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fadD10 fadD10 ML1234 ML1234 xclC xclC ML0243 ML0243 fadD28 fadD28 fadD22 fadD22 fadD29 fadD29 fadD32 fadD32 ML2661 ML2661 fadD2 fadD2 fadD26 fadD26 menE menE nrp nrp
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fadD10acyl-CoA synthase; Similar to Mycobacterium tuberculosis putative acyl-CoA synthases e.g. Rv0099 or MTCY251.18 TR:Q10878 (EMBL:Z74410) (540 aa) fasta scores: E(): 0, 74.6% id in 531 aa. Previously sequenced as TR:Q50176 (EMBL:Z46257). Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (532 aa)
ML1234Highly similar to acyl-CoA synthases from Mycobacterium tuberculosis Rv1185c TR:O50441 (EMBL:AL010186) (578 aa); Fasta score E(): 0, 72.4% identity in 579 aa overlap and Mycobacterium bovis TR:P71495 (EMBL:U7568) (582 aa); Fasta score E(): 0, 63.4% identity in 579 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML0100, ML0132, ML0138, ML0243 and ML2358; Belongs to the ATP-dependent AMP-binding enzyme family. (579 aa)
xclCacyl-CoA synthase; Identical to the previously sequenced Mycobacterium leprae XclC TR:Q50017 (EMBL:U15181) (476 aa); Fasta score E(): 0, 99.8% identity in 476 aa overlap. Also highly similar to many others including: Mycobacterium tuberculosis acyl-CoA synthase Rv1193 fadD36 TR:O05295 (EMBL:Z93777) (473 aa); Fasta score E(): 0, 81.3% identity in 476 aa overlap and Escherichia coli long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) SW:LCFA_ECOLI (P29212) (561 aa); Fasta score E(): 1.3e-28, 31.7% identity in 378 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme [...] (476 aa)
ML0243Similar to several putative acyl-CoA synthases from M.tuberculosis e.g. pks16, Rv1013, possible polyketide synthase, TR:O05598 (EMBL:AL123456) (544 aa); Fasta score E(): 0, 82.2% identity in 544 aa overlap. Similar to domains of polyketide synthases e.g. Bacillus subtilis mycA, mycosubtilin synthetase, TR:Q9R9J1 (EMBL:AF184956) (3971 aa); Fasta score E(): 0, 33.7% identity in 404 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature; Similar to ML0887, ML0100, ML0132, ML0138, ML1051, ML1234, ML1994, ML23 [...] (544 aa)
fadD28Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2941, fadD29, putative acyl-CoA synthase, TR:P96290 (EMBL:AL123456) (580 aa); Fasta score E(): 0, 81.9% identity in 580 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 81.4% identity in 580 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 35.8% identity in 590 aa overlap. Contains Pfam match to entry PF0050 [...] (579 aa)
fadD22Putative acyl-CoA synthetase; Similar to M. tuberculosis Rv2948c, acyl-CoA synthase, TR:P96283 (EMBL:AL123456) (705 aa); Fasta score E(): 0, 75.9% identity in 705 aa overlap. Similar to many acyl-CoA synthases e.g. Rhodopseudomonas palustris, badA, benzoate-coenzyme A ligase, TR:Q59760 (EMBL:L42322) (521 aa); Fasta score E(): 0, 31.4% identity in 494 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML1051, ML1994, ML2257 and ML2546. (707 aa)
fadD29Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2950c, fadD29, putative acyl-CoA synthase, TR:P95141 (EMBL:AL123456) (619 aa); Fasta score E(): 0, 80.2% identity in 620 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 58.5% identity in 585 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 36.2% identity in 589 aa overlap. Contains Pfam match to entry PF005 [...] (680 aa)
fadD32Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv3801c, fadD32, putative acyl-CoA synthase, TR:O53580 (EMBL:AL123456) (637 aa); Fasta score E(): 0, 93.2% identity in 632 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 36.8% identity in 581 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 36.4% identity in 605 aa overlap. Contains Pfam match to entry PF005 [...] (635 aa)
ML2661acyl-CoA synthase; Similar to many Prokaryotic and Eukaryotic acyl-CoA synthases including: Mycobacterium tuberculosis fadd7 protein TR:O07169 (EMBL:Z96071) fasta scores: E(): 0, 71.3% in 520 aa, and to Saccharomyces cerevisiae peroxisomal-coenzyme a synthetase SW:FAT2_YEAST (P38137) fasta scores: E(): 0, 35.6% in 526 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (548 aa)
fadD2acyl-CoA synthase; Similar to Rhizobium trifolii malonyl CoA synthetase MATB TR:Q9ZIP5 (EMBL:AF117694) fasta scores: E(): 2.4e-31, 31.2% id in 507 aa and Mycobacterium tuberculosis hypothetical 59.9 kda protein RV0270 TR:P95227 (EMBL:Z86089) fasta scores: E(): 0, 82.3% id in 558 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (548 aa)
fadD26Probable acyl-CoA synthase; Similar to Mycobacterium tuberculosis acyl-CoA synthase Rv1185c TR:O50441 (EMBL:AL010186) (578 aa) fasta scores: E(): 0, 56.9% id in 580 aa, and to Myxococcus xanthus saframycin synthetase B TR:Q50857 (EMBL:U24657) (1770 aa) fasta scores: E(): 0, 36.5% id in 578 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML0132, ML1234, ML0138 and ML0100. (583 aa)
menEO-succinylbenzoic acid-CoA ligase; Similar to Mycobacterium tuberculosis MenE or RV0542C or MTCY25D10.21C TR:O06408 (EMBL:Z95558) fasta scores: E(): 0, 78.3% id in 359 aa, and to Escherichia coli o-succinylbenzoic acid--coa ligase MENE SW:MENE_ECOLI (P37353; P78253; P78178) fasta scores: E(): 7e-18, 30.0% id in 377 aa. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. (368 aa)
nrpProbable peptide synthase; Similar in N-terminus to M. tuberculosis probable peptide synthetase nrp Rv0101 TR:Q10896 (EMBL:Z74410) (2512 aa); Fasta score E(): 0, 65.7% identity in 1089 aa overlap, and to e.g. Streptomyces sp streptothricin peptide synthase TR:O33743 (EMBL:Y10293) (481 aa); Fasta score E(): 5.6e-20, 31.2% identity in 382 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00455 Putative AMP-binding domain signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML1051 and ML0243. (1401 aa)
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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