Putative two-component response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity).

RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

Putative two-component response regulator; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a transcriptional regulator that recognizes a 19-bp nucleotide motif comprizing two loosely conserved 8-bp direct DNA-binding motif repeats separated by a 3-bp spacer region (By similarity).

Possible transcriptional regulator; Highly similar to many from Mycobacterium tuberculosis e.g. probable transcriptional regulatory protein RV1358 TR:Q11028 (EMBL:Z75555) (1159 aa); Fasta score E(): 0, 58.1% identity in 1084 aa overlap. Contains a probable helix-turn-helix motif at aa 1063-1084 (Score 1080, SD +2.87) Contains Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00622 Bacterial regulatory proteins.

Similar to M. tuberculosis Rv0067c, putative transcriptional regulator, TR:O53612 (EMBL:AL123456) (189 aa); Fasta score E(): 0, 68.8% identity in 189 aa overlap. Similar to many putative transcriptional regulators e.g. Streptomyces coelicolor SCF6.16, putative tetR family transcriptional regulator, TR:Q9RJL5 (EMBL:AL121849) (194 aa); Fasta score E(): 2.5e-18, 39.5% identity in 185 aa overlap. Previously sequenced as TR:Q9ZBM6 (EMBL:AL035159) (189 aa); Fasta score E(): 0, 100.0% identity in 189 aa overlap. Contains a probable helix-turn-helix motif at aa 45-66 (Score 1800, SD +5.32) Con [...]

Possible transcriptional regulator; Highly similar to many from Mycobacterium tuberculosis e.g. probable transcriptional regulatory protein RV1358 TR:Q11028 (EMBL:Z75555) (1159 aa); Fasta score E(): 0, 58.1% identity in 1084 aa overlap. Contains a probable helix-turn-helix motif at aa 1063-1084 (Score 1080, SD +2.87) Contains Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00622 Bacterial regulatory proteins.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa); Fasta score E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis RV2069 SW:RPSC_MYCTU (Q10679) (185 aa); Fasta score E(): 0, 81.2% identity in 181 aa overlap. Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Similar to Mycobacterium tuberculosis putative transcriptional regulator Rv3676 or MTV025.024 TR:O69644 (EMBL:AL022121) (224 aa) fasta scores: E(): 0, 96.0% id in 224 aa. Similar to many e.g. Haemophilus influenzae catabolite gene activator crp or cap or HI0957 SW:CRP_HAEIN (P29281) (224 aa) fasta scores: E(): 2.4e-14, 32.6% id in 187 aa. Contains a probable helix-turn-helix motif at aa 175-196 (Score 1990, SD +5.96) Contains Pfam match to entry PF00325 crp, Bacterial regulatory proteins, crp family. Contains Pfam match to entry PF00027 cNMP_binding, Cyclic nucleotide-binding domain.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Transcription elongation factor G; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...]

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Probable transcription termination/antitermination factor; Participates in both transcription termination and antitermination.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Putative transcription termination protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Transcription antitermination protein nusG; Participates in transcription elongation, termination and antitermination.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

[alpha] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

[beta] subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

[beta]' subunit of RNA polymerase; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

ECF subfamily sigma subunit; Highly similar to many proposed ECF-family RNA-polymerase sigma factors including: Mycobacterium tuberculosis SigE TR:O06289 (EMBL:U87242) (257 aa); Fasta score E(): 0, 82.1% identity in 252 aa overlap, Mycobacterium avium SigE TR:O05735 (EMBL:U87308) (251 aa); Fasta score E(): 0, 80.6% identity in 247 aa overlap and Bacillus subtilis SW:SIGW_BACSU (Q45585) (187 aa); Fasta score E(): 2.9e-16, 35.7% identity in 171 aa overlap. Contains a probable helix-turn-helix motif at aa 213-234 (Score 1147, SD +3.09) Contains Pfam match to entry PF00776 Sigma70_ECF, Sig [...]

Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).

Putative transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.