E(): 2.5e-12, 29.6% identity in 274 aa overlap. Contains Pfam match to entry PF01488 Shikimate_DH, Shikimate / quinate 5-dehydrogenase. (278 aa)
gapGlyceraldehyde 3-phosphate dehydrogenase; Catalyzes the oxidative phosphorylation of glyceraldehyde 3- phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. (339 aa)
folDPutative methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (282 aa)
rmlDPutative dTDP-rhamnose modification protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. (311 aa)
sahHPutative S-adenosyl-L-homocysteine hydrolase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (492 aa)
ML0860Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 31.7 kDa protein Rv2216 or MTCY190.27 SW:YM16_MYCTU (Q10403) (301 aa) fasta scores: E(): 0, 84.2% id in 297 aa. Similar to many hypothetical proteins from both bacteria and eukaryotes e.g. to Drosophila melanogaster CG8768 TR:Q9V6F9 (EMBL:AE003821) (297 aa) fasta scores: E(): 6.3e-26, 31.3% id in 304 aa. Previously sequenced as SW:YM16_MYCLE (O32960); Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. (307 aa)
ephDPutative oxidoreductase; Similar to Mycobacterium tuberculosis probable oxidoreductase ephD or Rv2214c or MTCY190.25C SW:EPHD_MYCTU (Q10402) (592 aa) fasta scores: E(): 0, 80.4% id in 596 aa. Similar to many putative oxidorecuctases e.g. Streptomyces coelicolor putative oxidoreductase SCD78.21C TR:Q9ZBX8 (EMBL:AL034355) (585 aa) fasta scores: E(): 0, 42.4% id in 582 aa. C-terminal half is similar to Pseudomonas paucimobilis C alpha-dehydrogenase ligD SW:LIGD_PSEPA (Q01198) (305 aa) fasta scores: E(): 1.1e-15, 26.8% id in 269 aa. Previously sequenced as TR:O32958 (EMBL:Z98741). Contains [...] (596 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (329 aa)
ML1094Short chain alcohol dehydrogenase; Highly similar to several Mycobacterium tuberculosis putative oxidoreductases e.g. Rv1245c TR:O50460 (EMBL:AL021006) (276 aa); Fasta score E(): 0, 78.3% identity in 277 aa overlap. Also similar to many others including: Pseudomonas paucimobilis SW:LINX_PSEPA (P50198) (250 aa); Fasta score E(): 9.3e-17, 35.6% identity in 194 aa overlap 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. (277 aa)
fasFatty acid synthase; Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa); Fasta score E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa); Fasta score E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa); Fasta score E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 [...] (3076 aa)
pks3Mycocerosic acid synthase (polyketide synthase); Identical to many polyketide synthases involved in the biosynthesis of mycocerosyl lipids e.g. Mycobacterium tuberculosis probable mycocerosic acid synthase Rv2940c TR:P96291 (EMBL:Z83858) (2111 aa); Fasta score E(): 0, 60.8% identity in 2127 aa overlap and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa); Fasta score E(): 0, 58.8% identity in 2127 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase [...] (2118 aa)
ML1249Conserved hypothetical protein; Similar to several proteins of undefined function including: Mycobacterium tuberculosis RV2476C TR:O53203 (EMBL:AL021246) (1624 aa); Fasta score E(): 0, 81.5% identity in 1634 aa overlap and Rickettsia prowazekii TR:Q9ZCI2 (EMBL:AJ235273) (1581 aa); Fasta score E(): 0, 32.9% identity in 1494 aa overlap. (1622 aa)
argCN-acetyl-[gamma]-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa)
aldHighly similar to many alanine dehydrogenases (EC 1.4.1.1) including: Bacillus sphaericus SW:DHA_BACSH (P175566) (372 aa); Fasta score E(): 0, 53.4% identity in 365 aa overlap and Mycobacterium tuberculosis RV2780 SW:DHA_MYCTU (P30234) (371 aa); Fasta score E(): 0, 85.4% identity in 371 aa overlap. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. Contains PS00837 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 2. Contains PS00836 Alanine dehydrogenase & pyridine nucleotide transhydrogenase signature 1; Be [...] (371 aa)
ML1583Possible 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (406 aa)
gpdAHighly similar to many glycerol-3-phosphate dehydrogenases (EC 1.1.1.8) including: Escherichia coli SW:GPDA_ECOLI (P37606) (339 aa); Fasta score E(): 0, 39.9% identity in 341 aa overlap and Mycobacterium tuberculosis RV2982C TR:P95113 (EMBL:Z83018) (334 aa); Fasta score E(): 0, 77.9% identity in 349 aa overlap. Contains Pfam match to entry PF01210 NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase. (351 aa)
serAD-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (528 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (333 aa)
adhAAlcohol dehydrogenase; Highly similar to many Prokaryotic and Eukaryotic dehydrogenases including: Mycobacterium tuberculosis RV3045 SW:ADH_MYCTU (P31975) (346 aa); Fasta score E(): 0, 85.8% identity in 346 aa overlap and Arabidopsis thaliana SW:CAD1_ARATH (P42734) (360 aa); Fasta score E(): 0, 48.8% identity in 344 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00059 Zinc-containing alcohol dehydrogenases signature; Similar to ML2053. (362 aa)
ML1740Possible short chain reductase; Similar to several including: Thermotoga maritima 3-oxoacyl-[acyl-carrier protein] reductase SW:FABG_THEMA (Q9X248) (246 aa); Fasta score E(): 1.4e-18, 33.2% identity in 193 aa overlap and Mycobacterium tuberculosis possible ketoacyl reductase RV3057C TR:P95101 (EMBL:Z83866) (287 aa); Fasta score E(): 0, 81.8% identity in 280 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature. (312 aa)
adhE2Putative alcohol dehydrogenase (Zn dependent); Similar to M. tuberculosis adhE2 Rv2259 TR:O53533 (EMBL:AL021925) (361 aa); Fasta score E(): 0, 88.9% identity in 361 aa overlap, and to other alcohol dehydrogenases e.g. Amycolatopsis methanolica NAD/mycothiol-dependent formaldehyde dehydrogenase SW:FADH_AMYME (P80094) (360 aa); Fasta score E(): 0, 80.4% identity in 358 aa overlap. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00190 Cytochrome c family heme-binding site signature. Contains PS00059 Zinc-containing alcohol dehydrogenases signature; S [...] (361 aa)
inhAenoyl-[ACP] reductase; Similar to M. tuberculosis inhA Rv1484 SW:INHA_MYCTU (P46533) (269 aa); Fasta score E(): 0, 90.3% identity in 269 aa overlap, and to many others e.g. Escherichia coli enoyl-[acyl-carrier-protein] reductase [NADH] SW:FABI_ECOLI (P29132) (261 aa); Fasta score E(): 1.2e-17, 33.2% identity in 268 aa overlap; Similar to and ML1807. (269 aa)
fabG13-oxoacyl-[ACP] reductase (aka MabA); Similar to M. tuberculosis fabG Rv1483 SW:FABG_MYCTU (Q48930) (247 aa); Fasta score E(): 0, 68.6% identity in 245 aa overlap, and to many others e.g. Escherichia coli fabG 3-oxoacyl-[acyl-carrier protein] reductase SW:FABG_ECOLI (P25716) (244 aa); Fasta score E(): 0, 47.3% identity in 241 aa overlap. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature; Simil [...] (253 aa)
ML1942Similar to M. tuberculosis cholesterol dehydrogenase Rv1106c TR:O53454 (EMBL:AL021897) (370 aa); Fasta score E(): 0, 75.5% identity in 375 aa overlap, and to Nocardia sp NAD(P)-dependent cholesterol dehydrogenase TR:Q03704 (EMBL:D90244) (364 aa); Fasta score E(): 0, 71.0% identity in 366 aa overlap. Contains Pfam match to entry PF01073 3Beta_HSD, 3-beta hydroxysteroid dehydrogenase/isomerase family; Similar to ML0204 and ML1964. (376 aa)
rmlBSimilar to M. tuberculosis dTDP-glucose 4,6-dehydratase rmlB Rv3464 TR:O06329 (EMBL:Z95390) (331 aa); Fasta score E(): 0, 84.0% identity in 331 aa overlap, and TR:Q50556 (EMBL:U43540) (329 aa); Fasta score E(): 0, 78.2% identity in 331 aa overlap, and to others e.g. Streptococcus pneumoniae DTDP-glucose-4,6-dehydratase cpsN TR:O54611 (EMBL:AF030364) (349 aa); Fasta score E(): 0, 59.9% identity in 334 aa overlap. Contains Pfam match to entry PF01370 Epimerase, NAD dependent epimerase/dehydratase family; Similar to ML0204, ML0751, ML1942 and ML2428. (333 aa)
nrpProbable peptide synthase; Similar in N-terminus to M. tuberculosis probable peptide synthetase nrp Rv0101 TR:Q10896 (EMBL:Z74410) (2512 aa); Fasta score E(): 0, 65.7% identity in 1089 aa overlap, and to e.g. Streptomyces sp streptothricin peptide synthase TR:O33743 (EMBL:Y10293) (481 aa); Fasta score E(): 5.6e-20, 31.2% identity in 382 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML1051 and ML0243. (1401 aa)
ML2053Putative alcohol dehydrogenase; Similar to Mycobacterium tuberculosis adhA or Rv1862 or MTCY359.11 TR:P95153 (EMBL:Z83859) (346 aa) fasta scores: E(): 0, 84.5% id in 336 aa. Similar to Rhizobium meliloti alcohol dehydrogenase adhA SW:ADHA_RHIME (O31186) (340 aa) fasta scores: E(): 6.3e-26, 33.1% id in 344 aa and many putative alcohol dehydrogenases. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains PS00059 Zinc-containing alcohol dehydrogenases signature; Similar to ML1730, ML1784 and ML2025. (335 aa)
ML2059Short-chain dehydrogenase/reductase family; Similar to Mycobacterium tuberculosis hypothetical 23.2 kda protein TR:P95158 (EMBL:Z83859) fasta scores: E(): 0, 80.5% in 220 aa, and to Streptomyces argillaceus ketoreductase TR:O86486 (EMBL:AJ007932) fasta scores: E(): 0.00044, 24.9% in 201 aa. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogenase/reductase C-terminus. (224 aa)
gnd6-phosphogluconate dehydrogenase; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (483 aa)
fadBPutative fatty oxidation complex alpha subunit; Similar to Mycobacterium tuberculosis hypothetical 76.1 kda protein TR:O53872 (EMBL:AL022004) fasta scores: E(): 0, 88.6% in 719 aa, and to Escherichia coli fatty oxidation complex alpha subunit SW:FADB_ECOLI (P21177) fasta scores: E(): 0, 33.0% in 684 aa. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family; Similar to ML1724, ML2402, ML2401, ML1241 and ML2118. (714 aa)
asdAspartate semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (351 aa)
ML2354Similar to many polyketide synthases e.g.Mycobacterium tuberculosis Rv2934 TR:P96203 (EMBL:Z83857) (1827 aa) fasta scores: E(): 0, 80.3% id in 1836 aa, and to Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 32.7% id in 2136 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00017 ATP/G [...] (1822 aa)
ML2355Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...] (2201 aa)
ML2356Similar to many polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthesis polyketide synthase Rv2932 SW:PPSB_MYCTU (Q10978; O53234) (1538 aa) fasta scores: E(): 0, 76.3% id in 1561 aa and Mycobacterium bovis mycocerosic acid synthase SW:MCAS_MYCBO (Q02251) (2110 aa) fasta scores: E(): 0, 42.2% id in 879 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00606 Be [...] (1540 aa)
ML2357Polyketide synthase; Highly similar to many Prokaryotic and Eukaryotic polyketide synthases including: Mycobacterium tuberculosis phenolpthiocerol synthase rv2931 SW:PPSA_MYCTU (Q10977) (1876 aa) fasta scores: E(): 0, 76.1% id in 1888 aa and to Penicillium patulum 6-methylsalicylic acid synthase SW:MSAS_PENPA (P22367) (1774 aa) fasta scores: E(): 0, 33.8% id in 1823 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains 2 Pfam matches to entry PF00550 pp-binding, Phosphopantethe [...] (1871 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (467 aa)
ML2428Possible glucose epimerase/dehydratase; Similar to Mycobacterium tuberculosis UDP-glucose 4-epimerase Rv0501 SW:Y501_MYCTU (Q11166) (376 aa) fasta scores: E(): 0, 84.0% id in 368 aa, and to Streptomyces violaceoruber dTDP-glucose dehydratase TR:Q56173 (EMBL:L37334) (321 aa) fasta scores: E(): 2.9e-07, 30.4% id in 332 aa. (364 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (294 aa)
fadB23-hydroxyacyl-CoA dehydrogenase; Similar to Mycobacterium tuberculosis putative 3-hydroxyacyl-CoA dehydrogenase Rv0468 TR:O53753 (EMBL:AL021933) fasta scores: E(): 0, 89.5% id in 287 aa, and to Clostridium acetobutylicum 3-hydroxybutyryl-CoA dehydrogenase SW:HBD_CLOAB (P52041) fasta scores: E(): 0, 43.3% id in 282 aa. Contains Pfam match to entry PF00725 3HCDH, 3-hydroxyacyl-CoA dehydrogenase. (287 aa)
ML2472Possible prephenate dehydrogenase; Similar to Mycobacterium tuberculosis putative oxidoreductase Rv3754 TR:O69721 (EMBL:AL022121) fasta scores: E(): 0, 80.0% id in 300 aa and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) fasta scores: E(): 1.6e-15, 29.1% id in 285 aa. Contains Pfam match to entry PF02153 PDH, Prephenate dehydrogenase. (327 aa)
fabG4Possible oxidoreductase; The C-terminal portion of the predicted product of this CDS is highly similar to many 3-oxoacyl-[acyl-carrier protein] reductases e.g. Vibrio harveyi FabG SW:FABG_VIBHA (P55336) fasta scores: E(): 4.5e-27, 41.1% id in 241 aa. The N-terminus does not appear to be related to anything currently in the database except for the highly similar Mycobacterium tuberculosis putative 3-oxoacyl-[acyl-carrier protein] reductase RV0242C TR:O53665 (EMBL:AL021929) fasta scores: E(): 0, 84.8% id in 454 aa. Contains Pfam match to entry PF00678 adh_short_C2, Short chain dehydrogen [...] (454 aa)
pntAAPyridine transhydrogenase subunit [alpha]1; Similar to Mycobacterium tuberculosis PntAA OR RV0155 TR:P96832 (EMBL:Z92770) fasta scores: E(): 0, 87.9% id in 365 aa, Haemophilus influenzae NAD PntA SW:PNTA_HAEIN (P43842) fasta scores: E(): 0, 42.6% id in 364 aa, and to Escherichia coli NAD PntA SW:PNTA_ECOLI (P07001; P76888) fasta scores: E(): 0, 42.1% id in 363 aa. Contains Pfam match to entry PF01262 AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase. (367 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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